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Is convenience really king? Comparative evaluation of catastrophic costs due to tuberculosis in the public and private healthcare sectors of Viet Nam: a longitudinal patient cost study

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贫困所致传染病(英文) 2024年第2期13卷 1-12页

作者： Nguyen Hoa Binh Quang Vo Luan Nguyen Forse Rachel Jeanette Wiemers Anja Maria Christine Huynh Huy Ba dong thuy thi thu Phan Yen thi Hoang Creswell Jacob Dang thi Minh Ha Nguyen Lan Huu Shedrawy Jad L?nnroth Knut Nguyen Tuan Dinh Van Dinh Luong Annerstedt Kristi Sidney Codlin Andrew James National Lung Hospital Ha Noi Viet Nam Friends for International TB Relief Ha Noi Viet Nam Department of Global Public Health WHO Collaboration Centre On Tuberculosis and Social Medicine Karolinska Institute Stockholm Sweden Stop TB Partnership Geneva Switzerland Pham Ngoc Thach Hospital Ho Chi Minh City Viet Nam

Background In Viet Nam, tuberculosis (TB) represents a devastating life-event with an exorbitant price tag, partly due to lost income from daily directly observed therapy in public sector care. thus, persons with TB may seek care in the private sector for its flexibility, convenience, and privacy. Our study aimed to measure income changes, costs and catastrophic cost incurrence among TB-affected households in the public and private *** Between October 2020 and March 2022, we conducted 110 longitudinal patient cost interviews, among 50 patients privately treated for TB and 60 TB patients treated by the National TB Program (NTP) in Ha Noi, Hai Phong and Ho Chi Minh City, Viet Nam. Using a local adaptation of the WHO TB patient cost survey tool, participants were interviewed during the intensive phase, continuation phase and post-treatment. We compared income levels, direct and indirect treatment costs, catastrophic costs using Wilcoxon rank-sum and chi-squared tests and associated risk factors between the two cohorts using multivariate *** The pre-treatment median monthly household income was significantly higher in the private sector versus NTP cohort (USD 868 vs USD 578;P=0.010). However, private sector treatment was also significantly costlier (USD 2075 vs USD 1313;P=0.005), driven by direct medical costs which were 4.6 times higher than costs reported by NTP participants (USD 754 vs USD 164;Pthis resulted in no significant difference in catastrophic costs between the two cohorts (Private: 55% vs NTP: 52%;P=0.675). Factors associated with catastrophic cost included being a single-person household [adjusted odds ratio [(aOR=13.71; 95% confidence interval (CI): 1.36–138.14;P=0.026], unemployment during treatment (aOR=10.86; 95%CI: 2.64–44.60;P<0.001) and experiencing TB-related stigma (aOR=37.90; 95%CI: 1.72–831.73;P=0.021).Conclusions Persons with TB in Viet Nam face similarly high risk of catastrophic costs whether treated in the

关键词： Tuberculosis Patient cost Catastrophic cost Private sector Comparative analysis Viet Nam

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Transient response of doubly-curved bio-inspired composite shells resting on viscoelastic foundation subject to blast load using improved first-order shear theory and isogeometric approach

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Defence Technology（防务技术） 2024年第8期38卷 171-193页

作者： thuy Tran thi thu Tu Nguyen Anh Hue Nguyen thi Hong Nguyen thi School of Mechanical and Automotive Engineering Hanoi University of IndustryHanoiViet Nam Faculty of Technical Fundamental University of Transport TechnologyHanoiViet Nam Faculty of Mechanical Engineering Thuyloi University175 Tay SonDong DaHanoiViet Nam

Investigating natural-inspired applications is a perennially appealing subject for scientists. The current increase in the speed of natural-origin structure growth may be linked to their superior mechanical properties and environmental resilience. Biological composite structures with helicoidal schemes and designs have remarkable capacities to absorb impact energy and withstand damage. However, there is a dearth of extensive study on the influence of fiber redirection and reorientation inside the matrix of a helicoid structure on its mechanical performance and reactivity. The present study aimed to explore the static and transient responses of a bio-inspired helicoid laminated composite(B-iHLC) shell under the influence of an explosive load using an isomorphic method. The structural integrity of the shell is maintained by a viscoelastic basis known as the Pasternak foundation, which encompasses two coefficients of stiffness and one coefficient of damping. The equilibrium equations governing shell dynamics are obtained by using Hamilton's principle and including the modified first-order shear theory,therefore obviating the need to employ a shear correction factor. The paper's model and approach are validated by doing numerical comparisons with respected publications. The findings of this study may be used in the construction of military and civilian infrastructure in situations when the structure is subjected to severe stresses that might potentially result in catastrophic collapse. The findings of this paper serve as the foundation for several other issues, including geometric optimization and the dynamic response of similar mechanical structures.

