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Delayed arterial symptomatic epidural hematoma on the 14th day after posterior lumbar interbody fusion:A case report

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World Journal of Clinical Cases 2022年第22期10卷 7973-7981页

作者： Shen-Shen hao Zhen-fu Gao Hong-Ke Li Shuai Liu Sheng-Li dong Hong-Lei Chen Zhi-Fang Zhang Department of Spine and Bone Oncology General Hospital of Pingmei Shenma Medical GroupPingdingshan 467000Henan ProvinceChina

BACKGROUND Delayed arterial symptomatic epidural hematoma(SEH)on the 14th day after posterior lumbar interbody fusion(PLIF)is rare but it may lead to severe complications if not identified and treated in a timely *** diagnosis of the current case,early surgical removal of the hematoma and strict hemostasis treatment was *** case report highlights the importance of swift diagnosis and treatment in SEH *** SUMMARY A 41-year-old male patient with a single-segment lumbar disc herniation underwent left-side *** the 14th post-operative day,the patient complained of lumbar incision pain with sudden onset accompanied by left limb radiation pain and aggravated cauda equina *** resonance imaging examination and a puncture blood draw at the incision site confirmed a delayed arterial *** surgical removal of the hematoma and hemostasis was *** 70 mL of hematoma was found in the left *** bleeding was found in the anterior branch of the transverse process of the 4th lumbar artery in the muscle area about 2 cm below the transverse process of the 4th lumbar vertebra.A blood jet of about 10 cm in height was observed and bipolar electrocoagulation was used to stop the ***-operative lumbar incision pain and left lower limb pain were relieved immediately and gradually *** was no recurrence during the 12-mo *** For delayed arterial SEH on the 14th day after PLIF,preventive measures including pre-,intra-and post-operative prevention should be implemented.

关键词： Delayed arterial symptomatic epidural hematoma Treatment methods Preventive measures Posterior lumbar interbody fusion Case report

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Box-Behnken响应面法优化竹沥半夏炮制工艺

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时珍国医国药 2024年第2期35卷 352-355页

作者：罗美美朱伟豪郑琳玉朱星宇梅春梅陈富贵赵雨薇郝芳雨胡晓芳李伟东南京中医药大学药学院江苏南京210023 江苏省中药炮制重点实验室江苏南京210023

目的优化竹沥半夏炮制工艺,为竹沥半夏饮片临方炮制规范化研究提供参考。方法采用Box-Behnken响应面法设计分析,以浸出物、次黄嘌呤、尿苷、腺嘌呤、鸟苷的综合评分为评价指标,考察竹沥半夏辅料用量、炮制时间、干燥温度等3个因素,对竹... 详细信息

目的优化竹沥半夏炮制工艺,为竹沥半夏饮片临方炮制规范化研究提供参考。方法采用Box-Behnken响应面法设计分析,以浸出物、次黄嘌呤、尿苷、腺嘌呤、鸟苷的综合评分为评价指标,考察竹沥半夏辅料用量、炮制时间、干燥温度等3个因素,对竹沥半夏炮制工艺进行优选,同时对最佳工艺进行验证。结果竹沥半夏最佳炮制工艺为:每100 g姜半夏,鲜竹沥15 g,炮制时间1 h,干燥温度44℃。结论该工艺简易可行、竹沥半夏质量稳定可靠,为竹沥半夏的临床应用提供了科学依据。

关键词：竹沥半夏 Box-Behnken响应面法炮制工艺总评归一值

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Using preoperative N-terminal pro-B-type natriuretic peptide levels for predicting major adverse cardiovascular events and myocardial injury after noncardiac surgery in Chinese advanced-age patients

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Journal of Geriatric Cardiology 2022年第10期19卷 768-779页

作者： Kai ZHANG Chang LIU Jian TAN Yu-Hai XU Jiang-Bei CAO Yan-Hong LIU Qiang fu Jing-Sheng LOU Wei-dong MI hao LI Department of Anesthesiology the First Medical CentreChinese PLA General HospitalBeijingChina Medical School of Chinese PLA BeijingChina Department of Thoracic Surgery the Seventh Medical CentreChinese PLA General HospitalBeijingChina Department of Anesthesiology Air Force Medical CenterBeijingChina

