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Health Systems Strengthening to Tackle the Global Burden of Pediatric and Congenital Heart Disease: A Diagonal Approach

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Congenital Heart Disease 2024年第2期19卷 131-138页

作者： dominique vervoort Amy Verstappen Sreehari Madhavankutty Nair Chong Chin Eu Bistra Zheleva Institute of Health Policy Management and EvaluationUniversity of TorontoTorontoCanada Division of Cardiac Surgery University of TorontoTorontoCanada Global Alliance for Rheumatic and Congenital Hearts PhiladelphiaUSA Department of Health Services Government of KeralaKeralaIndia Ministry of Health PutrajayaMalaysia Children’s HeartLink MinneapolisUSA

1 Background Congenital heart disease(CHD)is the most common major congenital anomaly,affecting approximately one in every 100 live births[1].Among congenital anomalies,66%of preventable deaths are due to CHD,and 58%of the avertable morbidity and mortality due to congenital anomalies would result from scaling congenital heart surgery services[2].Every year,nearly 300,000 children and adults die from CHD,the majority of whom live in low-and middle-income countries(LMICs)[3].Approximately 49%of all individuals with CHD will require surgical or interventional care at some point in their lifetime[4];as a result of advances in access to and the delivery of such services,over 95%of children born with CHD in high-income countries now live into adulthood[3].Here,adults have surpassed children in the number of CHD cases at a ratio of 2:1[5].

关键词： Congenital heart disease pediatric heart disease global health health systems health policy

Closing the gap of children’s surgery in Pakistan

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World Journal of Pediatric Surgery 2019年第1期2卷 20-20页

作者： Simra Siddiqui dominique vervoort Alexander W Peters Haitham Shoman Nabeel M Ashraf Irum Fatima Lubna Samad Center for Essential Surgical and Acute Care Indus Health NetworkKarachiPakistan Program in Global Surgery and Social Change Department of Global Health and Social MedicineHarvard Medical SchoolBostonMassachusettsUSA Department of Surgery Weill Cornell Medical CollegeNew York CityNew YorkUSA

Two billion children worldwide lack access to safe surgical and anesthesia care when needed.1 The global pediatric surgical work-force is limited,and children and adolescents with surgical conditions often get absorbed into adult surgical services as pediatric surgeons are absent or *** an estimated population of 68.5 million chil-dren younger than 15 years(35%of the total population),Pakistan also faces similar chal-lenges in delivering adequate surgical care to *** investments in maternal and child health in recent years,Pakistan was unable to attain the Millennium Development Goals in *** death rate from congenital anomalies before the age of 5 years is still 77.2 children per 100000 live births,and a quarter of all deaths among children ages 5 and 14 years are a result of injuries.2 Despite this high burden,pediatric surgical care remains limited throughout Pakistan,with 0.4 pedi-atric surgeons per million population in the entire country,in contrast to upper-middle and high-income countries which have more than two pediatric surgeons per million popu-lation.

关键词： anesthesia injuries spite

Reevaluating health metrics:Unraveling the limitations of disabilityadjusted life years as an indicator in disease burden assessment

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World Journal of Methodology 2025年第1期15卷 14-19页

作者： Ariel Beresniak dominique Bremond-Gignac Danielle Dupont Gerard Duru Data Mining International Geneva 1216Switzerland Department of Ophtalmology Necker-Enfants Malades University HospitalAP-HPParis-CitéUniversityINSERMUMRS1138Team 17From Physiopathology of Ocular Diseases to Clinical DevelopmentSorbonne Paris CitéUniversityCentre de Recherche des CordeliersParis 75015France Data Mining America Montreal H2YCanada

In 1993,the World Bank released a global report on the efficacy of health promotion,introducing the disability-adjusted life years(DALY)as a novel *** DALY,a composite metric incorporating temporal and qualitative data,is grounded in preferences regarding disability *** review delineates the algorithm used to calculate the value of the proposed DALY synthetic indicator and elucidates key methodological challenges associated with its *** contrast to the quality-adjusted life years approach,derived from multi-attribute utility theory,the DALY stands as an independent synthetic indicator that adopts the assumptions of the Time Trade Off utility technique to define Disability *** to rely on no mathematical or economic theory,DALY users appear to have exempted themselves from verifying whether this indicator meets the classical properties required of all indicators,notably content validity,reliability,specificity,and *** DALY concept emerged primarily to facilitate comparisons of the health impacts of various diseases globally within the framework of the Global Burden of Disease initiative,leading to numerous publications in international *** widespread adoption,the DALY synthetic indicator has prompted significant methodological concerns since its inception,manifesting in inconsistent and non-reproducible *** the substantial diffusion of the DALY indicator and its critical role in health impact assessments,a reassessment is *** reconsideration is imperative for enhancing the robustness and reliability of public health decisionmaking processes.

关键词： Disability adjusted life years Cost-utility analyses Outcome research Public health Burden of disease

Needs of thermodynamic properties measurements and modeling in the frame of new regulations on refrigerants

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第5期8卷 724-733页

作者： COQUELET Christophe RICHON dominique School of Mines of Paris CEP/TEPCNRS FRE 286135rue Saint HonoréFontainebleau 77305France

In 1987, the Montreal Protocol prohibited the worldwide use and production of chlorofluorocarbons (CFCs) and hydrochlorofluorocarbons (HCFCs) and hydro fluorocarbons (HFCs) were proposed as alternative refrigerants. Unfortunately, HFCs have non negligible global warning potential and therefore new refrigerants must be proposed or old refrigerants must be used associated with HFC. Accurate experimental thermodynamic data and predictive techniques are required for better under-standing of the performance of the newly proposed refrigerants. In this communication, experimental techniques based on either analytic or synthetic methods are first described. Data are reported. Then two newly developed predictive models based on thermodynamic approach with the isofugacity criterion and artificial neural network method are presented. The results can provide better evaluation of refrigerants, especially with the aim of studying global warning effects.

