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氯胺酮抗抑郁作用的神经生物学机制研究进展

中国药理学通报 2024年第9期40卷 1622-1627页

作者：周冬雨章文欣翟晓静陈丹丹韩奕季然潘晓媛曹君利张红星江苏省麻醉学重点实验室江苏省麻醉与镇痛应用技术重点实验室国家药品监督管理局麻醉精神药物研究与评价重点实验室江苏徐州221004 徐州医科大学附属医院麻醉科江苏徐州221002

重性抑郁障碍又称临床抑郁症,具有发病率高、致残率高、治愈率低等特点。传统的抗抑郁药物起效缓慢、治愈率低,对难治性抑郁症治疗效果不佳。有研究提示,非选择性N-甲基-D-天门冬氨酸受体拮抗剂氯胺酮,单次亚麻醉剂量治疗即可产生快速... 详细信息

重性抑郁障碍又称临床抑郁症,具有发病率高、致残率高、治愈率低等特点。传统的抗抑郁药物起效缓慢、治愈率低,对难治性抑郁症治疗效果不佳。有研究提示,非选择性N-甲基-D-天门冬氨酸受体拮抗剂氯胺酮,单次亚麻醉剂量治疗即可产生快速起效和持续的抗抑郁作用,并且对难治性抑郁症患者有效,明显缓解了难治性抑郁症患者的自杀倾向,但其作用机制尚不完全清楚。既往研究显示,氯胺酮的抗抑郁作用机制可能涉及单胺能系统、谷氨酸能系统、多巴胺能系统,该文将从以上几个系统分别总结氯胺酮抗抑郁的药理学机制,并对未来的研究方向进行展望。

关键词：氯胺酮抑郁症抗抑郁单胺能系统谷氨酸能系统多巴胺能系统

Relation between microstructure and magnetic properties of shock wave-compressed Nd-Fe-B magnets

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Rare Metals 2022年第7期41卷 2353-2356页

作者： Ming-Gang Zhu Yan-Feng Li Wei Li Li-Yun Zheng dong zhou Hai-Bo Feng Lang Chen An Du Division of Functional Materials Central Iron and Steel Research InstituteBeijing 100081China State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China College of Science Northeastern UniversityShenyang 110819China

The relationship between the microstructure and magnetic properties of Nd-Fe-B sintered magnet compressed by shock wave with 6.26 GPa≤p≤7.16 GPa was *** reveals that Nd-Fe-B magnets show a demagnetization behavior after compressed by shock *** intergranular fracture is the main occurring phe-nomenon in the shock wave-compressed *** coercivity of the shock wave-compressed Nd-Fe-B magnets could be recovered after repeating the annealing *** suggests that only the morphology change just like the intergranular fracture occurs,and there is no structural change in the grain boundary phase in the shock wave-compressed *** phase grain interconnection,microcracks and pores,and alterant orientation relationship between matrix phase and grain boundaries phase are con-sidered as induced factors of demagnetization.

关键词： Permanent magnets Coercivity Shock wave Demagnetization

Clarification of underneath capacity loss for O3-type Ni, co free layered cathodes at high voltage for sodium ion batteries

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Journal of Energy Chemistry 2023年第2期77卷 479-486,I0012页

作者： dong zhou De Ning Jun Wang Jiahua Liu Gaoyuan Zhang Yinguo Xiao Jiaxin Zheng Yongli Li Jie Li Xinzhi Liu Guangdong Provincial Key Laboratory of Magnetoelectric Physics and Devices School of PhysicsSun Yat-sen UniversityGuangzhou 510275GuangdongChina School of Innovation and Entrepreneurship Southern University of Science and TechnologyShenzhen 518055GuangdongChina Centre for Photonics Information and Energy Materials Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055GuangdongChina School of Advanced Materials Peking University Shenzhen Graduate SchoolShenzhen 518055GuangdongChina Institute for Clean Energy Technology North China Electric Power UniversityBeijing 102206China Department of Energy Politecnico di MilanoVia Lambruschini 4Milano 20156Italy Centre for Physical Mechanics and Biophysics School of PhysicsSun Yat-sen UniversityGuangzhou 510275GuangdongChina

Earth abundant O3-type NaFe_(0.5)Mn_(0.5)O_(2)layered oxide is regarded as one of the most promising cathodes for sodium ion batteries due to its low cost and high energy ***,its poor structural stability and cycle life strongly impede the practical ***,the dynamic phase evolution as well as charge compensation mechanism of O3-type NaFe_(0.5)Mn_(0.5)O_(2)cathode during sodiation/desodiation are revealed by a systemic study with operando X-ray diffraction and X-ray absorption spectroscopy,high resolution neutron powder diffraction and neutron pair distribution *** layered structure experiences a phase transition of O3→P3→OP2→ramsdellite during the desodiation,and a new O3’phase is observed at the end of the discharge state(1.5 V).The density functional theory(DFT)calculations and nPDF results suggest that depletion of Na^(+)ions induces the movement of Fe into Na layer resulting the formation of an inert ramsdellite phase thus causing the loss of capacity and structural ***,the operando XAS clarified the voltage regions for active Mn^(3+)/Mn^(4+)and Fe^(3+)/Fe^(4+)redox *** work points out the universal underneath problem for Fe-based layered oxide cathodes when cycled at high voltage and highlights the importance to suppress Fe migration regarding the design of high energy O3-type cathodes for sodium ion batteries.

