检索结果-南通市图书馆

Human neural stem cell-derived extracellular vesicles protect against ischemic stroke by activating the PI3K/AKT/mTOR pathway

引用

Neural Regeneration Research 2025年第11期20卷 3245-3258页

作者： Jiayi Wang Mengke Zhao dong fu Meina Wang Chao Han Zhongyue Lv Liang Wang Jing Liu Stem Cell Clinical Research Center The First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning ProvinceChina Dalian Innovation Institute of Stem Cell and Precision Medicine DalianLiaoning ProvinceChina Institute(College)of Integrative Medicine Dalian Medical UniversityDalianLiaoning ProvinceChina

Human neural stem cell-derived extracellular vesicles exhibit analogous functions to their parental cells,and can thus be used as substitutes for stem cells in stem cell therapy,thereby mitigating the risks of stem cell therapy and advancing the frontiers of stem cell-derived *** lays a foundation for the development of potentially potent new treatment modalities for ischemic ***,the precise mechanisms underlying the efficacy and safety of human neural stem cell-derived extracellular vesicles remain unclear,presenting challenges for clinical *** promote the translation of therapy based on human neural stem cell-derived extracellular vesicles from the bench to the bedside,we conducted a comprehensive preclinical study to evaluate the efficacy and safety of human neural stem cell-derived extracellular vesicles in the treatment of ischemic *** found that administration of human neural stem cell-derived extracellular vesicles to an ischemic stroke rat model reduced the volume of cerebral infarction and promoted functional recovery by alleviating neuronal *** human neural stem cell-derived extracellular vesicles reduced neuronal apoptosis by enhancing phosphorylation of phosphoinositide 3-kinase,mammalian target of rapamycin,and protein kinase B,and these effects were reversed by treatment with a phosphoinositide 3-kinase *** findings suggest that human neural stem cell-derived extracellular vesicles play a neuroprotective role in ischemic stroke through activation of phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin signaling ***,we showed that human neural stem cell-derived extracellular vesicles have a good in vivo safety ***,human neural stem cell-derived extracellular vesicles are a promising potential agent for the treatment of ischemic stroke.

关键词： behavior exosome extracellular vesicles ischemic stroke mammalian target of rapamycin(mTOR) middle cerebral artery occlusion neural stem cells neuronal apoptosis phosphoinositide 3-kinase(PI3K) protein kinase B(AKT)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Investigation of the interfacial properties for CO_2-methanol and CO_2-ethanol mixtures

引用

Science China Chemistry 2011年第5期54卷 856-862页

作者： fu dong School of Environmental Science and Engineering North China Electric Power UniversityBaoding 071003China

An equation of state (EOS) applicable for the interfacial properties of CO2-methanol and CO2-ethanol mixtures was established by combining the cross-association EOS and the density gradient theory (DGT). The correlated surface tensions of CO2-ethanol mixtures agreed well with the experimental data. The results illustrated the temperature and pressure dependence of the cross-association between CO2 and alcohol hydroxyls in the whole vapor-liquid surface,and the influence of the cross-association on the calculation of the surface tensions of binary mixtures.

关键词： CO2-methanol CO2-ethanol cross-association density gradient theory interfacial properties

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Coherent quantum transport in normal-metal/d-wave superconductor/normal-metal double tunnel junctions

引用

Science China(Physics,Mechanics & Astronomy) 2004年第2期47卷 256-264页

作者： dong Zhengchao fu Hao Department of Physics Huaiyin Teachers College Huaiyin 223001 China Department of Physics Huaiyin Teachers College Huaiyin 223001 China

Taking into account the effects of quantum interference and interface scattering, combining the electron current with hole current contribution to tunnel current, we study the coherent quantum transport in normal-metal/d-wave superconductor/ normal-metal (NM/d-wave SC/NM) double tunnel junctions by using extended Blonder-Tinkham-Klapwijk (BTK) approach. It is shown that all quasiparticle transport coefficients and conductance spectrum exhibit oscillating behavior with the energy, in which periodic vanishing of Andreev reflection (AR) above superconducting gap is found. In tunnel limit for the interface scattering strength taken very large, there are a series of bound states of quasiparticles formed in SC.

关键词： effects of quantum interference, tunneling spectroscopy, bound state.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Design,fabrication and kinematics of a bio-inspired robotic bat wing

引用

Science China(Technological Sciences) 2016年第12期59卷 1921-1930页

作者： YIN dong fu ZHANG Zhi Sheng School of Mechanical Engineering Southeast University

The current work is oriented toward the development of a novel biologically inspired bat aerial robot with morphing wings. Based on the flight characteristics data of natural bats(Eptesicus fuscus), a novel four degrees of freedom robotic bat wing was developed to emulate the movements of bat wing. The design, fabrication, programing and wind tunnel experiments of the robot bat wing are described in this paper. Based on this robotic wing, the influence of flap amplitude, wind speed, flight frequency, downstroke ratio and stroke plane angle as well as the contributions of flap, elbow, sweep and wrist motions on the aerodynamic force and mechanical power were studied and analyzed. Results of wind tunnel experiments validated that higher lift would bring greater power consumption, and the flap motion would generate the most force and need more energy expenditure compared with other motions of bat. The experimental results suggest that the flap and fold motions are indispensable to make a robotic bat wing that has a better flight performance. This study provides some implications and a better understanding for the future robotic bat.

