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The germline genetics of mild-to-moderate penetrance:An intriguing role of PRAME in multiple carcinogenesis

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Genes & Diseases 2024年第3期11卷 7-10页

作者： Diaddin Hamdan van Tai nguyen Justine Paris Christophe Leboeuf Morad El Bouchtaoui Marc Espie Anne Janin Geraldine Falgarone Melanie Di Benedetto Guithem Bousquet Universite de Paris Cite INSERMUMR_S942MASCOTParis F-75006France Hopital La Porte Verte Versailles F-78004France National Cancer Hospital Cancer Research and Clinical Trials CenterHaNoi100000VietNam AP-HP-Hopital Saint Louis Centre de Maladies du SeinParisF-75010France Universite Sorbonne Paris Nord Bobigny F-93000France AP-HP-Hopital Avicenne Unite de Medecine AmbulatoireBobigny F-93000France

Germline genetics of high penetrance such as BRCA genes,mutations might be sufficient for carcinogenesis,but this only explains fewer than 10%of *** assume that most cancers are the result of germline mutations of low to moderate penetrance,combined with acquired mutations due to external carcinogenic *** their accumulation over time,aging is associated with an increased risk of multiple cancer development in a given *** decades,germline genetics have been based on familial linkage studies enabling most high-penetrance genes to be *** recently,population-wide studies have led to the identification of considerable numbers of polymorphisms associated with cancer ***,most of them are of unknown functional value,thus limiting their translational application.

关键词： carcinogenesis BRCA linkage

Prevalence and risk factors associated with long COVID symptoms in children and adolescents in a southern province of Vietnam

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Asian Pacific Journal of Tropical Medicine 2024年第3期17卷 119-128,I0001,I0002页

作者： Huynh Ngoc Linh nguyen The Tan Le Thi Minh Thu nguyen Tu Loan nguyen Thi To Uyen Le Thanh Thao Trang Truong Thanh Nam Doan Hoang Phu Faculty of Medicine Ca Mau Medical CollegeCa Mau 98000Vietnam Ca Mau Obstetrics and Pediatrics Hospital Ca Mau 98000Vietnam Faculty of Basic Science and Public Health Dong Thap Medical CollegeDong Thap 81000Vietnam Graduate University of Sciences and Technology Vietnam Academy of Science and TechnologyHa Noi 10000Vietnam Community Public Health Research Program School of Public HealthWalailak UniversityNakhon Si Thammarat 80160Thailand Faculty Public Health Can Tho University of Medicine and PharmacyCan Tho City 94000Vietnam Doctoral Program in Health Sciences College of Graduate StudiesWalailak UniversityNakhon Si Thammarat 80160Thailand

Objective:To investigate the prevalence and risk factors associated with long COVID symptoms among children and adolescents who have recovered from ***:This study applied a cross-sectional approach within community settings in a southern province of Vietnam.A structured questionnaire featuring socio-demographic information and common long COVID symptoms was *** correlation coefficients assessed associations among pairs of long COVID ***,multivariable logistic regression models were performed to investigate the risk factors of long COVID in recovered COVID-19 children and ***:Among 422 participants,39.3%reported long COVID symptoms,with a prevalence of 45.2%(SD=0.5)in children and 22.2%(SD=0.4)in *** symptoms reported were cough 34.6%(SD=0.5),fatigue 20.6%(SD=0.4),shortness of breath 10.9%(SD=0.3),and lack of appetite 6.6%(SD=0.3).Concerning risk factors of long COVID,a higher risk was observed among demographic groups,including girls(OR 1.25,95%CI 1.15-1.37;P<0.001,reference:boys),children compared to adolescents(OR 1.24,95%CI 1.12-1.37;P<0.001),overweight individuals(OR 1.14,95%CI 1.02-1.27;P=0.018,reference:healthy weight),and participants without any COVID-19 vaccination(OR 1.36,95%CI 1.20-1.54;P<0.001),or have received only one single dose(OR 1.35,95%CI 1.10-1.64;P=0.004)compared to those who have received two ***,patients with a COVID-19 treatment duration exceeding two weeks also had a higher risk of long COVID(OR 1.32,95%CI 1.09-1.60;P=0.003)than those who recovered less than seven ***:The insights from this study provide crucial guidance for predicting the factors associated with the occurrence of long COVID in pediatric patients,contributing to strategic interventions aimed at mitigating the long COVID risks among children and adolescents in Vietnam.

