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Selecting SNP markers reflecting population origin for cacao(Theobroma cacao L.)germplasm identification

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Beverage Plant Research 2021年第1期1卷 133-141页

作者： Osman A.Gutiérrez Kathleen Martinez Dapeng Zhang donald S.Livingstone Chris j.Turnbull j.an Carlos Motamayor USDA-ARS Subtropical Horticulture Research Station 13601 Old Cutler RoadMiamiFL 33158USA USDA-ARS Beltsville Agricultural Research CenterSPCL10300 Baltimore AvenueBldg.001Rm.223BARC-WBeltsvilleMD 20705USA Mars Wrigley Plant Science Laboratory DavisCA 95616USA School of Agriculture Policy and DevelopmentUniversity of ReadingRG66ARUK Universal GeneticSolutions LLCOrlandoFLUSA

Cacao is one of the most economically important agricultural commodities in the world,providing the principal ingredient for the global chocolate *** genotype identification is essential for effective conservation and utilization of cacao ***,we report the screening of 956 candidate SNPs,pre-selected from the 6 and 15K Theobroma cacao SNP Arrays using targeted Genotyping-by-Sequencing on 451 cacao germplasm accessions,representing ten known genetic groups from the tropical *** on call rate(No call rate0.15)and Linkage Disequilibrium(LD≤0.5),a total of 219 SNPs were *** efficacy of these SNP markers for population classification was compared with the previous SSR-based analysis in *** population assignment results of the retained 420 cacao accessions was highly comparable with the SSR *** matrix of genetic distance between SSR and SNP markers is highly correlated(r=0.718;Pj.ct for the development of SNP markers reflecting population origin for cacao germplasm *** SNP markers and the selected reference germplasm for different populations are suitable for use in cacao germplasm management and crop improvement,including genotype identification,seed gardens and nursery accreditation,and cocoa *** is being continued with the emphasis on selecting SNP markers for the detection of sub-population structures in the primary gene pool of ***.

关键词： germplasm origin continued

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生物利用度和生物等效性研究的设计

药学进展 1991年第3期15卷 156-161页

作者： donald j.SCHUIRMANN 闻玉玲

生物利用度和生物等效性研究得到的血药浓度或尿药浓度数据最显著的特征之一就是个体差异极大,故在大多数情况下选择交叉设计来进行这项研究。在大多数情况下,生物利用度和生物等效性研究应按照平行设计的原则进行,但偶而可以例外。然而... 详细信息

生物利用度和生物等效性研究得到的血药浓度或尿药浓度数据最显著的特征之一就是个体差异极大,故在大多数情况下选择交叉设计来进行这项研究。在大多数情况下,生物利用度和生物等效性研究应按照平行设计的原则进行,但偶而可以例外。然而,由于个体差异很大,这样的研究所需的样本规模通常是有限制的。

关键词：生物利用度生物等效性设计

Development of a mechanism-based pharmacokinetic/pharmacodynamic model to characterize the thermoregulatory effects of serotonergic drugs in mice

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Acta Pharmaceutica Sinica B 2016年第5期6卷 492-503页

作者： Xi-Ling j.ang Hong-Wu Shen donald E.Mager Stephan Schmidt Ai-Ming Yu Department of Pharmaceutical Sciences School of Pharmacy and Pharmaceutical SciencesUniversity at BuffaloThe State University of New York Department of Pharmaceutics Center for Pharmacometrics and Systems PharmacologyUniversity of Florida Department of Biochemistry & Molecular Medicine UC Davis School of Medicine2700 Stockton Boulevard

We have shown recently that concurrent harmaline,a monoamine oxidase-A inhibitor(MAOI),potentiates serotonin(5-HT) receptor agonist 5-methoxy-N,N-dimethyltryptamine(5-Me O-DMT)-induced *** obj.ctive of this study was to develop an integrated pharmacokinetic/pharmacodynamic(PK/PD) model to characterize and predict the thermoregulatory effects of such serotonergic drugs in *** thermoregulation was described by a mechanism-based indirect-response model with adaptive feedback ***-induced hypothermia and 5-Me O-DMT–elicited hyperthermia were attributable to the loss of heat through the activation of 5-HT1 Areceptor and thermogenesis via the stimulation of 5-HT2 Areceptor,*** serotonergic 5-Me O-DMT–induced hyperthermia was readily distinguished from handling/inj.ction stress-provoked hyperthermic *** PK/PD model was able to simultaneously describe all experimental data including the impact of drug-metabolizing enzyme status on5-Me O-DMT and harmaline PK properties,and drug- and stress-induced simple hypo/hyperthermic and complex biphasic ***,the modeling results revealed a 4-fold decrease of apparent SC_(50) value(1.88–0.496 mmol/L) for 5-Me O-DMT when harmaline was co-administered,providing a quantitative assessment for the impact of concurrent MAOI harmaline on 5-Me ODMT–induced *** addition,the hyperpyrexia caused by toxic dose combinations of harmaline and 5-Me O-DMT were linked to the increased systemic exposure to harmaline rather than5-Me O-DMT,although the body temperature profiles were mispredicted by the *** results indicate that current PK/PD model may be used as a new conceptual framework to define the impact of serotonergic agents and stress factors on thermoregulation.

