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Multiple reaction monitoring for the detection of disease-related synaptic proteins

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Neural Regeneration Research 2014年第23期9卷 2042-2043页

作者： Rachel Yoon kyung chang Peter R.Dodd School of Chemistry and Molecular Biosciences University of Queensland

Synaptic dysfunction occurs early in Alzheimer＇s disease （AD） and is acknowledged as a primary pathologic target for treatment. Synaptic degeneration is the pathological feature most strongly correlated with loss of cognitive function ante mortern （Terry et al., 1991）. Synapses are heavily damaged in hippocampal and neocortical regions of AD brain, whereas motor and occipital cortices are relatively spared （Honer et al., 1992）. Despite extensive work, the molecular mechanisms underlying synaptic degeneration are largely unknown.

关键词： MRM Multiple reaction monitoring for the detection of disease-related synaptic proteins

New Fossil Beetles of the Family Elateridae from the Jehol Biota of China(Coleoptera:Polyphaga)

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Acta Geologica Sinica(English Edition) 2008年第2期82卷 236-243页

作者： chang Huali REN dong College of Life Sciences Capital Normal University. Beijing 100037 China

Two new species of elaterids assigned to two new genera with intriguing fossa on prosternum are described and illustrated： Bilineariselaterfoveatus gen. et sp. nov. and Curtelater wui gen. et sp. nov. from the Upper Jurassic-Lower Cretaceous Yixian Formation of western Liaoning, China. The origin of the clicking mechanism in these beetles and the systematic position of the two genera are briefly discussed.

关键词： Insecta click-beetles (Elateridae) Late Jurassic-Early Cretaceous Yixian Formation,Jehol fauna

Combination of cell signaling molecules can facilitate MYOD1-mediated myogenic transdifferentiation of pig fibroblasts

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Journal of Animal Science and Biotechnology 2021年第4期12卷 1662-1674页

作者： Jinsol Jeong Kwang-Hwan Choi Seung-Hun Kim dong-kyung Lee Jong-Nam Oh Mingyun Lee Gyung Cheol Choe chang-Kyu Lee Department of Agricultural Biotechnology Animal Biotechnology Majorand Research Institute of Agriculture and Life ScienceSeoul National UniversitySeoul 08826South Korea Present address:Research and Development Center Space F corporationHwasung-siGyeonggi-do 18471South Korea Institute of Green Bio Science and Technology Seoul National UniversityPyeong ChangKangwon-do 25354South Korea

Background:Myogenic transdifferentiation can be accomplished through ectopic MYOD1 expression,which is facilitated by various signaling pathways associated with *** this study,we attempted to transdifferentiate pig embryonic fibroblasts(PEFs)myogenically into skeletal muscle through overexpression of the pig MYOD1 gene and modulation of the FGF,TGF-β,WNT,and cAMP signaling ***:The MYOD1 overexpression vector was constructed based on comparative sequence analysis,demonstrating that pig MYOD1 has evolutionarily conserved domains across various *** forced MYOD1 expression through these vectors triggered the expression of endogenous muscle markers,transdifferentiated muscle cells from fibroblasts were not ***,various signaling molecules,including FGF2,SB431542,CHIR99021,and forskolin,along with MYOD1 overexpression were applied to enhance the myogenic *** modified conditions led to the derivation of myotubes and activation of muscle markers in PEFs,as determined by qPCR and ***,a sarcomere-like structure was observed,indicating that terminally differentiated skeletal muscle could be obtained from transdifferentiated ***:In summary,we established a protocol for reprogramming MYOD1-overexpressing PEFs into the mature skeletal muscle using signaling *** myogenic reprogramming can be used as a cell source for muscle disease models in regenerative medicine and the production of cultured meat in cellular agriculture.

关键词： MYOD1 Pig Sequence analysis Skeletal muscle Transdifferentiation

Effect of chirality on conformation and cellular uptake of poly(S-(o-nitrobenzyl)-L,D-cysteine) polypeptides

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Chinese Chemical Letters 2017年第4期28卷 827-831页

作者： Yang Liu chang-Ming dong Department of Polymer Science & Engineering School of Chemistry and Chemical Engineering Shanghai Jiao Tong University Shanghai 200240 China

A series of poly（S-（o-nitrobenzyl）-L,D-cysteine） polypeptides with different chirality was synthesized and their molecular structures,secondary conformations,drug release and biological properties were thoroughly *** chirality of the polypeptides had effect on secondary conformations and the cellular uptake behavior of the related nanoparticles.

关键词： Chiral polypeptide Secondary conformation Nanoparticle Drug release Cellular uptake

Quadruple thermo-photo-redox-responsive random copolypeptide nanogel and hydrogel

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Chinese Chemical Letters 2018年第6期29卷 927-930页

作者： Yuanfeng Gao chang-Ming dong School of Chemistry and Chemical Engineering Shanghai Key Laboratory of Electrical Insulation and Thermal Aging Shanghai Jiao Tong University

A series of random copolypeptides of poly（methoxy-diethylene glycol–L-glutamate）-co-poly（S-（onitrobenzyl）-L-cysteine）was synthesized by ring-open copolymerization of methoxydiethylene glycol-Lglutamate-N-carboxyanhydride（EG2-Glu-NCA） and S-（o-nitrobenzyl）-L-cysteine-N-carboxyanhydride（NBC-NCA） in dried dimethylformamide solution, which presents quadruple thermo-photo-redox responsive self-assembly behavior and forms the related nanogel and hydrogel in water.

