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Neuroprotective Effect and Mechanism of Tanreqing Injection on Ischemic Stroke:Insights from Network Pharmacology and in vivo Experiments

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Chinese Journal of Integrative Medicine 2024年第8期30卷 713-720页

作者： LI Zhong-hao PU xiao-qi LI Sha-sha dong xiao-ke ZHANG Guo-qiang WANG Yu LIU Jin-min Department of Emergency China-Japan Friendship HospitalBeijing100029China Department of Neurology Beijing University of Chinese Medicine Dongfang HospitalBeijing100078China Department of Radiology China-Japan Friendship HospitalBeijing100029China Graduate School Beijing University of Chinese MedicineBeijing100029China

Objective To explore the neuroprotective effects and mechanism of Tanreqing Injection(TRQ)on treating ischemic stroke based on network pharmacology and in vivo experimental *** The chemical compounds of TRQ were retrieved based on published data,with targets retrieved from PubChem,Therapeutic Target Database and *** visualization and analysis were performed using Cytoscape,with protein-protein interaction networks derived from the STRING *** analysis was performed using Kyoto Encyclopedia of Genes Genomes pathway and Gene Ontology *** in vivo experiments,the middle cerebral artery occlusion(MCAO)model was *** volume was determined by 2,3,5-triphenyltetrazolium hydrochloride staining and protein expressions were analyzed by Western *** docking was performed to predict ligand-receptor *** We screened 81 chemical compounds in TRQ and retrieved their therapeutic *** the targets,116 were therapeutic targets for *** enrichment analysis showed that the apelin signaling pathway was a key pathway for ischemic ***,in in vivo experiment we found that administering with intraperitoneal injection of 2.5 mL/kg TRQ every 6 h could significantly reduce the infarct volume of MCAO rats(P<0.05).In addition,protein levels of the apelin receptor(APJ)/phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)pathway were increased by TRQ(P<0.05).In addition,41 chemical compounds in TRQ could bind to *** The neuroprotective effect of TRQ may be related to the APJ/PI3K/AKT signaling ***,further studies are needed to confirm the findings.

关键词： Tanreqing Injection Chinese medicine ischemic stroke middle cerebral artery occlusion quantitative estimate of drug-likeness

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RELATIONSHIP OF HOMOCYSTEINE AND GENE POLYMORPHISMS OF ITS RELATED METABOLIC ENZYMES WITH ALZHEIMER'S DISEASE

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Chinese Medical Sciences Journal 2005年第4期20卷 247-251,页

作者： Ying-dong Zhang xiao-yan ke Wei Shen Yang Liu Neuropsychiatric Institute Nanjing Brain Hospital Nanjing Medical University Nanjing 210029

Objective To investigate the relationship of plasma homocysteine (Hcy) levels and the gene polymorphisms of N5, N10-methylenetetrahydrofolate reductase (MTHFR), cystathionine β-synthase (CBS) with Alzheimer’s disease (AD). Methods Plasma Hcy levels were measured by means of high voltage capillary electrophoresis with ultra-violet detection, the polymorphisms of C677T in exon 4 of MTHFR gene and 844ins68 in exon 8 of CBS gene were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 105 AD patients and 102 non-AD controls. All controls were excluded from cardiocerebrovascular disorders and other diseases. Results The plasma Hcy level in AD patients (16.04 ± 3.84 μmol/L) was significantly higher than that in the controls(11.94 ± 3.87 μmol/L, P < 0.001). There were no significant differences of the genotype and allele frequencies of MTHFR C677T mutation and CBS 844ins68 mutation between the patients and controls. However, the T allele of MTHFR gene was found to relate with the plasma Hcy level increase in all subjects. Conclusion The elevated plasma Hcy level in AD patients is probably involved in the pathogenesis of AD, which may be due to the environmental factor rather than genetic factors of the mutations of MTHFR and CBS.

关键词： Alzheimer's disease homocysteine N^5, N^10-methylenetetrahydrofolate reductase cystathionine [3-synthase

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New clinical trial design in precision medicine:discovery,development and direction

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1293-1321页

作者： xiao-Peng Duan Bao-dong Qin xiao-dong Jiao ke Liu Zhan Wang Yuan-Sheng Zang Department of Medical Oncology Changzheng HospitalNaval Medical UniversityShanghaiChina

In the era of precision medicine,it has been increasingly recognized that individuals with a certain disease are complex and different from each *** to the underestimation of the significant heterogeneity across participants in traditional"one-sizefits-all"trials,patient-centered trials that could provide optimal therapy customization to individuals with specific biomarkers were developed including the basket,umbrella,and platform trial designs under the master protocol *** recent years,the successive FDA approval of indications based on biomarker-guided master protocol designs has demonstrated that these new clinical trials are ushering in tremendous *** the rapid increase in the number of basket,umbrella,and platform trials,the current clinical and research understanding of these new trial designs,as compared with traditional trial designs,remains *** majority of the research focuses on methodologies,and there is a lack of in-depth insight concerning the underlying biological logic of these new clinical trial ***,we provide this comprehensive review of the discovery and development of basket,umbrella,and platform trials and their underlying logic from the perspective of precision ***,we discuss future directions on the potential development of these new clinical design in view of the"Precision Pro","Dynamic Precision",and"Intelligent Precision".This review would assist trial-related researchers to enhance the innovation and feasibility of clinical trial designs by expounding the underlying logic,which be essential to accelerate the progression of precision medicine.