关键词： Blast load Modified first-order shear theory Biological composite structures

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CRISPRi在结核分枝杆菌生物学研究中的应用及优化

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中华结核和呼吸杂志 2024年第4期47卷 376-382页

作者： Le thi thu thuy 黄煜谢建平西南大学生命科学学院现代生物医药研究所重庆400715

结核分枝杆菌(MTB)感染导致的结核病仍然是全球公共卫生的巨大挑战。耐多药结核病(MDR-TB)和广泛耐药结核病(XDR-TB)菌株使得结核病治疗更加困难。不断研发新遗传工具,探索MTB生理,有望发现新的药物靶点。其中,最近用于MTB研究的成簇规... 详细信息

结核分枝杆菌(MTB)感染导致的结核病仍然是全球公共卫生的巨大挑战。耐多药结核病(MDR-TB)和广泛耐药结核病(XDR-TB)菌株使得结核病治疗更加困难。不断研发新遗传工具,探索MTB生理,有望发现新的药物靶点。其中,最近用于MTB研究的成簇规律间隔短回文重复序列干扰(CRISPRi)与高通量测序相结合,为揭示MTB生理和遗传提供了基础。本文综述了CRISPRi在MTB生物学研究中的应用及技术发展。

关键词：结核病治疗耐多药结核病全球公共卫生结核分枝杆菌广泛耐药结核病药物靶点成簇规律间隔短回文重复序列高通量测序

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Prevalence and risk factors associated with long COVID symptoms in children and adolescents in a southern province of Vietnam

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Asian Pacific Journal of Tropical Medicine 2024年第3期17卷 119-128,I0001,I0002页

作者： Huynh Ngoc Linh Nguyen The Tan Le thi Minh thu Nguyen Tu Loan Nguyen thi To Uyen Le Thanh Thao Trang Truong Thanh Nam Doan Hoang Phu Faculty of Medicine Ca Mau Medical CollegeCa Mau 98000Vietnam Ca Mau Obstetrics and Pediatrics Hospital Ca Mau 98000Vietnam Faculty of Basic Science and Public Health Dong Thap Medical CollegeDong Thap 81000Vietnam Graduate University of Sciences and Technology Vietnam Academy of Science and TechnologyHa Noi 10000Vietnam Community Public Health Research Program School of Public HealthWalailak UniversityNakhon Si Thammarat 80160Thailand Faculty Public Health Can Tho University of Medicine and PharmacyCan Tho City 94000Vietnam Doctoral Program in Health Sciences College of Graduate StudiesWalailak UniversityNakhon Si Thammarat 80160Thailand

Objective:To investigate the prevalence and risk factors associated with long COVID symptoms among children and adolescents who have recovered from ***:this study applied a cross-sectional approach within community settings in a southern province of Vietnam.A structured questionnaire featuring socio-demographic information and common long COVID symptoms was *** correlation coefficients assessed associations among pairs of long COVID ***,multivariable logistic regression models were performed to investigate the risk factors of long COVID in recovered COVID-19 children and ***:Among 422 participants,39.3%reported long COVID symptoms,with a prevalence of 45.2%(SD=0.5)in children and 22.2%(SD=0.4)in *** symptoms reported were cough 34.6%(SD=0.5),fatigue 20.6%(SD=0.4),shortness of breath 10.9%(SD=0.3),and lack of appetite 6.6%(SD=0.3).Concerning risk factors of long COVID,a higher risk was observed among demographic groups,including girls(OR 1.25,95%CI 1.15-1.37;Pthis study provide crucial guidance for predicting the factors associated with the occurrence of long COVID in pediatric patients,contributing to strategic interventions aimed at mitigating the long COVID risks among children and adolescents in Vietnam.

关键词： Long COVID Prevalence Risk factors Children Adolescent Vietnam

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Polyacrylate modified Cu electrode for selective electrochemical CO_(2) reduction towards multicarbon products

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Science Bulletin 2024年第15期69卷 2395-2404页

作者： Yuchuan Shi Kaini Zhang Chung-Li dong Ta thi thuy Nga Miao Wang Daixing Wei Jialin Wang Yiqing Wang Shaohua Shen International Research Center for Renewable Energy State Key Laboratory of Multiphase Flow in Power EngineeringXi’an Jiaotong UniversityXi’an 710049China Department of Physics Tamkang UniversityNew Taipei City 25137China

