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Ultrasonic backscatter characterization of cancellous bone using a general Nakagami statistical model

Chinese Physics B 2019年第2期28卷 313-320页

作者： Chengcheng Liu rui dong Boyi Li Ying Li Feng Xu Dean Ta Weiqi Wang Institute of Acoustics School of Physics Science and EngineeringTongji University Department of Electronic Engineering Fudan University State Key Laboratory of ASIC and System Fudan University

The goal of this study is to analyze the statistics of the backscatter signal from bovine cancellous bone using a Nakagami model and to evaluate the feasibility of Nakagami-model parameters for cancellous bone characterization. Ultrasonic backscatter measurements were performed on 24 bovine cancellous bone specimens in vitro and the backscatter signals were compensated for the frequency-dependent attenuation prior to the envelope detection. The statistics of the backscatter envelope were modeled using the Nakagami distribution. Our results reveal that the backscatter envelope mainly followed pre-Rayleigh distributions, and the deviations of the backscatter envelope from Rayleigh distribution decreased with increasing bone density. The Nakagami shape parameter(i.e., m) was significantly correlated with bone densities(R = 0.78–0.81, p < 0.001) and trabecular microstructures(|R| = 0.46–0.78, p < 0.05). The scale parameter(i.e.,?) and signal-to-noise ratio(SNR) also yielded significant correlations with bone density and structural features. Multiple linear regressions showed that bone volume fraction(BV/TV) was the main predictor of the Nakagami parameters,and microstructure produced significantly independent contribution to the prediction of Nakagami distribution parameters,explaining an additional 10.2% of the variance at most. The in vitro study showed that statistical parameters derived with Nakagami model might be useful for cancellous bone characterization, and statistical analysis has potential for ultrasonic backscatter bone evaluation.

关键词： ultrasonic backscatter cancellous bone statistical analysis Nakagami model

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Involvement of Angiotensin II Type 1 Receptor and Calcium Channel in Vascular Remodeling and Endothelial Dysfunction in Rats with Pressure Overload

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Current Medical Science 2020年第2期40卷 320-326页

作者： dong-rui CHEN Hui JIANG- Jing CHEN Cheng-chao RUAN Wei-qing HAN Ping-jin GAO State Key Laboratory of Medical Genomics Shanghai Key Laboratory of HypertensionRiuijin HospitalShanghai Jiao Tong Universitry School of MedicineShanghai 200025China Shanghai Institule of Hypertension Shanghai 200025China

Vascular remodeling is an adaptive response to various stimuli,including mechanical forces,inflammatory cy tokines and *** the present study,we investigated the role of angiotensinII type 1 receptor(ATIR)and calcium channel in carotid artery remodeling in response to increased biomechanical forces by using the transverse aortic constriction(TAC)rat *** was induced on ten week-old male Sprague Dawley rats and these models were treated with ATIR blocker olmesartan(1 mg/kg/day)or/and calcium channel blocker(CCB)amlodipine(0.5 mgkgday)for 14 *** the treatment,the right common carotid artery proximal to the band(RCCA-B)was collected for further *** showed that olmesartan,but not amlodipine,significantly prevented TAC-induced adventitial ***,olmesartan,but not amlodipine,significantly prevented vascular inflammation,as indicated by increased tumor necrosis factor a(TNF-a)and increased p65 phosphorylation,an indicator of nuclear factor K-light-chain-enhancer of activated B cells(NFkB)activation in *** contrast,both olmesartan and amlodipine reversed the decreased expression of endothelial nitric oxidase synthase(eNOS)and improved endothelium-dependent vasodilation,whereas combination of olmesartan and amlodipine showed no further synergistic protective *** results suggest that AT1R was involved in vascular remodeling and inflammation in response to pressure overload,whereas ATIR and subsequent calcium channel were involved in endothelial dysfunction.

关键词： transverse aortic constriction angiotensin II type I receptor calcium channel vascular remodcling endothelial dysfunction

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磁场方向调制的InAs量子点分子量子比特

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物理学报 2007年第9期56卷 5436-5440页

作者：董庆瑞山东师范大学物理与电子科学学院济南250014

在有效质量近似条件下研究了由两个垂直耦合自组织InAs量子点组成的双电子量子点分子的电子结构,在此基础上利用系统的总自旋提出了一种磁场方向调制的量子比特方案.电子的相关效应可以导致系统的总自旋在0和1之间转换,值得注意的是,通... 详细信息

在有效质量近似条件下研究了由两个垂直耦合自组织InAs量子点组成的双电子量子点分子的电子结构,在此基础上利用系统的总自旋提出了一种磁场方向调制的量子比特方案.电子的相关效应可以导致系统的总自旋在0和1之间转换,值得注意的是,通过调节外部磁场的方向来实现这种转换,而不是像以往那样通过改变外部磁场的大小.结果支持利用系统的总自旋作为磁场方向调制的量子比特的可能性,而且因为高质量的垂直耦合量子点分子的制作工艺已经成熟,所以这是一个非常现实的量子比特设计方案.