关键词： Sodium ion batteries Layered oxide cathode Iron migration Operando X-ray absorption spectroscopy Neutron measurements

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有源医疗器械使用期限研究资料常见问题分析

中国医疗器械信息 2024年第1期30卷 15-17,59页

作者：王志远吴璠黄珊珊朱静周冬安徽省药品审评查验中心安徽合肥230041

医疗器械注册申请人应保证医疗器械产品在使用期限内安全有效,并在注册申报时提交使用期限研究资料。文章汇总自2020年4月~2022年1月安徽审评中心受理的有源医疗器械注册申请件,梳理和分析使用期限研究资料的共性问题,总结使用期限研究... 详细信息

医疗器械注册申请人应保证医疗器械产品在使用期限内安全有效,并在注册申报时提交使用期限研究资料。文章汇总自2020年4月~2022年1月安徽审评中心受理的有源医疗器械注册申请件,梳理和分析使用期限研究资料的共性问题,总结使用期限研究的重难点。以期帮助申请人提高注册申报资料的完整性和合规性,提升使用期限研究的科学性和系统性,在加快医疗器械产品上市的同时保证质量可靠。

关键词：有源医疗器械使用期限研究资料技术审评

Nonlinear Registration of Brain Magnetic Resonance Images with Cross Constraints of Intensity and Structure

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Computers, Materials & Continua 2024年第5期79卷 2295-2313页

作者： Han zhou HongtaoXu Xinyue Chang Wei Zhang Heng dong Digital Fujian Research Institute of Big Data forAgriculture and Forestry Fujian Agriculture and Forestry UniversityFuzhou350002China College of Computer and Information Science Fujian Agriculture and Forestry UniversityFuzhou350002China

Many deep learning-based registration methods rely on a single-stream encoder-decoder network for computing deformation fields between 3D ***,these methods often lack constraint information and overlook semantic consistency,limiting their *** address these issues,we present a novel approach for medical image registration called theDual-VoxelMorph,featuring a dual-channel cross-constraint *** innovative network utilizes both intensity and segmentation images,which share identical semantic information and feature *** encoder-decoder structures calculate deformation fields for intensity and segmentation images,as generated by the dual-channel cross-constraint *** design facilitates bidirectional communication between grayscale and segmentation information,enabling the model to better learn the corresponding grayscale and segmentation details of the same anatomical *** ensure semantic and directional consistency,we introduce constraints and apply the cosine similarity function to enhance semantic *** on four public datasets demonstrates superior performance compared to the baselinemethod,achieving Dice scores of 79.9%,64.5%,69.9%,and 63.5%for OASIS-1,OASIS-3,LPBA40,and ADNI,respectively.

关键词： Medical image registration cross constraint semantic consistency directional consistency dual-channel

Ecological effect of the plantation of Sabina vulgaris in the Mu Us Sandy Land,China

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Journal of Arid Land 2024年第1期16卷 14-28页

作者： NAN Weige dong Zhibao zhou Zhengchao LI Qiang CHEN Guoxiang School of Geography and Tourism Shaanxi Normal UniversityXi'an 710062China Shaanxi Key Laboratory of Ecological Restoration in Shaanbei Mining Area Yulin UniversityYulin 719000China College of Prataculture Gansu Agricultural UniversityLanzhou 730070China

Vegetation restoration through artificial plantation is an effective method to combat desertification,especially in arid and semi-arid *** study aimed to explore the ecological effect of the plantation of Sabina vulgaris on soil physical and chemical properties on the southeastern fringe of the Mu Us Sandy Land,*** collected soil samples from five depth layers(0-20,20-40,40-60,60-80,and 80-100 cm)in the *** plantation plots across four plantation ages(4,7,10,and 16 years)in November 2019,and assessed soil physical(soil bulk density,soil porosity,and soil particle size)and chemical(soil organic carbon(SOC),total nitrogen(TN),available nitrogen(AN),available phosphorus(AP),available potassium(AK),cation-exchange capacity(CEC),salinity,p H,and C/N ratio)*** results indicated that the soil predominantly consisted of sand particles(94.27%-99.67%),with the remainder being silt and *** plantation age increased,silt and very fine sand contents progressively *** 16 years of planting,there was a marked reduction in the mean soil particle *** initial soil fertility was low and declined from 4 to 10 years of planting before witnessing an *** positive correlations were observed for the clay,silt,and very fine sand(mean diameter of 0.000-0.100 mm)with SOC,AK,and p *** contrast,fine sand and medium sand(mean diameter of 0.100-0.500 mm)showed significant negative correlations with these *** findings ascertain that the plantation of *** requires 10 years to effectively act as a windbreak and contribute to sand fixation,and needs 16 years to improve soil physical and chemical ***,these improvements were found to be highly beneficial for vegetation restoration in arid and semi-arid *** research can offer valuable insights for the protection and restoration of the vegetation ecosystem in the sandy lands in China.

