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Epidemiological and Clinical Profile of Patients Undergoing Primary nephrological Consultation at the Fousseyni DAOU Hospital in Kayes, Mali

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Open Journal of nephrology 2022年第1期12卷 142-153页

作者： Magara Samaké Seydou Sy Aboubacar Sidiki Fofana Hamadoun Yattara Sah Dit baba Coulibaly djénéba diallo nanko Doumbia Moctar Coulibaly Kodio Atabieme djénéba Maiga Aboudou Messoum Dolo nouhoum Coulibaly Saharé Fongoro nephrology Unit Fousseyni DAOU Hospital Kayes Mali national Center for Scientific and Technological Research (CnRST) Bamako Mali nephrology and Hemodialysis Department Point G Teaching Hospital Bamako Mali Faculty of Medicine of bamako University of Bamako Bamako Mali nephrology Unit Somine DOLO Hospital Mopti Mali Department of Medicine Mali Hospital Bamako Mali nephrology Unit Mali GAVARDO Hospital Sebenicoro Bamako Mali nephrology Unit Sikasso Hospital Sikasso Mali

Introduction: The first nephrological consultation is often late, even in developed countries. This delay is related to the insidious nature of renal disease, the lack of qualified personnel and structures for the management of these conditions and the context of chronic insecurity in our country. In Kayes, there is no data related to the first consultations of patients with the nephrologist, hence the interest of this study, which aimed to describe the epidemiological and clinical characteristics of patients undergoing a first nephrological consultation in Kayes hospital. Materials and methods: This was a retrospective, descriptive study conducted from January 1 to December 31, 2020 at the nephrology unit of the Fousseyni DAOU hospital in Kayes. All patients received for nephrological consultation for whom a medical record was made were included. The following data were collected and analyzed: the specialty of the medical referent, the reason for consultation, sociodemographic characteristics and the renal assessment of patients. Patients who consulted for non-nephrological pathologies and those who had no medical record were not included. Results: We collected the records of 346 patients, composed of 180 (52%) women and 166 (48%) men, i.e. a sex ratio of 0.92. The age group [20 - 40 years] was the most represented, 107 cases or 30.9%, with a mean age of 48.84 ± 21.33 years and extremes of 1 and 90 years. Housewives were the most consulted population, 149 cases (41.33%). Patients consulted more between the months of January and February, 116 cases (33.5%), this period was followed by the months of October-December, July-September and April-June with respectively 94 cases (27.2%), 76 cases (22.0%) and 60 cases (17.3%). The patients were referred by the general practitioner in 59.5% (209 cases), specialist doctor, 26.0% (90 cases). The patients came mainly from hospital practitioners, 172 cases (49.7%), private clinic and practice 81 cases (23.4%), community health c

关键词： Primary Consultation nephrology Kayes Mali

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Acute Renal Failure Secondary to Paracetamol Intoxication: A Case Report

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Open Journal of nephrology 2022年第3期12卷 235-240页

作者： Moctar Coulibaly Magara Samaké Konaré Samba Fofana Aboubacar Sidiki Ossil Ampion Marc batcho Jimmy Mansour Janette Seydou Sy Hamadoun Yattara Atabième Kodio djénéba Maiga Sah Dit baba Coulibaly djénèba diallo Aboudou M. Dolo Moustapha Tangara nouhoum Coulibaly Kalilou Coulibaly Ibrahima Koné Saharé Fongoro nephrology Unit of Mali GAVARDO Hospital in Sebénicoro Bamako Mali nephrology Unit of the Fousseyni DAOU Hospital Kayes Mali national Center for Scientific and Technological Research (CnRST) Bamako Mali nephrology Department of the Soissons Hospital Soissons France nephrology and Hemodialysis Department of the UHC du Point G Bamako Mali Faculty of Medicine of bamako Bamako Mali nephrology Unit of Sikasso Hospital Sikasso Mali nephrology Unit of Somino DOLO Hospital Mopti Mali

Renal damage secondary to paracetamol intoxication is rare, estimated between 1% and 2% of intoxication cases. Its pathophysiology is still debated, the clinical involvement consisting in an acute tubular necrosis with a good prognosis if it is rapidly treated. Renal damage can sometimes occur without prior hepatic damage, and the onset of renal manifestations is generally between the 2nd and 7th day after taking paracetamol. If its management remains exclusively symptomatic, its late onset can sometimes lead to serious metabolic complications. It is therefore important to systematically monitor renal function following paracetamol drug intoxication. We report the case of a 60-year-old male subject hospitalized for the management of voluntary drug intoxication (VDI) with paracetamol complicated by acute hepatocellular failure and acute renal failure. His management required extrarenal purification (hemodialysis) and the evolution was favorable with recovery ad integrumof renal function. Conclusion: Although less known and of unelucidated physiopathology, nephrotoxicity secondary to voluntary drug intoxication with paracetamol is a reality and can lead in extreme cases to the use of extrarenal purification technique (hemodialysis).

