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AF1q inhibited T cell attachment to breast cancer cell by attenuating Intracellular Adhesion Molecule-1 expression

12th International Congress of Protozoology

作者： Won-Tae kim Hyun-Hee Kong Young-Ran Ha yeon-Chul Hong Hae-Jin Jeong Hak-Sun Yu dong-II Chung Department of Parasitology Kyungpook National University School of Medicine Taegu 700-422 Department of Parasitology Kyungpook National University School of Medicine Taegu 700-422 Department of Parasitology Kyungpook National University School of Medicine Taegu 700-422 Department of Parasitology Kyungpook National University School of Medicine Taegu 700-422 Department of Parasitology Pusan National University School of Medicine Pusan 602-702KOREA Department of Parasitology Pusan National University School of Medicine Pusan 602-702KOREA Department of Parasitology Kyungpook National University School of Medicine Taegu 700-422

＜正＞The pathogenic mechanism of granulomatous amoebic encephalitis （GAE） and amoebic keratitis （AK） by Acanthamoeba has yet to be clarified. Protease has been recognized to play an important role in the pathogenesis of GAE and AK. In the present study, we have compared specific activity and cytopathic effects of purified 33-kDa serine proteinases from Acanthamoeba strains with different degree of virulence (4. healyi OC-3A, A. lugdunensis KA/E2, A. castellanii Neff. Trophozoites of three strains

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Journal of Cancer Metastasis and Treatment 2019年第3期4卷 20-31页

作者： Jino Park Jae yeon Hwang Alexandra Thore Soojin kim Tomiteru Togano Shotaro Hagiwara Juw Won Park William Tse James Graham Brown Cancer Center University of Louisville School of MedicineLouisvilleKY 40202USA Division of Blood and Bone Marrow Transplantation Department of MedicineUniversity of Louisville School of MedicineLouisvilleKY 40202USA Department of Computer Science and Computer Engineering University of LouisvilleLouisvilleKY 40292USA Division of Haematology National Center for Global Health and MedicineTokyo 162-8655Japan Division of Haematology Tokyo Women’s Medical UniversityTokyo 162-8666Japan

Aim: To investigate whether AF1q, overexpressed in metastatic cells compared with the primary tumor cells, plays a pivotal role in breast cancer metastasis. Methods: To investigate whether AF1q has a responsibility in the acquisition of a metastatic phenotype, we performed RNA-sequencing (RNA-Seq) to identify the gene signature and applied the Metacore direct interactions network building algorithm with the top 40 amplicons of RNA-Seq. Results: Most genes were directly linked with intercellular adhesion molecule-1 (ICAM-1). Likewise, we identified that ICAM-1 expression is attenuated in metastatic cells compared to primary tumor cells. Moreover, overexpression of AF1q attenuated ICAM-1 expression, whereas suppression of AF1q elicited the opposite effect. AF1q had an effect on ICAM-1 promoter region and regulated its transcription. Decreased ICAM-1 expression ;affected the attachment of T cells to a breast cancer cell monolayer. We confirmed the finding by performing the analysis on Burkitt's lymphoma. Conclusion: Attenuation of ICAM-1 by AF1q on tumor cells disadvantages host anti-tumor defenses through the trafficking of lymphocytes, which affects tumor progression and metastasis.

关键词： MLLT11 AF1q intercellular adhesion molecule-1 breast cancer metastasis RNA-sequencing

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一等奖：和平墙，首尔，韩国

中国园林 2008年第1期24卷 67-67,68页

作者： kim Suk-Ha HA Min-Ho KANG Han-Duck YUN Ryu-Kyung kim Ah-yeon 张杨首尔大学

韩国有一道坚固的防御工事用以抵御朝鲜的入侵，它的名字叫做“防御坦克的墙”。这座20世纪70年代在韩国首都首尔建起的防御墙成为冷战时期的纪念碑，也勾起韩国民众对朝鲜战争的痛苦回忆。

关键词：韩国墙朝鲜战争冷战时期防御纪念碑

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Current Usage of Terminologies Related to Acupotomy: A Literature Research and Standardization Suggestion

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Chinese Journal of Integrative Medicine 2019年第2期25卷 147-150页

