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Transgenic Poplar Plants for the Investigation of ABA-Dependent Salt and Drought Stress Adaptation in Trees

American Journal of Plant Sciences 2016年第9期7卷 1337-1356页

作者： domenica hamisch David Kaufholdt Jennifer-Christin Kuchernig Florian Bittner Ralf R. Mendel Robert Hänsch Jennifer Popko Institut für Pflanzenbiologie Technische Universitat Braunschweig Braunschweig Germany Albrecht-von-Haller-Institutfür Pflanzenwissenschaften Abteilung Biochemie der Pflanzen Georg-August-Universitat Gottingen Germany

Important functions of the plant hormone abscisic acid (ABA) in stress reactions, growth and photosynthetic processes are extensively studied in the model plant Arabidopsis thaliana. This paper investigates the importance of Moco-sulphurase ABA3 and aldehyde oxidase (AO) on ABA-biosynthesis in Populus × canescens. ABA3 is essential for activation of the molybdenum enzymes AO and xanthine dehydrogenase (XDH). AO itself catalyzes the last step in ABA-biosynthesis. Generation of transgenic poplar plants altered in ABA3 and AO-activity using RNAi knock down and overexpression was performed. Whereas RNAi-AO plants show a specific loss of AO activity, the RNAi-ABA3 plants has a strongly reduced activity of both molybdenum enzymes: AO and XDH. Constructs of AO and ABA3-promoters fused to β-glucuronidase provide the basis to investigate transcriptional regulation of ABA-biosynthetic processes under stress conditions. Application of high salt concentrations and different drought stress intensities does change the endogenous AO or XDH neither on the side of transcription nor on protein activity. On phytohormone level however, water loss leads to increased ABA-amounts regardless of whether transgenic or wildtype plants are studied. Salt application resulted in higher ABA-levels in all analyzed plant lines. The down regulation of AO in the two different RNAi-plant lines strongly prevented a wildtype-like increase of ABA-levels. Whereas the WT plants accumulated up to 6000 ng ABA g-1 FW-1 after 16 h of salt stress exposure, plants of the RNAi lines revealed a markedly lower increase of only up to 2000 ng ABA g-1 FW-1. Opposing to these observations, ABA-levels increased during drought without any influence by the RNAi-effect. These results revealed that although stresses did not result in a visible increased AO-activity, ABA-production was influenced by AO and ABA3 at least under salinity.

关键词： ABA Biosynthesis Drought Stress Populus × canescens Transgenic Poplar Salt Stress

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Erratum to:Superlubricity of epitaxial monolayer WS_(2)on graphene

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Nano Research 2024年第6期17卷 5754-5754页

作者： Holger Büch Antonio Rossi Stiven Forti domenica Convertino Valentina Tozzini Camilla Coletti Center for Nanotechnology Innovation@NEST Istituto Italiano di TecnologiaPiazza S.Silvestro 1256127 PisaItaly NEST Istituto Nanoscienze–CNR and Scuola Normale SuperiorePiazza San Silvestro 1256127 PisaItaly Graphene Labs Istituto Italiano di TecnologiaVia Morego 3016163 GenovaItaly

The article"Superlubricity of epitaxial monolayer WS2 on graphene",written by Holger Büch,Antonio Rossi,Stiven Forti,domenica Convertino,Valentina Tozzini,and Camilla Coletti,was originally published electronically on the publisher’s internet portal(currently SpringerLink)on June 18th 2018 without open *** the author(s)’decision to opt for Open Choice the copyright of the article changed in August 2018 to©The Author(s)2018 and the article is forthwith distributed under the terms of the Creative Commons Attribution 4.0 International License(http://***/licenses/by/4.0/),which permits use,duplication,adaptation,distribution and reproduction in any medium or format,as long as you give appropriate credit to the original author(s)and the source,provide a link to the Creative Commons license and indicate if changes were made.

关键词： monolayer epitaxial license

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New perspectives in the treatment of advanced or metastatic gastric cancer

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World Journal of Gastroenterology 2009年第22期15卷 2689-2692页

作者： Gerardo Rosati domenica Ferrara Luigi Manzione Medical Oncology Unit S.Carlo Hospital

Metastatic gastric cancer remains an incurable disease,with a relative 5-year survival rate of 7%-27%.Chemotherapy,which improves overall survival(OS) and quality of life,is the main treatment *** has demonstrated that the best survival results obtained in earlier randomized studies were achieved with three-drug regimens containing a fluoropyrimidine,an anthracycline,and cisplatin(ECF).Although there has been little progress in improving median OS times beyond the 9-mo plateau achievable with the standard regimens,the availability of newer agents has provided some measure of optimism.A number of new combinations incorporating docetaxel,oxaliplatin,capecitabine,and S-1 have been explored in randomized *** combinations,such as epirubicin-oxaliplatin-capecitabine,have been shown to be as effective as(or perhaps more effective than) ECF,and promising early data have been derived for S-1 in combination with *** factor that might contribute to extending median OS is the advancement whenever possible to second-line cytotoxic ***,the biggest hope for signif icant survival advances in the near future would be the combination of new targeted biological agents with existing chemotherapy f irst-line regimens.