关键词： Acute Renal Failure Paracetamol Intoxication Hemodialysis

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Renal Failure of Lithiasis Origin: Frequency and Management in the nephrology and Haemodialysis Department of the Point G University Hospital in Mali

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Open Journal of nephrology 2022年第3期12卷 276-292页

作者： Seydou Sy Magara Samaké Aboubacar Sidiki Fofana Atabieme Kodio Oligue Prudence Oman djibril Sy Hamadoun Yattara djénèba diallo Sah Dit baba Coulibaly nouhoum Coulibaly Modi Sidibé Alkaya Touré Moustapha Tangara Mamadou Lamine Diakité Assétou Soukho Kaya Saharé Fongoro nephrology and Hemodialysis Department University Teaching Hospital of Point-G Bamako Mali Faculty of Medicine and Odontostomatology University of Sciences Techniques and Technologies of Bamako Bamako Mali nephrology Unit Fousseyni Daou Hospital in Kayes Kayes Mali national Center for Scientific and Technological Research (CnRST) Bamako Mali Department of Internal Medicine University Teaching Hospital of Point-G Bamako Mali Department of Urology University Teaching Hospital of Point-G Bamako Mali

background: The term urinary lithiasis (UL) from the Greek “lithos” refers to the disease characterised by the result of abnormal precipitation of normal constituents of the urine within the urinary tract. The aim of this work was to determine the frequency of obstructive renal failure (ORF) of lithiasis origin and to describe the therapeutic indications. Methods: This was a retrospective prospective study in patients hospitalised in the nephrology department of Point G University Hospital for ORF of lithiasis origin over a 26-month period from 1 January 2018 to 1 February 2020 inclusive. Results: Among 1898 hospitalized patients, 32 met the inclusion criteria, i.e. a frequency of 1.7%. The male sex was 68.75% with a sex ratio of 2.2. The mean age was 48.38 ± 13.423 years with extremes of 20 and 65 years. Dysuria and urinary bilharzia were the main uro-nephrological antecedents, accounting for 25% of the cases each. Pain syndrome was the main functional sign, accounting for 100%. Ultrasound of the urinary tract (n = 28) showed stones in 92.85%. These stones were bilateral in 22.22% of cases. The dilatation was pyelocalic in 14 cases (51.8%). The uroscanner showed a pyelic location of the stones in both kidneys;42.1% on the right and 33.3% on the left. Hydronephrosis was the most common dilatation: 37.8% on the right and 29.7% on the left. Renal lithiasis was complicated by acute kidney injury (ARI) in 17 cases (53.1%) versus 15 cases (46.9%) of chronic kidney disease (CKD). Urethral catheter was the means of drainage in 24 (75%) followed by nephrostomy in 8 cases (25%). nephrolithotomy accounted for 9.4% of cases. The case fatality rate was 28.12% (9 cases). Deaths occurred in the context of uraemic coma 6 cases and cardiorespiratory arrest 3 cases. Conclusions: The management of urinary lithiasis complicated by renal failure calls for the correction of hydrolytic disorders, drainage of the excretory tract and treatment of the stone, of which percutaneous nephrolith

关键词： Renal Failure Urinary Lithiasis nephrology University Teaching Hospital of Point-G

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Oesophageal Mycosis: Epidemiological and Clinical Aspects and Risk Factors for Occurrence in the Digestive Endoscopy Unit of the Donka national Hospital, Conakry CHU

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Open Journal of Gastroenterology 2024年第2期14卷 31-40页

作者： diallo Mamadou Sarifou Youssouf Oumarou Yaogo Abdoulatif diallo Kadiatou diallo djéinabou Wann Thierno Amadou bah Mamadou Lamine Yaya Diakhaby Mamadou Kanté Mamadou Aliou Sylla djibril Hepato-Gastroenterology Department of the Donka national Hospital Conakry Guinea Faculty of Health Sciences and Techniques Gamal Abdel Nasser University Conakry Guinea Centre Hospitalier Universitaire Communautaire de bangui Internal Medicine Department Bangui République Centrafricaine Hepato-Gastroenterology Department Angré University Hospital Abidjan Ivory Coast Department of Internal Medicine Donka National Hospital Conakry Guinea