Highly selective production of value-added multicarbon(C^(2+))products via electrochemical CO_(2) reduction reaction(eCO_(2)RR)on polycrystalline copper(Cu)remains ***,the facile surface modification using poly(α-ethyl cyanoacrylate)(PECA)is presented to greatly enhance the C^(2+)selectivity for eCO_(2)RR over polycrystalline Cu,with Faradaic efficiency(FE)towards C^(2+)products increased from30.1%for the Cu electrode to 72.6%for the obtained Cu-PECA electrode at-1.1 V *** hydrogen electrode(RHE).Given the well-determined FEs towards C^(2+)products,the partial current densities for C^(2+)production could be estimated to be-145.4 mA cm~(-2)for the Cu-PECA electrode at-0.9 V *** in a homemade flow ***-situ spectral characterizations and theoretical calculations reveal that PECA featured with electron-accepting-C≡N and-COOR groups decorated onto the Cu electrode could inhibit the adsorption of^(*)H intermediates and stabilize the^(*)CO intermediates,given the redistributed interfacial electron density and the raised energy level of d-band center(E_(d))of Cu active sites,thus facilitating the C-C coupling and then the C^(2+)selective *** study is believed to be guidable to the modification of electrocatalysts and electrodes with polymers to steer the surface adsorption behaviors of reaction intermediates to realize practical eCO_(2)RR towards value-added C^(2+)products with high activity and selectivity.

关键词： Electrochemical CO_(2)reduction Polymer modification Electron transfer C_(2+)products

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Chalcogen heteroatoms doped nickel-nitrogen-carbon single-atom catalysts with asymmetric coordination for efficient electrochemical CO_(2)reduction

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Chinese Journal of Catalysis 2024年第9期64卷 54-65页

作者： Jialin Wang Kaini Zhang Ta thi thuy Ng Yiqing Wang Yuchuan Shi Daixing Wei Chung-Li dong Shaohua Shen International Research Center for Renewable Energy State Key Laboratory of Multiphase Flow in Power EngineeringXi'an Jiaotong UniversityXi'an 710049ShaanxiChina Department of Physics Tamkang UniversityNew Taipei City 25137TaiwanChina

The electronic configuration of central metal atoms in single-atom catalysts(SACs)is pivotal in electrochemical CO_(2)reduction reaction(eCO_(2)RR).Herein,chalcogen heteroatoms(e.g.,S,Se,and Te)were incorporated into the symmetric nickel-nitrogen-carbon(Ni-N4-C)configuration to obtain Ni-X-N3-C(X:S,Se,and Te)SACs with asymmetric coordination presented for central Ni *** these obtained Ni-X-N3-C(X:S,Se,and Te)SACs,Ni-Se-N3-C exhibited superior eCO_(2)RR activity,with CO selectivity reaching~98%at-0.70 V versus reversible hydrogen electrode(RHE).The Zn-CO_(2)battery integrated with Ni-Se-N3-C as cathode and Zn foil as anode achieved a peak power density of 1.82 mW cm-2 and maintained remarkable rechargeable stability over 20 ***-situ spectral investigations and theoretical calculations demonstrated that the chalcogen heteroatoms doped into the Ni-N4-C configuration would break coordination symmetry and trigger charge redistribution,and then regulate the intermediate behaviors and thermodynamic reaction pathways for eCO_(2)***,for Ni-Se-N3-C,the introduced Se atoms could significantly raise the d-band center of central Ni atoms and thus remarkably lower the energy barrier for the rate-determining step of*COOH formation,contributing to the promising eCO_(2)RR performance for high selectivity CO production by competing with hydrogen evolution reaction.

关键词： Electrochemical CO_(2)reduction reaction Chalcogen heteroatoms Single-atom catalysts Asymmetric coordination CO production

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Static and dynamic analysis of functionally graded fluidinfiltrated porous skew and elliptical nanoplates using an isogeometric approach

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Frontiers of Structural and Civil Engineering 2023年第3期17卷 477-502页

作者： Tran thi thu thuy Faculty of Mechanical Engineering Hanoi University of IndustryHanoi 100000Vietnam

