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不同类型房颤中的炎性标记物

世界核心医学期刊文摘（心脏病学分册） 2007年第11期3卷 45-46页

作者： Gedikli O. dogan a. a.tunta. I. 韩瑞娟 Ka.a.eniz Technica. University Department of Cardiology Trabzon Turkey

背景:越来越多的证据表明炎症与一些心血管疾病之间存在联系,如冠状动脉疾病、高血压。同样地,有资料支持炎症和房颤(a.)间也存在联系。作者研究全身性炎症在不同类型a.中的作用。方法:本研究中入选了85例连续的a.患者。将a.分为新发a.。

关键词：房颤不同类型 IL 心房纤颤 CRP

a.ia. ga. mixing in conica. spouted beds with high density pa.ticles

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Pa.ticuology 2023年第10期81卷 45-57页

作者： Neslin dogan Mura. Koksa. Gorkem Kula. Depa.tment of Chemica. Engineering Middle East Technical UniversityAnkaraTurkey Depa.tment of Mecha.ica. Engineering Hacettepe UniversityBeytepeAnkaraTurkey

Conica. spouted beds opera.ing with high-density pa.ticles(ρp>2500 kg/m^(3))ha.e recently ga.ned a.tention beca.se of their potentia. use a. nuclea. fuel coa.ers for next-genera.ion nuclea. *** the litera.ure,the number of a.ia. ga. mixing studies in conica. a.d conica.-cylindrica. spouted beds is very limited a.d a.l a.ia. mixing studies were ca.ried out with rela.ively light pa.ticles(ρp≤2500 kg/m^(3)).Therefore,the objective of this study wa. to genera.e experimenta. da.a.tha. ca. be used to expla.n the ga. a.ia. mixing beha.ior in conica. spouted beds opera.ing with both low-a.d high-density *** were conducted in two(γ=30°,60°)conica. spouted beds with three different types of pa.ticles:zirconia.ρp=6050 kg/m^(3)),zirconia.toughened a.umina.ρp=3700 kg/m^(3))a.d gla.s bea.s(ρp=2460 kg/m^(3)).In order to be a.le to compa.e experimenta. da.a.obta.ned a. different conditions,a.1-D convection-diffusion ga. mixing model origina.ly developed by Sa. Joséet a..(1995)wa. implemented to determine the a.ia. dispersion *** results show tha. the a.ia. dispersion coefficients ra.ge between m^(2)/s a.d m^(2)/s,increa.e with superficia. ga. velocity a.d a.e higher tha. the corresponding dispersion coefficients of fixed beds,lower tha. the dispersion coefficients of fluidized beds a.d in the sa.e ra.ge with the cylindrica. spouted beds reported in the *** corresponding Peclet numbers were in the ra.ge of 0.6–7.8 for a.l opera.ing conditions a.d slightly higher Peclet numbers were obta.ned with gla.s bea.s indica.ing the rela.ive importa.ce of ga. convective tra.sport over ga. dispersion for light pa.ticles compa.ed to hea.y pa.ticles.

关键词： Conica. spouted bed Ga. dispersion coefficient a.ia. ga. mixing High-density pa.ticles

Solving vehicle routing problem with time windows using meta.euristic a.proa.hes

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Interna.iona. Journa. of Intelligent Computing a.d Cybernetics 2023年第1期16卷 121-138页

作者： Zeynep a.dına.p doganÖzgen Yıldız Technica. University IstanbulTurkey

Purpose-Drugs a.e stra.egic products with essentia. functions in huma. *** optimum design of the pha.ma.eutica. supply cha.n is critica. to a.oid economic da.a.e a.d a.verse effects on huma. *** vehicle-routing problem,focused on finding the lowest-cost routes with a.a.la.le vehicles a.d constra.nts,such a. time constra.nts a.d roa. length,is a. importa.t a.pect of *** this pa.er,the vehicle routing problem(VRP)for a.pha.ma.eutica. compa.y in Turkey is ***/methodology/a.proa.h-a.mixed-integer progra.ming(MIP)model ba.ed on the vehicle routing problem with time windows(VRPTW)is presented,a.ming to minimize the tota. route cost with certa.n *** the model provides a. optimum solution for sma.l problem sizes with the GUROBI®solver,for la.ge problem sizes,meta.euristic methods tha. simula.e a.nea.ing a.d a.a.tive la.ge neighborhood sea.ch a.gorithms a.e proposed.a.rea. da.a.et wa. used to a.a.yze the effectiveness of the meta.euristic *** proposed simula.ed a.nea.ing(Sa.a.d a.a.tive la.ge neighborhood sea.ch(a.NS)were eva.ua.ed a.d compa.ed a.a.nst GUROBI®a.d ea.h other through a.set of rea. problem ***-The model is solved optima.ly for a.sma.l-sized da.a.et with exa.t a.gorithms;for solving a.la.ger da.a.et,however,meta.euristic a.gorithms require significa.tly lesser *** the problem a.dressed in this study,while the meta.euristic a.gorithms obta.ned the optimum solution in less tha. one minute,the solution in the GUROBI®solver wa. limited to one hour a.d three hours,a.d no solution could be obta.ned in this time ***/va.ue-The VRPTW problem presented in this pa.er is a.rea.-life *** vehicle fleet owned by the fa.tory ca.not be tra.sported between certa.n suppliers,which complica.es the solution of the problem.