关键词： Long COVID Prevalence Risk factors Children Adolescent Vietnam

Is convenience really king? Comparative evaluation of catastrophic costs due to tuberculosis in the public and private healthcare sectors of Viet Nam: a longitudinal patient cost study

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贫困所致传染病(英文) 2024年第2期13卷 17-28页

作者： nguyen Hoa Binh Quang Vo Luan nguyen Forse Rachel Jeanette Wiemers Anja Maria Christine Huynh Huy Ba dong Thuy Thi Thu Phan Yen Thi Hoang Creswell Jacob Dang Thi Minh Ha nguyen Lan Huu Shedrawy Jad L?nnroth Knut nguyen Tuan Dinh van Dinh Luong Annerstedt Kristi Sidney Codlin Andrew James National Lung Hospital Ha Noi Viet Nam Friends for International TB Relief Ha Noi Viet Nam Department of Global Public Health WHO Collaboration Centre On Tuberculosis and Social Medicine Karolinska Institute Stockholm Sweden Stop TB Partnership Geneva Switzerland Pham Ngoc Thach Hospital Ho Chi Minh City Viet Nam

Background In Viet Nam, tuberculosis (TB) represents a devastating life-event with an exorbitant price tag, partly due to lost income from daily directly observed therapy in public sector care. Thus, persons with TB may seek care in the private sector for its flexibility, convenience, and privacy. Our study aimed to measure income changes, costs and catastrophic cost incurrence among TB-affected households in the public and private *** Between October 2020 and March 2022, we conducted 110 longitudinal patient cost interviews, among 50 patients privately treated for TB and 60 TB patients treated by the National TB Program (NTP) in Ha Noi, Hai Phong and Ho Chi Minh City, Viet Nam. Using a local adaptation of the WHO TB patient cost survey tool, participants were interviewed during the intensive phase, continuation phase and post-treatment. We compared income levels, direct and indirect treatment costs, catastrophic costs using Wilcoxon rank-sum and chi-squared tests and associated risk factors between the two cohorts using multivariate *** The pre-treatment median monthly household income was significantly higher in the private sector versus NTP cohort (USD 868 vs USD 578;P=0.010). However, private sector treatment was also significantly costlier (USD 2075 vs USD 1313;P=0.005), driven by direct medical costs which were 4.6 times higher than costs reported by NTP participants (USD 754 vs USD 164;P<0.001). This resulted in no significant difference in catastrophic costs between the two cohorts (Private: 55% vs NTP: 52%;P=0.675). Factors associated with catastrophic cost included being a single-person household [adjusted odds ratio [(aOR=13.71; 95% confidence interval (CI): 1.36–138.14;P=0.026], unemployment during treatment (aOR=10.86; 95%CI: 2.64–44.60;P<0.001) and experiencing TB-related stigma (aOR=37.90; 95%CI: 1.72–831.73;P=0.021).Conclusions Persons with TB in Viet Nam face similarly high risk of catastrophic costs whether treated in the

关键词： Tuberculosis Patient cost Catastrophic cost Private sector Comparative analysis Viet Nam

Photocatalytic degradation of antibiotic sulfamethizole by visible light activated perovskite LaZnO_(3)

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Journal of Environmental Sciences 2024年第10期144卷 212-224页