关键词： bio-inspiration wing robotic bat flight kinematics wrist motion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Non-coding RNA: a new frontier in regulatory biology

引用

National Science Review 2014年第2期1卷 190-204页

作者： Xiang-dong fu Department of Cellular and Molecular Medicine Institute of Genomic Medicine University of California

A striking inding in the past decade is the production of numerous non-coding RNAs(nc RNAs) from mammalian genomes. While it is entirely possible that many of those nc RNAs are transcription noises or by-products of RNA processing, increasing evidence suggests that a large fraction of them are functional and provide various regulatory activities in the cell. hus, functional genomics and proteomics are incomplete without understanding functional ribonomics. As has been long suggested by the ‘RNA world’hypothesis, many nc RNAs have the capacity to act like proteins in diverse biochemical processes. he enormous amount of information residing in the primary sequences and secondary structures of nc RNAs makes them particularly suited to function as scafolds for molecular interactions. In addition, their functions appear to be stringently controlled by default via abundant nucleases when not engaged in speciic interactions. his review focuses on the functional properties of regulatory nc RNAs in comparison with proteins and emphasizes both the opportunities and challenges in future nc RNA research.

关键词： the RNA world non-coding RNA biological functions regulatory mechanisms experimental approaches functional genomics

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Numerical Analysis and Verification of the Gas Jet from Aircraft Engines Impacting a Jet Blast Deflector

引用

Chinese Journal of Mechanical Engineering 2018年第5期31卷 127-137页

作者： fu-dong Gao De-Xin Wang Hai-dong Wang Ming-Ming Jia Department of Carrier Aviation Security and Station Management Naval Aeronautical University

The process of the gas jet from aircraft engines impacting a jet blast deflector is not only a complex fluid–solid coupling problem that is not easy to compute, but also a safety issue that seriously interferes with flight deck envi?ronment. The computational fluid dynamics(CFD) method is used to simulate numerically the impact e ect of gas jet from aircraft engines on a jet blast deflector by using the Reynolds?averaged Navier?Stokes(RANS) equations and turbulence models. First of all, during the pre?processing of numerical computation, a sub?domains hybrid meshing scheme is adopted to reduce mesh number and improve mesh quality. Then, four di erent turbulence models includ?ing shear?stress transport(SST) k-w, standard k-w, standard k-ε and Reynolds stress model(RSM) are used to compare and verify the correctness of numerical methods for gas jet from a single aircraft engine. The predicted values are in good agreement with the experimental data, and the distribution and regularity of shock wave, velocity, pressure and temperature of a single aircraft engine are got. The results show that SST k?w turbulence model is more suitable for the numerical simulation of compressible viscous gas jet with high prediction accuracy. Finally, the impact e ect of gas jet from two aircraft engines on a jet blast deflector is analyzed based on the above numerical method, not only the flow parameters of gas jet and the interaction regularity between gas jet and the jet blast deflector are got, but also the thermal shock properties and dynamic impact characteristics of gas jet impacting the jet blast deflector are got. So the dangerous activity area of crew and equipments on the flight deck can be predicted qualitatively and quantitatively. The proposed research explores out a correct numerical method for the fluid–solid interaction during the impact process of supersonic gas jet, which provides an e ective technical support for design, thermal ablation and structural damage analysis

关键词： Aircraft engine Gas jet Computational fluid dynamics Jet blast deflector Impact effect

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dynamic recrystallization behavior and microstructure evolution of high-performance Cu-3.28Ni-0.6Si-0.22Zn-O.11Cr-0.04P during hot compression

引用

Rare Metals 2021年第1期40卷 156-167页

作者： Chang-Sheng Wang Hua-dong fu Jian-Xin Xie Beijing Advanced Innovation Center for Materials Genome Engineering Institute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing 100083China Beijing Laboratory of Metallic Materials and Processing for Modern Transportation Institute for Advanced Materials and TechnologyBeijing 100083China

By means of isothermal compression at temperatures in the range of 650-900℃and strain rates in the range of 0.001-1 s^(-1),the dynamic recrystallization behavior and microstructural evolution of a Cu-3.28 Ni-0.6 Si-0.22 Zn-0.11 Cr-0.04 P(wt%)alloy designed by a machine learning method were investigated.A semiempirical constitutive equation,processing maps and an average activation energy were *** microstructure under different conditions and the effect of strain rate on the texture of the alloy at 800-900℃were *** results show that the suitable temperature is800-900℃;when the strain is less than 0.4,the appropriate strain rate is 0.01-0.5 s^(-1);and when the strain is greater than 0.4,the appropriate strain rate is below0.05 s^(-1).After deformation at 800℃,the main texture changed from{112}of copper to a uniform distribution with the increase in strain rate,but the sample did not have obvious texture after deformation at 850 and900℃.The above results can provide a reference for the selection of process parameters.