关键词： Random copolypeptide Quadruple stimuli Photoresponsive Redox Thermosensitive Nanogel Supramolecular hydrogel

Investigation on halogen-doped n-type SnTe thermoelectrics

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Rare Metals 2022年第11期41卷 3803-3814页

作者： chang-Rong Guo Bing-Chao Qin dong-Yang Wang Li-dong Zhao School of Materials Science and Engineering Beihang UniversityBeijing100191China

Recent theoretical predictions and experimental findings on the transport properties of n-type SnTe have triggered extensive researches on this simple binary compound,despite the realization of n-type SnTe being a great ***,Cl as a donor dopant can effectively regulate the position of Fermi level in Sn_(0.6)Pb_(0.4)Te matrix and successfully achieve the n-type transport behavior in *** outstanding power factor of~14.7μW·cm^(-1)·K^(-2) at 300 K was obtained for Cl-doped Sn_(0.6)Pb_(0.4)Te *** combining the experimental analysis with theoretical calculations,the transport properties of n-type SnTe thermoelectrics doped with different halogen dopants(Cl,Br,and I)were then systematically investigated and *** results demonstrated that Br and I had better doping efficiencies compared with Cl,which contributed to the well-optimized carrier concentrations of~1.03×10^(19)and~1.11×10^(19)cm^(-3)at 300 K,*** improved n-type carrier concentrations effectively lead to the significant enhancement on the thermoelectric performance of n-type *** study further promoted the experimental progress and deep interpretation of the transport features in n-type SnTe *** present results could also be crucial for the development of n-type counterparts for SnTe-based thermoelectric devices.

关键词： Thermoelectric performance n-type SnTe Halogen doping Doping efficiency

Impact of Horizontal Resolution and Cumulus Parameterization Scheme on the Simulation of Heavy Rainfall Events over the Korean Peninsula

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Advances in Atmospheric Sciences 2011年第1期28卷 1-15页

作者： Seung-Woo LEE dong-Kyou LEE dong-Eon chang School of Earth and Environmental Sciences Seoul National University National Institute of Meteorological Research Korea Meteorological Administration

In this paper, we present the results from high-resolution numerical simulations of three heavy rainfall events over the Korean Peninsula. The numerical results show that the prediction accuracy for heavy rainfall events improved as horizontal resolution increased. The fine-grid precipitation fields were much closer to the real precipitation fields in the case of large synoptic forcing over the Korean Peninsula. In the case of large convective available potential energy and weak synoptic forcing, it seems that even when using a high resolution, the models still showed poor performance in reproducing the observed high precipitation amounts. However, activation of the cumulus parameterization scheme in the intermediate resolution of 9 km, even at a grid spacing of 3 km, had a positive impact on the simulation of the heavy rainfall event.

关键词： high resolution cumulus parameterization scheme heavy rainfall numerical simulation

Integral domains with finitely many spectral semistar operations

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Frontiers of Mathematics in China 2017年第1期12卷 35-49页

作者： Gyu Whan chang dong Yeol OH Department of Mathematics Education Incheon National University Incheon 22012 Republic of Korea Department of Mathematics Education Chosun University Gwangju 61452Republic of Korea

Let D be a finite-dimensional integral domain, Spec（D） be the set of prime ideals of D, and SpSS（D） be the set of spectral semistar operations on D. Mimouni gave a complete description for the prime ideal structure of D with ｜SpSS（D）｜ = n ＋ dim（D） for 1 ≤ n ≤5 except for the quasi-local cases of n = 4, 5. In this paper, we show that there is an integral domain D such that ｜SpSS（D）｜ = n＋dim（D） for all positive integers n with n ≠ 2. As corollaries, we completely characterize the quasi-local domains D with ｜SpSS（D）｜= n＋dim（D） for n = 4, 5. Furthermore, we also present the lower and upper bounds of ISpSS（D）I when Spee（D） is a finite tree.

关键词： (Spectral) semistar operation prime spectrum (Krull) dimension

Cheeger's cut, maxcut and the spectral theory of1-Laplacian on graphs

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Science China Mathematics 2017年第11期60卷 1963-1980页

作者： chang KungChing SHAO SiHong ZHANG dong LMAM and School of Mathematical Sciences Peking University

This is primarily an expository paper surveying up-to-date known results on the spectral theory of1-Laplacian on graphs and its applications to the Cheeger cut, maxcut and multi-cut problems. The structure of eigenspa... 详细信息

关键词： spectral graph theory Laplacian graph cut optimization critical point theory