Introduction: Oesophageal mycosis (OM) is one of the most common opportunistic infections in patients infected with HIV (Human Immunodeficiency Virus). However, this condition is increasingly observed in immunocompetent subjects. The aim of this study was to determine the endoscopic prevalence, clinical characteristics and risk factors for the occurrence of oesophageal mycosis in our department. Patients and Method: This was a prospective cross-sectional study of all patients who underwent oeso-gastroduodenal fibroscopy during the period from 1st January to 31st December 2022, i.e. one year, at the digestive endoscopy unit of the hepato-gastroenterology department of the Donka CHU national hospital in Conakry. All patients found to have oesophageal mycosis by FOGD were included. The endoscopy was performed using appropriate equipment: A Fujinon 4400 video endoscopy column;Three Fujinon EG 590 video gastroscopes;A hoover;Data were collected using a pre-established survey form and analysed using Epi info software version 6.0.4;Pearson’s Chi2 test as a test of independence and the exact 5% threshold ficher test. Results: Out of 1343 upper gastrointestinal endoscopies performed, 107 cases of oesophageal mycosis were found, representing a prevalence of 7.96%. The mean age was 40 years, with a male predominance of 55.42%. The sex ratio M/F was 1.24. The 45 and over age group was the most affected, with a prevalence of 40.43%, followed by the [35 - 45] age group, with a prevalence of 22.43%. Clinical symptoms were dominated by epigastralgia in 74.76% of cases, followed by odynophagia in 37.38% of cases, nausea and vomiting in 28.03% of cases, and pyrosis in 26.16% of cases. Oesophageal mycosis without oesophagitis was the most common endoscopic finding in 70% of cases. The main associated endoscopic lesions were erythemato-erosive and congestive gastropathy in 28.03% of cases, peptic oesophagitis (9.34%) and gastric ulcer (5.60%). The main risk factor

关键词： Endoscopy CHU Conakry Risk Factors Immunosuppression Oesophageal Mycosis

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bacteriological Profile of Pneumopathies in Chronic Renal Failure at the University Hospital Center of Point-G in Mali

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Open Journal of Clinical Diagnostics 2020年第1期10卷 18-28页

作者： Seydou Sy Magara Samaké Hamadoun Yattara Moctar Coulibaly ba Oumou diallo Aboubacar Sidiki Fofana djénéba diallo Atabieme Kodio Modi Sidibé nouhoum Coulibaly Alkaya Touré djibril Sy Moustapha Tangara Saharé Fongoro nephrology and Haemodialysis Department of the University Hospital Center (CHU) of Point G Bamako Mali Faculty of Medicine of bamako University of Bamako Bamako Mali nephrology Unit of the Fousseyni DAOU Hospital of Kayes Kayes Mali nephrology Unit of Mali GAVARDO Hospital Bamako Mali Internal Medicine Service of the University Hospital Center of Point G (CHU du Point-G) Bamako Mali

Introduction: Chronic renal failure (CKD) is defined as a glomerular filtration rate (GFR) of less than 60 ml/min/1.73m2 for more than 3 months [1]. Infectious complications are a major source of morbidity in patients with chronic renal failure. In Mali, we have no data on pneumopathies in this population, hence the interest of this study. The objective of this work was to determine the frequency of pneumopathies in patients with chronic renal failure, describe the clinical radio-types, identify the microorganisms involved, and assess the renal prognosis of pneumopathies. Materials and Methods: This was an 18-month prospective and descriptive study from January 1, 2018 to June 30, 2019 conducted in the nephrology and hemodialysis department of the University Hospital of Point G. Included were patients hospitalized during our study period with CKD associated with pneumopathy on a chest X-ray. not included were all patients hospitalized outside the study period, all CKD cases without pneumonia, patients with incomplete records, and non-consenting patients. Results: We examined 1111 patients, 35 of whom presented an image on chest X-ray related to pneumopathy, a frequency of 3.15% of cases. Twenty-one men (60%) and 14 women (40%) with a sex ratio of 1.5. The mean age was 46.8 ± 13.9 years with extremes of 23 and 76 years. The types of pneumopathy on the chest X-ray were: alveolar pneumopathy: 23 cases (65.7%), pleuropneumopathy: 10 cases (28.6%) and cavitary pneumopathy: 2 cases (5.7%). Cytobacteriological sputum examination was positive in 65.7%;leukocytes (68.6% of cases). The germs found were: Klebsiella pneumoniae (25.7% of cases), Escherica coli (11.4%), Pseudomonas aeruginosa (5.7%), Staphylococcus aureus (5.7%), Citrobacter freundi (5.7%), Enterococus sp. (2.9%), Enterobacter cloacae (2.9%), Candida albicans (5.7%). The search for acid-alcohol-resistant bacilli (baAR) in sputum was positive in 4 cases (11.4%). There was an association between the results of cyto