BACKGROUND N-terminal pro-B-type natriuretic peptide(NT-proBNP)is often viewed as an indicator for heart ***,the prognostic association and the predictive utility of NT-proBNP for postoperative major adverse cardiovascular events(MACEs)and myocardial injury after noncardiac surgery(MINS)among older patients are *** In this study,we included 5033 patients aged 65 years or older who underwent noncardiac surgery with preoperative NT-proBNP *** regression was adopted to model the associations between preoperative NT-proBNP and the risk of MACEs and *** receiver operating characteristic curve was used to determine the predictive value of *** A total of 5033 patients were enrolled,63 patients(1.25%)and 525 patients(10.43%)had incident postoperative MACEs and MINS,*** of the receiver operating characteristic curve indicated that the cutoff values of ln(NT-proBNP)for MACEs and MINS were 5.16(174 pg/mL)and 5.30(200 pg/mL),*** preoperative ln(NT-proBNP)to the Revised Cardiac Risk Index score and the Cardiac and Stroke Risk Model boosted the area under the receiver operating characteristic curves from 0.682 to 0.726 and 0.787 to 0.804,*** inclusion of preoperative NT-proBNP in the prediction models significantly increased the reclassification and *** Increased preoperative NT-proBNP was associated with a higher risk of postoperative MACEs and *** inclusion of NT-proBNP enhances the predictive ability of the preexisting models.

关键词： patients preoperative surgery

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Nonlinear Propagation of Coupling Optical Pulse under Compton Scattering in Laser Medium

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Semiconductor Photonics and Technology 2006年第3期12卷 178-183,204页

作者： hao dong-shan ZHANG Xiao-fu Department of Electronic Science and Engineering Huanghuai University Zhumadian 463000 CHN

After considering Kerr nonlinear effect, group velocity dispersion of host and gain distribution of active particle in laser amplifying medium, a basic equation describing propagation of the coupling optical pulse under the multi-photon nonlinear Compton scattering in the laser amplifying medium has been deduced. Besides, the profile and power spectrum of a picosecond-level super-Gaussian coupling pulse in the laser amplifying medium have been discussed when its central frequency coincides with the gain peak frequency of the laser amplifying medium.

关键词： Laser amplifying medium Compton scattering Group velocity dispersion Gain distribution

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Engineered AAV13 variants with enhanced transduction and confined spread

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动物学研究 2024年第4期 781页

作者： Neng-Song Luo Yu-Xiang Cai Zeng-Peng Han Xiao-Kai Sui Wen-Jia Yuan Zi-Lian Zhang hao-dong Guo Jie Wang Kun-Zhang Lin fu-Qiang Xu

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赵炳南经验治疗乳腺疾病探析

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现代中医临床 2024年第5期31卷 112-116页

作者：张董晓王梦洁付娜黄巧赵文洁东浩周玉首都医科大学附属北京中医医院北京100010

赵炳南老师为杰出中医外科专家,其学术思想对外科各专业都具有深远影响和指导价值。本文总结赵老学术思想在乳腺疾病中的应用,如其针对外科疑难杂症使用的调和阴阳法,创立的沟通内外、条达阴阳的四藤组合;外治特色如自创外治药物黑布药... 详细信息

赵炳南老师为杰出中医外科专家,其学术思想对外科各专业都具有深远影响和指导价值。本文总结赵老学术思想在乳腺疾病中的应用,如其针对外科疑难杂症使用的调和阴阳法,创立的沟通内外、条达阴阳的四藤组合;外治特色如自创外治药物黑布药膏及在外治剂型上传承和发展,使用内裹药捻对窦道的治疗;外治理论的创新如首次明确提出引血疗法可用于阴证治疗及在复杂性疾病中提出的具有半清半托、半补半托的“缓托法”;赵老尤为重视脾胃,在饮食宜忌等方面也有其个人观点。本文总结名家经验,与同道共同提高。

关键词：赵炳南学术思想乳腺疾病中医外科

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Jiao-tai-wan Up-regulates Hypothalamic and Peripheral Circadian Clock Gene Cryptochrome and Activates PI3K/AKT Signaling in Partially Sleep-deprived Rats

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Current Medical Science 2018年第4期38卷 704-713页

作者： Wen-ya HUANG Xin ZOU fu-er LU hao SU Chu ZHANG Yan-lin REN Ke FANG Li-jun XU Kai- fu WANG Qing-jie CHEN Hui dong Institute of Integrated Traditional Chinese and Western Medicine Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Department of Biochemistry and Molecular Biology Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