The analysis of static bending and free and forced vibration responses of functionally graded fluidinfiltrated porous(FGFP)skew and elliptical nanoplates placed on Pasternak’s two-parameter elastic foundation is performed for the first time using isogeometric analysis(IGA)based on the non-uniform rational B-splines(NURBSs)basis *** types of porosity distributions affect the mechanical characteristics of materials:symmetric distribution,upper asymmetric distribution,and lower asymmetric *** stress–strain relationship for Biot porous materials was determined using the elastic *** general equations of motion of the nanoplates were established using the four-unknown shear deformation plate theory in conjunction with the nonlocal elastic theory and Hamilton’s principle.A computer program that uses IGA to determine the static bending and free and forced vibration of a nanoplate was developed on MATLAB software *** accuracy of the computational program was validated via numerical comparison with confidence *** set of programs presents the influence of the following parameters on the static bending and free and forced vibrations of nanoplates:porosity distribution law,porosity coefficient and geometrical parameters,elastic foundation,deviation angle,nonlocal coefficient,different boundary conditions,and Skempton *** numerical findings demonstrated the uniqueness of the FGFP plate’s behavior when the porosities are saturated with liquid compared with the case without *** findings of this study have significant implications for engineers involved in the design and fabrication of the aforementioned type of ***,this can form the basis for future research on the mechanical responses of the structures.

关键词： static bending free and forced vibrations nonlocal theory isogeometric analysis fluid-infiltrated porous nanoplates

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Activated carbon derived from rice husk by NaOH activation and its application in supercapacitor

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Progress in Natural Science:Materials International 2014年第3期24卷 191-198页

作者： Khu Le Van thu thuy Luong thi Physical Chemistry Department Hanoi University of Education

Four activated carbon(AC) samples prepared from rice husk under different activation temperatures have been characterized by N2adsorption–desorption isotherms, thermogravimetric analysis(TGA–DTA), Fourier transform infrared spectroscopy(FTIR) and scanning electron microscopy(SEM). The specific surface area of AC sample reached 2681 m2 g 1under activation temperature of 800 1C. The AC samples were then tested as electrode material; the specific capacitance of the as-prepared activated carbon electrode was found to be 172.3 F g 1using cyclic voltammetry at a scan rate of 5 mV s 1and 198.4 F g 1at current density 1000 mA g 1in the charge/discharge mode.& 2014 Chinese Materials Research Society. Production and hosting by Elsevier B.V. All rights reserved.

关键词： Rice husk Activated carbon Supercapacitor Surface area Micropore

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Usefulness of Mac-2 binding protein glycosylation isomer in noninvasive probing liver disease in the Vietnamese population

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World Journal of Hepatology 2020年第5期12卷 220-229页

作者： thuy thi thu Pham Dat Tan Ho Toan Nguyen MEDIC Medical Center Ho Chi Minh 72517Vietnam

BACKGROUND Early diagnosis is critical for successful intervention before liver disease progresses to cirrhosis and hepatocellular *** To examine a novel biomarker for probing early liver disease quickly using an automated immunology *** this was a cross-sectional study.140 patients at various stages of liver disease were randomly *** cohort consisted of patients who were treatment naïve and currently undergoing *** included patients with diverse liver disease ***-2 binding protein glycosylation isomer(M2BPGi)levels in addition to different clinical parameters,co-morbidities and transient elastography results were collected and *** M2BPGi levels were significantly correlated with transient elastography for liver fibrosis staging across all disease *** significant differences were observed in patients with F0-1;F2 and>F3 liver *** examination showed that M2BPGi levels were two-fold higher in F4 than F3 hepatitis C(HCV)patients.M2BPGi was observed to be etiology-specific and HCV patients had higher mean M2BPGi *** also observed significant correlations with aspartate aminotransferase to platelet ratio index and fibrosis-4 index as well as HBV DNA *** M2BPGi levels for HBV patients with a viral load lower than 2000 IU/mL was 1.75-fold lower than those with a viral load greater than 2000 IU/*** M2BPGi was observed to be a good indicator of early liver disease in patients with different *** results provide reference cut-offs for different causes of liver disease and demonstrated the utility of this marker for early disease *** is useful for remote regions in developing countries.

关键词： Hepatitis B Hepatitis C Noninvasive fibrosis markers Mac-2 binding protein glycosylation isomer Liver disease

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A crate of Pandora:do amyloids from bacteria promote Alzheimer’s disease?

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Neural Regeneration Research 2021年第5期16卷 988-989页

作者： Vu thu thuy Nguyen Kristina Endres Department of Psychiatry and Psychotherapy University Medical Center Johannes Gutenberg-University MainzMainzGermany

Incidence for microbes as drivers of Alzheimer’s disease(AD)pathology:AD is the predominant neurodegenerative disease within the *** 50 million patients suffer from dementia currently world-wide and an estimated tripling of numbers within the next 30 years is *** one to maximally five percent of all cases of AD are based on mutations in the amyloid precursor protein(APP)gene or within the presenilin genes(PS1/PS2)and therefore are called familial(FAD).The majority of cases has to be designated as sporadic,which frankly only means that the origin of these cases is still enigmatic.

关键词： amyloid Alzheimer pathology

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