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Electroacupuncture with different waveforms for primary dysmenorrhea: A randomized controlled trial

j.urnal of Traditional Chinese Medical Sciences 2024年第3期11卷 357-362页

作者： Wu X. Yuan j. Ni j. Ma X. Zhang Z. Hua Y. dong j. Wang B.P. dongzhimen Hospital Beijing University of Chinese Medicine Beijing 100700 China These authors have contributed equally to this work. New Zealand College of Chinese Medicine Auckland 17467 New Zealand

Obj.ctive: To observe and compare the clinical effects of different electroacupuncture waveforms on primary dysmenorrhea. Methods: This was a prospective, randomized, three-group, parallel-controlled trial. Participants with primary dysmenorrhea were randomly divided into dense-sparse wave, continuous wave, and discontinuous wave groups in a 1:1:1 ratio. Two lateral Ciliao (BL 32) points were used. All three groups started treatment 3–5 days before menstruation, once a day for six sessions per course of treatment, one course of treatment per menstrual cycle, and three menstrual cycles. The primary outcome measure was the proportion with an average visual analog scale (VAS) score reduction of ≥50% from baseline for dysmenorrhea in the third menstrual cycle during treatment. The secondary outcome measures included changes in dysmenorrhea VAS scores, Cox Menstrual Symptom Scale scores and the proportion of patients taking analgesic drugs. Results: The proportion of cases where the average VAS score for dysmenorrhea decreased by ≥50% from baseline in the third menstrual cycle was not statistically significant (P > .05). Precisely 30 min after acupuncture and regarding immediate analgesia on the most severe day of dysmenorrhea, there was a statistically significant difference in the dense-sparse wave group compared with the other two groups during the third menstrual cycle (P j.ng University of Chinese Medicine

关键词： Ciliao (BL 32) Continuous waves Dense-sparse waves Discontinuous waves Electroacupuncture Primary dysmenorrhea Randomized controlled trial Waveforms

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A comparative study of the anti-fatigue activity of extracts from different parts of Cistanche tubulosa (Schenk) Wight

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j.urnal of Traditional Chinese Medical Sciences 2024年第2期11卷 222-231页

作者： dong j. Li j. Liu Y. Cui L. Liu X. Wang G. Wang Q. Criddle D.N. Tu P. Li C. School of Traditional Chinese Medicine Beijing University of Chinese Medicine Beijing 102488 China Modern Research Center for Traditional Chinese Medicine School of Chinese Materia Medica Beijing University of Chinese Medicine Beijing 102488 China Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing 100700 China Department of Molecular & Clinical Cancer Medicine Institute of Systems Molecular & Integrative Biology University of Liverpool Liverpool L69 3BX United Kingdom Peking University School of Pharmaceutical Sciences Beijing 100191 China

Obj.ctive: To evaluate the anti-fatigue effects of different extracts from Cistanche tubulosa (Schenk) Wight (C. tubulosa, Rou Cong Rong), focusing on central and exercise-induced fatigue in mice. This study investigated the pharmacological effects of the total oligosaccharides, polysaccharides, and phenylethanoid glycosides (CPhGs) extracted from C. tubulosa. Methods: Models of sleep deprivation and forced swimming fatigue were established to simulate central and exercise-induced fatigue. The mice were treated with different extracts of C. tubulosa, and their effects were assessed using behavioral tests to measure exercise capacity, learning, and memory function. Biochemical analyses were performed to evaluate the changes in serum and brain neurotransmitter levels, liver and muscle glycogen storage, and various fatigue-related biomarkers. Results: This study found that treatment with C. tubulosa extract improved exercise capacity, learning, and memory in mice. Total oligosaccharides from C. tubulosa enhanced adrenocorticotropic hormone, cholinesterase, and thyroid-stimulating hormone levels, reduced cortisol levels in central fatigue models, and ameliorated biochemical markers of exercise-induced fatigue, including lowering lactic acid, blood urea nitrogen, and malondialdehyde levels. Among the tested extracts, the total oligosaccharides showed the most comprehensive anti-fatigue effects. Conclusion: The anti-fatigue effects of C. tubulosa, particularly those of its total oligosaccharides, are pronounced in both central and exercise-induced fatigue. These effects are mediated by the regulation of neurotransmitter levels, enhancement of glycogen storage, and improvement of antioxidant enzyme activity, suggesting potential therapeutic benefits in fatigue-related conditions. © 2024 Beij.ng University of Chinese Medicine