关键词： clinical approval successive

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基于缺铁诊断指标筛选的猕猴桃叶片黄化诱因分析

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植物营养与肥料学报 2024年第3期30卷 550-562页

作者：王南南董晓珂牛友怡陈元磊洪蔚金马百全袁雨婷冯亚青刘占德西北农林科技大学园艺学院陕西杨凌712100

[目的]筛选适宜的缺铁诊断指标,据此分析导致陕西关中地区猕猴桃园叶片黄化的主要因子,并利用施肥矫治试验对该因子进行验证,为猕猴桃叶片黄化防控提供理论依据。[方法]在陕西关中地区,依据叶片黄化后土施Fe-EDDHA可以复绿确定了3个缺... 详细信息

[目的]筛选适宜的缺铁诊断指标,据此分析导致陕西关中地区猕猴桃园叶片黄化的主要因子,并利用施肥矫治试验对该因子进行验证,为猕猴桃叶片黄化防控提供理论依据。[方法]在陕西关中地区,依据叶片黄化后土施Fe-EDDHA可以复绿确定了3个缺铁猕猴桃果园,采集当年强旺营养枝顶端第2~3个叶片,共采集不同黄化度叶片64份,缺铁叶片样品的黄化度以SPAD值表征,将SPAD值与5个缺铁诊断指标进行相关分析。在关中地区选择5个健康果园、80个出现不同程度黄化症状的猕猴桃果园,采集叶片样品,将黄化果园叶片按照黄化程度分为绿叶、轻度黄化叶和重度黄化叶,测定12种元素、活性铁和硝态氮含量及SPAD值,并将其与SPAD值进行相关分析。在85个果园各采集1份土壤样品,分析其基础理化性状。选择两个黄化果园进行施肥矫治效果验证。[结果]64份缺铁黄化叶片中,鲜样邻二氮菲浸提铁与其SPAD值的相关性明显高于干样全铁、0.1 mol/L盐酸浸提铁、1 mol/L盐酸浸提铁和鲜样1 mol/L盐酸浸提铁,说明鲜样邻二氮菲浸提铁最适于猕猴桃缺铁的黄化诊断。健康园绿叶和黄化园绿叶中所测的12种元素、活性铁和硝态氮含量均无显著差异。SPAD和邻二氮菲浸提铁含量的顺序为黄化园绿叶>轻度黄化叶>重度黄化叶,而叶片硝态氮、磷、钾和硼含量则相反。轻度和重度黄化叶钙、全铁和锰含量低于绿叶。相关分析表明,猕猴桃叶片SPAD与叶片邻二氮菲浸提铁、全铁、锰和钙含量正相关,而与叶片钾、磷、硝态氮、全氮、硼、铜等含量负相关。随机森林和通径分析进一步表明,与猕猴桃叶片黄化关系最密切的指标为邻二氮菲浸提铁、钾及硝态氮。线性加平台函数拟合表明,邻二氮菲浸提铁5.084 mg/kg是猕猴桃叶片缺铁黄化诊断的临界值。土壤分析结果表明,黄化园土壤pH和碳酸氢根含量均偏高,而速效钾和硝态氮含量均适宜,说明土壤重碳酸盐诱发缺铁很可能是导致叶片黄化的主要原因。与健康园相比,黄化园土壤阳离子交换量偏低,说明叶片黄化还与土壤阳离子交换能力不足有关。施用Fe-EDDHA和蓝铁矿[Fe_(3)(PO_(4))_(2)·8H_(2)O]均可提高叶片SPAD和邻二氮菲浸提铁含量,降低叶片钾和硝态氮含量,从而矫治猕猴桃叶片缺铁黄化。[结论]叶片鲜样中邻二氮菲铁最适于猕猴桃缺铁黄化诊断,其临界浓度为5.084 mg/kg。陕西关中地区猕猴桃园叶片黄化主要是由土壤重碳酸盐诱发缺铁所致,且与土壤阳离子交换能力不足有关;黄化叶中钾和硝态氮的累积是由缺铁造成的。因此,生产上应注意黄化园铁肥的补充和土壤阳离子交换能力的提升。