作者： Bui The Huy XCuong nguyen Vu Khac Hoang Bui nguyen Ngoc Tri Iqra Rabani Nhu Hoa Thi Tran Quang Viet Ly Hai Bang Truong Major of Biomedical Engineering Division of Smart HealthcareCollege of Information Technology and ConvergencePukyong National UniversityBusan 48513Korea Center for Advanced Chemistry Institute of Research and DevelopmentDuy Tan UniversityDa Nang 550000Viet Nam Faculty of Environmental and Chemical Engineering Duy Tan UniversityDa Nang 550000Viet Nam Department of Environment and Energy Sejong UniversitySeoul 05006Korea Lab of Computational Chemistry and Modelling Department of ChemistryFaculty of Natural SciencesQuy Nhon UniversityQuy NhonViet Nam Department of Nanotechnology and Advanced Materials Engineering Sejong UniversitySeoul 05006Korea Faculty of Materials Science and Technology University of ScienceHo Chi Minh City 700000Viet Nam Vietnam National University Ho Chi Minh City 700000Viet Nam Department of Environmental Engineering Seoul National University of Science and TechnologySeoul 01811Korea Optical Materials Research Group Science and Technology Advanced InstituteVan Lang UniversityHo Chi Minh CityViet Nam Faculty of Applied Technology School of TechnologyVan Lang UniversityHo Chi Minh CityViet Nam

In thiswork,the perovskite LaZnO_(3) was synthesized via sol-gel method and applied for photocatalytic treatment of sulfamethizole(SMZ)antibiotics under visible light *** was almost completely degraded(99.2%±0.3%)within 4 hr by photocatalyst LaZnO3 at the optimal dosage of 1.1 g/L,with amineralization proportion of 58.7%±0.4%.The efficient performance of LaZnO_(3) can be attributed to itswide-range light absorption and the appropriate energy band edge levels,which facilitate the formation of active agents such as·O_(2)^(−),h^(+),and·*** integration of RP-HPLC/Q-TOF-MS and DFT-based computational techniques revealed three degradation pathways of SMZ,which were initiated by the deamination reaction at the aniline ring,the breakdown of the sulfonamidemoieties,and a process known as Smile-type rearrangement and SO2 *** toxicity of SMZ and the intermediateswere analyzed by quantitative structure activity relationship(QSAR),indicating the effectiveness of LaZnO_(3)-based photocatalysis in preventing secondary pollution of the intermediates to the ecosystem during the degradation *** visible-light-activated photocatalyst LaZnO_(3) exhibited efficient performance in the occurrence of inorganic anions and maintained high durability across multiple recycling tests,making it a promising candidate for practical antibiotic treatment.

关键词： Perovskite Antibiotics Photocatalysis Density functional theory Toxicity

采石场粉尘和海砂混合物力学性能试验和数值研究

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岩土力学 2024年第9期45卷 2728-2740页

作者： TIEP Pham Duc TU nguyen van PHONG Pham Duc CHINH Mai Viet PHONG nguyen Viet 越南勒奎东技术大学特殊工程技术研究所河内越南

越南等发展中国家的道路基础设施建设需要大量天然砂。河砂日益紧缺,其供应量将持续下降。因此,建筑行业必须实施可持续发展战略,将废弃材料与各种可利用资源相结合,以有效应对这一严峻形势。本研究的目的是测试采石场粉尘和海砂混合物... 详细信息

越南等发展中国家的道路基础设施建设需要大量天然砂。河砂日益紧缺,其供应量将持续下降。因此,建筑行业必须实施可持续发展战略,将废弃材料与各种可利用资源相结合,以有效应对这一严峻形势。本研究的目的是测试采石场粉尘和海砂混合物的力学性能,并评估其在高速公路路基层中的潜在应用。进行了一系列试验,包括材料的含水率、相对密度、休止角测试和三轴试验,以研究不同配比下混合物的组成。结合Plaxis土工试验中的校准进行了广泛的参数研究,得出了割线模量E_(50)和围压曲线。根据加州承载比CBR对公路路基层所用材料的评估结果,证明海砂和采石场粉尘混合物具有适当性能,可用于公路路基的建设。