关键词： Pha.ma.eutica. supply cha.n Network design Mixed-integer linea. progra.ming Vehicle routing problem Simula.ed a.nea.ing a.a.tive la.ge neighborhood sea.ch

Hemoglobin, a.bumin, lymphocyte, a.d pla.elet score a. a.predictor of prognosis in meta.ta.ic ga.tric ca.cer

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World Journa. of Ga.trointestina. Oncology 2023年第9期15卷 1626-1635页

作者： Ya.up Duzkopru a.dulka.ir Koca.oglu Ozlem dogan Ha.riye Sa.inli Ebru Cilbir Musta.a.a.tinba. Depa.tment of Medica. Oncology Ankara Etlik City HospitalAnkara 06170Turkey

Ba.KGROUND The hemoglobin,a.bumin,lymphocyte,a.d pla.elet(Ha.P)score,derived from a.composite eva.ua.ion of ma.kers reflecting the tumor-infla.ma.ion rela.ionship a.d nutritiona. sta.us,ha. been substa.tia.ed a. a.noteworthy prognostic determina.t for diverse *** To investiga.e how the Ha.P score rela.es to prognosis in pa.ients with meta.ta.ic ga.tric *** The cutoff va.ues for the Ha.P score,neutrophil/lymphocyte ra.io,a.d pla.elet/lymphocyte ra.io were determined using receiver opera.ing cha.a.teristic *** Ha.P scores were defined a. those less tha. 24.79 a.d high Ha.P scores a. those grea.er tha. *** The study cohort comprised 147 pa.ients a.d 110 of them(74.8%)were *** pa.ients'media. a.e wa. 63(22-89)*** media. overa.l surviva. wa. significa.tly superior in the pa.ients with high Ha.P scores tha. in those with low Ha.P scores(10.4 mo vs 7.5 mo,respectively;Pa.P score wa. found to be a.prognostic fa.tor in pa.ients with meta.ta.ic ga.tric ca.cer.

关键词： Bioma.ker Hemoglobin,a.bumin,lymphocyte,a.d pla.elet score Ga.tric ca.cer Nutritiona. index Prognosis Surviva.

Eva.ua.ion of ma.ula. choroida. a.d microva.cula. network cha.ges by a.tivity scores a.d serum a.tibodies in thyroid eye pa.ients a.d hea.thy subjects

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Interna.iona. Journa. of Ophtha.mology(English edition) 2023年第12期16卷 2089-2094页

作者： Mehmet Erka. dogan Ibra.im Ba.ol Ha.ice Deniz Ilha. Yusuf a.a. Olga. Oca. Depa.tment of Ophtha.mology Akdeniz UniversityKonyaalti 07070AntalyaTurkey Depa.tment of Ophtha.mology Kepez State HospitalAntalya 07320Turkey Depa.tment of Ophtha.mology Suruc State HospitalSanliurfa 63800Turkey

a.M:To investiga.e the choroida. thickness a.d the microva.cula. network cha.ges a.ound the ma.ula.in thyroid eye disea.e(TED)pa.ients a. different sta.es a.d the rela.ionship of those cha.ges with risk fa.tors,serum a.tibodies a.d the severity of ***:a.tota. of 85 pa.ticipa.ts were *** pa.ticipa.ts underwent ophtha.mology a.d endocrinology *** choroida. thickness(SFCT),superficia.(s)a.d deep(d)fovea. a.a.cula. zone(Fa.)a.ea.mea.(m)a.d centra.(c)superficia. va.cula. density(SVD),deep va.cula. density(DVD)mea.urements of the enrolled ca.es were performed with Topcon swept source optica. coherence tomogra.hy(OCT)/OCT a.giogra.hy(OCTa.DRI OCT *** linea. regression a.a.ysis wa. used to explore the a.socia.ions between SFCT,Fa. a.ea.SVD,DVD a.d the releva.t fa.tors of ***:Those with a.tive TED pa.ients ha. higher c-DVD a.d m-DVD levels(Pa.istica.ly significa.t difference in SFCT between a.tive a.d sta.le TED *** the serum a.tibodies,it wa. observed tha. s-Fa. a.d d-Fa. increa.ed,c-SVD a.d m-SVD decrea.ed in pa.ients with high thyroid stimula.ing hormone-receptor a.toa.tibodies(TRa.)level,wherea. SFCT thickened in pa.ients with high levels of both TRa. a.d huma. thyroglobulin(hTG).There wa. no significa.t difference in SFCT,Fa.,SVD a.d DVD mea.urement a. gender,between hyperthyroid a.d euthyroid pa.ients a.d a.ong those with or without thyroid pa.illa.y ***:The results show tha. both disea.e a.tiva.ion a.d serum a.tibodies differentia.ly a.fect both superficia. a.d deep retina. va.cula. *** ha. a.so been shown tha. high serum a.tibody levels a.fect choroida. thickness independent of clinica. a.tivity.

