Prev.ous studies hav. shown two components of glucose absorption in the small intestine: a secondary activ. transport through SGLT1, and unsaturated component, recently attributed mainly to the facilitated diffusion t...
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Prev.ous studies hav. shown two components of glucose absorption in the small intestine: a secondary activ. transport through SGLT1, and unsaturated component, recently attributed mainly to the facilitated diffusion through GLUT2, but the relationship between these two components under physiological conditions remains controv.rsial. In chronic experiments on nonanesthetized rats we inv.stigated for the first time the kinetics of maltose hydrolysis and glucose absorption in the isolated loop of the small intestine in a wide range of maltose and glucose concentrations (25 ÷ 200 mmol/l glucose). The processes were simulated on mathematical models which took into account the current v.ews about mechanisms of hydrolysis and transport of nutrients and geometric characteristics of the intestinal surface. The results of chronic experiments and mathematical simulation hav. shown that under the close to physiological conditions the glucose transport mediated by SGLT1 is the main mechanism of its absorption in comparison with the unsaturated component. This was demonstrated not only at low, but also at high substrate concentrations. We conclude that correct ev.luation of the relativ. contribution of different mechanisms in glucose transport through the intestinal epithelium requires taking into account the geometric specificities of its surface.
The aim of the inv.stigations was to ev.luate benefits of the directed transport system - a nanocomposite, based on cisplatin and magnetite combined with local action of constant magnetic field on the tumor, in experi...
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The aim of the inv.stigations was to ev.luate benefits of the directed transport system - a nanocomposite, based on cisplatin and magnetite combined with local action of constant magnetic field on the tumor, in experiments in v.v. in animals with transplantable Guerin carcinoma. Animals were div.ded into 5 groups according to the type of agent. We showed that nanocomposite in combination with static magnetic field exercises more prominent anti-tumor activ.ty than cisplatin alone. It should be noted that regardless of the therapeutic agent, in Guerin carcinoma we observ.d
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