关键词： Anti-fatigue Central fatigue Cistanche tubulosa Exercise fatigue Oligosaccharides

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Comparing the biological coherence of network clusters identified by different detection algorithms

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Chinese Science Bulletin 2007年第21期52卷 2938-2944页

作者： dong dong ZHOU Bing j.ng-dong j. HAN Graduate School College of Life Sciences Beijing Normal University Beijing 100875 China Chinese Academy of Science Key Laboratory for Molecular Developmental Biology Institute of Genetics and Developmental Biol- ogy Chinese Academy of Sciences Beijing 100101 China

Protein-protein interaction networks serve to carry out basic molecular activity in the cell. Detecting the modular structures from the protein-protein interaction network is important for understanding the organization, function and dynamics of a biological system. In order to identify functional neighbor- hoods based on network topology, many network cluster identification algorithms have been devel- oped. However, each algorithm might dissect a network from a different aspect and may provide dif- ferent insight on the network partition. In order to obj.ctively evaluate the performance of four com- monly used cluster detection algorithms: molecular complex detection (MCODE), NetworkBlast, shortest-distance clustering (SDC) and Girvan-Newman (G-N) algorithm, we compared the biological coherence of the network clusters found by these algorithms through a uniform evaluation framework. Each algorithm was utilized to find network clusters in two different protein-protein interaction net- works with various parameters. Comparison of the resulting network clusters indicates that clusters found by MCODE and SDC are of higher biological coherence than those by NetworkBlast and G-N algorithm.

关键词：网络簇检测算法生物学函数熵双蛋白相互网络

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Decolorization of Direct Black 22 by Aspergillus ficuum

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j.urnal of Environmental Sciences 2001年第4期13卷 472-475页

作者： dong, X.-j. Du, Z.-y. Chen, Z. Dept. of Biology/Environmental Sci. Wenzhou Normal College Wenzhou 325003 China

The decolorization of Direct Black 22 by Aspergillus ficuum has been studied. It was found that Aspergillus ficuum could effectively decolorize Direct Black 22 especially when grown as pelleted mycelia. Results showed that the media containing Direct Black 22 at 50 mg/L could be decolorized by 98.05% of the initial color in 24 h. The optimum pH and temperature of decolorization are 4.0 and 33 °C respectively. Aeration was quite beneficial to decolorization. Medium composition and the concentration of Direct Black 22 could affect the rate of decolorization. The dye degraded products assayed by UV-visible spectrophotometer and macroscopic observation showed that the decolorization of Direct Black 22 by mycelial pellets includes two important processes: bioadsorption and biodegradation. The degradation experiment agree with the Michaelis-Menten kinetics equation.

关键词： Bioassay Biodegradation Color Concentration (process) Dyes pH Ultraviolet spectrophotometers

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STUDY ON THE NUMERICAL SIMULATION OF MULTI-STAGE ROTARY FORGING OF A NON-AXISYMMETRIC PART AND THE CAE ANALYSIS OF THE DIE STRENGTH

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Acta Metallurgica Sinica(English Letters) 2005年第5期18卷 627-634页

作者： H. Tian j. Wang W.P. dong j. Chen Z. Zhao G.M. Wu National Die ＆ Mold CAD Engineering Research Center Shanghai Jiaotong UniversityShanghai 200030 China

Traditionally a rotary forging process is a kind of metal forming method where a conic upper die, whose axis is deviated an angle from the axis of machine, forges a billet continuously and partially to finish the whole deformation. For the rotary forging process simulation, more researches were focused on simulating the simple stage forming process with axisymmetric part geometry. Whereas in this paper, the upper die is not cone-shaped, and the billet is non-axisymmetric. So the movement of the punch is much more complicated than ever. The 3D FEM simulation models for the preforming ＆ final forming processes are set up aider carefully studying the complicated movement pattern. Deform-3D is used to simulate the material flow, and the boundary nodal resisting forces calculated by the final stage process simulation is used to analyze the final forming die strength. The CAE analysis of the die shows that the design of the final forming die is not reasonable with lower pre-stress which is easy to crack at the critical corners. An optimum die design is also provided with higher pre-stress, and verified by CAE analysis.

