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Biocompatibility and internalization of molecularly imprinted nanoparticles

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Nano Research 2016年第11期9卷 3463-3477页

作者： Francesco Canfarotta Alicia Waters Robyn Sadler Paul McGill Antonio Guerreiro dmitri Papkovsky Karsten Haupt Sergey Piletsky MIP Diagnostics Ltd. University of Leicester Fielding Johnson Building University Road Leicester LE 1 7RH UK School of Biochemistry and Cell Biology University College Cork College Road Cork Ireland GSK David Jack Centre for R&D Park Road Ware Hertfordshire SG 12 0DP UK Chemistry Department University of Leicester Leicester LE1 7RH UK Compiegne University of Technology CNRS Enzyme and Cell Engineering Laboratory Rue Roger Couttolenc CS 50319 50203 Compiegne Cedex France

Molecularly imprinted polymers （MIP） are receiving increasing attention thanks to their robustness, stability, and inexpensive manufacture compared with their bio-analogues such as antibodies. The molecular imprinting process can be defined as the generation of molecular recognition sites in a synthetic polymer. The template-derived sites created within a polymeric matrix allow MIPs （often referred as plastic antibodies） to selectively recognize and bind to the target molecule. Therefore, MIPs can be used in sensors and in separation and diagnostics. Owing to their size and functional properties, MIP nanoparticles （NPs） can potentially be used in biomedicine, but comprehensive analysis of their interaction with cells and in vitro toxicological tests must be performed first. Herein, we report the synthesis of bare and core-shell imprinted NPs using an innovative solid-phase approach and the toxicological evaluation of such NPs in different cell lines （HaCaT, MEFs, HT1080, and macrophages）. We also evaluated the influence of the protein corona on particle stability, the internalization of NPs in cells, and the influence of various surface coatings. Studies on the metabolic effects of imprinted NPs on fibroblasts showed that bare MIPs do not alter cell metabolism, whereas some issues arise when specific particle coatings are used. Furthermore, in vitro cytokine release studies revealed that macrophages were not activated in the presence of the MIPs evaluated in this study. The results suggest that MIP NPs are biocompatible, paving the way for their in vivo application.

关键词： pegylation core-shell toxicology inflammatory response particle uptake metabolism

Nanotubes in a Gradient Electric Field as Revealed by STM TEM Technique

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Nano Research 2008年第2期1卷 166-175页

作者： dmitri Golberg Pedro M.F.J.Costa Masanori Mitome Yoshio Bando Nanoscale Materials Center Namiki 1-1TsukubaIbaraki 305-0044Japan International Center for Materials Nanoarchitectonics(MANA) National Institute for Materials ScienceNamiki 1-1TsukubaIbaraki 305-0044Japan Center for Research in Ceramics and Composite Materials University of Aveiro3810-193 AveiroPortugal

We have investigated the behavior of two nanotube systems,carbon and boron nitride,under controlled applied voltages in a high-resolution transmission electron microscope(TEM)equipped with a scanning tunneling microscope(STM)*** nanotubes(or thin bundles)were positioned between a piezo-movable gold electrode and a biased(up to±140 V)STM tip inside the pole-piece of the *** structures studied include double-and multi-walled carbon nanotubes(the latter having diverse morphologies due to the various synthetic procedures utilized),few-layered boron nitride nanotube bundles and multi-walled boron nitride nanotubes(with or without functionalized surfaces).The electrical breakdown,physical failure,and electrostatic interactions are documented for each system.

关键词： Carbon nanotubes boron nitride nanotubes transmission electron microscope scanning tunneling microscope

Understanding important features of deep learning models for segmentation of high-resolution transmission electron microscopy images

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npj Computational Materials 2020年第1期6卷 765-773页

作者： James P.Horwath dmitri N.Zakharov Rémi Mégret Eric A.Stach Department of Materials Science and Engineering University of PennsylvaniaPhiladelphiaPAUSA Center for Functional Nanomaterials Brookhaven National LaboratoryUptonNYUSA Department of Computer Science University of Puerto RicoRío PiedrasSan JuanPRUSA

Cutting edge deep learning techniques allow for image segmentation with great speed and ***,application to problems in materials science is often difficult since these complex models may have difficultly learning meaningful image features that would enable extension to new *** situ electron microscopy provides a clear platform for utilizing automated image *** this work,we consider the case of studying coarsening dynamics in supported nanoparticles,which is important for understanding,for example,the degradation of industrial *** systematically studying dataset preparation,neural network architecture,and accuracy evaluation,we describe important considerations in applying deep learning to physical applications,where generalizable and convincing models are *** a focus on unique challenges that arise in high-resolution images,we propose methods for optimizing performance of image segmentation using convolutional neural networks,critically examining the application of complex deep learning models in favor of motivating intentional process design.