关键词： Renal Failure Dialysis Pneumopathy Mali

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Digestive Pathologies during Chronic Renal Failure in the nephrology and Haemodialysis Department at the University Hospital Center of Point G in Mali

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Open Journal of Clinical Diagnostics 2020年第1期10卷 41-48页

作者： Magara Samaké Seydou Sy Hamadoun Yattara Moctar Coulibaly Mamadou badou Sanogo Aboubacar Sidiki Fofana Aboudou Messoum Dolo djénéba Maiga djénéba diallo Atabieme Kodio bakary Diarra Karamoko djiguiba djibril Sy Saharé Fongoro nephrology Unit of the Fousseyni DAOU Hospital Kayes Mali nephrology and Haemodialysis Department of the CHU of Point G Bamako Mali Faculty of Medicine of bamako University of Bamako Bamako Mali nephrology Unit of Mali GAVARDO Hospital Bamako Mali nephrology Unit of the Sikasso Regional Hospital Sikasso Mali nephrology Unit of the Mother and Child Hospital The Luxembourg Bamako Mali Internal Medicine Service of the University Hospital Center of Point G Bamako Mali

Introduction: Chronic kidney disease (CKD) is the progressive and irreversible loss of kidney function. It exposes to many complications, among which, digestive complications. In Mali, we do not have data on the prevalence of digestive pathologies in people with chronic renal failure, hence the interest of this study. Objective: To determine the prevalence of digestive pathologies and to describe their manifestations during chronic renal failure. Patients and Methods: This was a prospective cross-sectional study conducted from September 2016 to August 2017, a period of 12 months. Included were patients hospitalized in our department with CKD who received digestive endoscopy and/or liver serology. Results: Seventy-one patients underwent digestive endoscopy with oesogastroduodenal fibroscopy (60 patients), rectoscopy (6 patients) and anoscopy (5 patients), i.e. 15.9% of those hospitalized. The mean age of the patients was 48 ± 14 years with extremes of 15 and 84 years. The sample consisted of 59.2% men versus 40.8% women, for a sex ratio of 1.5. The functional signs are in order of frequency: vomiting (72.4%), anorexia (51.3%) and epigastralgia (48.7%). Terminal CKD by creatinine clearance accounted for 88.2% of cases, of which 47.4% were monitored by hemodialysis. Hepatitis C virus infection was present in 21.3% of cases, hepatitis B (18%) and HIV (7.5%). Endoscopic examinations were represented by fibroscopy (84.5%), rectoscopy (8.5%) and anuscopy (7%). The fibroscopic lesions were respectively gastric (96.8%), duodenal (14.1%) and esophageal (12.5%). They were dominated by gastritis (40.5%), duodeno-gastric reflux (16.4%), pyloric gap (12.6%). Rectoscopy found 4 cases of hemorrhoids, 2 cases of rectitis and no lesions were observed at anuscopy. Conclusion: The prevalence of these digestive manifestations and the endoscopic lesions encountered indicate the importance of digestive endoscopy and the performance of hepatic serologies in chronic renal failure patients w

关键词： Chronic Renal Failure Digestive Signs Mali

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Interest of Beta-2-Microglobilin Plasma Assay in Iterative Haemodialysis in the nephrology and Haemodialysis Department of University Teaching Hospital of Point G, bamako, Mali

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Open Journal of nephrology 2020年第4期10卷 282-289页

作者： Saharé Fongoro Magara Samaké Seydou Sy Hamadoun Yattara djénèba diallo Jacques Coulibaly Moctar Coulibaly Aboubacar Sidiki Fofana Atabième Kodio djénéba Maiga Aboudou M. Dolo Moustapha Tangara nouhoum Coulibaly Brahima Dégoga Ibrahima Koné nephrology and Haemodialysis Department of the University Teaching Hospital of Point-G Bamako Mali Faculty of Medicine of bamako Bamako Mali nephrology Unit of the Fousseyni DAOU Hospital in Kayes Kayes Mali nephrology Unit of Ségou Hospital Ségou Mali nephrology Unit of the Mali GAVARDO Hospital of Sébénicoro Bamako Mali nephrology Unit of Sikasso Hospital Sikasso Mali nephrology Unit of Somino DOLO Hospital in Mopti Mopti Mali