关键词：量子点分子磁场方向调制量子比特

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Cryoglobulinemic vasculitis and glomerulonephritis: concerns in clinical practice

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Chinese Medical Journal 2019年第14期132卷 1723-1732页

作者： Yi-Pu Chen Hong Cheng Hong-Liang rui Hong-rui dong Division of Nephrology Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China

Objective:Cryoglobulinemia often causes systemic vasculitis,thereby damaging to skin and internal organs including kidneys,even *** review aimed to introduce the advances in understanding,detection,and treatment of this disease in recent years,with a particular concern to clinical *** sources:All the data in this review were from the English or Chinese literature in the PubMed and China National Knowledge Infrastructure databases as of March *** selection:This review selected important original articles,meaningful reviews,and some reports on cryoglobulinemia published in recent years and in history,as well as the guidelines for treatment of underlying diseases which lead to ***:Diagnosis of cryoglobulinemia relies on serum cryoglobulin test,in which to ensure that the blood sample temperature is not less than 37℃ in the entire pre-analysis phase is the key to avoid false negative *** vasculitis (Cryo Vas),including cryoglobulinemic glomerulonephritis (Cryo GN),usually occurs in types Ⅱ and Ⅲ mixed cryoglobulinemia,and can also be seen in type Ⅰ cryoglobulinemia caused by monoclonal IgG3 or *** purpura,positive serum rheumatoid factor,and decreased serum levels of C4 and C3 are important clues for prompting types Ⅱ and Ⅲ Cryo *** biopsy is an important means for diagnosis of Cryo GN,while membranous proliferative GN is the most common pathological type of Cryo *** recent years,great advances have been made in the treatment of Cryo Vas and its underlying diseases,and this review has briefly introduced these ***:Laboratory examinations of serum cryoglobulins urgently need *** recent advances in the diagnosis and treatment of Cryo Vas and GN need to be popularized among the clinicians in related disciplines.

关键词： Cryoglobulin Vasculitis Glomerulonephritis Monoclonal immunoglobulin Hepatitis C virus Autoimmune disease

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Going beyond the limit of an LCD’s color gamut

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Light(Science & Applications) 2017年第1期6卷 567-576页

作者： Hai-Wei Chen rui-dong Zhu Juan He Wei Duan Wei Hu Yan-Qing Lu Ming-Chun Li Seok-Lyul Lee Ya-Jie dong Shin-Tson Wu College of Optics and Photonics University of Central FloridaOrlandoFL 32816USA National Laboratory of Solid State Microstructures Collaborative Innovation Center of Advanced Microstructures and College of Engineering and Applied SciencesNanjing UniversityNanjing 210093China AU Optronics Corp NanoScience Technology Center University of Central FloridaOrlandoFL 32826USA

In this study,we analyze how a backlight’s peak wavelength,full-width at half-maximum(FWHM),and color filters affect the color gamut of a liquid crystal display(LCD)device and establish a theoretical limit,even if the FWHM approaches 1 *** overcome this limit,we propose a new backlight system incorporating a functional reflective polarizer and a patterned half-wave plate to decouple the polarization states of the blue light and the green/red *** a result,the crosstalk between three primary colors is greatly suppressed,and the color gamut is significantly *** the experiment,we prepare a white-light source using a blue light-emitting diode(LED)to pump green perovskite polymer film and red quantum dots and demonstrate an exceedingly large color gamut(95.8%Rec.2020 in Commission internationale de l'éclairage(CIE)1931 color space and 97.3%Rec.2020 in CIE 1976 color space)with commercial high-efficiency color *** results are beyond the color gamut limit achievable by a conventional *** design works equally well for other light sources,such as a 2-phosphorconverted white LED.