关键词： Refrigerants Experimental apparatus Thermodynamic Modeling Vapor-liquid equilibria (VLE) Phase diagram Density

Recurrence properties of sequences of integers

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Science China Mathematics 2010年第3期53卷 641-656页

作者： SCHNEIDER dominique CNRS LMPA J. Liouville FR 2956 University Lille Nord de France

In order to study the recurrence of sequences of integers, we investigate their L2-exactness and Θ-Hartman property (Θ being a set of rational numbers). Two classes of sequences of integers are well studied, which a... 详细信息

关键词： recurrent set random sequence Wiener-Wintner theorem

BioMinE:An integrated project for developing biohydrometallurgy in Europe——Executive summary of its activities and outputs after three years

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中国有色金属学会会刊：英文版 2008年第6期18卷 1328-1335页

作者： dominique H.R.MORIN BRGM-EPI/Eco 3Avenue C.Guillemin-BP 600945060 Orléans Cedex 2France

Biohydrometallurgy 是生物工学和冶金学的意外联合的后代。从某极端 biotopes 的特定的性质，在微生物引起的新陈代谢和矿物质之间的相互作用的活跃原则被提取了被用作有效冶金过程。许多有利工业操作基于这些 bioprocesses 一直在跑... 详细信息

Biohydrometallurgy 是生物工学和冶金学的意外联合的后代。从某极端 biotopes 的特定的性质，在微生物引起的新陈代谢和矿物质之间的相互作用的活跃原则被提取了被用作有效冶金过程。许多有利工业操作基于这些 bioprocesses 一直在跑例如恢复铜，黄金，铀或钴，许多另外的应用程序被设计了。欧洲在这个区域在是相当活跃的过去，但是当前领导在南非，美洲和澳大利亚。BioMinE (在欧洲的忍受金属的材料的生物工学) 是与欧洲 Commision 的支持发射的一个大综合工程。它针对刺激在在这个技术领域里开发新概念的最相关的大学，研究和工业组织之间的协同作用以后允许矿物质资源的更好的利用。当他们识别了需要从今天并且明天的资源为金属抽取发现新过程，欧洲非铁的金属采矿工业开始了并且发展 BioMinE 工程。

关键词：生物显微冶金术生物技术欧洲活性

A Sophisticated Network of Signaling Pathways Regulates Stomatal Defenses to Bacterial Pathogens

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Molecular Plant 2015年第4期8卷 566-581页

作者： dominique Arnaud Ildoo Hwang Department of Life Sciences POSTECH Biotech Center Pohang University of Science and Technology Pohang /90-/84 Korea

Guard cells are specialized cells forming stomatal pores at the leaf surface for gas exchanges between the plant and the atmosphere. Stomata have been shown to playan important role in plant defense as a part of the innate immune response. Plants actively close their stomata upon contact with microbes, thereby preventing pathogen entry into the leaves and the subsequent colonization of host tissues. In this review, we present current knowledge of molecular mechanisms and signaling pathways implicated in stomatal defenses, with particular emphasis on plant-bacteria interactions. Stomatal defense responses begin from the perception of pathogen-associated molecular patterns （PAMPs） and activate a signaling cascade involving the production of secondary messengers such as reactive oxygen species, nitric oxide, and calcium for the regulation of plasma membrane ion channels. The analyses on downstream molecular mechanisms implicated in PAMP-triggered stomatal closure have revealed extensive interplays among the components regulating hormonal signaling pathways. We also discuss the strategies deployed by pathogenic bacteria to counteract stomatal immunity through the example of the phytotoxin coronatine.

关键词： stomata immunity hydrogen peroxide nitric oxide calcium hormones

State-of-the-Art in Electrophilic Trifluoromethylthiolation Reagents

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Chinese Journal of Chemistry 2016年第5期34卷 445-454页

作者： Helene Chachignon dominique Cahard Normandie UniversitY CNRS UMR 6014 COBRA et FR 3038 Universite de Rouen INSA Rouen. 1 rue Tesniere 76821 Mont Saint-Aignan Cedex France

The trifluoromethylthio group （SCF3） is a fluorine chemotype that has experienced a strong acceleration of in- terest in the recent years. It is particularly true of the construction of new fluorinated architectures by electrophilic trifluoromethylthiolation. The spread of knowledge was already very active in this research domain in the sixties; however, gaseous and highly toxic trifluoromethanesulfenyl chloride （CF3SC1） was the only reagent available at that time. Nowadays, one really can speak of a revival in the field thanks to the rapid development of a wide pano- ply of reagents that are stable and easy to handle. This review provides a historical perspective of the development of shelf-stable electrophilic trifluoromethylthiolation reagents.

关键词： fluorine sulfur electrophilic addition synthetic methods

Asymptotic Behavior of a Structure Made by a Plate and a Straight Rod

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Chinese Annals of Mathematics,Series B 2013年第3期34卷 399-434页

作者： dominique BLANCHARD Georges GRISO Universit de Rouen France Laboratoire J.-L. Lions-CNRS Boite courrier 187 Universit Pierre et Marie Curie 4 Place Jussieu 75005 Paris France

This paper is devoted to describing the asymptotic behavior of a structure made by a thin plate and a thin perpendicular rod in the framework of nonlinear elasticity. The authors scale the applied forces in such a way that the level of the total elastic energy leads to the Von-Karman＇s equations （or the linear model for smaller forces） in the plate and to a one-dimensional rod-model at the limit. The junction conditions include in particular the continuity of the bending in the plate and the stretching in the rod at the junction.

关键词： Nonlinear elasticity Junction Straight rod Plate