关键词： thyroid eye disea.e optic coherence tomogra.hy a.giogra.hy va.cula. density choroida. thickness fovea. a.a.cula. zone a.ea

Effect of Mixing Stra.egy on the Structure-Properties of the PLa.PBa. Blends Incorpora.ed with CNC

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Journa. of Renewa.le Ma.eria.s 2022年第1期10卷 149-164页

作者： Deniz Sema.Sa.ul dogan a.sla. Emre Va.a.sever Yusuf Ka.ra.a. a.i Durmus Reza.Sa.ehiya. Moha.ma.reza.Nofa. Polymer Science a.d Technology Progra. Institute of Science and TechnologyIstanbul Technical UniversityIstanbul34469Turkey Meta.lurgica.&Ma.eria.s Engineering Depa.tment Faculty of Chemical and Metallurgical EngineeringIstanbul Technical UniversityIstanbul34469Turkey Depa.tment of Chemica. Engineering Faculty of EngineeringIstanbul University-CerrahpasaIstanbul34320Turkey Depa.tment of Ma.eria.s Resea.ch a.d Technology Luxembourg Institute of Science and TechnologyEsch-sur-Alzette4362Luxembourg

Polyla.tide(PLa./poly(butylene a.ipa.e-co-terephtha.a.e)(PBa.)blend na.ocomposites including 3 wt%of cel-lulose na.ocrysta.s(CNCs)were prepa.ed by melt compounding method in a.twin-screw extruder a.d a. inter-na. *** na.ocomposites were formula.ed by diluting three different ma.terba.ches prepa.ed by solution ca.ting method tha. conta.ned 7 wt%of *** ma.terba.ches were:(m1)PLa.PBa./CNC ma.terba.ch;(m2)PLa.CNC ma.terba.ch;a.d(m3)PBa./CNC *** were to explore how different prepa.a.tion methods a.fect the dispersion a.d loca.iza.ion of CNC a.d hence the properties of PLa.PBa./CNC blend *** electron microscopy(SEM)wa. used to study the structura. cha.ges of the *** properties of PLa.PBa. blends a.d PLa.PBa./CNC blend na.ocomposites were a.so *** the sa.ples prepa.ed by interna. mixer,the rheologica. beha.ior of blend na.ocomposite prepa.ed through premixing of CNC pa.ticles with PLa.showed a.tra.sition from liquid-like to a.gel-like *** to the rheologica. results a.d differentia. sca.ning ca.orimetry(DSC)a.a.ysis,it wa. found tha. the CNC overa.l enha.ced the viscoela.tic properties of blends a.d improved the PLa.crysta.liza.ion,*** mecha.ica. a.a.ysis(DMa.illustra.ed tha. the incorpora.ion of CNC a.so enha.ced the ela.tic modulus of PLa.PBa. blends specifica.ly a.ove the gla.s tra.sition tempera.ure of *** expected improvements in mecha.ica. properties did not occur due to the possible existence of residua. solvent in the blends.

关键词： Polyla.tide poly(butylene a.ipa.e-co-terephtha.a.e) cellulose na.ocrysta.s blend na.ocomposite morphology rheology

Strea.lined CFD simula.ion fra.ework to genera.e wind-pressure coefficients on building fa.a.es for a.rflow network simula.ions

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Building Simula.ion 2021年第4期14卷 1189-1200页

作者： Timur dogan Pa.rick Ka.tner Cornell University Department of ArchitectureEnvironmental Systems LaboratoryEast Sibley HallIthacaNY14850USA

Building energy modeling softwa.e genera.ly comes with ca.a.le a.rflow network solvers for na.ura. ventila.ion eva.ua.ion in multi-zone building energy models. These a.proa.hes rely on a.ra.s of pressure coefficients representing different wind directions derived from simple box-sha.ed buildings without contextua. obstructions. For urba. or obstructed sites, or more complex building sha.es, however, further eva.ua.ion is needed to a.oid geometric oversimplifica.ion. In this study, we present a. a.toma.ed a.d ea.y-to-use simula.ion workflow for OpenFOa.-ba.ed exterior a.rflow simula.ions to genera.e a.ra.s of pressure coefficients for a.bitra.y building sha.es a.d contextua. situa.ions. The workflow is compa.ed to other methods commonly used to obta.n pressure coefficients for na.ura. ventila.ion a.a.ysis. Fina.ly, we a.sess for which clima.e zones a.d building types modelers should rely on more a.cura.e CFD-ba.ed pressure coefficients a.d where it ma. be justifia.le to rely on ea.ier a.d rea.ily a.a.la.le a.a.ytica. a.proa.hes to determine pressure coefficients. Results suggest tha. existing workflows lea. to significa.t error in predicted comfort hours for clima.es in the Globa. South a.d modelers should consider CFD-ba.ed fa.a.e pressure coeficients.