关键词： color gamut liquid crystal displays perovskite polarization quantum dot

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Polyphyllin I promotes cell death via suppressing UPR-mediated CHOP ubiquitination and degradation in non-small cell lung cancer

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Chinese Journal of Natural Medicines 2021年第4期19卷 255-266页

作者： LIU Ming-Ming ZHU Miao-Lin dong rui-Fang ZHANG Chao ZHANG Hao YANG Lei KONG Ling-Yi XIA Yuan-Zheng Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China Jiangsu Cancer Hospital Nanjing 210009China

Polyphyllin I(PPI)purified from Polyphylla rhizomes displays puissant cytotoxicity in many kinds of *** researches investigated its anti-cancer *** novel mechanisms are still worth *** study aimed to explore PPI-induced endoplasmic reticulum(ER)stress as well as the underlying mechanism in non-small cell lung cancer(NSCLC).Cell viability or colony-forming was detected by MTT or crystal violet *** cycle,apoptosis,reactive oxygen species(ROS)and mitochondrial membrane potential were assessed by flow *** and protein levels were evaluated by q RT-PCR and immunoblotting *** interaction was determined by immunoprecipitation or immunofluorescence *** overexpression or silencing was carried out by transient transfection with plasmids or small interfering *** Cancer Genome Atlas(TCGA)database was used for Gene Set Enrichment Analysis(GSEA),survival analysis,gene expression statistics or pathway enrichment *** inhibited the propagation of NSCLC cells,increased non-viable apoptotic cells,arrested cell cycle at G2/M phase,induced ROS levels but failed to decrease mitochondrial membrane *** levels of GRP78 indicates poor prognosis in NSCLC *** selectively suppressed unfolded protein response(UPR)-induced GRP78 expression,subsequently protected CHOP from GRP78-mediated ubiquitination and *** demonstrated that the natural product PPI,obtained from traditional herbal medicine,deserves for further study as a valuable candidate for lead compound in the chemotherapy of NSCLC.

关键词： Non-small cell lung cancer Polyphyllin I Endoplasmic reticulum stress C/EBP homologous protein Ubiquitination

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Third generation of vortex identification methods:Omega and Liutex/Rortex based systems

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Journal of Hydrodynamics 2019年第2期31卷 205-223页

作者： Chaoqun Liu Yi-sheng Gao Xiang-rui dong Yi-qian Wang Jian-ming Liu Yu-ning Zhang Xiao-shu Cai Nan Gui Department of Mathematics University of Texas at ArlingtonArlington 76019TexasUSA College of Energy and Power Engineering University of Shanghai for Science and TechnologyShanghai 200093China School of Aerospace Engineering Tsinghua UniversityBeijing 100084China School of Mathematics and Statistics Jiangsu Normal UniversityXuzhou 221116China Key Laboratory of Condition Monitoring and Control for Power Plant Equipment(Ministry of Education) School of EnergyPower and Mechanical EngineeringNorth China Electric Power UniversityBeijing 102206China Institute of Nuclear and New Energy Technology Collaborative Innovation Center of Advanced Nuclear Energy TechnologyKey Laboratory of Advanced Reactor Engineering and Safety of Ministry of EducationTsinghua UniversityBeijing 100084China

A vortex is intuitively recognized as the rotational/swirling motion of fluids,but a rigorous and universally-accepted definition is still not *** tube/filament has been regarded equivalent to a vortex since Helmholtz proposed the concepts of vorticity tube/filament in 1858 and the vorticity-based methods can be categorized as the first generation of vortex identification *** the last three decades,a lot of vortex identification methods,including 0,A,and Aci criteria,have been proposed to overcome the problems associated with the vorticity-based *** of these criteria are based on the Cauchy-Stokes decomposition and/or eigenvalues of the velocity gradient tensor and can be considered as the second generation of vortex identification *** from 2014,the Vortex and Turbulence Research Team at the University of Texas at Arlington(the UTA team)focus on the development of a new generation of vortex identification *** first fruit of this effort,a new Omega(/2)vortex identification method,which defined a vortex as a connected region where the vorticity overtakes the deformation,was published in *** 2017 and 2018,a Liutex(previously called Rortex)vector was proposed to provide a mathematical definition of the local rigid rotation part of the fluid motion,including both the local rotational axis and the rotational ***/Rortex is a new physical quantity with scalar,vector and tensor forms exactly representing the local rigid rotation of ***,a decomposition of the vorticity to a rotational part namely Liutex/Rortex and an anti-symmetric shear part(RS decomposition)was introduced in 2018,and a universal decomposition of the velocity gradient tensor to a rotation part(7?)and a non-rotation part(NR、was also given in 2018 as a counterpart of the traditional Cauchy-Stokes *** in early 2019,a Liutex/Rortex based Omega method called Omega-Liutex,which combines the respective advantages o

关键词： Vortex definition vortex identification Omega Liutex/Rortex direct numerical simulation turbulence

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Histopathological characteristics of needle core biopsy and surgical specimens from patients with solitary hepatocellular carcinoma or intrahepatic cholangiocarcinoma