Beta-2-microglobulin (B2M) is a low molecular weight polypeptide (11,800 Da) that exists in a free form and a form bound to cell membranes (light chains of HLA class I molecules). Their dosage is used in the exploration and monitoring of renal function in haemodialysis patients, hence the interest of this study, the objective of which is to study the different players involved in the increase of beta-2-microglobulin. ng>Materials and Methods:ng> This was a prospective and descriptive study from January 1st, 2017 to August 31, 2017 (08 months). All patients with chronic hemodialysis for 3 years or more were included. We analyzed sociodemographic, clinical and paraclinical data. ng>Results:ng> We collected 50 patients. The mean age was 50 ± 4.6 years with extremes of 30 and 82 years. The female sex predominated (52%). Chronic end-stage renal failure was hypertensive (86%), diabetic (4%). All patients benefited from intermittent hemodialysis for 8 hours per week using a low permeability membrane (cuprophane). The average duration of hemodialysis was 68 ± 6.4 months with extremes of 36 and 204 months. Twenty percent (20%) and four percent (4%) of chronic dialysis patients had joint pain and sensory deficit. Phalen’s sign was positive in 2% (1 case), Tinel’s sign in 2% (1 case) and carpal tunnel syndrome in 2% (1 case). The mean serum beta-2-microglobulin level was 58.34 ng/l with extremes of 16.99 and 112.24 ng/l. There was a correlation between hypertensive nephropathies and beta-2-microglobulin levels above 50 ng/l (P ng>Conclusion:ng> Our study has objectified factors such as inadequate dialysis (8 hours/week), use of low permeability membrane in the increase of beta-2-microglobulin. The increase in serum beta-2-microglobulin levels in our patients is evidence of poor purification of medium molecules. Its reduction can be established by improving the quality of dialysis, in particular by

关键词： Chronic Hemodialysis Beta-2-Microglobulin Carpal Tunnel Syndrome

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Diabetes Screening and Cardiovascular Risk in Tuberculosis Patients in Conakry and Surrounding Towns

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Open Journal of Endocrine and Metabolic Diseases 2024年第1期14卷 7-13页

作者： Mamadou Chérif diallo Mamadou Dian Mamoudou diallo Mody Abdoulaye barry Kadija Dieng Alpha Mamadou diallo Mamadou Mansour diallo Oumou diallo Amadou Kaké Gamal Abdel nasser University of Conakry Conakry Guinea Endocrinology-Diabetology Department of Donka University Hospital Conakry Guinea Foundation for The Fight against Diabetes and non-Communicable Diseases Conakry Guinea

Objective: To determine the prevalence of diabetes and the level of cardiovascular risk in tuberculosis patients treated in Conakry and surrounding towns. Method: This was a cross-sectional study carried out at tuberculosis treatment centers in Conakry and surrounding towns (Coyah and Dubréka) on World TB Day, november 14, 2022, among 350 tuberculosis patients. We determined the proportion of TB patients with diabetes and high hyperglycemia. We determined the Chi-square to identify the factors associated with the occurrence of diabetes in tuberculosis patients, and a significance threshold with p Results: The average age of participants was 33.5 ± 14.5 years, and they were predominantly male (59.7%). The majority of participants lived in Conakry (96.3%). 5.7% were known diabetics and 4.6% were known hypertensives. We found a prevalence of diabetes of 9.4%. Among diabetics, 39% were diabetes discoveries. 30% were hypertensive or had high blood pressure. Of these hypertensive patients, 26.4% were unrecognized hypertensives. Age and hypertension were statistically significantly associated with the onset of diabetes in tuberculosis patients. Medium, high and very high levels of cardiovascular risk were present in 23.4%, 8.9% and 3.4% respectively. Conclusion: Diabetes is common in tuberculosis patients. Cardiovascular risk factors, notably hypertension and cardiovascular risk level, are frequently associated with tuberculosis. Tuberculosis patients with cardiovascular risk factors should be screened for diabetes.