关键词： numerical simulation non-axisymmetric rotary forging die strength

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Understanding human diseases with high-throughput quantitative measurement and analysis of molecular signatures

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Science China(Life Sciences) 2013年第3期56卷 213-219页

作者： YANG Li WEI Gang TANG Kun NARDINI Christine HAN j.ng-dong j. CAS Key Laboratory of Computational Biology CAS-MPG Institute for Computational BiologyShanghai Institutes of Biological SciencesChinese Academy of Sciences

Microarray and deep sequencing technologies have provided unprecedented opportunities for mapping genome mutations,RNA transcripts,transcription factor binding,and histone modifications at high resolution at the genome-wide *** has revolutionized the way in which transcriptomes,regulatory networks and epigenetic regulations have been studied and large amounts of heterogeneous data have been *** efforts are being made to integrate these datasets unbiasedly and efficiently,how best to do this still remains a *** we review maj.r impacts of high-throughput genome-wide data generation,their relevance to human diseases,and various bioinformatics approaches for data ***,we provide a case study on inflammatory diseases.

关键词： genomics epigenomics phenomics integration data analysis

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CXXC5 suppresses hepatocellular carcinoma by promoting TGF-β-induced cell cycle arrest and apoptosis

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j.urnal of Molecular Cell Biology 2018年第1期10卷 48-59页

作者： Xiaohua Yan j.ngyi Wu Quanlong j.ang Hao Cheng j.ng-dong j. Han Ye-Guang Chen The State Key Laboratory of Membrane Biology Tsinghua-Peking Center for Life Sciences School of Life Sciences Tsinghua University Beijing 100084 China Department of Biochemistry and Molecular Biology School of Basic Medical Sciences Nanchang University Nanchang 330006 China Chinese Academy of Sciences-Max Planck Partner Institute for Computational Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China

Evading TGF-β-mediated growth inhibition is often associated with tumorigenesis in liver, including hepatocellular carcinoma （HCC）. To better understand the functions and the underlying molecular mechanisms of TGF-β in HCC initiation and progression, we carried out transcriptome sequencing （RNA-Seq） to identify the target genes of TGF-β. CXXCS, a member of the CXXC-type zinc finger domain-containing protein family, was identified as a novel TGF-β target gene in Hep3B HCC cells. Knockdown of CXXC5 attenuated the expression of a substantial portion of TGF-p target genes and ameliorated TGF-13-induced growth inhibition or apoptosis of Hep3B cells, suggesting that CXXC5 is required for TGF-p-mediated inhibition of HCC progression. Analysis of the TCGA database indicated that CXXC5 expression is reduced in the maj.rity of HCC tissue samples in comparison to that in normal tissues. Furthermore, CXXC5 associates with the histone deacetylase HDAC1 and competes its interaction with Smad2/3, thereby abolishing the inhibitory effect of HDAC1 on TGF-β signaling. These observations together suggest that CXXC5 may act as a tumor suppressor by promoting TGF-β signaling via a positive feedback loop, and reveal a strategy for HCC to bypass TGF-β-mediated cytostasis by disrupting the positive feedback regulation. Our findings shed new light on TGF-β signaling regulation and demon- strate the function of CXXC5 in HCC development.

关键词： hepatocellular carcinoma (HCC) TGF-β CXXC5 HDAC signaling regulation

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The system capacity view of aging and longevity

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Frontiers of Electrical and Electronic Engineering in China 2017年第3期5卷 251-259页

作者： j.ng-dong j. Han Lei Hou Na Sun Chi Xu j.seph McDermott Dan Wang Key Laboratory of Computational Biology CAS Center for Excellence in Molecular Cell Science Collaborative Innovation Center for Genetics and Developmental Biology Chinese Academy of Sciences-Max Planck Partner Institute for Computational Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China