关键词：猕猴桃缺铁黄化缺铁诊断邻二氮菲浸提铁叶片养分土壤肥力

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Evaluating effectiveness and safety of combined percutaneous transhepatic gallbladder drainage and laparoscopic cholecystectomy in acute cholecystitis patients:Meta-analysis

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1407-1419页

作者： Yu Li Wei-ke xiao xiao-Jun Li Hui-Yuan dong Department of General Surgery No.942 Hospital of PLAYinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Acute cholecystitis(AC)is a common disease in general *** cholecystectomy(LC)is widely recognized as the"gold standard"surgical procedure for treating *** low-risk patients without complications,LC is the recommended treatment plan,but there is still controversy regarding the treatment strategy for moderate AC patients,which relies more on the surgeon's experience and the medical platform of the visiting *** transhepatic gallbladder puncture drainage(PTGBD)can effectively alleviate gallbladder inflammation,reduce gallbladder wall edema and adhesion around the gallbladder,and create a"time window"for elective *** To compare the clinical efficacy and safety of LC or PTGBD combined with LC for treating AC patients,providing a theoretical basis for choosing reasonable surgical methods for AC *** In this study,we conducted a clinical investigation regarding the combined use of PTGBD tubes for the treatment of gastric cancer patients with *** performed searches in the following databases:PubMed,Web of Science,EMBASE,Cochrane Library,China National Knowledge Infrastructure,and Wanfang *** search encompassed literature published from the inception of these databases to the ***,relevant data were extracted,and a meta-analysis was conducted using RevMan 5.3 *** A comprehensive analysis was conducted,encompassing 24 studies involving a total of 2564 *** patients were categorized into two groups:1371 in the LC group and 1193 in the PTGBD+LC *** outcomes of the meta-analysis revealed noteworthy disparities between the PTGBD+LC group and the LC group in multiple dimensions:(1)Operative time:Mean difference(MD)=17.51,95%CI:9.53-25.49,P<0.01;(2)Conversion to open surgery rate:Odds ratio(OR)=2.95,95%CI:1.90-4.58,P<0.01;(3)Intraoperative bleeding loss:MD=32.27,95%CI:23.03-41.50,P<0.01;(4)Postoperative hospital stay:MD=1.44,95%CI:0.14-2.73,P=0.03;(5)Overall posto

关键词： Acute cholecystitis Laparoscopic cholecystectomy Percutaneous transhepatic gallbladder drainage Metaanalysis Efficacy

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Balancing act:The dilemma of rapid hyperglycemia correction in diabetes management

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World Journal of Diabetes 2024年第2期15卷 129-132页

作者： ke-Xin Zhang Cheng-Xia Kan xiao-dong Sun Department of Endocrinology and Metabolism Affiliated Hospital of Weifang Medical UniversityWeifang 261031Shandong ProvinceChina

The global diabetes surge poses a critical public health challenge,emphasizing the need for effective glycemic ***,rapid correction of chronic hyperglycemia can unexpectedly trigger microvascular complications,necessitating a reevaluation of the speed and intensity of glycemic *** suggest swift blood sugar reductions may cause inflammation,oxidative stress,and neurovascular changes,resulting in *** providers should cautiously approach aggressive glycemic control,especially in long-standing,poorly controlled *** and managing these complications requires a personalized,comprehensive approach with education,monitoring,and interdisciplinary *** management must balance short and longterm goals,prioritizing overall *** editorial underscores the need for a personalized,nuanced approach,focusing on equilibrium between glycemic control and avoiding overcorrection.

关键词： Diabetes Hyperglycemia correction Management Microvascular complications Glucose control

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On Minor Left Prime Factorization Problem for Multivariate Polynomial Matrices

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Journal of Systems Science & Complexity 2024年第3期37卷 1295-1307页

作者： LU dong WANG Dingkang xiao Fanghui School of Mathematics Southwest Jiaotong UniversityChengdu 610031China KLMM Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100049China MOE-LCSM School of Mathematics and StatisticsHunan Normal UniversityChangsha 410081China

A new necessary and sufficient condition for the existence of minor left prime factorizations of multivariate polynomial matrices without full row rank is *** key idea is to establish a relationship between a matrix and any of its full row rank *** on the new result,the authors propose an algorithm for factorizing matrices and have implemented it on the computer algebra system *** examples are given to illustrate the effectiveness of the algorithm,and experimental data shows that the algorithm is efficient.

