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Integrating 16S sequencing and metabolomics study on anti-rheumatic mechanisms against collagen-induced arthritis of Wantong Jingu Tablet

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Chinese Journal of Natural Medicines 2022年第2期20卷 120-132页

作者： LI zhao-dong QI Fang-Yuan LI Fan Department of Pathogenobiology the Key Laboratory of ZoonosisMinistry of Education of ChinaSchool of Basic MedicineJilin UniversityChangchun 130000China Key Laboratory for Bionics Engineering Ministry of Education of ChinaJilin UniversityChangchun 130000China Engineering Research Center for Medical Biomaterials of Jilin Province Jilin UniversityChangchun 130000China Key Laboratory for Biomedical Materials of Jilin Province Jilin UniversityChangchun 130000China State Key Laboratory of Pathogenesis Prevention and Treatment of High Incidence Diseases in Central AsiaUrumqi 830000China

Wantong Jingu Tablet(WJT),a mixture of traditional Chinese medicine,was reported to relieve the symptoms of rheumatoid arthritis(RA),but its pharmacological mechanism was not completely *** aim of this study was to investigate the therapeutic mechanisms of WJT for RA in *** effects of WJT on joint pathology,as well as the levels of Bax,Bcl-2,caspase-3,cleaved-caspase-3,ERK1/2,pERK1/2,TNF-α,IL-1β,and IL-6 were measured using collagen-induced arthritis(CIA)*** intestinal flora composition and the metabolites alteration were analyzed by 16S rDNA sequencing and metabolomics method,*** found that WJT ameliorated the severity of the CIA rats which might be mediated by inducing apoptosis,inactivating the MEK/ERK signals and reducing the production of pro-inflammatory ***,in part,relieved the gut microbiota dysbiosis,especially bacterial phylum Bacteroidetes,Tenericutes and Deferribacteres,as well as bacterial genus Vibrio,Macrococcus and Vagococcus.3’-N-debenzoyl-2’-deoxytaxol,tubulysin B,and magnoline were significantly associated with the specific *** identified serotonin,glutathione disulfide,N-acetylneuraminic acid,naphthalene and thromboxane B2 as targeted molecules via *** findings contributed to the understanding of RA pathogenesis,and WJT played essential roles in gut microbiota health and metabolite modulation in the CIA rats.

关键词： Rheumatoid arthritis 16S rDNA sequencing Metabolomics Pathogenesis Wantong Jingu Tablet

Unsupervised Martian Dust Storm Removal via Disentangled Representation Learning

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Research in Astronomy and Astrophysics 2022年第9期22卷 255-266页

作者： dong zhao Jia Li Hongyu Li Long Xu State Key Laboratory of Virtual Reality Technology and Systems School of Computer Science and EngineeringBeihang UniversityBejing 100191China State Key Laboratory of Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China Peng Cheng Laboratory Shenzhen 518000China

Mars exploration has become a hot spot in recent years and is still advancing rapidly. However, Mars has massive dust storms that may cover many areas of the planet and last for weeks or even months. The local/global dust storms are so influential that they can significantly reduce visibility, and thereby the images captured by the cameras on the Mars rover are degraded severely. This work presents an unsupervised Martian dust storm removal network via disentangled representation learning(DRL). The core idea of the DRL framework is to use the content encoder and dust storm encoder to disentangle the degraded images into content features(on domain-invariant space) and dust storm features(on domain-specific space). The dust storm features carry the full dust storm-relevant prior knowledge from the dust storm images. The “cleaned” content features can be effectively decoded to generate more natural, faithful, clear *** primary advantages of this framework are twofold. First, it is among the first to perform unsupervised training in Martian dust storm removal with a single image, avoiding the synthetic data requirements. Second, the model can implicitly learn the dust storm-relevant prior knowledge from the real-world dust storm data sets, avoiding the design of the complicated handcrafted priors. Extensive experiments demonstrate the DRL framework’s effectiveness and show the promising performance of our network for Martian dust storm removal.

