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CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin Yin Yalan Xu Jie Mu Yu Leng Lei Ma Yu Zheng Ruizhi Li Yin wang Peifeng Li Hai Zhu dong wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

Overview of in-situ oxygen production technologies for lunar resources

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International Journal of Minerals,Metallurgy and Materials 2025年第02期 233-255页

作者： Youpeng Xu Sheng Pang Liangwei Cong Guoyu Qian dong wang Laishi Li Yusheng Wu Zhi wang College of Materials Science and Engineering Shenyang University of Technology CAS Key Laboratory of Green Process and Engineering National Engineering Research Center for Green Recycling of Strategic Metal ResourcesInstitute of Process EngineeringChinese Academy of Sciences Innovation Academy for Green Manufacture Chinese Academy of Sciences School of Chemical Engineering University of Chinese Academy of Sciences

The rich resources and unique environment of the Moon make it an ideal location for human expansion and the utilization of extraterrestrial resources. Oxygen, crucial for supporting human life on the Moon, can be extracted from lunar regolith, which is highly rich in oxygen and contains polymetallic oxides. This oxygen and metal extraction can be achieved using existing metallurgical techniques. Furthermore, the ample reserves of water ice on the Moon offer another means for oxygen production. This paper offers a detailed overview of the leading technologies for achieving oxygen production on the Moon, drawing from an analysis of lunar resources and environmental conditions. It delves into the principles, processes, advantages, and drawbacks of water-ice electrolysis, two-step oxygen production from lunar regolith, and one-step oxygen production from lunar regolith. The two-step methods involve hydrogen reduction, carbothermal reduction, and hydrometallurgy, while the one-step methods encompass fluorination/chlorination, high-temperature decomposition, molten salt electrolysis, and molten regolith electrolysis(MOE). Following a thorough comparison of raw materials, equipment, technology, and economic viability, MOE is identified as the most promising approach for future in-situ oxygen production on the Moon. Considering the corrosion characteristics of molten lunar regolith at high temperatures, along with the Moon's low-gravity environment, the development of inexpensive and stable inert anodes and electrolysis devices that can easily collect oxygen is critical for promoting MOE technology on the Moon. This review significantly contributes to our understanding of in-situ oxygen production technologies on the Moon and supports upcoming lunar exploration initiatives.

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Effect of hydrogen on deformation behavior of Alloy 725 revealed by in-situ bi-crystalline micropillar compression test

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Journal of Materials Science & Technology 2021年第8期67卷 243-253页

作者： Xu Lu dong wang Department of Mechanical and Industrial Engineering Norwegian University of Science and TechnologyNo-7491TrondheimNorway

Nickel-based Alloy 725 bi-crystalline micropillars with different types of grain boundaries(GBs)were compressed in hydrogen-free and in-situ hydrogen-charged conditions to investigate the hydrogen effect on the deformation behavior of the selected *** the presence of hydrogen,the compressive stresses on the micropillars increase regardless of the GB *** was proposed that this hydrogen-induced hardening behavior is the synergistic effect of hydrogen-enhanced dislocation multiplication and interactions,the pinning effect of hydrogen on dislocation motion,and hydrogen-enhanced lattice *** electron backscatter diffraction(t-EBSD)results demonstrate that both low-angle GBs and high-angle GBs can effectively suppress dislocation transmission through the GBs,resulting in dislocations pile up along the GBs in the hydrogen-charged *** contrast,this behavior was not observed in the micropillars with twin boundaries.

关键词： Hydrogen Nickel-based alloy Micropillar compression Plastic deformation Grain boundary

Nonlinear Dynamic Modeling for Joint Interfaces by Combining Equivalent Linear Mechanics with Multi-objective Optimization

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Acta Mechanica Solida Sinica 2020年第4期33卷 564-578页

作者： dong wang Xuanliua Fan Institute of Systems Engineering China Academy of Engineering PhysicsMianyang 621099China Shock and Vibration of Engineering Materials and Structures Key Laboratory of Sichuan Province Mianyang 621999China

The nonlinear dynamic modeling by combining the equivalent linear mechanics with the multi-objective optimization algorithm is proposed to describe the nonlinear behaviors of the joint *** joint interfaces are simplified as the equivalent virtual material or linear spring damper *** genetic algorithm for multi-objective optimization is then used to identify the mechanical properties of the equivalent joint by minimizing the error between the simulated dynamic characteristics and the experimental results,including the modal frequencies of the bolted joint beam and the frequency response functions(FRFs)of the rubber isolation *** FRFs are divided into several subsections with frequency-varied dynamic properties of the joint to consider the nonlinear dynamic behaviors,and the effects of subsection number and excitation amplitudes on the FRFs are also *** results show that the simulated dynamic characteristics of modal frequencies and FRFs agree well with the experimental *** the increase in the subsection number,the simulated FRFs agree better with the experimental results,indicating a good performance of modeling the nonlinear dynamic behaviors of the joint interfaces forced by different excitation *** excitation amplitudes will decrease the joint stiffness.