关键词： High-performance copper alloy Hot compression Dynamic recrystallization Processing map Texture evolution

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dissemination of brain inflammation in traumatic brain injury

引用

Cellular & Molecular Immunology 2019年第6期16卷 523-530页

作者： Kaibin Shi Jianning Zhang Jing-fei dong fu-dong Shi Departments of Neurology and Neurosurgery Tianjin Neurological InstituteTianjin Medical University General HospitalTianjin 300052China Center for Neuroinflammation Beijing Tiantan HospitalCapital Medical UniversityBeijing 100050China Department of Neurology Barrow Neurological InstituteSt.Joseph’s Hospital and Medical CenterPhoenixAZ 85013USA BloodWorks Northwest Research Institute Division of HematologyDepartment of MedicineSchool of MedicineUniversity of WashingtonSeattleWA 98195USA

Traumatic brain injury(TBI)is recognized as a global health problem due to its increasing occurrence,challenging treatment,and persistent impacts on brain *** cell death in patients with TBI swiftly causes inflammation in the injured brain areas,which is recognized as focal brain *** brain inflammation causes secondary brain injury by exacerbating brain edema and neuronal death,while also exerting divergent beneficial effects,such as sealing the damaged limitans and removing cellular *** evidence from patients with TBI and studies on animal models suggest that brain inflammation after TBI is not only restricted to the focal lesion but also disseminates to remote areas of the *** dissemination of inflammation has been detected within days after the primary injury and persists *** state of inflammation may be related to remote complications of TBI in patients,such as hyperthermia and hypopituitarism,and may lead to progressive neurodegeneration,such as chronic traumatic *** studies should focus on understanding the mechanisms that govern the initiation and propagation of brain inflammation after TBI and its impacts on post-trauma brain pathology.

关键词： disseminated brain inflammation traumatic brain injury microglia post-injury neurodegeneration

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Directivity effect of unloading bedding coal induced fracture evolution and its application

引用

International Journal of Mining Science and Technology 2017年第5期27卷 825-829页

作者： Pan Rongkun fu dong Yu Minggao Chen Lei Department of Safety&Science Engineering Henan Polytechnic UniversityJiaozuo 454003China The Collaborative Innovation Center of Coal Safety Production of Henan Province Henan Polytechnic UniversityJiaozuo 454003China Henan Key Laboratory of Prevention and Cure of Mine Methane&Fires Jiaozuo 45403China State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing UniversityChongqing 400044China

In the coal mining process, the gas contained in the coalbed is one source of the most serious accident hazards. Stress releasing from the coal deposit is the main controlling factor that leads to such *** on the bedding of coal samples, the gas permeability well describes the evolution of fracture, so the paper carries out research on the permeability properties of coal under different unloading *** research obtains that when the stress unloading direction is perpendicular to bedding, more penetrating fractures and bedding fractures occur, and the permeability significantly increases. Although the axial stress reduced, the confining pressure makes the permeability of the bedding plane fracture exist under constant. The permeability obtained when the unloading direction was perpendicular to the bedding is 52 times larger than that when it is parallel to the bedding. The results show that the efficiency of gas drainage is impacted by the relative direction of gas drainage drilling in relation to the bedding orientations. The maximum amount of gas extraction when drilling is perpendicular to the bedding is 1.3 times than that when drilling is oblique to the bedding, and 1.75 times than that when drilling is parallel to the bedding.

关键词： Unloading direction Bedding structure Gas permeability Fracture evolution

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Morphology and distribution of precipitates and their effects on compression cracks in Fe-6.5Si-0.02B electrical steel

引用

Journal of Iron and Steel Research International 2018年第1期25卷 99-107页

作者： Zhi-hao Zhang Jun-li Wang Hua-dong fu Institute for Advanced Materials and Technology Universityof Science and Technology Beijing Beijing 100083 China Beijing Amorphous Energy Conservation Materials IndustryAlliance Beijing 100081 China

Morphology and distribution of precipitates in the Fe-6.5Si-0.02B alloy were characterized, and these effects on room- temperature compression cracks were investigated. The results showed that the precipitate in the Fe-6.5Si-0.02B alloy is FezB with body-centered tetragonal structure, and its nano-hardness is 15.0 GPa which is higher than that of the matrix （- 8.5 GPa）. In the as-cast alloys, most of the intragranular precipitates are coarse lath-like with the length of 5-15 μm and width of 2-5 μm, and the precipitates formed at the grain boundaries are of about 2-3 μm in width. After oil quenching followed by heat treatment at 1100 ℃ for more than 30 min, the precipitates inside grains are refined with a size of several hundred nanometers and the precipitates at the grain boundaries are refined with a size of 〈 1 μm. After compression test, transgranular and intergranular cracks occur in the as-cast alloys with coarse precipitates. For the quenched alloys with fine precipitates, the number of cracks decreases significantly, and no transgranular cracks happen because some cracks are blocked or the propagation direction is changed by grain boundary.

关键词： Fe-6.5 wt% Si alloy Precipitates Nano-hardness Room-temperature compression

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：