关键词： planets and satellites:atmospheres planets and satellites:general planets and satellites:surfaces

Derivative Formula and Coupling Property for Linear SDEs Driven by Lévy Processes

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Acta Mathematicae Applicatae Sinica 2019年第4期35卷 708-721页

作者： zhao dong Yu-lin SONG Ying-chao XIE Institute of Applied Mathematics Academy of Mathematics and Systems Sciences Chinese Academy of Sci- ences Beijing 100190 China School of Mathematical Sciences Beijing Normal University Beijing 100875 China School of Mathematics and Statistics Jiangsu Normal University Jiangsu Province Xuzhou 221116 China

In this paper we investigate an integration by parts formula for Lévy processes by using lower bound conditions of the corresponding Lévy measure. As applications, derivative formula and coupling property are derive... 详细信息

关键词： Lévy processes integration by parts formula derivative formula coupling property

Electrochemical performance of graphene nanosheets as electrode material for supercapacitors

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Electrochemical performance of graphene nanosheets as electr...

Constraining the anisotropy of the Universe with the Pantheon supernovae sample

第八届中国功能材料及其应用学术会议

作者： LI Liang-yu zhao dong-lin ZHANG dong-dong State Key Laboratory of Chemical Resource Engineering Key Laboratory of Carbon Fiber and Functional PolymersMinistry of EducationBeijing University of Chemical Technology

ISBN: (纸本)9783037859698

Graphene nanosheets(GNSs) were prepared from flake natural graphiteby oxidation,rapid expansion and ultrasonic *** morphology,structure and electrochemical performance of GNSs as electrode materials forsupercapacitors were systematically investigated via high-resolution transmission electron microscopy,X-ray diffraction,nitrogen adsorption and desorption isotherms and a variety of electrochemical testing *** electrodes with freestanding GNSs prepared by coating methodexhibited good rate capability and reversibility at high scan rates in electrochemical *** electrode with specific surface area of 243mg1maintained a stable specific capacitanceof 200 F g under specific current of 0.1 A gfor 500 cycles of charge/discharge.

关键词： Graphene nanosheets Supercapacitors Electrochemical performance

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Chinese Physics C 2019年第12期43卷 180-187页

作者： Zhe Chang dong zhao Yong Zhou Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China

We test the possible dipole anisotropy of the Finslerian cosmological model and the other three dipolemodulated cosmological models,*** dipole-modulated ACDM,wCDM and Chevallier-Polarski-Linder(CPL)models,by using the recently released Pantheon sample of SNe *** Markov chain Monte Garlo(MGMC)method is used to explore the whole parameter *** find that the dipole anisotropy is very weak in all cosmological models *** the dipole amplitudes of four cosmological models are consistent with zero within the 1σuncertainty,the dipole directions are close to the axial direction of the plane of the SDSS subsample in *** may imply that the weak dipole anisotropy in the Pantheon sample originates from the inhomogeneous distribution of the SDSS subsample.A more homogeneous distribution of SNe la is necessary to constrain the cosmic anisotropy.

关键词： supernovae:general large-scale structure of the Universe cosmology

Current status of liver transplantation for human immunodeficiency virus-infected patients in China's Mainland

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World Journal of Gastroenterology 2024年第14期30卷 1958-1962页

作者： Jian-Xin Tang dong zhao Department of Liver Surgery and Organ Transplantation Center Shenzhen Third People’s HospitalThe Second Affiliated Hospital of Southern University of Science and TechnologyNational Clinical Research Center for Infectious DiseaseShenzhen 518000Guangdong ProvinceChina

According to the report from the Chinese Center for Disease Control and Prevention,the prevalence of human immunodeficiency virus(HIV)infection exceeded 1.2 million individuals by the year 2022,with an annual increase of about 80000 *** overall prevalence of hepatitis B surface antigen among individuals co-infected with HIV reached 13.7%,almost twice the rate of the general population in *** addition to the well-documented susceptibility to opportunistic infections and new malignancies,HIV infected patients frequently experience liver-related organ damage,with the liver and kidneys being the most commonly *** often leads to the development of end-stage liver and kidney ***,organ transplantation has emerged as an important part of active treatment for HIV infected ***,the curative effect is not *** infection has been considered a contraindication for organ *** the emergence of highly active anti-retroviral therapy in 1996,the once intractable replication of retrovirus was effectively *** prolonged survival,the failure of important organs has become the main cause of death among HIV ***,transplant centers worldwide have resu-med exploration of organ transplantation for HIV-infected individuals and reached a positive *** study provides an overview of the current landscape of HIV-positive patients receiving liver transplantation(LT)in main-land *** date,our transplant center has conducted LT for eight end-stage liver disease patients co-infected with HIV,and all but one,who died two months postoperatively due to sepsis and progressive multi-organ failure,have *** analysis with hepatitis B virus-infected patients during the same period revealed no statistically significant differences in acute rejection reactions,cytomegalovirus infection,bacteremia,pulmonary infections,acute kidney injury,new-onset cancers,or vascular and biliary co