关键词： Advanced gastric cancer Biological agents Chemotherapy

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Superlubricity of epitaxial monolayer WS2 on graphene

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Nano Research 2018年第11期11卷 5946-5956页

作者： Holger Buch Antonio Rossi Stiven Forti domenica Convertino Valentina Tozzini Camilla Coletti Center for Nanotechnology Innovation @NEST Istituto Italiano di Tecnologia Piazza S. Silvestro 12 56127 Pisa Italy NEST Istituto Nanoscienze - CNR and Scuola Normale Supefiore Piazza San Silvestro 12 56127 Pisa Italy Graphene Labs Istituto Italiano di Tecnologia Via Morego 30 16163 Genova Italy

We report the superlubric sliding of monolayer tungsten disulfide (WS2) on epitaxial graphene (EG) grown on silicon carbide (SiC). Single-crystalline WS2 flakes with lateral size of hundreds of nanometers are obtained via chemical vapor deposition (CVD) on EG. Microscopic and diffraction analyses indicate that the WS2/EG stack is predominantly aligned with zero azimuthal rotation. The present experiments show that, when perturbed by a scanning probe microscopy (SPM) tip, the WS2 flakes are prone to slide over the graphene surfaces at room temperature. Atomistic force field-based molecular dynamics simulations indicate that, through local physical deformation of the WS2 flake, the scanning tip releases enough energy to the flake to overcome the motion activation barrier and trigger an ultralow-friction rototranslational displacement, that is superlubric. Experimental observations show that, after sliding, the WS2 flakes come to rest with a rotation of nπ/3 with respect to graphene. Moreover, atomically resolved measurements show that the interface is atomically sharp and the WS2 lattice is strain-free. These results help to shed light on nanotribological phenomena in van der Waals (vdW) heterostacks, and suggest that the applicative potential of the WS2/graphene heterostructure can be extended by novel mechanical prospects.

关键词： superlubricity graphene tungsten disulfide scanning tunneling microscopy (STM) two-dimensional (2D) materials nanomechanical

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Schistosomiasis and soil-transmitted helminthiasis in Rwanda:an update on their epidemiology and control

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Infectious Diseases of Poverty 2017年第1期6卷 59-69页

作者： Nadine Rujeni domenica Morona Eugene Ruberanziza Humphrey D.Mazigo Department of Biomedical Laboratory Sciences School of Health SciencesCollege of Medicine and Health SciencesUniversity of RwandaP.O.Box 3286NyarugengeRwanda Department of Medical Parasitology School of MedicineCatholic University of Health and Allied SciencesP.O.Box 1464MwanzaTanzania Rwanda Biomedical Center Institute of HIVDisease Prevention and ControlMalaria and Other Parasitic Diseases DivisionNeglected Tropical Diseases and Other Parasitic Diseases UnitKigaliRwanda

Even though Rwanda lies within a region that has a high prevalence of schistosomiasis and soil-transmitted helminth(STH)infections,epidemiological information regarding these infections in the country remains *** present review attempts to compile the available data on schistosomiasis and STHs,from 1940 to 2014,to provide an insight on the epidemiological profile of these *** information will,in turn,support the design and implementation of sustainable control *** available records indicate that only Schistosoma mansoni and all the major species of STHs are endemic in *** 2008,the national prevalence of *** was reported to be 2.7%,ranging from 0 to 69.5%,and that of STH infections was 65.8%(diagnosed using the Kato-Katz technique).The prevalence of these infections varies from one district to another,with schoolchildren remaining a highly affected *** main control approach is mass drug administration using albendazole and praziquantel,mostly targeting school-aged children in school *** 2008,adult individuals living in areas with a prevalence of ***≥30%were also included in the mass drug administration ***,despite Rwanda achieving an almost 100%coverage of this programme in 2008-2010,the transmission of *** and STHs continues to take place,as illustrated by the most recent *** Rwanda is to achieve sustainable control and elimination of schistosomiasis and STHs,there is a need to revise the country’s control strategy and adopt an integrated control approach that involves a combination of measures.