关键词： Joint interfaces Nonlinear dynamic Equivalent linear mechanics Frequencyvaried properties Multi-objective optimization

Two-dimensional Covalent Organic Frameworks: Tessellation by Synthetic Art

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Chemical Research in Chinese Universities 2022年第2期38卷 265-274页

作者： wang Lu wang dong Key Laboratory of Molecular Nanostructure and Nanotechnology Beijing National Laboratory for Molecular SciencesCAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing 100190P.R.China University of the Chinese Academy of Sciences Beijing 100049P.R.China

Covalent organic frameworks(COFs)featuring designable nanoporous structures exhibit many fascinating properties and have attracted great attention in recent years for their intriguing application potential in sensing,catalysis,gas storage and separation,optoelectronics,*** design of twodimensional(2D)COFs through judiciously selecting chemical building blocks is critical to acquiring predetermined skeleton and pore *** this perspective,we review the reticular synthesis of 2D COFs with different topologies,highlighting the important role of various characterization techniques in crystal structure determination.2D COFs with simple tessellations have been widely investigated,while the synthesis of complex tessellated COFs is still a great *** recent examples of 2D COFs with novel topological structures are also surveyed.

关键词： Reticular design Covalent organic framework Topology Characterization technique

On maximal non-selfadjoint reflexive algebras associated with a double triangle lattice

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Science China Mathematics 2015年第11期58卷 2373-2386页

作者： dong AiJu wang dong School of Mathematics and Computer Engineering Xi'an University of Arts and Science Academy of Mathematics and Systems Science Chinese Academy of Sciences Department of Mathematics and Statistics University of New Hampshire

We show that the reflexive algebra Alg(L) given by a double triangle lattice L in a finite factor M(with L" = M) is maximal non-selfadjoint in the class of all weak operator closed subalgebras with the same diagonal subalgebra Alg(L) ∩ Alg(L)^+.Our method can be used to prove similar results in finite-dimensional matrix *** a consequence,we give a new proof to the main theorem by Hou and Zhang(2012).

关键词： Kadison-Singer algebra Kadison-Singer lattice reflexive algebra double triangle lattice factorof type II1

Keyword Extraction from Scientific Research Projects Based on SRP-TF-IDF

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Chinese Journal of Electronics 2021年第4期30卷 652-657页

作者： wang Zhuohao wang dong LI Qing Institute of Scientific and Technical Information of China

Keyword extraction by Term frequencyInverse document frequency(TF-IDF) is used for text information retrieval and mining in many domains, such as news text, social contact text, and medical ***, keyword extraction in special domains still needs to be improved and optimized, particularly in the scientific research field. The traditional TF-IDF algorithm considers only the word frequency in documents, but not the domain characteristics. Therefore, we propose the Scientific research project TF-IDF(SRP-TF-IDF) model,which combines TF-IDF with a weight balance algorithm designed to recalculate candidate keywords. We have implemented the SRP-TF-IDF model and verified that our method has better precision, recall, and F1 score than the traditional TF-IDF and TextRank methods. In addition, we investigated the parameter of our weight balance algorithm to find an optimal value for keyword extraction from scientific research projects.

关键词： extraction TF-IDF Scientific research project Word vector

Universal resources for quantum computing

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Communications in Theoretical Physics 2023年第12期75卷 57-74页

作者： dong-Sheng wang CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China

Unravelling the source of quantum computing power has been a major goal in the field of quantum information *** recent years,the quantum resource theory(QRT)has been established to characterize various quantum resources,yet their roles in quantum computing tasks still require *** so-called universal quantum computing model(UQCM),*** circuit model,has been the main framework to guide the design of quantum algorithms,creation of real quantum computers *** this work,we combine the study of UQCM together with *** find,on one hand,using QRT can provide a resource-theoretic characterization of a UQCM,the relation among models and inspire new ones,and on the other hand,using UQCM offers a framework to apply resources,study relation among these resources and classify *** develop the theory of universal resources in the setting of UQCM,and find a rich spectrum of UQCMs and the corresponding universal *** on a hierarchical structure of resource theories,we find models can be classified into *** this work,we study three natural families of UQCMs in detail:the amplitude family,the quasi-probability family,and the Hamiltonian *** include some well known models,like the measurement-based model and adiabatic model,and also inspire new models such as the contextual model that we *** family contains at least a triplet of models,and such a succinct structure of families of UQCMs offers a unifying picture to investigate resources and design *** also provides a rigorous framework to resolve puzzles,such as the role of entanglement versus interference,and unravel resource-theoretic features of quantum algorithms.

关键词： quantum resource computing model quantum algorithm

A prototype of quantum von Neumann architecture

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Communications in Theoretical Physics 2022年第9期74卷 49-63页

作者： dong-Sheng wang CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China

A modern computer system,based on the von Neumann architecture,is a complicated system with several interactive modular *** requires a thorough understanding of the physics of information storage,processing,protection,readout,*** computing,as the most generic usage of quantum information,follows a hybrid architecture so far,namely,quantum algorithms are stored and controlled classically,and mainly the executions of them are quantum,leading to the so-called quantum processing *** a quantum-classical hybrid is constrained by its classical ingredients,and cannot reveal the computational power of a fully quantum computer system as conceived from the beginning of the ***,the nature of quantum information has been further recognized,such as the no-programming and no-control theorems,and the unifying understandings of quantum algorithms and computing *** a result,in this work,we propose a model of a universal quantum computer system,the quantum version of the von Neumann *** uses ebits(*** states)as elements of the quantum memory unit,and qubits as elements of the quantum control unit and processing *** a digital quantum system,its global configurations can be viewed as tensor-network *** universality is proved by the capability to execute quantum algorithms based on a program composition scheme via a universal quantum gate *** is also protected by the uncertainty principle,the fundamental law of quantum information,making it quantum-secure and distinct from the classical *** particular,we introduce a few variants of quantum circuits,including the tailed,nested,and topological ones,to characterize the roles of quantum memory and control,which could also be of independent interest in other *** all,our primary study demonstrates the manifold power of quantum information and paves the way for the creation of quantum computer systems in the near future.

关键词： quantum computation quantum channel von Neumann architecture