关键词： Liver transplantation Human immunodeficiency virus Infection Hepatitis B virus End-stage liver disease China'Mainland

Origin of off-centering effect and the influence on heat transport in thermoelectrics

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Materials Futures

Materials Futures 2024年第1期3卷 142-149页

作者： Hongyao Xie Li-dong zhao School of Materials Science and Engineering Beihang UniversityBeijing 100191People’s Republic of China

Recently,off-centering behavior has been discovered in a series of thermoelectric *** behavior indicates that the constituent atoms of the lattice displace from their coordination centers,leading to the locally distorted state and local symmetry breaking,while the material still retains its original crystallographic *** effect has been proved to be the root cause of ultralow thermal conductivity in off-centering materials,and is considered as an effective tool to regulate the thermal conductivity and improve the thermoelectric ***,we present a collection of recently discovered off-centering compounds,discuss their electronic origins and local coordination structures,and illuminate the underlying mechanism of the off-centering effect on phonon transport and thermal *** paper presents a comprehensive view of our current understanding to the off-centering effect,and provides a new idea for designing high performance thermoelectrics.

关键词： thermoelectric thermal conductivity off-centering behavior acoustic-optical phonon scattering

Solidification microstructure of Ti-43Al alloy by twin-roll strip casting

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China Foundry 2023年第2期20卷 99-107页

作者： Yang Chen Guo-huai Liu Ye Wang zhao-dong Wang State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China College of Material Science and Chemical Engineering Harbin University of Science and TechnologyHarbin 150080China

As a near-net-shape technology,the twin-roll strip casting(TRC)process can be considered to apply to the fabrication of TiAl alloy ***,the control of the grain distribution is very important in strip casting because the mechanical properties of strips are directly determined by the solidification microstructure.A three-dimensional(3D)cellular automation finite-element(CAFE)model based on ProCAST software was established to simulate the solidification microstructure of Ti-43Al ***,the influence of casting temperature and the maximum nucleation density(nmax)on the solidification microstructure was investigated in *** simulation results provide a good explanation and prediction for the solidification microstructure in the molten pool before leaving the kissing *** and simulated microstructure show the common textureorientation in the columnar grains ***,the microstructure evolution of the Ti-43Al alloy was analyzed and the solidification phase transformation path during the TSC process was determined,i.e.,L→L+β→β→β+α→α+γ+β/B2 phase under a faster cooling rate and L→L+β→β→β+α→γ+lamellar(α_(2)+γ)+β/B2 phase under a slower cooling rate.

关键词： TiAl alloy simulation microstructure strip casting solidification

Delay-dependent Stability Analysis for Markovian Jump Systems with Interval Time-varying-delays

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International Journal of Automation and computing 2010年第2期7卷 224-229页

作者： Xu-dong zhao Qing-Shuang Zeng Space Control and Inertial Technology Center Harbin Institute of Technology Harbin 150001 PRC

This paper proposes improved stochastic stability conditions for Markovian jump systems with interval time-varying delays. In terms of linear matrix inequalities （LMIs）, less conservative delay-range-dependent stability conditions for Markovian jump systems are proposed by constructing a different Lyapunov-Krasovskii function. The resulting criteria have advantages over some previous ones in that they involve fewer matrix variables but have less conservatism. Numerical examples are provided to demonstrate the efficiency and reduced conservatism of the results in this paper.

关键词： Stochastic stability Markovian jump systems linear matrix inequality (LMI).