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Downregulation of Serum PTEN Expression in Mercury-Exposed Population and PI3K/AKT Pathway-Induced Inflammation

Biomedical and Environmental Sciences 2024年第4期37卷 354-366页

作者： MEI Peng DING En Min YIN Hao Yang DING Xue Xue WANG Huan WANG Jian Feng HAN Lei ZHANG heng dong ZHU Bao Li School of Public Health Nanjing Medical UniversityNanjing 210000JiangsuChina Institute of Occupational Disease Prevention Jiangsu Province Center for Disease Prevention and ControlNanjing 21000JiangsuChina Suzhou Center for Disease Prevention and Control Suzhou 215004JiangsuChina Center for Global Health School of Public HealthNanjing Medical UniversityNanjing 210000JiangsuChina

Objective This study investigated the impact of occupational mercury(Hg) exposure on human gene transcription and expression, and its potential biological *** Differentially expressed genes related to Hg exposure were identified and validated using gene expression microarray analysis and extended validation. Hg-exposed cell models and PTEN lowexpression models were established in vitro using 293T cells. PTEN gene expression was assessed using qRT-PCR, and Western blotting was used to measure PTEN, AKT, and PI3K protein levels. IL-6 expression was determined by *** Combined findings from gene expression microarray analysis, bioinformatics, and population expansion validation indicated significant downregulation of the PTEN gene in the high-concentration Hg exposure group. In the Hg-exposed cell model(25 and 10 μmol/L), a significant decrease in PTEN expression was observed, accompanied by a significant increase in PI3K, AKT, and IL-6 ***, a low-expression cell model demonstrated that PTEN gene knockdown led to a significant decrease in PTEN protein expression and a substantial increase in PI3K, AKT, and IL-6 *** This is the first study to report that Hg exposure downregulates the PTEN gene, activates the PI3K/AKT regulatory pathway, and increases the expression of inflammatory factors, ultimately resulting in kidney inflammation.

关键词： PTEN Occupational mercury exposure Occupational health PI3K/AKT pathway 293T cell IL-6

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Gender difference in network relationship between inter-temporal decisions and prefrontal activation levels in internet gaming disorder

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Psychoradiology 2023年第1期3卷 254-265页

作者： Hui Zheng Weiran Zhou Min Wang Hao-hao dong Chunlei Lu Jia-lin Zhang Xue-feng Ma Yanbo Hu Guang-heng dong Department of Psychology Yunnan Normal UniversityKunmingYunnan Province 650500China Shanghai Key Laboratory of Psychotic Disorders Brain Health InstituteNational Center for Mental DisordersShanghai Mental Health CenterShanghaijiao Tong University School of MedicineShanghai 200030China Center for Cognition and Brain Disorders The Affliated Hospital of Hangzhou Normal UniversityHangzhouZhejiang Province 11121 China School of Humanities and Social Science University of Science and Technology of ChinaHefei 230022PR.China Department of Psychology Nanjing UniversityNanjingJiangsu Province 210008China Department of Psychology Zhejiang Normal UniversityJinhuaZhejiang Province 321004China Institute of Developmental Psychology Beijing Normnal UniversityBeijing 100875China State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research Beijing 100875China

Background:Impulsivity and decision-making are key factors in ***,little is known about how gender and time sensitivity affect impulsivity in internet gaming disorder(IGD).Objective:To investigate the gender difference of impulsive decision-making and relevant brain responses in ***:We conducted a functional magnetic resonance imaging(fMRI)study with 123 participants,including 59 IGD individuals(26 females)and 64 matched recreational game users(RGUs,23 females).Participants performed a delay-discounting task during fMRI *** examined gender-by-group effects on behavioral and neural measures to explore the preference for immediate over delayed rewards and the associated brain *** also investigated the network correlations between addiction severity and behavioral and neural measures,and analyzed the mediating role of brain activity in the link between delay discounting parameters and IGD ***:We found significant gender-by-group *** imaging results revealed gender-by-group interactions in the dor-solateral prefrontal cortex,medial frontal gyrus,and inferior frontal gyrus(IFG).Post hoc analysis indicated that,for females,RGUs showed higher activity than IGD individuals in these brain regions,while for males IGD individuals exhibited higher activity than *** activation in the left IFG mediated the relation between Internet Addiction Test score and discount rate in *** males,the activation in the right dlPFC mediated the relation between IAT score and time ***:Our findings imply that male IGD participants demonstrate impaired intertemporal decisions associated with neural *** factors for impulsive decision-making in IGD diverge between males(time sensitivity)and females(discount rate).These findings augment our comprehension of the neural underpinnings of gender differences in IGD and bear significant implications for devising effective intervention strategie