关键词：采石场粉尘海砂土工试验模块固结试验三轴试验路基层公路加州承载比

Traveling wave solutions of the nonlinear Gilson-Pickering equation in crystal lattice theory

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Journal of Ocean Engineering and Science 2024年第1期9卷 40-49页

作者： A.T.nguyen O.Nikan Z.Avazzadeh Division of Applied Mathematics Science and Technology Advanced InstituteVan Lang UniversityHo Chi Minh CityVietnam Faculty of Technology Van Lang UniversityHo Chi Minh CityVietnam School of Mathematics Iran University of Science and TechnologyNarmakTehranIran Department of Applied Mathematics Xi’an Jiaotong-Liverpool UniversitySuzhou 215123China

This paper focuses on obtaining the traveling wave solutions of the nonlinear Gilson-Pickering equa-tion(GPE),which describes the prorogation of waves in crystal lattice theory and plasma *** solution of the GPE is approximated via the finite difference technique and the localized meshless radial basis function generated finite *** association of the technique results in a meshless approach that does not require linearizing the nonlinear *** the first step,the PDE is converted to a system of nonlinear ODEs with the help of the radial *** the second step,a high-order ODE solver is adopted to discretize the nonlinear ODE *** global collocation techniques pose a considerable computationl burden due to the calculation of the dense algebraic *** proposed method approx-imates differential operators over the local support domain,leading to sparse differentiation matrices and decreasing the computational *** results and comparisons are provided to confirm the efficiency and accuracy of the method.

关键词： Nonlinear Gilson–Pickering equation Soliton wave solutions Meshless technique RBF LRBF-FD Optimal shape parameter

A deep neural network based surrogate model for damage identification in full-scale structures with incomplete noisy measurements

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Frontiers of Structural and Civil Engineering 2024年第3期18卷 393-410页

作者： Tram BUI-NGOC Duy-Khuong LY Tam T TRUONG Chanachai THONGCHOM T.nguyen-THOI Laboratory for Computational Mechanics Institute for Computational Science and Artificial IntelligenceVan Lang UniversityHo Chi Minh City 70000Vietnam Faculty of Mechanical-Electrical and Computer Engineering School of TechnologyVan Lang UniversityHo Chi Minh City 70000Vietnam Faculty of Civil Engineering School of TechnologyVan Lang UniversityHo Chi Minh City 70000Vietnam Department of Computer Science Aarhus UniversityAarhus 8000Denmark Thammasat University research unit in structural and foundation engineering Department of Civil EngineeringThammasat UniversityPathumthani 12120Thailand Laboratory for Applied and Industrial Mathematics Institute for Computational Science and Artificial IntelligenceVan Lang UniversityHo Chi Minh City 70000Vietnam Thammasat School of Engineering Thammasat UniversityPathumthani 12120Thailand

The paper introduces a novel approach for detecting structural damage in full-scale structures using surrogate models generated from incomplete modal data and deep neural networks(DNNs).A significant challenge in this field is the limited availability of measurement data for full-scale structures,which is addressed in this paper by generating data sets using a reduced finite element(FE)model constructed by SAP2000 software and the MATLAB programming *** surrogate models are trained using response data obtained from the monitored structure through a limited number of measurement *** proposed approach involves training a single surrogate model that can quickly predict the location and severity of damage for all potential *** achieve the most generalized surrogate model,the study explores different types of layers and hyperparameters of the training algorithm and employs state-of-the-art techniques to avoid overfitting and to accelerate the training *** approach’s effectiveness,efficiency,and applicability are demonstrated by two numerical *** study also verifies the robustness of the proposed approach on data sets with sparse and noisy measured ***,the proposed approach is a promising alternative to traditional approaches that rely on FE model updating and optimization algorithms,which can be computationally *** approach also shows potential for broader applications in structural damage detection.