作者： Sang-Hoon Yoon Yoon-Sik kim Hee-Guen Jo Chan-Young Kwon Chung-yeon Medical Institute Department of Clinical Korean Medicine Graduate SchoolKyung Hee University Yanggu Public Health Center

Objective: To investigate the current usage of terminologies related to acupotomy through systematic search and analyze the pros and cons of each for proposing a standard terminology. Methods: Seven medical journal databases were searched including PubMed, EMBASE, Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure, Oriental Medicine Advanced Searching Integrated System, KoreaMed, and Korean studies Information Service System using 10 candidate terminologies as searching terms. All studies published from their inception to July 26, 2017 were collected. Articles were included if the title stated one of the 10 candidate terminologies consistent with the definition of acupotomy. Priorly established frequency and consistency of each candidate terminology from medical databases were calculated and evaluated. Moreover, the pros and cons of each were analyzed to propose a standard terminology. Results: A total of 112 studies in English databases, 1,129 studies in Chinese database, and 44 studies in Korean databases were included. The most frequently used terminologies were needle knife(35.71%), acupotomy(48.54%) and acupotomy(90.90%) in English, Chinese and Korean database, respectively. Overall, acupotomy and needle knife were the most frequently used. Others like acupotomology, needle scalpel, miniscalpel acupuncture and miniscalpel needle were used within 10% of the total searched literature. Acupotome, stiletto needle, sword like needle, and Xiaozhendao were rarely used. Acupotomy had the advantages of high frequency and consistency but lacked representativeness. Needle knife also showed a high frequency, but the consistency was poor. Though miniscalpel acupuncture and miniscule needle were used less frequently, they had advantages of inclusiveness and clarity. Conclusions: A debate for standardization of the terminology is necessary. This preliminary research can provide a basic outline for the standardization consensus process, and

关键词： acupuncture Chinese medicine acupotomy terminology

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经济、社会结构的变化与韩国社会保险的未来——劳动市场两极化,人口变动,以及社会保险的相应变化

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社会保障研究(北京) 2005年第2期 25-40页

作者：金渊明韩国中央大学

韩国社会保险的扩大过程被形容为'超速压缩增长'。20世纪90年代中期以后出现的劳动市场两极化和出生率下降、人口结构老龄化等形成了大量的社会保险的死角地带,同时又加剧了社会保险财政的紧张状况。也就是说,韩国的社会保险正面临全新... 详细信息

韩国社会保险的扩大过程被形容为'超速压缩增长'。20世纪90年代中期以后出现的劳动市场两极化和出生率下降、人口结构老龄化等形成了大量的社会保险的死角地带,同时又加剧了社会保险财政的紧张状况。也就是说,韩国的社会保险正面临全新的挑战,这是在社会保险的扩张过程中从未遇到过的挑战。在大型流水线生产(福特式生产方式)和社会人口结构相对比较年轻的前提下,韩国的国民年金和健康保险制度被引向比较严格的社会保险的轨道,这一方式在消除因劳动市场两极化而出现的社会保障的死角地带时具有明显的局限性,因而有必要对采取了严格的俾斯麦方式的社会保险的基本框架进行重新探讨。为了应对人口老龄化,医疗保险的财政稳定战略采取了引进新的报酬支付体系(综合型支付制度)、扩充公共医疗等措施,如果这些对策能够顺利实施的话,将对医疗保险中长期的财政稳定产生一定的作用。

关键词：社会保险医疗保险国民年金劳动市场两极化

An Interesting Case of Cardiac Amyloidosis Initially Misdiagnosed as Syndrome X

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International Journal of Clinical Medicine 2011年第5期2卷 617-620页

作者： Hyung Rae Sohn Bong Gun Song Eun Jin kim Seong yeon Jeong Su-Min Hong Hyun Gul Jung Hye-Jin Jung Wook-Hyun Cho Suk-Koo Choi 不详

Cardiac infiltration of amyloid fibril results in progressive cardiomyopathy with a grave prognosis and results in cardiac diseases such as congestive heart disease, cardiomyopathy, valvular heart disease, and arrhythmias. We present a rare case of cardiac amyloidosis initially misdiagnosed as syndrome X in which recurrent chest pain and progressive heart failure could be managed finally by heart transplantation.