关键词： internet gaming disorder delay discounting discount rate time sensitivity

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Biofilm Microenvironment-Responsive Nanotheranostics for Dual-Mode Imaging and Hypoxia-Relief-Enhanced Photodynamic Therapy of Bacterial Infections

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Research 2020年第1期2020卷 1814-1828页

作者： Weijun Xiu Siyu Gan Qirui Wen Qiu Qiu Sulai Dai heng dong Qiang Li Lihui Yuwen Lixing Weng Zhaogang Teng Yongbin Mou Lianhui Wang Key Laboratory for Organic Electronics and Information Displays&Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials(IAM)Jiangsu National Synergetic Innovation Centre for Advanced Materials(SICAM)Nanjing University of Posts and TelecommunicationsNanjing 210023China Department of Oral Implantology Nanjing Stomatological HospitalSchool of MedicineNanjing UniversityNanjing 210023China School of Geography and Biological Information Nanjing University of Posts and TelecommunicationsNanjing 210023China Department of Medical Imaging Jinling HospitalSchool of MedicineNanjing UniversityNanjing 210002China

The formation of bacterial biofilms closely associates with infectious *** now,precise diagnosis and effective treatment of bacterial biofilm infections are still in great ***,a novel multifunctional theranostic nanoplatform based on MnO_(2)nanosheets(MnO_(2)NSs)has been designed to achieve pH-responsive dual-mode imaging and hypoxia-relief-enhanced antimicrobial photodynamic therapy(aPDT)of bacterial biofilm *** this study,MnO_(2)NSs were modified with bovine serum albumin(BSA)and polyethylene glycol(PEG)and then loaded with chlorin e_(6)(Ce_(6))as photosensitizer to form MnO_(2)-BSA/PEG-Ce_(6)nanosheets(MBP-Ce_(6)NSs).After being delivered into the bacterial biofilm-infected tissues,the MBP-Ce_(6)NSs could be decomposed in acidic biofilm microenvironment and release Ce_(6)with Mn^(2+),which subsequently activate both fluorescence(FL)and magnetic resonance(MR)signals for effective dual-mode FL/MR imaging of bacterial biofilm ***,MnO_(2)could catalyze the decomposing of H2O_(2)in biofilm-infected tissues into O_(2)and relieve the hypoxic condition of biofilm,which significantly enhances the efficacy of *** in vitro study showed that MBP-Ce_(6)NSs could significantly reduce the number of methicillin-resistant Staphylococcus aureus(MRSA)in biofilms after 635nm laser *** by FL/MR imaging,MRSA biofilm-infected mice can be efficiently treated by MBP-Ce_(6)NSs-based ***,MBP-Ce_(6)NSs not only possess biofilm microenvironment-responsive dual-mode FL/MR imaging ability but also have significantly enhanced aPDT efficacy by relieving the hypoxia habitat of biofilm,which provides a promising theranostic nanoplatform for bacterial biofilm infections.

关键词： diagnosis Relief precise

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Association between the HOTAIR Polymorphism and Susceptibility to Lead Poisoning in a Chinese Population

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Biomedical and Environmental Sciences 2018年第6期31卷 473-478页

作者： CHEN Lin ZHAO Qiu Ni QIAN Xiu Rong ZHU Bao Li DING En Min WANG Bo Shen ZHANG heng dong YANG Hong Key Laboratory of Environmental Medicine and Engineering Ministry of EducationSchool of Public HealthSoutheast UniversityNanjing 210009JiangsuChina Institute of Occupational Disease Prevention Jiangsu Provincial Center for Disease Prevention and ControlNanjing 210028JiangsuChina Nanjing Center for Disease Prevention and Control Nanjing 210003JiangsuChina School of Public Health Nantong UniversityNantong 226019JiangsuChina

This study explored the association between the lncRNA HOTAIR polymorphism and susceptibility to lead poisoning in a Chinese population. We speculated that lead poisoning caused elevated levels of oxidative stress, which, in turn, activate the HOTAIR gene to cause apoptosis. Three lncRNA HOTAIR tagSNPs（rs7958904, rs4759314, and rs874945） were genotyped by TaqM an genotyping technology in 113 lead-sensitive and 113 lead-resistant Chinese workers exposed to lead. Rs7958904 was significantly associated with susceptibility to lead poisoning（P = 0.047）. The rs7958904 G allele had a protective effect compared with the C allele and reduced the risk of lead poisoning（P = 0.016）. Rs7958904 may act as a potential biomarker for predicting the risk of lead poisoning and distinguishing lead-sensitive individuals from lead-resistant individuals.