Background： Aging is a complex systems level problem that needs a systems level solution. However, system models of aging and longevity, although urgently needed, are still lacking, largely due to the paucity of conceptual frameworks for modeling such a complex process. Results： We propose that aging can be viewed as a decline in system capacity, defined as the maximum level of output that a system produces to fulfill demands. Classical aging hallmarks and anti-aging strategies can be well-aligned to system capacity. Genetic variants responsible for lifespan variation across individuals or species can also be explained by their roles in system capacity. We further propose promising directions to develop systems approaches to modulate system capacity and thus extend both healthspan and lifespan. Conclusions： The system capacity model of aging provides an opportunity to examine aging at the systems level. This model predicts that the extent to which aging can be modulated is normally limited by the upper bound of the system capacity of a species. Within such a boundary, aging can be delayed by moderately increasing an individual＇s system capacity. Beyond such a boundary, increasing the upper bound is required, which is not unrealistic given the unlimited potential of regenerative medicine in the future, but it requires increasing the capacity of the whole system instead of only part of it.

关键词： systems system capacity aging longevity

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Network pharmacology and experimental validation to reveal the pharmacological mechanisms of Qizhu prescription for treating breast cancer

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j.urnal of Traditional Chinese Medical Sciences 2024年第3期11卷 303-315页

作者： Sheng j. Cheng j. Chu W. dong M. j.ang K. Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine Shanghai 200437 China

Obj.ctive: To investigate the mechanism underlying the effects exerted by the Qizhu prescription (QZP) in breast cancer (BC), and the respective targets. Methods: Expression data from the ArrayExpress and The Cancer Genome Atlas (TCGA) were used to identify differentially expressed genes (DEGs) in BC. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed on the DEGs to identify genes involved in protein–protein interactions. Molecular docking was used to explore the dynamic relationship between active molecules and targets. Cell function experiments and animal studies were conducted to evaluate the effects of hub genes and active QZP compounds on BC cell behavior. Results: Among the 25 evaluated BC-related targets of QZP, matrix metalloproteinase-1 (MMP1) and epidermal growth factor receptor (EGFR) exhibited the highest degrees of dysregulation. GO and KEGG enrichment analyses revealed that the anti-BC targets of QZP primarily affected drug responses and pathways in cancer cells. Molecular docking analysis suggested potential interactions between EGFR and quercetin/luteolin, as well as between MMP1 and luteolin/kaempferol/quercetin. Quercetin significantly reduced BC cell proliferation, migration, invasion, and tumor development in vivo. Treatment of BC cells with quercetin decreased the expression or activation of several associated proteins. Conclusion: The findings of our study provide new insights into the therapeutic potential of traditional Chinese medicine against BC, with particular reference to QZP. © 2024 Beij.ng University of Chinese Medicine

关键词： Breast cancer Network pharmacology Qizhu prescription Quercetin Traditional Chinese medicine

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Developmental systems biology flourishing on new technologies

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j.urnal of Genetics and Genomics 2008年第10期35卷 577-584页

作者： j.ng-dong j. Han Yi Liu Huiling Xue Kai Xia Hong Yu Shanshan Zhu Zhang Chen Wei Zhang Zheng Huang Chunyu j.n Bo Xian j.ng Li Lei Hou Yixing Han Chaoqun Niu Timothy C. Alcon Chinese Academy of Sciences Key Laboratory of Molecular Developmental Biology Center for Molecular Systems Biology Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China Key Laboratory of Machine Perception （Ministry of Education） Peking University Beijing 100871 China Bioinformatics and Computational Biology Graduate Program Iowa State University Ames IA 50011-1040 USA

Organism development is a systems level process. It has benefited greatly from the recent technological advances in the field of systems biology. DNA microarray, phenome, interactome and transcriptome mapping, the new generation of deep sequencing technologies, and faster and better computational and modeling approaches have opened new frontiers for both systems biologists and developmental biologists to reexamine the old developmental biology questions, such as pattern formation, and to tackle new problems, such as stem cell reprogramming. As showcased in the International Developmental Systems Biology Symposium organized by Chinese Academy of Sciences, developmental systems biology is flourishing in many perspectives, from the evolution of developmental systems, to the underlying genetic and molecular pathways and networks, to the genomic, epigenomic and noncoding levels, to the computational analysis and modeling. We believe that the field will continue to reap rewards into the future with these new approaches.

关键词： developmental systems biology new technologies symposium

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