关键词： neural networks image

Revealing the dynamics of the alloying and segregation of Pt-Co nanoparticles via in-situ environmental transmission electron microscopy

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Nano Research 2023年第2期16卷 3055-3062页

作者： Xing Li Shaobo Cheng Yanghua He Lixiang Qian dmitri Zakharov Gang Wu Chongxin Shan Liang Zhang Dong Su Henan Key Laboratory of Diamond Optoelectronic Materials and Devices Key Laboratory of Material PhysicsSchool of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450052China Center for Functional Nanomaterials Brookhaven National LaboratoryUptonNY 11973USA Department of Chemical and Biological Engineering University at BuffaloThe State University of New YorkBuffaloNY 14260USA Center for Combustion Energy School of Vehicle and MobilityTsinghua UniversityBeijing 100084China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China

Thermal treatment is a general and efficient way to synthesize intermetallic catalysts and may involve complicated physical *** far,the mechanisms leading to the size and composition heterogeneity,as well as the phase segregation behavior in Pt-Co nanoparticles(NPs)are still not well *** in-situ environmental transmission electron microscopy,the formation dynamics and segregation behaviors of Pt-Co alloyed NPs during the thermal treatment were *** is found that Pt-Co NPs on zeolitic imidazolate frameworks-67-derived nanocarbon(NC)are formed consecutively through both particle migration coalescence and the Ostwald ripening *** existence of Pt NPs is found to affect the movement of Co NPs during their *** the help of theoretical calculations,the correlations between the composition and migration of the Pt and Co during the ripening process were *** complex alloying processes are revealed as key factors leading to the heterogeneity of the synthesized Pt-Co alloyed *** oxidation environment,the Pt-Co NPs become surface faceted gradually,which can be attributed to the oxygen facilitated relatively higher segregation rate of Co from the(111)*** work advances the fundamental understanding of design,synthesis,and durability of the Pt-based nanocatalysts.

关键词： intermetallic catalyst alloying ripening segregation dynamics environmental transmission electron microscopy(ETEM)

Dual Additives for Stabilizing Li Deposition and SEI Formation in Anode-Free Li-Metal Batteries

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Energy & Environmental Materials 2024年第3期7卷 84-92页

作者： Baolin Wu Chunguang Chen dmitri L.Danilov Zhiqiang Chen Ming Jiang Rüdiger-A.Eichel Peter H.L.Notten Forschungszentrum Jülich(IEK-9) D-52425Jülich Germany RWTH Aachen University D-52074Aachen Germany LNM Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Engineering Sciences University of Chinese Academy of SciencesBeijing 100049China Eindhoven University of Technology P.O.Box 5135600 MBEindhoven The Netherlands School of Electronics and Information Institute of Carbon Neutrality and New EnergyHangzhou Dianzi UniversityHangzhou 310018China University of Technology Sydney BroadwaySydney NSW 2007Australia

Anode-free Li-metal batteries are of significant interest to energy storage industries due to their intrinsically high ***,the accumulative Li dendrites and dead Li continuously consume active Li during *** results in a short lifetime and low Coulombic efficiency of anode-free Li-metal *** effective electrolyte additives can improve the Li deposition homogeneity and solid electrolyte interphase(SEI)stability for anode-free Li-metal ***,we reveal that introducing dual additives,composed of LiAsF6 and fluoroethylene carbonate,into a low-cost commercial carbonate electrolyte will boost the cycle life and average Coulombic efficiency of NMC‖Cu anode-free Li-metal *** NMC‖Cu anode-free Li-metal batteries with the dual additives exhibit a capacity retention of about 75%after 50 cycles,much higher than those with bare electrolytes(35%).The average Coulombic efficiency of the NMC‖Cu anode-free Li-metal batteries with additives can maintain 98.3%over 100 *** contrast,the average Coulombic efficiency without additives rapidly decline to 97%after only 50 *** situ Raman measurements reveal that the prepared dual additives facilitate denser and smoother Li morphology during Li *** dual additives significantly suppress the Li dendrite growth,enabling stable SEI formation on anode and cathode *** results provide a broad view of developing low-cost and high-effective functional electrolytes for high-energy and long-life anode-free Li-metal batteries.

关键词： anode-free lithium metal battery dual additives in situ Raman Li growth SEI formation

The Specification of Agent Interaction in Multi-Agent Systems

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Intelligent Information Management 2009年第2期1卷 65-72页

作者： dmitri CHEREMISINOV 不详

The problem of the description of interaction between agents in a multi-agent system (MAS) in the form of dialogues of negotiations is considered. For formalization of the description of interaction at a level of steps of the dialogue which is carried out in common by two spatially divided agents, the concept of synchronization of processes is analyzed. The approach to formalization of the description of conditions of synchronization when both the independent behaviour, and the communications of agents can be presented at a level of logic is offered. It is shown, that the collective behavior of agents can be described by the synthetic temporal logic that unite linear and branching time temporal logics.

