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Expanding the liver donor pool worldwide with hepatitis C infected livers, is it the time?

World Journal of Transplantation 2024年第2期14卷 13-27页

作者： Mai Hashem Mohammed A Medhat doaa abdeltawab Nahed A Makhlouf Fellow of Tropical Medicine and Gastroenterology Assiut University HospitalAssiut 71515Egypt Department of Tropical Medicine and Gastroenterology Faculty of MedicineAssiut UniversityAssiut 71515Egypt Department of Tropical Medicine and Gastroenterology Al-Rajhi Liver HospitalAssiut UniversityAssiut 71515Egypt

Liver transplantation(LT)provides a life-saving option for cirrhotic patients with complications and hepatocellular *** the increasing number of liver transplants performed each year,the number of LT candidates on the waitlist remains unchanged due to an imbalance between donor organ supply and the demand which increases the waitlist time and *** donor liver transplant had a great role in increasing the donor pool and shortened waitlist time for LT ***,further strategies can be implemented to increase the pool of potential donors in deceased donor LT,such as reducing the rate of organ *** hepatitis C virus(HCV)seropositive liver grafts is one of the expanded donor organ criteria.A yearly increase of hundreds of transplants is anticipated as a result of maximizing the utilization of HCV-positive organs for HCV-negative ***-acting antiviral therapy's efficacy has revolutionized the treatment of HCV infection and the use of HCV-seropositive donors in *** American Society of Transplantation advises against performing transplants from HCV-infected liver donors(D+)into HCV-negative recipient(R-)unless under Institutional Review Board-approved study rules and with full informed consent of the knowledge gaps associated with such *** selection of patients to be transplanted with HCV-infected grafts and confirming their access to direct-acting antivirals if needed is *** and international consensuses are needed to regulate this process to ensure the maximum benefit and the least adverse events.

关键词： Donor pool Hepatitis C-viremic organs Non-viremic organs Direct acting antivirals Hepatitis C virus treated Liver transplantation

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Colorectal cancer in Arab world:A systematic review

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World Journal of Gastrointestinal Oncology 2021年第11期13卷 1791-1798页

作者： Nahed A Makhlouf Muhammad Abdel-Gawad Aya M Mahros Sameh A Lashen Mariam Zaghloul Ahmed Eliwa Eman E Elshemy Zainab Ali-Eldin doaa abdeltawab Fathiya El-Raey Dalia Omran Marwa Khalaf Nancy Fanous Ahmed Shawkat Abdelmohsen Ahmed Abu-Elfatth Mohamed Abdelghani Mahmoud Farouk Mohamed Abdelaziz Mohamed Alboraie Department of Tropical Medicine and Gastroenterology Faculty of MedicineAssiut UniversityAssiut 71515Egypt Department of Hepatology Gastroenterologyand Infectious DiseasesAl-Azhar UniversityAssiut 71631Egypt Department of Hepatology Gastroenterology and Infectious DiseasesKafrelsheikh UniversityKafrelsheikh 33656Egypt Department of Internal Medicine Alexandria UniversityAlexandria 21521Egypt Department of Internal Medicine Al-Azhar UniversityCairo 11884Egypt Department of Hepatogastroenterology and Infectious Diseases Al-Azhar UniversityCairo 11651Egypt Department of Internal Medicine Ain Shams UniversityCairo 11646Egypt Department of Hepatogastroenterology and Infectious diseases Faculty of MedicineAl-Azhar UniversityDamietta 34511CairoEgypt Department of Endemic Medicine Cairo UniversityCairo 12613Egypt Department of Tropical Medicine and Gastroenterology Assiut Liver CenterAssiut 71511Egypt Department of Gastroenterology Hepatology and EndoscopyPolice Authority HospitalCairo 12654Egypt Department of Clinical Oncology and Nuclear Medicine Al-Azhar UniversityCairo 11824Egypt