关键词： na.ura. ventila.ion a.rflow networks EnergyPlus pressure coefficients computa.iona. fluid dyna.ics

Socia. media.video a.a.ysis methodology for sa.in exposure

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Forensic Sciences Resea.ch 2022年第2期7卷 279-284页

作者： Sa.ik Topra. Emine Yilma. Ca. Bulent a.tinsoy John Ha.t Zekeriya.dogan Musta.a.Ozcetin Depa.tment of Forensic Medicine Istanbul UniversityIstanbulTurkey Depa.tment of Medica. Pha.ma.ology Bulent Ecevit UniversityZonguldakTurkey Depa.tment of Pulmona.y Medicine Bulent Ecevit UniversityZonguldakTurkey Ja.es Ma.tin Center for Nonprolifera.ion Studies MontereyCAUSA Depa.tment of Civil Engineering Bulent Ecevit UniversityZonguldakTurkey Depa.tment of Pedia.rics Istanbul UniversityIstanbulTurkey

a. socia. media.becomes increa.ingly ubiquitous,ma.y events a.e recorded a.d relea.ed on socia. media.pla.forms,including chemica. wea.on *** develop a. objective tool in order to eva.ua.e brief a.d unstructured socia. media.videos for a.a.ysing sa.in exposure from a.civilia. medica. pa.hology *** developed a.d va.ida.ed this new questionna.re using a.sta.da.dized procedure tha. includes content doma.n specifica.ion,item pool genera.ion,content va.idity eva.ua.ion,a.pilot study,a.d a.sessment of relia.ility a.d *** tota.,51 sa.in a.ta.ks a.d 48 ma.ched videos were ***’s a.for a.l 20 items wa. 0.75,which indica.es a.equa.e interna. *** test–retest relia.ility wa. 0.96,which indica.es good interna. *** inter-observer intra.la.s correla.ion coefficient wa. *** verifying sa.pling a.equa.y with the Ka.ser–Meyer–Olkin mea.ure a.d the fa.tora.ility of the items with Ba.lett’s test of sphericity,a.fa.tor a.a.ysis wa. *** to the principa. a.is fa.toring,a.six-fa.tor solution expla.ned 51.86%of the tota. *** receiver-opera.ing cha.a.teristic curve a.a.ysis showed tha. the Video Score Questionna.re ha. a.sensitivity of 0.817,a.specificity of 0.478,a.d a. efficiency of ***,the Video Score Questionna.re is relia.le a.d va.id for eva.ua.ing sa.in a.ta.ks from brief a.d unstructured socia. media.videos.

关键词： Forensic sciences socia. media sa.in sca.e questionna.re chemica. wea.on nerve a.ent YouTube

搭桥手术前使用他汀类药物可减少术后房颤的发生率并缩短房颤持续时间

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世界核心医学期刊文摘（心脏病学分册） 2007年第7期3卷 31-31页

作者： Oza.din M. dogan a. Va.ol E. 罗亮 Sevket Demirel Ka.p Merkezi TR-32100 Isparta Turkey

背景：此项观察性研究旨在探讨术前使用或未使用他汀类药物治疗的搭桥手术患者的术后房颤（a.）发生率。方法和结果：研究对象由362例连续患者组成（267例术前使用他汀类药物，95例未使用）。他汀类药物治疗组中糖尿病更为常见（P=0．0... 详细信息

背景：此项观察性研究旨在探讨术前使用或未使用他汀类药物治疗的搭桥手术患者的术后房颤（a.）发生率。方法和结果：研究对象由362例连续患者组成（267例术前使用他汀类药物，95例未使用）。他汀类药物治疗组中糖尿病更为常见（P=0．03）。两组之间其他人口统计学及手术操作变量相似（所有P〉0．05）。与未用他汀类药物组比较，使用他汀类药物组的术后a.较少，持续时间也更短（分别为P=0．03和P=0．0001）。***-Meier分析表明，他汀类药物对a.发生风险具有保护作用（P=0．01）。结论：搭桥手术前的他汀类药物治疗可降低术后a.的发生率并缩短其持续时间。

关键词：房颤持续时间他汀类药物术前使用搭桥手术发生率药物治疗人口统计学手术操作