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Specific contribution of mannose-binding lectin murine isoforms to brain ischemia/reperfusion injury

Cellular & Molecular Immunology 2020年第3期17卷 218-226页

作者： Laura Neglia Marco Oggioni domenico mercurio Maria-Grazia De Simoni Stefano Fumagalli1 Istituto di Ricerche Farmacologiche Mario Negri IRCCS Department of NeuroscienceMilanItaly

Mannose-binding lectin(MBL),an initiator of the lectin pathway(LP)of complement activation,is detrimental in ischemic stroke,as shown in clinical studies and rodent *** humans have one functional MBL protein,rodents have two isoforms,MBL-A and MBL-C,whose functions relative to that of human MBL are *** permit the clinical translation of preclinical data,we aimed to define the specific contributions of MBL-A and MBL-C to brain *** subjected mice with double(MBL^(−/−))or single(MBL-A^(−/−)or MBL-C^(−/−))MBL isoform depletion to transient middle cerebral artery occlusion(tMCAo).MBL^(−/−) mice had fewer neurological deficits and smaller ischemic lesions than WT ***-A^(−/−) mice had smaller lesions than WT mice and exhibited no significant behavioral defects,whereas MBL-C^(−/−) mice did not differ from WT *** induction of Mbl1 and Mbl2(the MBL-A and MBL-C genes)expression 48 h after tMCAo was similar across *** time course of Mbl1 and Mbl2 expression in WT ischemic mice showed that Mbl1 activation occurred earlier(24 h)than Mbl2 activation(48 h).The plasma levels of MBL-A and MBL-C in MBL-C^(−/−) and MBL-A^(−/−) mice,respectively,were similar to those in WT mice both at baseline and at 48 h after *** 48 h,MBL-A^(−/−)ischemic mice showed higher MBL-C levels in the brain than WT *** and MBL-C^(−/−) ischemic mice had higher LP activity in plasma and,accordingly,higher levels of C3 deposition in the brain than MBL-A^(−/−) and MBL^(−/−) *** conclusion,mice with depletion of both MBL isoforms exhibited strong protection from ischemia/reperfusion ***-A was the main contributor to injury,likely owing to its earlier activation after ischemia and more efficient activation of the complement system than MBL-C.

关键词： injury depletion likely

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New challenges in hepatocellular carcinoma:A role for PIWIinteracting RNAs?

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World Journal of Gastroenterology 2024年第22期30卷 2843-2848页

作者： domenico Tierno Gabriele Grassi Bruna Scaggiante Department of Medicine Surgery and Health SciencesUniversity Hospital of CattinaraUniversity of TriesteTrieste 34149Italy Department of Life Sciences University of TriesteTrieste 34127Italy

Hepatocellular carcinoma(HCC)is the most common and deadliest subtype of liver cancer worldwide and,therefore,poses an enormous threat to global *** the molecular mechanisms underlying the development and progression of HCC is central to improving our clinical *** RNAs(piRNAs)are a class of small non-coding RNAs that bind to PIWI family proteins to regulate gene expression at transcriptional and posttranscriptional levels.A growing body of work shows that the dysregulation of piRNAs plays a crucial role in the progression of various human *** this editorial,we report on the current knowledge of HCC-associated piRNAs and their potential clinical *** on the editorial by Papadopoulos and Trifylli,on the role and clinical evaluation of exosomal circular RNAs in HCC,we highlight this other emerging class of non-coding RNAs.

关键词： Biomarker Hepatocellular carcinoma Liquid biopsy Non-coding RNA PIWI-interacting RNA Next-generation sequencing

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Cardioprotective effects of glucagon-like peptide 1 receptor agonists in heart failure: Myth or truth?

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World Journal of Diabetes 2024年第5期15卷 818-822页

作者： Lorenzo Nesti domenico Trico Department of Clinical and Experimental Medicine University of PisaPisa 56126Italy Laboratory of Metabolism Nutritionand AtherosclerosisUniversity of PisaPisa 56126Italy

Therapy with glucagon-like peptide 1(GLP1)receptor agonists has raised great interest for its beneficial cardiovascular effects in preventing atherosclerosis and heart failure-related ***,while evidence about atherosclerosis consistently suggests a cardioprotective potential with class effect,controversies remain on its impact on heart ***1 receptor agonists appear to prevent hospitalization for new-onset heart failure and reduce symptoms in heart failure with preserved ejection fraction(as demonstrated by the recent STEP-HFpEF Trial).Still,GLP1 agonism has resulted in neutral or even harmful effects in patients with established heart failure with reduced ejection fraction(the LIVE trial).GLP1 receptor agonists benefit the cardiovascular system indirectly through their marked metabolic effects(improved weight management,glycemic control,blood pressure,systemic and tissue inflammation),while direct effects on the heart have been ***,weight loss alone achieved through GLP1 receptor agonists has failed in improving left ventricular *** is a dual agonist of GLP1 and glucose-dependent insulinotropic polypeptide,representing an innovative treatment option in diabetes with a major impact on weight loss and promising cardiovascular *** this class of therapies is going to change the history of heart failure is an ongoing debate.