BACKGROUND The incidence of colorectal cancer(CRC)is increasing among young individuals in the Arab world as well as in other regions of the *** To explore the incidence and prevalence of CRC in the Arab *** The PubMed,Scopus,Web of Science,EBSCO and Wiley databases were searched to retrieve relevant articles irrespective of the language or the publication *** search terms were("colon OR rectum OR sigmoid OR rectal OR colonic OR colorectal")AND("cancer OR malignancy OR malignant OR neoplasm")AND("Jordan"OR"United Arab Emirates"OR"Bahrain"OR"Tunisia"OR"Algeria"OR"Djibouti"OR"Saudi Arabia"OR"Sudan"OR"Syria"OR"Somalia"OR"Iraq"OR"Oman"OR"Palestine"OR"Qatar"OR"Comoros"OR"Kuwait"OR"Lebanon"OR"Libya"OR"Egypt"OR"Morocco"OR"Mauritania"OR"Yemen").Reviews,metaanalyses,and articles containing nonoriginal data were *** articles were screened,and relevant data were *** statistics were used for data *** Nine studies were *** of the studies provided information regarding the prevalence of *** prevalence of CRC was 0.72% in Saudi Arabia and 0.78% in the United Arab Emirate,while in Egypt,it ranged from 0.4% to 14%.Four studies showed information regarding the *** annual incidence rate of CRC in Qatar was 7.5/100000/*** Egypt,the crude incidence rate(CIR)in males was 3.1 for colon cancer and 1 for rectal cancer,while in females,it was 2.3 for colon cancer and 0.8 for rectal *** age-standardized rate for CRC incidence in 2003 was 36.90 for males,26.50 for females,and 30.49 for both sexes in Saudi *** 2016,the CIRs in Saudi Arabia were 3.6 and 2.1 in females for colon cancer and rectal cancer,respectively,while in males,it was 3.3 and 2.8 for colon cancer and rectal cancer,*** study in Egypt revealed that 25% of CRC cases occurred among individuals younger than 40 years *** There is a considerable prevalence of CRC in some Arab *** studies are n

关键词： Colorectal cancer Incidence Prevalence Arab world

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Barriers for resuming endoscopy service in the context of COVID-19 pandemic:A multicenter survey from Egypt

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World Journal of Gastroenterology 2020年第43期26卷 6880-6890页

作者： Omar Elshaarawy Sameh Aldesoky Lashen Nahed A Makhlouf doaa abdeltawab Mariam Salah Zaghloul Rasha M Ahmed Hayam Fathy Shimaa Afifi Muhammad Abdel-Gawad Eman Abdelsameea Sherief Abd-Elsalam Salem Youssef Mohamed Mohammed Tag-Adeen Mina Tharwat Ahmed Alzamzamy Ahmed Nasr Bekhit Alshaimaa M Eid Abeer Awad Mohamed-Naguib Wifi Mohammad Aamr Waleed A Abd El Dayem Mohamed Alboraie Department of Hepatology Gastroenterology and Liver TransplantationNational Liver InstituteMenoufia UniversityShebine Elkom 32511Egypt Department of Internal Medicine and Center of Alcohol Research and Liver Diseases Salem Medical CenterHeidelberg UniversityHeidelberg 69121Germany Department of Internal Medicine Faculty of MedicineUniversity of AlexandriaAlexandria 21521Egypt Department of Tropical Medicine and Gastroenterology Faculty of MedicineAssiut UniversityAssiut 71515Egypt Department of Hepatology Gastroentrology and Infectious DiseasesKafrelsheikh UniversityFaculty of MedicineKafrelsheikh 33565Egypt Department of Internal Medicine Faculty of MedicineAssiut UniversityAssiut 71515Egypt National Hepatology and Tropical Medicine Research Institute Cairo 11638Egypt Department of Hepatology Gastroenterology and Infectious DiseasesFaculty of MedicineAl-Azhar UniversityAssiut 71524Egypt Department of Tropical Medicine and Infectious Diseases Faculty of MedicineTanta UniversityTanta 31527Egypt Department of Internal Medicine Gastroenterology and Hepatology UnitFaculty of MedicineZagazig UniversityZagazig 44519Egypt Department of Internal Medicine Gastroenterology UnitQena Faculty of MedicineSouth Valley UniversityQena 83523Egypt Department of Tropical Medicine and Gastroenterology Faculty of MedicineAswan UniversityAswan 81528Egypt Department of Gastroenterology and Hepatology Military Medical AcademyCairo 11771Egypt Department of Tropical Medicine Zagazig General HospitalZagazig 42511Egypt Department of Hepatology and Gastroenterology and Infectious Disease Faculty of MedicineAlAzhar UniversityCairo 11562Egypt Department of Internal Medicine Faculty of MedicineCairo UniversityCairo 11759Egypt Department of Hepatology and Gastroentorolgy Shebin Elkom Teaching HospitalShebine Elkom 3521Egypt Department of Tropical Medicine Faculty of MedicineZagazig UniversityZagazig 44519Egypt Department of Internal Medicine Al-Azhar UniversityCairo 11651Egypt