关键词： HOTAIR Association between the HOTAIR Polymorphism and Susceptibility to Lead Poisoning in a Chinese Population

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Connectome-based prediction of the severity of autism spectrum disorder

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Psychoradiology 2023年第1期3卷 266-275页

作者： Xuefeng Ma Weiran Zhou Hui Zheng Shuer Ye Bo Yang Lingxiao Wang Min Wang Guang heng dong Department of Psychology Yunnan Normal UniversityKunmingYunnan Province 650500China Center for Cognition and Brain Disorders Hangzhou Normal UniversityHangzhouZhejiang Province 311121China Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments Hangzhou Normnal UniversityHangzhouZhejiang Province 311121 China Institutes of Psychological Sciences Hangzhou Normal UniversityHangzhouZhejiang Province 311121China Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiaotong University School of MedicineShanghai 200030China Kavli Institute for Systems Neuroscience Centre for Neural ComputationNorwegian University of Science and TechnologyTrondheim 7491Norway

Background:Autism spectrum disorder(ASD)is characterized by social and behavioural *** diagnosis relies on be-havioural criteria,but machine learning,particularly connectome-based predictive modelling(CPM),offers the potential to uncover neural biomarkers for ***:This study aims to predict the severity of ASD traits using CPM and explores differences among ASD subtypes,seeking to enhance diagnosis and understanding of ***:Resting-state functional magnetic resonance imaging data from 151 ASD patients were used in the *** with leave-one-out cross-validation was conducted to identify intrinsic neural networks that predict Autism Diagnostic Observation Schedule(ADOS)*** the model was constructed,it was applied to independent samples to test its replicability(172 ASD patients)and specificity(36 healthy control participants).Furthermore,we examined the predictive model across different aspects of ASD and in subtypes of ASD to understand the potential mechanisms underlying the ***:The CPM successfully identified negative networks that significantly predicted ADOS total scores[r(df=150)=0.19,P=0.008 in all patients;r(df=104)=0.20,P=0.040 in classic autism]and communication scores[r(df=150)=0.22,P=0.010 in all patients;r(df=104)=0.21,P=0.020 in classic autism].These results were reproducible across independent *** networks were characterized by enhanced inter-and intranetwork connectivity associated with the occipital network(OCC),and the sensorimotor network(SMN)also played important ***:A CPM based on whole-brain resting-state functional connectivity can predicted the severity of ***-scale net-works,including the OCC and SMN,played important roles in the predictive *** findings may provide new directions for the diagnosis and intervention of ASD,and maybe could be the targets in novel interventions.

关键词： autism spectrum disorder connectome-based predictive modelling resting-state functional connectivity severity

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金属簧片阻尼隔振器性能分析

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振动与冲击 2011年第5期30卷 263-266页

作者：王东衡石秀东江南大学机械工程学院无锡214122

建立了金属簧片隔振器振动系统的动力学模型,通过有限元计算得出摩擦力曲线,进一步采用动力学方程研究了系统在简谐激励和冲击激励下的响应。结果表明:电子机柜采用该隔振器,能使最大加速度降低72%,说明该隔振器具有良好的减振隔振和抗... 详细信息

建立了金属簧片隔振器振动系统的动力学模型,通过有限元计算得出摩擦力曲线,进一步采用动力学方程研究了系统在简谐激励和冲击激励下的响应。结果表明:电子机柜采用该隔振器,能使最大加速度降低72%,说明该隔振器具有良好的减振隔振和抗冲击性能,为干摩擦隔振器优化设计提供了理论依据。

关键词：隔振器干摩擦阻尼动态特性非线性振动

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认知无线电网络中基于业务自适应的干扰对齐新机制探索

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通信学报 2014年第4期35卷 25-34页

作者：董恒宋荣方南京邮电大学宽带无线通信与传感网技术教育部重点实验室江苏南京210003 东南大学移动通信国家重点实验室江苏南京210096

提出了一种基于自适应干扰对齐的认知无线电网络干扰协调新方法。这种方法采用基于离线搜索的干扰对齐模式优化和基于用户业务需求的自适应最佳模式选择,通过收发两端联合设计的干扰对齐算法实现主次用户的动态信道共享;为了简便有效地... 详细信息