关键词： PK/PD model Thermoregulation Indolealkylamine Serotonin Monoamine oxidase-A inhibitor Stress

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特朗普的成功之道

Radial artery pseudoaneurysm diagnosed by pointof-care ultrasound five days after transradial catheterization: A case report

作者：唐纳德·j. 特朗普(donald j. Trump) 梅雷迪思·麦基弗(Meredith Mclver)

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World j.urnal of Emergency Medicine 2018年第3期9卷 223-226页

作者： Stephen Alerhand donald Apakama Adam Nevel Bret P.Nelson Emergency Medicine Department Icahn School of Medicine at Mount Sinai

Dear editor,Radial artery pseudoaneurysm from arterial wall disruption is an extremely rare complication of arterial *** prior case reports describe this complication occurring from continuous blood pressure monitoring or serial blood-gas analysis requiring extended *** increasing use of radial artery access for coronary angiography and percutaneous coronary intervention(PCI)introduces another susceptible patient population.[1–4]We report a case of a 57-year-old female with right radial artery pseudoaneurysm,diagnosed by bedside ultrasound(US)in the emergency department(ED)five days after transradial cardiac catheterization.

关键词： point-of-care Radial artery pseudoaneurysm

Orthopaedic education in the era of surgical simulation: Still at the crawling stage

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World j.urnal of Orthopedics 2017年第4期8卷 290-294页

作者： Kivanc Atesok Peter Mac donald j.ff Leiter j.mes Dubberley Richard Satava Ann Van Heest Shepard Hurwitz j.Lawrence Marsh Department of Surgery Section of Orthopaedic SurgeryUniversity of Manitoba Department of Surgery University of Wash-ington Department of Orthopaedic Surgery University of Minnesota Department of Orthopaedic Surgery University of North Carolina Department of Orthopedics and Rehabilitation University of Iowa

Surgical skills education is in the process of a crucial transformation from a master-apprenticeship model to simulation-based training. Orthopaedic surgery is one of the surgical specialties where simulation-based skills training needs to be integrated into the curriculum efficiently and urgently. The reason for this strong and pressing need is that orthopaedic surgery covers broad human anatomy and pathologies and requires learning enormously diverse surgical procedures including basic and advanced skills. Although the need for a simulationbased curriculum in orthopaedic surgery is clear, several obstacles need to be overcome for a smooth transformation. The main issues to be addressed can be summarized as defining the skills and procedures so that simulation-based training will be most effective; choosing the right time period during the course of orthopaedic training for exposure to simulators; the right amount of such exposure; using obj.ctive, valid and reliable metrics to measure the impact of simulation-based training on the development and progress of surgical skills; and standardization of the simulation-based curriculum nationwide and internationally. In the new era of surgical education, successful integration of simulation-based surgical skills training into the orthopaedic curriculum will depend on efficacious solutions to these obstacles in moving forward.

关键词： Surgical simulation Orthopaedic surgery Education Skills training

Real-time PCR diagnosis of Schistosoma j.ponicum in low transmission areas of China

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Infectious Diseases of Poverty 2018年第1期7卷 87-97页

作者： Pei He Catherine A.Gordon Gail M.Williams Yuesheng Li Yuanyuan Wang j.nj.an Hu Darren j.Gray Allen G.Ross donald Harn donald P.McManus Hunan Institute of Parasitic Diseases YueyangPeople’s Republic of China Molecular Parasitology Laboratory Infectious Diseases DivisionQIMR Berghofer Medical Research InstituteBrisbaneAustralia Discipline of Epidemiology and Biostatistics School of Population HealthUniversity of QueenslandBrisbaneAustralia Research School of Population Health The Australian National UniversityCanberraAustralia Menzies Health Institute Queensland Griffith UniversityGold CoastQLDAustralia University of Georgia College of Veterinary MedicineAthensGAUSA.