BACKGROUND The current coronavirus disease 2019(COVID-19)pandemic has affected routine endoscopy service across the gastroenterology *** led to the suspension of service provision for elective *** To assess the potential barriers for resuming the endoscopy service in *** A national online survey,four domains,was disseminated over a period of 4 wk in August *** primary outcome of the survey was to determine the impact of the COVID-19 pandemic on the endoscopy service and barriers to the full resumption of a disabled center(s).RESULTS A hundred and thirteen Egyptian endoscopy centers participated in the *** waiting list was increased by≥50% in 44.9% of areas with clusters of COVID-19 cases(n=49)and in 35.5% of areas with sporadic cases(n=62).Thirty nine(34.8%)centers suffered from staff shortage,which was considered a barrier against service resumption by 86.4% of centers in per-protocol *** multivariate analysis,the burden of cases in the unit locality,staff shortage/recovery and the availability of separate designated rooms for COVID-19 cases could markedly affect the resumption of endoscopy practice(P=0.029,<0.001 and 0.02,respectively)and Odd’s ratio(0.15,1.8 and 0.16,respectively).CONCLUSION The COVID-19 pandemic has led to restrictions in endoscopic *** staff shortage/recovery and the availability of COVID-19 designed rooms are the most important barriers against *** working hours and dividing endoscopy staff into teams may help to overcome the current situation.

关键词： COVID-19 Endoscopy Practice Pandemic Egypt Barriers

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GIS approach for assessment of land suitability for different land use alternatives in semi arid environment in Jordan:Case study(Al Gadeer Alabyad-Mafraq)

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Information Processing in Agriculture 2019年第1期6卷 91-108页

作者： Safa Mazahreh Majed Bsoul doaa Abu Hamoor GIS Unit National Centre for Agricultural Research and Extension(NCARE)Baqa’Jordan

The semi arid lands of Jordan are fragile and severely degraded due to low rainfall and mismanagement of natural *** human demands increase,sustaining the productivity of land becomes more and more *** suitability evaluation can contribute towards better land management;mitigation of land degradation;and designing land use pattern that prevents environmental problems through segregation of competing land *** analysis allows identifying the main limiting factors for the agricultural production and enables decision makers to develop crop managements able to increase the land *** purpose of this study was to develop a Geographic Information System(GIS)based approach for land use suitability assessment in order to assist land managers to identify areas with physical limitations for different land use alternatives based on research criteria developed by FAO and modified by *** study was conducted using various data and maps incorporated within(GIS)in order to derive potential suitability for different Land Utilization Types(LUTs).Land suitability mapping was developed using an innovative approach that integrates soil and climatic data for land suitability *** maps for each land use were developed to show the suitability classes and display the spatial representation of soils suitable for *** output of suitability analyses provided not only the type of land use for which the land was suitable,but also information about the type of limitation(s)facing the utilization of the *** land use alternatives(scenarios)were formulated to improve and optimize the agricultural production in the study area.

关键词： Land utilization types Soil survey Land suitability criteria Suitability mapping GIS Scenarios

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Magnetic nanoparticles for environmental and biomedical applications： A review

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Particuology 2017年第1期15卷 1-14页

作者： Leena Mohammed Hassan G.Gomaa doaa Ragab Jesse Zhu Chemical and Biochemical Engineering Department Western UniversityLondonOntario N6A 5B9Canada

Engineered magnetic nanoparticles （MNPs） hold great potential in environmental, biomedical, and clin- ical applications owing to their many unique properties. This contribution provides an overview of iron oxide MNPs used in environmental, biomedical, and clinical fields. The first part discusses the use of MNPs for environmental purposes, such as contaminant removal, remediation, and water treatment, with a focus on the use of zero-valent iron, magnetite （Fe304）, and maghemite （~,-Fe203） nanoparticles, either alone or incorporated onto membrane materials. The second part of this review elaborates on the use of MNPs in the biomedical and clinical fields with particular attention to the application of superparamag- netic iron oxide nanoparticles （SP1ONs）, which have gained research focus recently owing to their many desirable features such as biocompatibility, biodegradability, ease of synthesis and absence of hysteresis. The properties of MNPs and their ability to work at both cellular and molecular levels have allowed their application in vitro and in vivo including drug delivery, hyperthermia treatment, radio-therapeutics, gene delivery, and biotherapeutics. Physiochemical properties such as size, shape, and surface and magnetic properties as well as agglomeration of MNPs and methods to enhance their stability are also discussed.