关键词： Schistosomiasis Soil-transmitted helminths Control Epidemiology Rwanda

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Evidence for a role of mitogen-activated protein kinases in the treatment of experimental acute pancreatitis

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World Journal of Gastroenterology 2014年第44期20卷 16535-16543页

作者： Natasha Irrera Alessandra Bitto Monica Interdonato Francesco Squadrito domenica Altavilla Department of Clinical and Experimental Medicine University of Messina Department of Paediatric Gynaecological Microbiological and Biomedical Sciences University of Messina

Acute pancreatitis(AP) is an inflammatory disease characterized by acute inflammation and necrosis of the pancreatic parenchyma. AP is often associated with organ failure, sepsis, and high mortality. The pathogenesis of AP is still not well understood. In recent years several papers have highlighted the cellular and molecular events of acute pancreatitis. Pancreatitis is initiated by activation of digestive enzymes within the acinar cells that are involved in autodigestion of the gland, followed by a massive infiltration of neutrophils and macrophages and release of inflammatory mediators, responsible for the local and systemic inflammatory response. The hallmark of AP is parenchymal cell necrosis that represents the cause of the high morbidity and mortality, so that new potential therapeutic approaches are indispensable for the treatment of patients at high risk of complications. However, not all factors that determine the onset and course of the disease have been explained. Aim of this article is to review the role of mitogen-activated protein kinases in pathogenesis of acute pancreatitis.

关键词： Experimental acute pancreatitis Mitogen-activated protein kinases Mitogen-activated protein kinases inhibitors Cytokines Cholecystokinin Cerulein

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Building Expertise on FAIR Through Evolving Bring Your Own Data(BYOD) Workshops: Describing the Data, Software, and Management-focused Approaches and Their Evolution

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Data Intelligence 2024年第2期6卷 429-456页

作者： César H.Bernabé Lieze Thielemans Rajaram Kaliyaperumal Claudio Carta Shuxin Zhang Celia W.G.van Gelder Nirupama Benis Luiz Olavo Bonino da Silva Santos Ronald Cornet Bruna dos Santos Vieira Nawel Lalout Ines Henriques Alberto Camara Ballesteros Kees Burger Martijn G.Kersloot Friederike Ehrhart Esther van Enckevort Chris T.Evelo Alasdair J.G.Gray Marc Hanauer Kristina Hettne Joep de Ligt Arnaldo Pereira Nuria Queralt-Rosinach Erik Schultes domenica Taruscio Andra Waagmeester Mark D.Wilkinson Egon L.Willighagen Mascha Jansen Barend Mons Marco Roos Annika Jacobsen Biosemantics Group Department of Human GeneticsLeiden University Medical CentreLeidenThe Netherlands NIHR Academic Fellow in General Practice University College London and The Royal Free NHS Foundation Trust National Centre for Rare Diseases Istituto Superiore di SanitaRomeItaly Department of Medical Informatics Amsterdam UMC location University of AmsterdamMeibergdreef 9AmsterdamThe Netherlands Amsterdam Public Health Methodology&Digital HealthAmsterdamThe Netherlands Health-Rl UtrechtThe Netherlands Semantics Services and Cybersecurity groupUniversity of TwenteEnschedeThe Netherlands Department of Medical Imaging Radboud Institute for Health SciencesRadboud University Medical CenterNijmegenThe Netherlands Department of Medical BioSciences Radboud University Medical CenterNijmegenThe Netherlands The Duchenne Parent Project VeneendaalThe Netherlands Departamento de Biotecnologia-Biologia Vegetal Escuela Tecnica Superior de Ingenieria AgronomicaAlimentaria y de BiosistemasCentro de Biotecnologia y Genomica de PlantasUniversidad Politecnica de Madrid(UPM)-Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria-CSIC(INIA-CSIC).Campus MontegancedoPozuelo de Alarcon(Madrid)Spain Castor AmsterdamThe Netherlands Department of Bioinformatics-BiGCaT Maastricht UniversityMaastrichtThe Netherlands University Medical Center Groningen University of GroningenGroningenThe Netherlands Maastricht Centre for Systems Biology(MaCSBio) Maastricht UniversityMaastrichtThe Netherlands Department of Computer Science Heriot-Watt UniversityEdinburghUK INSERM US14-OrphanetPlateforme Maladies RaresParisFrance Centre for Digital Scholarship Leiden University LibrariesThe Netherlands Center for Molecular Medicine Cancer Genomics NetherlandsDepartment of GeneticsUniversity Medical Center UtrechtUniversity UtrechtThe Netherlands University of Aveiro DETI/IEETAAveiroPortugal GO FAIR Foundation LeidenThe Netherlands The Leiden Academic Center for Drug Research LeidenThe Netherlands Micel