关键词： Screening Diabetes Tuberculosis Cardiovascular Risk Conakry

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Kidney Damage during Sharp’s Syndrome: About Two Cases

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Open Journal of nephrology 2020年第4期10卷 290-297页

作者： Saharé Fongoro Seydou Sy Magara Samaké Hamadoun Yattara Moctar Coulibaly Aboubacar Sidiki Fofana Brahima Dégoga Atabième Kodio Eyram Yoan Makafui Amekoudi djénèba diallo djénéba Maiga Aboudou M. Dolo Moustapha Tangara nouhoum Coulibaly Kalilou Coulibaly Ibrahima Koné nephrology and Haemodialysis Department of the University Teaching Hospital of Point-G Bamako Mali Faculty of Medicine of bamako Bamako Mali nephrology Unit of the Fousseyni DAOU Hospital in Kayes Kayes Mali nephrology Unit of the Mali GAVARDO Hospital Bamako Mali nephrology Unit of Sikasso Hospital Sikasso Mali nephrology Unit of Somino DOLO Hospital in Mopti Mopti Mali

Context: The coexistence in the same patient of a mixed connectivitis or Sharp’s syndrome is a rare eventuality. Objective: To underline the presence of this mixed connectivitis in our practice, whose prevalence rema... 详细信息

ng>Context:ng> The coexistence in the same patient of a mixed connectivitis or Sharp’s syndrome is a rare eventuality. ng>Objective:ng> To underline the presence of this mixed connectivitis in our practice, whose prevalence remains unknown, particularly in Africa and more precisely in Mali. ng>Case Presentations:ng> We report two cases of Sharp’s syndrome in a 48-year-old man and a 40-year-old woman with impaired renal function. The picture achieved associated massive proteinuria, hypoalbuminemia, moderate renal failure and edematous syndrome in men. In women, the picture was associated with accelerated to malignant hypertension and severe renal failure. There were no osteoarticular manifestations and the diagnosis of Sharp’s syndrome was based on the presence of high levels of antibodies to U1RnP. Therapeutic management has been that of predominantly associated connective tissue disease (systemic lupus erythematosus). ng>Conclusion:ng> Mixed connectivitis or Sharp’s syndrome is increasingly recognized as a separate entity thanks to advances in molecular biology. Its prevalence is low in sub-Saharan African countries with renal disease that manifests itself as proteinuria or nephrotic syndrome associated with microscopic hematuria, renal failure, and hypertension. This renal impairment is more likely to occur in severe forms of the disease.

关键词： Sharp Syndrome/Mixed Connectivitis Renal Failure Mali

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Phenotypic Detection of Enterobacterales Strains Susceptible of Producing OXA-48 Carbapenemase

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Advances in Microbiology 2024年第2期14卷 115-121页

作者： Abdoulaye Seck Abdou Diop babacar ndiaye Assane Dieng Awa ba Amadou Diop Chantal Mahou Douala-djemba Thierno Abdoulaye diallo Cheikh Anta Diop University of Dakar Dakar Senegal Medical Biology Laboratory Pasteur Institute of Dakar Dakar Senegal

background: nowadays, emergence of Carbapenemase-Producing Enterobacterales (CPE) throughout the world has become a public health problem, especially in countries with limited resources. In recent years, CPE of type OXA-48 (Ambler class D) have been identified in Dakar. The aim of this study was to evaluate the phenotypic detection of OXA-48 CPE using a temocillin disc (30 μg). Methodology: A retrospective study was carried out at Medical Biology Laboratory of Pasteur Institute in Dakar on Ertapenem-Resistant Enterobacterales (ERE) strains isolated from 2015 to 2017. These strains were then tested with a 30 μg temocillin disc. Any strain resistant to temocillin (inhibition diameter Results: Forty-one ERE isolated during the study period were tested, of which 34 (82.9%) were OXA-48 based on phenotypic detection using temocillin disc and confirmed by PCR (100%). OXA-48 CPE strains detected were composed of Klebsiella pneumoniae (n = 14;41.2%), Enterobacter cloacae (n = 8;23.5%), Escherichia coli (n = 7, 20.5%), Citrobacter freundii (n = 3;8.8%), Cronobacter sakazakii (n = 1;3%) and Morganella morganii (n = 1;3%). Conclusion: Temocillin resistance has a good positive predictive value for detecting OXA-48 CPE by phenotypic method, confirmed by PCR. Temocillin is therefore a good marker for detection of OXA-48 CPE except Hafnia alvei.

关键词： Ertapenem Temocillin Phenotypic Detection Carbapenemase-Producing Enterobacterales OXA-48

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