Background:Schistosomiasis in the People’s Republic of China(PRC)can be traced back to *** the past 60 years,the Chinese government has made great efforts to control this persistent disease with elimination slated by 2020 through the implementation of a comprehensive control *** strategy aims to reduce the role of bovines and humans as sources of infection as a pre-requisite for elimination through transmission *** goal of elimination will be achievable only by the implementation of a sustainable surveillance and control system,with sensitive diagnosis a key feature so that the true disease burden is not *** used diagnostics lack the necessary sensitivity to accurately determine the prevalence of Schistosoma j.ponicum infection in areas with low infection *** is of critical importance to find and treat people and to identify animals with low-level infections if the National Control Programme for China is to achieve schistosomiasis ***:We evaluated a real-time polymerase chain reaction(qPCR)assay using 633 human stool samples collected from five villages in Hunan,Anhui,Hubei,and j.angxi provinces,and 182 bovine(70 cattle and 112 buffalo)stool samples obtained from four villages in Hunan,Anhui,and j.angxi provinces in the *** stool samples were subj.cted to the miracidium hatching test(MHT,a diagnostic procedure used in the National Schistosomiasis Control Programme)and the qPCR *** positive by MHT were subj.cted to either the Kato-Katz technique for humans,or the formalin-ethyl acetate sedimentation-digestion(FEA-SD)procedure for bovines,to determine infection ***:The qPCR assay exhibited a high level of sensitivity in the detection of *** *** both the human and bovine samples,a significantly higher prevalence was determined using the qPCR assay(11.06%humans,24.73%bovines)than with the MHT(0.93%humans,7.69%bovines).The animal contamination

关键词： Schistosomiasis Schistosoma j.ponicum China Real-time PCR Miracidium hatching test Kato-Katz FEA-SD Bovine Human

Estimation of alfalfa fall dormancy using spaced plant and sward trials across multiple environments

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Grassland Research 2023年第1期2卷 15-21页

作者： Scott A.Newell Daniel j.Undersander donald Viands j.lie Hansen Steve Orloff Daniel H.Putnam E.Charles Brummer Department of Plant Sciences University of CaliforniaDavisDavisCaliforniaUSA Department of Agronomy University of WisconsinMadisonMadisonWisconsinUSA Plant Breeding&Genetics Section School of Integrated Plant SciencesCornell UniversityIthacaNew YorkUSA Univeristy of California Cooperative Extension YrekaCaliforniaUSA

Background:Alfalfa is a globally important forage *** are characterized by fall dormancy(FD).FD affects biomass yield and winter survival and is used to identify appropriate growing regions of *** has historically been assessed by measuring the natural height of regrowth in autumn of spaced plants in the *** commercial alfalfa is normally grown as a solid planted sward,FD could be different if plants were grown under real production *** obj.ctive of this experiment was to assess whether FD ratings obtained from swards were similar to those obtained on spaced ***:We evaluated 20 alfalfa cultivars in field trials established in 2015 at five locations in the United *** harvested the trials in early autumn and measured regrowth plant height approximately 3 weeks later in 2015 and ***:Autumn plant height responded as expected for the established check cultivars in all *** dormancy ratings for cultivars under both management systems were highly ***:Estimating FD from spaced plant height measurements in autumn is very robust,and using height data from sward plots gives equivalent results to that measured in spaced plant *** finding has many practical advantages.

关键词： alfalfa fall dormancy lucerne Medicago sativa plant height

Management of adults with coarctation of aorta

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World j.urnal of Cardiology 2020年第5期12卷 167-191页

作者： Pradyumna Agasthi Sai Harika Puj.ri Andrew Tseng j.seph N Graziano Francois Marcotte David Maj.alany Farouk Mookadam donald j.Hagler Reza Arsanj.ni Department of Cardiovascular Diseases Mayo ClinicScottsdaleAZ 85259United States Department of Cardiovascular Diseases Mayo ClinicRochesterMN 55905United States Division of Cardiology Phoenix Children's HospitalChildren's Heart CenterPhoenixAZ 85016United States

Coarctation of the aorta(CoA)is a relatively common congenital cardiac defect often causing few symptoms and therefore can be challenging to *** hallmark finding on physical examination is upper extremity hypertension,and for this reason,CoA should be considered in any young hypertensive patient,j.stifying measurement of lower extremity blood pressure at least once in these *** presence of a significant pressure gradient between the arms and legs is highly suggestive of the *** diagnosis and treatment are important as long-term data consistently demonstrate that patients with CoA have a reduced life expectancy and increased risk of cardiovascular *** repair has traditionally been the mainstay of therapy for correction,although advances in endovascular technology with covered stents or stent grafts permit nonsurgical approaches for the management of older children and adults with native CoA and *** hypertension and vascular dysfunction can lead to an increased risk of coronary disease,which,remains the greatest cause of long-term ***,blood pressure control and periodic reassessment with transthoracic echocardiography and threedimensional imaging(computed tomography or cardiac magnetic resonance)for should be performed regularly as cardiovascular complications may occur decades after the intervention.

关键词： Coarctation of aorta Cardiac surgery Cardiac catheterization Balloon angioplasty Stents