提出了一种基于自适应干扰对齐的认知无线电网络干扰协调新方法。这种方法采用基于离线搜索的干扰对齐模式优化和基于用户业务需求的自适应最佳模式选择,通过收发两端联合设计的干扰对齐算法实现主次用户的动态信道共享;为了简便有效地构造波束成形矩阵和干扰抑制矩阵,还推导出了一种干扰对齐的闭式解,并且证明了其适用条件;还对所提方法的可达自由度做了分析,得到一个下界。采用统计模型进行的仿真结果表明,所提出的自适应方法相对于修正的机会干扰对齐和固定模式的干扰对齐具有明显的自由度优势,因而可以有效提高认知用户的容量。由于所提出的方法运算复杂度不高,可望未来应用于低成本的认知终端。

关键词：干扰对齐认知无线电波束成形自由度

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Ultrasound-responsive microbubbles in antibacterial therapy

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Biomedical Engineering Communications 2023年第2期2卷 1-3页

作者： Xiao-Ye Li Wei-Jun Xiu dong-Liang Yang heng dong Nanjing Stomatological Hospital Affiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008China Key Laboratory for Organic Electronics and Information Displays Jiangsu Key Laboratory for BiosensorsInstitute of Advanced MaterialsJiangsu National Synergetic Innovation Centre for Advanced MaterialsNanjing University of Posts and TelecommunicationsNanjing 210023China School of Physical and Mathematical Sciences Nanjing Tech University(NanjingTech)Nanjing 211800China

Microbubbles(MBs)are gas-filled micrometer-scale spheres that are commonly formed by the gas core encapsulated with stabilizing shells,including polymers,surfactants,proteins,or liposomes ***,MBs were originally used as contrast agents for enhanced ultrasound(US)imaging and ***,MBs were given expectations that they can be alternative platforms for drug delivery owing to their unique acoustic *** can respond to the US by cavitation effect which refers to a series of complex dynamic processes,such as oscillation,expansion,contraction,and implosion[1].Drug molecules or therapeutic agents can be associated with the MB shells by means of van-der-Waals forces,electrostatic or hydrophobic interactions,or merely by physical encapsulation[2].Therefore,strategies are emerging which take advantages of US-mediated MBs drug delivery systems,mainly focusing on sonothrombolysis,cancer therapy and central nervous system(CNS)pathologies[3].Nevertheless,several researchers have apperceived the promising potential of US-responsive MBs in antibacterial ***,we aimed to paint an overview of the latest published papers on MBs for antibacterial therapy,hoping to help understand the perspectives that the field may offer emerging generations of antibacterial agents.

关键词： properties. shells cavitation

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Association between Polymorphisms of MALAT1 and Blood Lead Levels in Lead-exposed Workers

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Biomedical and Environmental Sciences 2018年第7期31卷 527-530页

作者： QIAN Xiu Rong CHEN Lin LIU Ji Ting ZHU Bao Li ZHAO Qiu Ni DING En Min WANG Bo Shen ZHANG heng dong XU Ming School of Public Health Nantong University Nantong 226019 Jiangsu China Institute of Occupational Disease Prevention Jiangsu Provincial Center for Disease Prevention and Control Nanjing 210028 Jiangsu China Key Laboratory of Environmental Medicine and Engineering Ministry of Education School of Public Health Southeast University Nanjing 210009 Jiangsu China School of Public Health Suzhou University Suzhou 215021 Jiangsu China Nanjing center for disease prevention and control Nanjing 210003 Jiangsu China

Lead,a heavy metal,which is nonessential but may be harmful to the human body,has been widely used to manufacture many products for use in the modern ***-acid batteries have the advantages of low price,high safety,and... 详细信息

关键词： Association between Polymorphisms of MALAT1 and Blood Lead Levels in Lead-exposed Workers BLL

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Synthesis of 3- [ 1- (4-Ethoxyphenyl)-5-methyl-1,2,3-triazol-4-yl ]-6- substituted- s-triazolo [ 3,4- b ] -1,3,4-thiadiazoles

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有机化学 2003年第Z1期23卷 427-427页

作者： dong heng-Shan WANG Bin National Laboratory of Applied Organic Chemistry Institute of Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University Lanzhou 730000 National Laboratory of Applied Organic Chemistry Institute of Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University Lanzhou 730000

　　Several 3- [ 1- (4-ethoxyphenyl)-5-methyl- 1,2, 3-triazol-4-yl ]-6-substituted-s-triazolo [ 3,4- b ]- 1,3,4-thiadia zoles have been synthesized and the structures of these compounds were established by MS, IR and ... 详细信息

关键词： spectral data

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