关键词： Magnetic nanoparticle Water treatment SPION Biomedical application

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Aging effect and test-retest reliability of the sinusoidal harmonic acceleration test and velocity step test using nanotorque rotatory chair

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Journal of Otology 2023年第3期18卷 125-131页

作者： Nourhan Ghoraba Samir Assal doaa Elmoazen Audiovestibular Medicine Unit Otorhinolaryngology DepartmentFaculty of MedicineAlexandria UniversityEgypt

Introduction:Rotatory chair testing has been used to evaluate horizontal canal *** used tests include sinusoidal harmonic acceleration test(SHAT)and velocity step test(VST).Objectives:Assessment of age effect on the SHAT and VST and assessment of test-retest reliability of the parameters of those two ***:A prospective study was performed on 100 subjects with no ear or vestibular complaints and normal vestibular *** were divided into two groups;Group A:below 50 years of age and Group B:50 years of age or *** was presented at frequencies 0.02,0.04,0.08,0.16,0.32,0.64 Hz with a peak velocity of 60°/*** was performed using a maximum velocity of 100°/s with acceleration and deceleration of 200°/*** subjects were tested twice to assess ***:Study participants ranged in age from 20 to 67 *** group A,the mean age was30.92±7.31 and 55.36±4.61 for group *** significant differences were found in SHAT parameters between the two *** well,there was no significant difference in VST per-rotatory time constant,however,post-rotatory time constant was significantly longer for Group B(P value<0.05).Intraclass correlation coefficient(ICC)values showed moderate to good reliability(ICC 0.5800.818)for SHAT parameters for the lower frequencies and indicated moderate reliability for VST time constant(ICC 0.5090.652).Conclusions:Age has no significant effect on the parameters of SHAT and ***-retest reliability is generally good for both tests.

关键词： Rotatory chair testing Sinusoidal harmonic acceleration test Velocity step test Age effect Test-retest reliability

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Walking experience:Exploring the trilateral interrelation of walkability,temporal perception,and urban ambiance

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Frontiers of Architectural Research 2021年第3期10卷 516-539页

作者： doaa K.Hassan Ahmed Elkhateeb Department of Architecture Faculty of EngineeringAin Shams UniversityCairoEgypt

Walking experience through urban spaces is a frequent daily ***,planning and designing for walkability become crucial for building up quality of *** daily walks around the city are affected by fulfilling the needed psychological contentment that is in turn measured unconsciously by our temporal *** contentment is inherent in what we experience in accordance with urban ambiance that goes beyond the spatial attributes of spaces to include their social and sensorial ***,the question here is how walkability of urban routes is affected by urban ambiance and therefore perceived in terms of ***,this study aims to understate the trilateral interrelation of walkability,temporal perception,and urban ambiance in walkable routes for daily routine *** work depends on an experimental study where participants are asked to walk along two selected ***-gathering tools rely on documenting the lived experience of the target group via reporting their trips and answering a *** analysis demonstrates this trilateral interrelation to clarify the *** study concludes specific qualities of walkable routes for routine use that reduce sense of time,which is highly crucial to be realized in such daily walk journeys.

关键词： Walkability Urban ambiance Temporal perception People’s needs in open spaces

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Cellular preconditioning and mesenchymal stem cell ferroptosis

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World Journal of Stem Cells 2024年第2期16卷 64-69页

作者： doaa Hussein Zineldeen Mazhar Mushtaq Khawaja Husnain Haider Basic Sciences Sulaiman AlRajhi UniversityAlbukairiyah 52736AlQaseemSaudi Arabia Department of Medical Biochemistry and Molecular Biology Faculty of MedicineTanta UniversityTanta 6632110Egypt