关键词： vibration-based damage detection deep neural network full-scale structures finite element model updating noisy incomplete modal data

Building the ARIMA Model for Forecasting the Production of Vietnam’s Coffee Export

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Journal of Applied Mathematics and Physics 2024年第4期12卷 1237-1246页

作者： Duy Quang Phung Quoc Thang Trinh Quang Truong Do Ngan Giang nguyen van Ha nguyen Gia Khiem Ngo Thi Minh Ngoc Tran Faculty of Technology and Data Science Foreign Trade University Hanoi Vietnam School of Economics and International Business Foreign Trade University Hanoi Vietnam

Coffee is a significant industry, accounting for 3% of Vietnam’s GDP, with annual export turnover consistently exceeding USD 3 billion. Despite global economic challenges affecting purchasing power at various times, Vietnam’s coffee exports in December 2023 continued to surge, reaching the highest level in the past 9 months at 190,000 tons, a 59.3% increase compared to November 2023, but still a slight 3.5% decrease from the same period last year. The export turnover reached USD 538 million, a 51% increase from November 2023 and a 26.4% increase from the same period last year. Therefore, forecasting the coffee export volume holds significant importance for coffee producers nationwide. This research employs the Box-Jenkins method to construct an ARIMA model for forecasting Vietnam’s coffee export volume based on annual data published by the General Statistics Office. Results indicate that among the models considered, the ARIMA(1, 1, 2) model is the most suitable. The study also provides short-term forecasts for Vietnam’s coffee export volume. However, the current model is limited to forecasting and is not yet optimized, as the assumed linearity in the model is a simplification.

关键词： ARIMA Forecasting Coffee Export Volume Data Science

Exploring the Interplay between Job Stress,Work Performance,and Attitudes toward Professional Psychological Help among Employees

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International Journal of Mental Health Promotion 2024年第7期26卷 531-545页

作者： Cong Minh Le Son van Huynh Ky Luu Quynh-Nhi Ngoc Ho van Thi Le nguyen Vinh-Long Tran-Chi Center for Mental Health Research and Support University of Social Sciences and HumanitiesVietnam National University Ho Chi Minh CityHo Chi Minh City700000Vietnam Faculty of Psychology Ho Chi Minh City University of EducationHo Chi Minh City700000Vietnam Faculty of Tourism College of BusinessUniversity of Economics Ho Chi Minh CityHo Chi Minh City700000Vietnam Scientific Management Department Dong A UniversityDa Nang500000Vietnam

Objective:This study explores the interplay between job stress,job-related factors,work performance,and attitudes toward seeking professional psychological help among Vietnamese ***:A total of 374 employees in Vietnam were surveyed using random sampling and an online questionnaire from November 07 to November 28,*** data and self-reported from three scales:The New Job Stress Scale(NJSS),Work Performance(WP),and Attitudes Toward Seeking Professional Psychological Help(ATSPPH_SF)were ***:Significant variations were found across several variables,including forms of work,operating hours,education levels,monthly income,numbers of daily working hours,and the presence of a psychological counseling department within the *** analysis has highlighted direct relationships between key latent *** who were more open to seeking professional help tended to report higher levels of job *** negative relationship was found between job stress and attitudes toward seeking professional ***,work effort was positively associated with work *** analyses revealed the influence of co-worker support on role expectation conflict and work effort,role expectation conflict and work-life balance,as well as interactions between role expectation conflict and attitudes needed toward seeking professional *** analyses showed that work effort mediated relationships between openness to seeking professional help,co-worker support,work-life balance,role expectation conflict,and work *** toward seeking professional help also mediated relationships between work-life balance,job stress,and work ***:The study highlights the complex dynamics surrounding job stress,job-related factors,work performance,and attitudes toward seeking professional psychological help among Vietnamese *** highlights the importance of addressing help-seeking barriers,promoting work engagement

关键词： Stress co-worker support work-life balance role expectation conﬂict professional psychological help-seeking