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World Journal of Gastrointestinal Oncology 2019年第5期11卷 404-415页

作者： Ju-Shan Wu Ji-Liang Feng rui-dong Zhu San-Guang Liu Da-Wei Zhao Ning Li General Surgical Center Beijing You-An Hospital Capital Medical University Clinical-Pathology Center Beijing You-An Hospital Capital Medical University Department of Hepatobiliary Surgery the Second Hospital Hebei Medical University Medical Imaging Department Beijing You-An Hospital Capital Medical University

BACKGROUND Pathological manifestations of hepatic tumours are often associated with prognosis. Although surgical specimens(SS) can provide more information,currently, pre-treatment needle core biopsy(NCB) is increasingly showing important value in understanding the nature of liver tumors and even in diagnosis and treatment decisions. However, the concordance of the clinicopathological characteristics and immunohistochemical(IHC) staining between NCB and SS from patients with hepatic tumours were less *** To introduce a more accurate method for interpreting the IHC staining results in order to improve the diagnostic value of hepatic malignancy in NCB *** A total of 208 patients who underwent both preoperative NCB and surgical resection for hepatocellular carcinoma(HCC) or intrahepatic cholangiocarcinomaRESULTS Morphologically, the presence of compact tumour nests or a cord-like structure in NCB was considered the primary cause of misdiagnosis of HCC from ICC. The kappa statistic showed a moderate agreement in histomorphology(k = 0.504) and histological grade(k = 0.488) between NCB and SS of the tumours. A 4-tier(+++,++, +, and-) scoring scheme that emphasized the focal neoplastic cell immunoreactivity of tumour cells revealed perfect concordance of CK19, GPC3 and HepPar1 between NCB and SS(k = 0.717; k = 0.768; k = 0.633). Furthermore,with the aid of a binary classification derived from the 4-tier score, a high concordance was achieved in interpreting the IHC staining of the three markers between NCB and final SS(k = 0.931; k = 0.907; k = 0.803), increasing the accuracy of NCB diagnosis C(k = 0.987; area under the curve = 0.997, 95%CI: 0.990-1.000; P< 0.001).CONCLUSION These findings imply that reasonable interpretation of IHC results in NCB is vital for improving the accuracy of tumour diagnosis. The simplified binary classification provides an easy and applicable approach.

关键词： Histopathological Needle core biopsy Surgical specimens Solitary hepatocellular carcinoma Intrahepatic cholangiocarcinoma

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The rise of high-throughput computing

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Frontiers of Information Technology & Electronic Engineering 2018年第10期19卷 1245-1250页

作者： Ning-hui SUN Yun-gang BAO dong-rui FAN State Key Laboratory of Computer Architecture Institute of Computing TechnologyChinese Academy of SciencesUniversity of Chinese Academy of Sciences

In recent years, the advent of emerging computing applications, such as cloud computing, artificial intelligence, and the Internet of Things, has led to three common requirements in computer system design： high utilization, high throughput, and low latency. Herein, these are referred to as the requirements of ＇high-throughput computing （HTC）＇. We further propose a new indicator called ＇sysentropy＇ for measuring the degree of chaos and uncertainty within a computer system. We argue that unlike the designs of traditional computing systems that pursue high performance and low power consumption, HTC should aim at achieving low sysentropy. However, from the perspective of computer architecture, HTC faces two major challenges that relate to （1） the full exploitation of the application＇s data parallelism and execution concurrency to achieve high throughput, and （2） the achievement of low latency, even in the cases at which severe contention occurs in data paths with high utilization. To overcome these two challenges, we introduce two techniques： on-chip data flow architecture and labeled von Neumann architecture. We build two prototypes that can achieve high throughput and low latency, thereby significantly reducing sysentropy.

关键词： High-throughput computing Sysentropy Information superbahn

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Successful adult-to-pediatric liver transplantation of discarded partial liver allograft with benign caudate lobe tumor

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Hepatobiliary & Pancreatic Diseases International 2023年第1期22卷 92-95页

作者： Jia-Hao Pei Cong-Huan Shen rui-dong Li Yi-Feng Tao Lu Lu Zheng-Xin Wang Department of General Surgery Huashan Hospital of Fudan UniversityShanghai 200040China

To the Editor:Pediatric liver transplantation is the only treatment option for end-stage liver disease in children,and the 5-year and 20-year survival rates after living donor liver transplantation(LDLT)can reach 91.5% and 84.2%[1].Many Asian countries,including China,have begun to develop LDLT and achieved good ***,the shortage of donor livers in children remains a serious problem.

关键词： liver pediatric donor

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