关键词： interaction protocol temporal logic parallel algorithm

Monolithic Convex Limiting for Legendre-Gauss-Lobatto Discontinuous Galerkin Spectral-Element Methods

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Communications on Applied Mathematics and Computation 2024年第3期6卷 1860-1898页

作者： Andrés M.Rueda-Ramírez Benjamin Bolm dmitri Kuzmin Gregor J.Gassner Department of Mathematics and Computer Science University of CologneWeyertal 86-90Cologne 50931Germany Institute of Applied Mathematics(LS Ⅲ) TU Dortmund UniversityVogelpothsweg 87Dortmund 44227Germany Center for Data and Simulation Science University of CologneWeyertal 86-90Cologne 50931Germany

We extend the monolithic convex limiting(MCL)methodology to nodal discontinuous Galerkin spectral-element methods(DGSEMS).The use of Legendre-Gauss-Lobatto(LGL)quadrature endows collocated DGSEM space discretizations of nonlinear hyperbolic problems with properties that greatly simplify the design of invariant domain-preserving high-resolution *** to many other continuous and discontinuous Galerkin method variants,a particular advantage of the LGL spectral operator is the availability of a natural decomposition into a compatible subcellﬂux *** a highorder spatial semi-discretization in terms of intermediate states,we performﬂux limiting in a manner that keeps these states and the results of Runge-Kutta stages in convex invariant *** addition,local bounds may be imposed on scalar quantities of *** contrast to limiting approaches based on predictor-corrector algorithms,our MCL procedure for LGL-DGSEM yields nonlinearﬂux approximations that are independent of the time-step size and can be further modiﬁed to enforce entropy *** demonstrate the robustness of MCL/DGSEM schemes for the compressible Euler equations,we run simulations for challenging setups featuring strong shocks,steep density gradients,and vortex dominatedﬂows.

关键词： Structure-preserving schemes Subcellﬂux limiting Monolithic convex limiting(MCL) Discontinuous Galerkin spectral-element methods(DGSEMS) Legendre-Gauss-Lobatto(LGL)nodes

P53功能性失活在MLL白血病发生中的可能机制(英文)

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中南大学学报（医学版） 2006年第5期31卷 617-620页

作者： dmitri Wiederschain 袁志民哈佛大学公共卫生学院肿瘤细胞生物学实验室

在多种类型的急性白血病中,常发生MLL蛋白节段与其他多种非相关蛋白融合的现象。目前认为,这种融合引起MLL的激活直接促成了正常骨髓细胞向白血病癌细胞的转变。然而,此过程发生的机制目前尚不清楚。最近我们发现白血病MLL的融合可以消... 详细信息

在多种类型的急性白血病中,常发生MLL蛋白节段与其他多种非相关蛋白融合的现象。目前认为,这种融合引起MLL的激活直接促成了正常骨髓细胞向白血病癌细胞的转变。然而,此过程发生的机制目前尚不清楚。最近我们发现白血病MLL的融合可以消除肿瘤抑制蛋白P53的抑癌作用,后者则是通过引导受损细胞自毁来发挥抗癌作用的,与大多数癌症中p53基因的高突变率相比,在白血病中仅有少量p53基因的突变,提示白血病中MLL融合蛋白通过对P53功能的抑制,至少部分加速了疾病的进展。这一点如果被证实,则可能为白血病细胞中P53通路的重新激活提供一条新的途径,从而为那些检测出有MLL融合的白血病人处理提供一种合理的治疗方法。

关键词： P53 MLL 白血病

In-depth profiling of tumor tissue derived from malignant pleural mesothelioma patients identifies potential biomarkers predicting response to immune-checkpoint inhibitor therapy

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Genes & Diseases 2024年第6期11卷 28-31页

作者： dmitri Shek Bo Gao Hema Mahajan Adnan Nagrial Matteo S.Carlino Fabio Luciani Scott A.Read Golo Ahlenstiel Blacktown Clinical School Western Sydney UniversitySydneyNSW 2148Australia Westmead Institute for Medical Research SydneyNsw 2145Australia Blacktown Mt Druitt Hospital SydneyNSW 2148Australia Westmead Hospital SydneyNsw 2145Australia Westmead Clinical School University of SydneySydneyNSW 2145Australia Institute of Clinical Pathology and Medical Research SydneyNSW 2145Australia Melanoma Institute Australia SydneyNSW 2065Australia School of Medical Sciences University of New South WalesSydneyNSW 2052Australia Garvan Institute for Medical Research SydneyNSW 2010Australia

Malignant pleural mesothelioma(MPM)is a rare and aggressive cancer with low survival probability as it is generally diagnosed at later stages.'Using a combination of immune-checkpoint inhibitors(ICls)ipilimumab(IPl)and nivolumab(NivO)as a first-line treatment for unresectable MPM,the CheckMate 743 trial reported higher overall survival and prolonged duration of response compared with traditional chemotherapy.

关键词： pleural chemotherapy immune