关键词： Atherosclerosis Cardiovascular system Glucagon-like peptide-1 Heart failure Tirzepatide Type 2 diabetes Ventricular function Left

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Keep in mind sex differences when prescribing psychotropic drugs

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World Journal of Psychiatry 2024年第2期14卷 194-198页

作者： Marianna Mazza domenico De Berardis Giuseppe Marano Department of Neurosciences Fondazione Policlinico Universitario A Gemelli IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy Mental Health NHSASL 4 TeramoTeramo 64100Italy

Women represent the majority of patients with psychiatric diagnoses and also the largest users of psychotropic *** are inevitable differences in efficacy,side effects and long-term treatment response between men and *** research needs to develop adequately powered animal and human trials aimed to consider pharmacokinetics and pharmacodynamics of central nervous system drugs in both male and female *** professionals have the responsibility to prescribe sex-specific psychopharmacotherapies with a priority to differentiate between men and women in order to minimize adverse drugs reactions,to maximize therapeutic effectiveness and to provide personalized management of care.

关键词： Women Psychopharmacology Psychotropic drugs Sex differences

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Numerical modeling techniques for noise emission of free railway wheels

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Railway Engineering Science 2024年第2期32卷 144-161页

作者： Linus Taenzer Urs Pachale Bart Van Damme Andrea Bergamini domenico Tallarico Laboratory of Acoustics/Noise Control EmpaÜberlandstrasse 129DübendorfSwitzerland

In this article,we consider the numerical prediction of the noise emission from a wheelset in laboratory *** focus on the fluid-structure interaction leading to sound emission in the fluid domain by analyzing three different methods to account for acoustic *** are a discretized baffled piston using the discrete calculation method(DCM),a closed cylindrical volume using the boundary element method(BEM)and radiating elastic disks in a cubic enclosure solved with the finite element method(FEM).We provide the validation of the baffled piston and the BEM using measurements of the noise emission of a railway wheel by considering ground reflections in the numerical *** space-resolved waveforms are compared with experimental results as well as with a fluid-structure interaction finite element *** computational advantage of a discretized disk mounted on a baffle and BEM compared to FEM is highlighted,and the baffled pistons limitations caused by a lack of edge radiation effects are investigated.

关键词： Discretized baffled piston Finite element Boundary element Railway noise Acoustic emission Vibrations

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Three predictive scores compared in a retrospective multicenter study of nonunion tibial shaft fracture

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World Journal of Orthopedics 2024年第6期15卷 560-569页

作者： Davide Quarta Marco Grassi Giuliano Lattanzi Antonio Pompilio Gigante Alessio D'Anca domenico Potena Clinical Orthopedics Department of Clinical and Molecular ScienceUniversitàPolitecnica Delle MarcheAncona 60126Italy Department of Information and Engineering UniversitàPolitecnica delle MarcheAncona 60121Italy

BACKGROUND Delayed union,malunion,and nonunion are serious complications in the healing of *** the risk of nonunion before or after surgery is *** To compare the most prevalent predictive scores of nonunion used in clinical practice to determine the most accurate score for predicting *** We collected data from patients with tibial shaft fractures undergoing surgery from January 2016 to December 2020 in three different trauma *** this retrospective multicenter study,we considered only fractures treated with intramedullary *** calculated the tibia FRACTure prediction healING days(FRACTING)score,Nonunion Risk Determination score,and Leeds-Genoa Nonunion Index(LEG-NUI)score at the time of definitive *** Of the 130 patients enrolled,89(68.4%)healed within 9 months and were classified as *** remaining patients(n=41,31.5%)healed after more than 9 months or underwent other surgical procedures and were classified as *** calculation of the three scores,LEG-NUI and FRACTING were the most accurate at predicting *** LEG-NUI and FRACTING showed the best performances by accurately predicting union and nonunion.