This study aims to explore the effect and mechanism of Jiao-tai-wan （JTW） on systemic and tissue-specific inflammation and insulin resistance in obesity-resistant （OR） rats with chronic partial sleep deprivation （PSD）. OR rats with PSD were orally given JTW and Estazolam for 4 weeks. The amount of food intake and metabolic parameters such as body weight increase rate, fasting plasma glucose （FPG）, fasting insulin （FINS）, homeostasis model assessment-insulin resistance （HOMA-IR） and plasma inflammatory markers were measured. The expression levels of circadian proteins cryptochrome 1 （Cryl） and cryptochrome 2 （Cry2） in hypothalamus, adipose and liver tissues were also determined. Meanwhile, the mRNA expression of inflammatory markers, activity of nuclear factor kappa B （NF-κB） p65 protein, as well as the expression levels of insulin signaling pathway proteins in hypothalamus, adipose and liver tissues were measured. Additionally, cyclic adenosine 3＇, 5＇-monophosphate （cAMP） and activity of vasodilator-stimulated phosphoprotein （VASP） in hypothalamus tissue were measured. JTW significantly decreased the body weight increase rate and food intake, ameliorated systemic inflammation and insulin resistance. JTW effectively ameliorated inflammation and increased PI3K/AKT signaling activation in hypothalamus, adipose and liver. Interestingly, all these changes were associated with the up-regulation of circadian gene Cryl and Cry2 protein expression. We also found that in hypothalamus tissue of PSD rats, down-regulation of Cryl and Cry2 activated cAMP/PKA signaling and then led to inflammation, while JTW inhibited this signaling. These results suggested that JTW has the beneficial effect on ameliorating inflammation and insulin resistance in partially sleep-deprived rats by up-regulating Cry expression.

关键词： Jiao-tai-wan PI3K/AKT signaling cryptochrome sleep deprivation inflammation insulin resistance

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Anisotropic interfacial superconductivity induced at point contacts on topological semimetal grey arsenic

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中国科学:物理学、力学、天文学英文版 2023年第9期66卷 94-101页

作者： Meng-Di Zhang Qing Wang Xing-Yuan Hou Ling-Xiao Zhao Zong Wang Ya-dong Gu Fan Zhang Zhi-An Ren Gen-fu Chen Ning hao Lei Shan Beijing Academy of Quantum Information Sciences Beijing 100193China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Anhui Province Key Laboratory of Condensed Matter Physics at Extreme Conditions High Magnetic Field LaboratoryChinese Academy of SciencesHefei 230031China Science Island Branch of Graduate School University of Science and Technology of ChinaHefei 230026China Information Materials and Intelligent Sensing Laboratory of Anhui Province Institute of Physical Science and Information TechnologyAnhui UniversityHefei 230601China Key Laboratory of Structure and functional Regulation of Hybrid Materials(Anhui University) Ministry of EducationHefei 230601China Center of Free Electron Laser&High Magnetic Field Anhui UniversityHefei 230601China Songshan Lake Materials Laboratory Dongguan 523808China

The origin of superconductivity observed at the point contact between the normal metal tip and the topological material remains uncertain due to the potential presence of superconducting elements or allotropes *** is imperative to seek out a topological material entirely free of superconducting impurities and induce superconductivity between it and normal tips to verify the source of the induced ***,we report the observation of superconductivity up to 9 K induced at point contacts between normal metal tips and the topological material grey arsenic,which is free of *** determined temperature dependencies of superconducting gapsΔ(T)deviate from the Bardeen-Cooper-Schriefer(BCS)superconductivity law,exhibiting abnormal ***,the highly anisotropic upper critical field H_(c2)(T)suggests the anisotropy of the projected interfacial Fermi *** tuning the junction resistance,we obtained a negative correlation between the superconducting gapΔand the efective barrier height Z,which validates the interfacial coupling strength as a key factor in the observed tip-induced *** experimental results provide guidance for the relevant theory about tip-induced superconductivity on topological materials.

关键词： tip-induced superconductivity topological material interfacial superconductivity grey As

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枣庄市药用植物资源现状及中药材产业发展分析

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中国现代中药 2024年第4期26卷 609-615页

作者：沈亮马坤褚福浩梁继荣李润东陆希锋陈曦国家自然博物馆北京100050 枣庄市生态环境局台儿庄分局山东枣庄277400 北京中医药大学北京102401 枣庄市中医医院山东枣庄277099 枣庄市营养学会山东枣庄277000

目的:对山东省枣庄市药用植物资源现状进行调研,为该市中药材产业发展提供依据。方法:依据第四次全国中药资源普查相关数据,结合实地调查和走访,同时采用天眼查征信平台查询和SWOT分析法对枣庄市中药材产业发展现状进行分析,找出存在的... 详细信息