关键词： Sabina vulgaris plantation age soil physical and chemical properties soil particle size soil fertility vegetation restoration Mu Us Sandy Land

Corrosion of Duplex Stainless Steel Manufactured by Laser Powder Bed Fusion: A Critical Review

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Acta Metallurgica Sinica(English Letters) 2024年第4期37卷 587-606页

作者： Yiqi zhou Decheng Kong Ruixue Li Xing He Chaofang dong Beijing Advanced Innovation Center for Materials Genome Engineering Institute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing100083China Shanghai Key Laboratory of Advanced High-Temperature Materials and Precision Forming School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai200240China

Laser powder bed fusion (LPBF) is a commonly used additive manufacturing (AM) method for efficiently producing intricate geometric components. This investigation examines factors such as pores, cellular structure, grain size, and inclusions from the manufacturing process that contribute to the corrosion resistance of LPBF DSS. Furthermore, the as-built LPBF duplex stainless steel (DSS) is primarily ferrite due to the rapid cooling process. Therefore, the transformation of ferrite to austenite after various heat treatments in LPBF DSS and its corresponding corrosion resistance are presented. Additionally, a new mixed powder method is proposed to increase the austenite content in the as-built LPBF DSS. This review also focuses on the passivation capability and pitting corrosion performance in LPBF and conventional DSS. This article summarizes the variations in microstructure between as-built and heat-treated LPBF DSS, with their impacts on corrosion resistance, offering insights for manufacturing highly corrosion-resistant LPBF DSS.

关键词： Laser powder bed fusion Duplex stainless steel Microstructure Heat treatment Passivation Pitting corrosion

Effect of Mn Addition and Heat Treatment on the Corrosion Behaviour of Mg-Ag-Mn Alloy

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Acta Metallurgica Sinica(English Letters) 2024年第4期37卷 665-677页

作者： You Lv Yupeng Zhang Xi Liu Zehua dong Xiaorong zhou Xinxin Zhang Key Laboratory of Material Chemistry for Energy Conversion and Storage Ministry of EducationHubei Key Laboratory of Material Chemistry and Service FailureSchool of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan430074China Hubei Engineering Research Centre for Biomaterials and Medical Protective Materials Huazhong University of Science and TechnologyWuhan430074China Corrosion and Protection Centre Department of MaterialsThe University of ManchesterManchesterM139PLUK

The high corrosion sensitivity and the potential bio-toxicity of Mg-Ag alloys limit their wide applications for the production of implanted devices. In the present work, Mn is added into the Mg-Ag alloy to optimize its corrosion behaviour. The corrosion behaviour of Mg-Ag-Mn alloys is investigated with the underlying microstructural factors examined. The Mg-Ag alloy with 2 wt% Mn exhibits the highest corrosion resistance after post-casting heat treatment at 440 ℃. The addition of Mn results in α-Mn phase with the incorporation of Fe, which suppresses the cathodic activity of impurity Fe. Further, heat treatment of the cast alloys homogenizes the distribution of Ag and promotes the precipitation of α-Mn phase. The former removes Ag segregations as potential cathodes;the latter promotes a more uniform distribution of cathodes and, therefore, prevents localized corrosion.

关键词： Mg-Ag alloy Mn addition Post-casting heat treatment Cathodic activity Corrosion mechanism

Crack identification in concrete, using digital image correlation and neural network

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Frontiers of Structural and Civil Engineering 2024年第4期18卷 536-550页

作者： Jingyi WANG dong LEI Kaiyang zhou Jintao HE Feipeng ZHU Pengxiang BAI College of Mechanics and Materials Hohai UniversityNanjing 211100China

In engineering applications,concrete crack monitoring is very *** methods are of low efficiency,low accuracy,have poor timeliness,and are applicable in only a limited number of ***,more comprehensive detection of concrete damage under different scenarios is of high value for practical engineering *** image correlation(DIC)technology can provide a large amount of experimental data,and neural network(NN)can process very rich ***,NN,including convolutional neural networks(CNN)and back propagation neural networks(BP),can be combined with DIC technology to analyze experimental data of three-point bending of plain concrete and four-point bending of reinforced *** addition,strain parameters can be used for training,and displacement parameters can be added for comprehensive *** data obtained by DIC technology are grouped for training,and the recognition results of NN show that the combination of strain and displacement parameters,i.e.,the response of specimen surface and whole body,can make results more objective and *** identification results obtained by CNN and BP show that these technologies can accurately identify *** identification results for reinforced concrete specimens are less affected by noise than those of plain concrete *** is more convenient because it can identify some features directly from images,recognizing the cracks formed by macro *** can issue early warning of the microscopic cracks,but it requires a large amount of data and *** can be seen that CNN is more intuitive and efficient in image processing,and is suitable when low accuracy is adequate,while BP is suitable for occasions with greater accuracy *** two tools have advantages in different situations,and together they can play an important role in engineering monitoring.

关键词： digital image correlation convolutional neural network back propagation neural neural network damage detection concrete