In this editorial,we comment on the article published in the recent issue of the World Journal of Stem *** focus on stem cell preconditioning to prevent ferroptosis by modulating the cystathionineγ-lyase/hydrogen sulfide(H_(2)S)pathway as a novel approach to treat vascular disorders,particularly pulmonary *** stem cells are gaining popularity in regenerative medicine due to their unique ability to survive by resisting the harsh,unfavorable microenvironment of the injured *** also secrete various paracrine factors against apoptosis,necrosis,and ferroptosis to enhance cell ***,a regulated form of cell death characterized by iron accumulation and oxidative stress,has been implicated in various pathologies encompassing dege-nerative disorders to *** lipid peroxidation cascade initiates and sustains ferroptosis,generating many reactive oxygen species that attack and damage multiple cellular *** these intertwined mechanisms provi-des significant insights into developing therapeutic modalities for ferroptosis-related *** editorial primarily discusses stem cell preconditioning in modulating ferroptosis,focusing on the cystathionase gamma/H_(2)S ferroptosis *** presents a significant challenge in mesenchymal stem cell(MSC)-based therapies;hence,the emerging role of H_(2)S/cystathionase gamma/H_(2) S signaling in abrogating ferroptosis provides a novel option for therapeutic *** research into understanding the precise mechanisms of H_(2)S-mediated cytoprotection against ferroptosis is warranted to enhance the thera-peutic potential of MSCs in clinical settings,particularly vascular disorders.

关键词： Cell survival Cell therapy Hydrogen sulfide Ferroptosis Preconditioning Stem cells Umbilical cord

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Preparation of PVC/PVP composite polymer membranes via phase inversion process for water treatment purposes

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Chinese Journal of Chemical Engineering 2018年第4期26卷 715-722页

作者： Ahmed Bhran Abeer Shoaib doaa Elsadeq Ayman El-gendi Heba Abdallah Chemical Engineering Department College of Engineering Al Imam Mohammad Ibn Saud Islamic University (IMSIU) Department of Petroleum Refining and Petrochemical Engineering Faculty of Petroleum and Mining Engineering Suez University Chemical Engineering and Pilot Plant Department Engineering Research Division National Research Centre Chemical and Materials Engineering Department King Abdulaziz University

In this work, new composite membranes were successfully prepared via phase inversion technique using polyvinyl chloride(PVC) and polyvinylpyrrolidone(PVP) as polymers and tetrahydrofuran(THF) and N-methyl-2-pyrrolidone(NMP) as solvents. The prepared membranes have been characterized by scanning electron microscope(SEM), and fourier transforms infrared spectroscopy(FTIR). The scanning electron microscope results prove that the prepared membranes are smooth and their pores are distributed throughout the whole surface and bulk body of the membrane without any visible cracks. The stress–strain mechanical test showed an excellent mechanical behavior enhanced by the presence of PVP in the prepared membranes. The membranes performance results showed that the salt rejection reached 98% with a high flux. This, in turn, makes the prepared membranes can be applied for sea and brackish water treatment through membrane distillation technology.

关键词： Membrane Polyvinylchloride Polyvinylpyrrolidone Phase inversion

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Computerized Detection of Limbal Stem Cell Deficiency from Digital Cornea Images

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Computer Systems Science & Engineering 2022年第2期40卷 805-821页

作者： Hanan A.Hosni Mahmoud doaa S.Khafga Amal H.Alharbi Department of Computer Sciences College of Computer and Information SciencesPrincess Nourah Bint Abdulrahman UniversityRiyadh11047KSA

Limbal Stem Cell Deficiency(LSCD)is an eye disease that can cause corneal opacity and *** its advanced stage it can lead to a degree of visual *** involves the changing in the semispherical shape of the cornea to a drooping shape to downwards *** is hard to be diagnosed at early *** color and texture of the cornea surface can provide significant information about the cornea affected by *** such as shape and texture are very crucial to differentiate normal from LSCD *** several medical approaches exist,most of them requires complicated procedure and medical ***,in this paper,we pursued the development of a LSCD detection technique(LDT)utilizing image processing *** diagnosis of LSCD is very crucial for physicians to arrange for effective *** the proposed technique,we developed a method for LSCD detection utilizing frontal eye images.A dataset of 280 eye images of frontal and lateral LSCD and normal patients were used in this ***,the cornea region of both frontal and lateral images is segmented,and the geometric features are extracted through the automated active contour model and the spline *** the texture features are extracted using the feature selection *** experimental results exhibited that the combined features of the geometric and texture will exhibit accuracy of 95.95%,sensitivity of 97.91% and specificity of 94.05% with the random forest classifier of n=*** a result,this research developed a Limbal stem cell deficiency detection system utilizing features’fusion using image processing techniques for frontal and lateral digital images of the eyes.

关键词： Feature extraction corneal opacity geometric features computerized detection image processing

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