关键词： Cardiac Amyloidosis Syndrome X Heart Transplantation

经济社会结构的变化与韩国社会福利政策的回应

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社会保障研究(北京) 2007年第2期 11-22页

作者：金渊明韩国中央大学社会福祉学系

韩国正在经历着劳动力市场的分化、贫困阶层的扩大、人口出生率降低和人口结构老龄化等社会经济结构的变迁。这些变化彰显了韩国传统的以收入保障为中心的社会福利政策的局限性,并使得发展新的社会福利范式的必要性不断增强。本文着重... 详细信息

韩国正在经历着劳动力市场的分化、贫困阶层的扩大、人口出生率降低和人口结构老龄化等社会经济结构的变迁。这些变化彰显了韩国传统的以收入保障为中心的社会福利政策的局限性,并使得发展新的社会福利范式的必要性不断增强。本文着重分析并强调,西方社会新兴的社会投资战略可以作为韩国回应后工业化社会经济、社会结构变迁的一种新的社会福利范式。

关键词：社会投资战略韩国社会福利政策劳动力市场分化生育率降低人口老龄化

Gastrointestinal stromal tumor solitary distant recurrence in the left brachialis muscle

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World Journal of Gastroenterology 2015年第20期21卷 6404-6408页

作者： Su-Sin Jin Hyeong-Seok Jeong Hyun-Jin Noh Woo-Hyung Choi Seung-Hwa Choi Kang-yeon Won dong-Pil kim Ji-Chan Park Mi-Kyong Joung Jeong-Goo kim Hae-Joung Sul Seung-Woo Lee Division of Gastroenterology Department of Internal MedicineDaejeon St.Mary’s HospitalThe Catholic University of Korea Department of Internal Medicine Anyang Sam Hospital Department of General Surgery Daejeon St.Mary’s HospitalThe Catholic University of Korea Department of Pathology Daejeon St.Mary’s HospitalThe Catholic University of Korea

Gastrointestinal stromal tumors(GISTs) are mesenchymal tumors of the gastrointestinal tract that are most commonly found in the stomach. Although GISTs can spread to the liver and peritoneum, metastasis to the skeletal muscle is very rare and only four cases have previously been reported. These cases involved concurrent skeletal metastases of primary GISTs or liver metastases. Here, we report the first case of a distant recurrence in the brachialis muscle after complete remission of an extra-luminal gastric GIST following a wedge resection of the stomach, omental excision, and adjuvant imatinib therapy for one year. Ten months after therapy completion, the patient presented with swelling and tenderness in the left arm. Magnetic resonance imaging revealed a large mass in the brachialis muscle, which showed positivity for c-kit and CD34 upon pathologic examination. This is the first reported case of a solitary distant recurrence of a GIST in the muscle after complete remission had been achieved.

关键词： Brachialis muscle Distant recurrence Gastrointestinal stromal tumor Skeletal metastasis Tyrosine kinase inhibitor

城市设计、城市经济学和大型商业区——以首尔东大门和长新东为例

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北京规划建设 2013年第2期 62-82页

作者： Koo-Young HAN Elisabeth S.CHOI Seo-yeon YOON Kyung-Min kim 陈风首尔国立大学研究生院环境科

导言INTRODUCTION时装业在城市竞争力中起到越来越重要的作用。著名的时尚之都,如纽约、巴黎、米兰和伦敦,都是世界大城市,都以服装设计主题而繁荣和闻名。一些政府把服装设计纳入发展政策中,因为这个行业能够创造经济效益。在英国,服... 详细信息

导言INTRODUCTION时装业在城市竞争力中起到越来越重要的作用。著名的时尚之都,如纽约、巴黎、米兰和伦敦,都是世界大城市,都以服装设计主题而繁荣和闻名。一些政府把服装设计纳入发展政策中,因为这个行业能够创造经济效益。在英国,服装设计是作为创意产业而存在的,其定义如下所述：服装业是具有个体的创造性、技能和智慧的产业,它通过传承和知识产权的使用。

关键词：城市经济学城市设计商业区大门首尔服装设计创意产业城市竞争力

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