关键词： Free modules Grobner bases minor left prime(MLP) multivariate polynomial matrices polynomial matrix factorizations

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Constructing inter-diffusive PtCuNi/WO_(3)interface to enhance the catalytic activity and stability in oxygen reduction

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Tungsten 2024年第2期6卷 293-303页

作者： Hao-Zhe Xu dong Li Ying Chen Pin Fang xiao-Xing ke Olga Demidenko Yu-Jing Li Beijing key Laboratory of Construction Tailorable Advanced Functional Materials and Green Applications Experimental Center of Advanced MaterialsSchool of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China Faculty of Materials and Manufacturing Beijing University of TechnologyBeijing 100124China Scientifi c-Practical Materials Research Centre National Academy of Sciences of Belarus220072 MinskBelarus

Platinum-group-metal-based alloy nanocrystals have been considered as the most effi cient catalysts for oxygen reduction reaction(ORR).However,the poor stability issues limit their further deployment in *** oxide(WO_(3))has received attention due to its intrinsic electrochemical stability and proton absorption/desorption *** this work,we prepared PtCuNi/WO_(3)/C hybrid catalyst with inter-diff usive alloy/WO_(3)interface on *** catalyst exhibits enhanced activity and stability associated with the WO_(3)*** characterization results suggest that the increased activity originates from the complementary proton supply of non-stoichiometric H_(x)WO_(3).Moreover,WO_(3)prevents the particle from dissolution and detachment under vigorous electrochemical *** enhanced stability originates from the electronic interaction established between Pt and *** work provides new strategies to design high-performance ORR catalysts by taking the merits of WO_(3)。

关键词： Tungsten oxide PtCuNi Interface Electronic interaction

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Remote sensing of air pollution incorporating integrated-path differential-absorption and coherent-Doppler lidar

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Defence Technology（防务技术） 2024年第1期31卷 594-601页

作者： Ze-hou Yang Yong Chen Chun-li Chen Yong-ke Zhang Ji-hui dong Tao Peng xiao-feng Li Ding-fu Zhou School of Physics Beijing Institute of TechnologyBeijing 100081China Southwest Institute of Technical Physics Chengdu 610041SichuanChina School of Optics and Photonics Beijing Institute of TechnologyBeijing 100081China

An innovative complex lidar system deployed on an airborne rotorcraft platform for remote sensing of atmospheric pollution is proposed and *** system incorporates integrated-path differential absorption lidar(DIAL) and coherent-doppler lidar(CDL) techniques using a dual tunable TEA CO_(2)laser in the 9—11 μm band and a 1.55 μm fiber *** combining the principles of differential absorption detection and pulsed coherent detection,the system enables agile and remote sensing of atmospheric *** static tests validate the system’s real-time detection capabilities,including the measurement of concentration-path-length product(CL),front distance,and path wind speed of air pollution plumes over long distances exceeding 4 *** experiments is conducted with the *** of the pollutant concentration and the wind field is carried out in an approximately 1 km slant range over scanning angle ranges from 45°to 65°,with a radial resolution of 30 m and10 *** test results demonstrate the system’s ability to spatially map atmospheric pollution plumes and predict their motion and dispersion patterns,thereby ensuring the protection of public safety.

关键词： Differential absorption LIDAR Coherent Doppler lidar Remoting sensing Atmospheric pollution

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Unraveling the modulation essence of p bands in Co-based oxide stability on acidic oxygen evolution reaction

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Nano Research 2024年第7期17卷 5922-5929页

作者： Yafei Yang Yihao Xu Haiquan Liu Qi Zhang Boling Liu Menghua Yang Huan Dai Zunjian ke dong He xiaobo Feng Xiangheng xiao Department of Physics Zhongnan Hospital of Wuhan UniversityWuhan UniversityWuhan 430072China School of Physics and Electronic Information Yunnan Normal UniversityKunming 650500China Yunnan key Laboratory of Opto-electronic Information Technology Kunming 650500China

The oxygen evolution reaction(OER)electrocatalysts,which can keep active for a long time in acidic media,are of great significance to proton exchange membrane water ***,Ru-Co_(3)O_(4)electrocatalysts with transition metal oxide Co_(3)O_(4)as matrix and the noble metal Ru as doping element have been prepared through an ion exchange–pyrolysis process mediated by metal-organic framework,in which Ru atoms occupy the octahedral sites of Co_(3)O_(4).Experimental and theoretical studies show that introduced Ru atoms have a passivation effect on lattice *** strong coupling between Ru and O causes a negative shift in the energy position of the O p-band ***,the bonding activity of oxygen in the adsorbed state to the lattice oxygen is greatly passivated during the OER process,thus improving the stability of matrix *** addition,benefiting from the modulating effect of the introduced Ru atoms on the metal active sites,the thermodynamic and kinetic barriers have been significantly reduced,which greatly enhances both the catalytic stability and reaction efficiency of Co_(3)O_(4).

关键词： p-band modulation oxygen evolution reaction stability acidic oxygen evolution reaction(OER)

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