关键词： Trauma Bone Tibial fracture Nonunion Scores Prediction model

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Driving pressure:A useful tool for reducing postoperative pulmonary complications

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World Journal of Critical Care Medicine 2024年第3期13卷 91-94页

作者： domenico Posa Fabio Sbaraglia Giuliano Ferrone Marco Rossi Department of Emergency Intensive Care Medicine and AnaesthesiaFondazione Policlinico Universitario A.Gemelli IRCCSRome 00168LazioItaly

The operating room is a unique environment where surgery exposes patients to non-physiological changes that can compromise lung ***,raising clinicians’awareness of the potential risk of ventilator-induced lung injury(VILI)is *** pressure is a useful tool for reducing lung complications in patients with acute respiratory distress syndrome and those undergoing elective *** pressure has been most extensively studied in the context of single-lung ventilation during thoracic ***,the awareness of association of VILI risk and patient positioning(prone,beach-chair,parkbench)and type of surgery must be raised.

关键词： Ventilator-induced lung injury Protective ventilation Driving pressure Mechanical ventilation Surgery room Single-lung ventilation Operative room Surgery

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Resilience Against Replay Attacks:A Distributed Model Predictive Control Scheme for Networked Multi-Agent Systems

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IEEE/CAA Journal of Automatica Sinica 2021年第3期8卷 628-640页

作者： Giuseppe Franzè Francesco Tedesco domenico Famularo DIMES Department University of CalabriaArcavacata di Rende 87036Italy

In this paper,a resilient distributed control scheme against replay attacks for multi-agent networked systems subject to input and state constraints is *** methodological starting point relies on a smart use of predictive arguments with a twofold aim:1)Promptly detect malicious agent behaviors affecting normal system operations;2)Apply specific control actions,based on predictive ideas,for mitigating as much as possible undesirable domino effects resulting from adversary ***,the multi-agent system is topologically described by a leader-follower digraph characterized by a unique leader and set-theoretic receding horizon control ideas are exploited to develop a distributed algorithm capable to instantaneously recognize the attacked ***,numerical simulations are carried out to show benefits and effectiveness of the proposed approach.

关键词： Distributed model predictive control leader-follower networks multi-agent systems replay attacks resilient control

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Biofabrication of nanovesicles for brain diseases

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Neural Regeneration Research 2023年第3期18卷 525-526页

作者： Pasquale Picone domenico Nuzzo Istituto per la Ricerca e l’Innovazione Biomedica CNRDipartimento di Scienze e Tecnologie Biologiche Chimiche e FarmaceuticheUniversitàdi PalermoPalermoItaly

Background:Nanotechnologies promise to improve disease diagnosis and treatment,overcoming the limitations of conventional *** particular,extracellular vesicles(EVs)and artificial vesicles(AVs)are strongly emerging tools in nanomedicine(Leggio et al.,2020).EVs are cell-derived membrane structures secreted after the fusion of endosomes with the plasma membrane(exosomes)or shed from the plasma membrane(microvesicles).EVs are released by different brain cells(neurons,oligodendrocytes,astrocytes,and microglia)and constitute a physiological intercellular communication ***,EVs can deliver different types of molecules(nucleic acids and proteins),which often influence the phenotype of the recipient *** play a physiological role in the central nervous system(CNS),such as development,myelination,regeneration,and synaptic activity(Lai et al.,2012).Due to their content,EVs could therefore constitute an important biomarker for neurodegenerative diseases,represent candidates for therapeutic use,enclosing regulatory molecules,or be considered as vectors for brain drug delivery(Croese et al.,2018).

关键词： diseases diagnosis constitute

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A Resilient Control Strategy for Cyber-Physical Systems Subject to Denial of Service Attacks:A Leader-Follower Set-Theoretic Approach

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IEEE/CAA Journal of Automatica Sinica 2020年第5期7卷 1204-1214页

作者： Giuseppe Franzè domenico Famularo Walter Lucia Francesco Tedesco DIMES Department Universitàdella CalabriaVia Pietro Bucci 87036Italy CIISE Department Concordia UniversityMontrealQuebec H3G-1M8Canada IEEE

Multi-agent systems are usually equipped with open communication infrastructures to improve interactions efficiency,reliability and *** technologically costeffective,this makes them vulnerable to cyber-attacks with potentially catastrophic *** this end,we present a novel control architecture capable to deal with the distributed constrained regulation problem in the presence of time-delay attacks on the agents’communication *** basic idea consists of orchestrating the interconnected cyber-physical system as a leader-follower configuration so that adequate control actions are computed to isolate the attacked unit before it compromises the system *** on a multi-area power system confirm that the proposed control scheme can reconfigure the leader-follower structure in response to denial ofservice(DoS)attacks.

关键词： Denial-of-service(DoS)attacks distributed model predictive control leader-follower paradigm resilient control

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