目的:对山东省枣庄市药用植物资源现状进行调研,为该市中药材产业发展提供依据。方法:依据第四次全国中药资源普查相关数据,结合实地调查和走访,同时采用天眼查征信平台查询和SWOT分析法对枣庄市中药材产业发展现状进行分析,找出存在的问题并提出建议。结果:枣庄市现有药用植物460余种,野生资源蕴藏量较大的有侧柏、酸枣和野胡萝卜等,种植面积超过10万亩(1亩≈666.67 m^(2))的药用植物有花椒、石榴、枣、山楂等;中药材产业以小型农业合作社为主,规模小且分散,主要分布在滕州市、山亭区和市中区,缺少大型医药企业。SWOT分析表明,壮大酸枣仁、大枣、石榴皮、花椒等特色中药材产业规模,扶持中药材加工企业,引进及培养科技人才可促进该市中药材产业的健康快速发展。结论:枣庄市药用植物资源丰富,研究结果可为该市中药材产业发展提供参考。

关键词：枣庄市中药材资源调查种植产业 SWOT分析

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Searching for^(76)Ge neutrinoless double beta decay with the CDEX-1B experiment

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Chinese Physics C 2024年第10期48卷 11-22页

作者： Bing-Tao Zhang Jun-Zheng Wang Li-Tao Yang Qian Yue Ke-Jun Kang Yuan-Jing Li Hai-Peng An C.Greeshma Jian-Ping Chang Yun-Huan Chen Jian-Ping Cheng Wen-Han Dai Zhi Deng Chang-hao Fang Xin-Ping Geng Hui Gong Qiu-Ju Guo Xu-Yuan Guo Li He Sheng-Ming He Jin-Wei Hu Han-Xiong Huang Tu-Chen Huang Hai-Tao Jia Xi Jiang S.Karmakar hao-Bin Li Jian-Min Li Jin Li Qian-Yun Li Ren-Ming-Jie Li Xue-Qian Li Yu-Lan Li Yi-Fan Liang Bin Liao Fong-Kay Lin Shin-Ted Lin Jia-Xuan Liu Shu-Kui Liu Yan-dong Liu Yu Liu Yuan-Yuan Liu Zhong-Zhi Liu hao Ma Yu-Cai Mao Qi-Yuan Nie Jin-Hua Ning Hui Pan Ning-Chun Qi Jie Ren Xi-Chao Ruan Ze She Manoj Kumar Singh Tian-Xi Sun Chang-Jian Tang Wei-You Tang Yang Tian Guang-fu Wang Li Wang Qing Wang Yu-Feng Wang Yun-Xiang Wang Henry-Tsz-King Wong Shi-Yong Wu Yu-Cheng Wu hao-Yang Xing Rui Xu Yin Xu Tao Xue Yu-Lu Yan Nan Yi Chun-Xu Yu Hai-Jun Yu Jian-Feng Yue Ming Zeng Zhi Zeng Feng-Shou Zhang Lei Zhang Zhen-Hua Zhang Zhen-Yu Zhang Kang-Kang Zhao Ming-Gang Zhao Ji-Fang Zhou Zu-Ying Zhou Jing-Jun Zhou Key Laboratory of Particle and Radiation Imaging(Ministry of Education)and Department of Engineering Physics Tsinghua UniversityBeijing 100084 Department of Physics Tsinghua UniversityBeijing 100084 Institute of Physics Academia SinicaTaipei 11529 NUCTECH Company Beijing 100084 YaLong River Hydropower Development Company Chengdu 610051 College of Nuclear Science and Technology Beijing Normal UniversityBeijing 100875 College of Physics Sichuan UniversityChengdu 610065 School of Physics Peking UniversityBeijing 100871 Department of Nuclear Physics China Institute of Atomic EnergyBeijing 102413 Sino-French Institute of Nuclear and Technology Sun Yat-sen UniversityZhuhai 519082 School of Physics Nankai UniversityTianjin 300071 Department of Physics Banaras Hindu UniversityVaranasi 221005 Department of Physics Beijing Normal UniversityBeijing 100875

We operated a p-type point contact high purity germanium(PPCGe)detector(CDEX-1B,1.008 kg)in the China Jinping Underground Laboratory(CJPL)for 500.3 days to search for neutrinoless double beta(0νββ)decay of^(76)Ge.A total of 504.3 kg⋅day effective exposure data was *** anti-coincidence and the multi/single-site event(MSE/SSE)discrimination methods were used to suppress the background in the energy region of interest(ROI,1989–2089 keV for this work)with a factor of 23.A background level of 0.33 counts/(keV⋅kg⋅yr)was *** lower limit on the half life of^(76)Ge 0νββdecay was constrained as T_(1/2)^(0ν)>1.0×10^(23)yr(90%C.L.),corresponding to the upper limits on the effective Majorana neutrino mass:<3.2–7.5 eV.

关键词： neutrinoless double beta decay CDEX point-contact germanium detector ^(76)Ge

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