Since 2014,"Bring Your Own Data"workshops(BYODs)have been organised to inform people about the process and benefits of making resources Findable,Accessible,Interoperable,and Reusable(FAIR,and the FAIRification process).The BYOD workshops'content and format differ depending on their goal,context,and the background and needs of ***-focused BYODs educate domain experts on how to make their data FAIR to find new answers to research ***-focused BYODs promote the benefits of making data FAIR and instruct project managers and policy-makers on the characteristics of FAIRification ***-focused BYODs gather software developers and experts on FAIR to implement or improve software resources that are used to support ***,these BYODs intend to foster collaboration between different types of stakeholders involved in data management,curation,and reuse(*** experts,trainers,developers,data owners,data analysts,FAIR experts).The BYODs also serve as an opportunity to learn what kind of support for FAIRification is needed from different communities and to develop teaching materials based on practical examples and *** this paper,we detail the three different structures of the BYODs and describe examples of early BYODs related to plant breeding data,and rare disease registries and biobanks,which have shaped the structure of the *** discuss the latest insights into making BYODs more productive by leveraging our almost ten years of training experience in these workshops,including successes and encountered ***,we examine how the participants'feedback has motivated the research on FAIR,including the development of workflows and software.

关键词： FAIR FAIRification FAIR expertise Bring Your Own Data Workshop BYOD

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Subcapsular hepatic haematoma of the right lobe following endoscopic retrograde cholangiopancreatography: Case report and literature review

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World Journal of Gastroenterology 2016年第17期22卷 4411-4415页

作者： Marco Antonio Zappa Alberto Aiolfi Ilaria Antonini Cinzia domenica Musolino Andrea Porta Department of General and Emergency surgery Ospedale S Famiglia Fatabenefratelli 22036 Erba Italy

Sub capsular hepatic haematoma is a rare complication after endoscopic retrograde cholangiopancreatography (ERCP). Exact pathological mechanism is still unclear and few reports are nowadays available in literature. We report the case of a 58-year-old woman with recurrent episodes of upper abdominal pain, nausea and vomiting. On the basis of laboratory exams, abdomen ultrasound and magnetic resonance imaging she was diagnosed with a common bile duct stone. Endoscopic biliary sphincterotomy was performed. On the following day the patient complaint severe abdominal pain with rebound and hemodynamic instability. A computed tomography scan reveal a 14 cm × 6 cm × 19 cm sub-capsular hepatic haematoma on the right lobe that was successfully managed via percutaneous embolization. Sub capsular liver haematoma is a rare life threatening complication after ERCP that should be managed according to patients’ haemodynamic and clinic.

关键词： Endoscopic guidewire Endoscopic retrograde cholangiopancreatography Abdominal pain Subcapsular hepatic hematoma Embolization

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IgA nephropathy: Causes, prognosis and treatment

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肾脏病与透析肾移植杂志 2005年第6期14卷 584-587页

作者： Francesco Paolo Schena Diletta domenica Torres Giuseppina Cerrullo Renal Unit Department of Emergency and Organ Trans-plant University of Bari Bari Italy

IgA nephropathy (IgAN) or Berger's disease is the most common form of primary glomerulonephritis in many renal biopsy registries and it is very frequent in the Eastern regions of the world, such as China (32,1%), Hong... 详细信息

关键词： IgA肾病治疗病理机制免疫疾病

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Multiscale modeling of ultrafast melting phenomena

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npj Computational Materials 2022年第1期8卷 324-333页

作者： Gaetano Calogero domenica Raciti Pablo Acosta-Alba Fuccio Cristiano Ioannis Deretzis Giuseppe Fisicaro Karim Huet Sébastien Kerdilès Alberto Sciuto Antonino La Magna CNR IMM CataniaItaly UniversitéGrenoble Alpes CEA-LETIGrenobleFrance LAAS CNRSUniversitéde ToulouseToulouseFrance Laser Systems&Solutions of Europe(LASSE) GennevilliersFrance Dipartimento di Fisica e Astronomia Universitàdi CataniaCataniaItaly

Ultraviolet Nanosecond Laser Annealing(LA)is a powerful tool for both fundamental investigations of ultrafast,nonequilibrium phase-change phenomena and technological applications(e.g.,the processing of 3D sequentially integrated nano-electronic devices)where strongly confined heating and melting is *** the LA process along with the experimental design is challenging,especially when involving complex 3D-nanostructured systems with various shapes and *** this purpose,it is essential to model critical nanoscale physical LA-induced phenomena,such as shape changes or formation and evolution of point and extended *** date,LA simulators are based on continuum models,which cannot fully capture the microscopic kinetics of a solid–liquid *** this work a fully atomistic LA simulation methodology is presented,based on the parallel coupling of a continuum,finite elements,μm-scale electromagnetic-thermal solver with a super-lattice Kinetic Monte Carlo atomistic model for *** against phase-field models and experimental data validate the *** of a Si(001)surface is studied varying laser fluence and pulse shape,assuming both homogeneous and inhomogeneous nucleation,revealing how liquid Si nuclei generate,deform and coalesce during *** proposed methodology is applicable to any system where the atom kinetics is determined by a strongly space-and time-dependent field,such as temperature or strain.

关键词： kinetics shape melting

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