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Identification of a novel germline missense mutation of the androgen receptor in African American men with familial prostate cancer

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Asian Journal of Andrology 2010年第3期12卷 336-343,I0008,I0009页

作者： Si-Yi Hu Tao Liu Zhen-Zhen Liu Elisa Ledet Cruz Velasco-Gonzalez diptasri m mandal Shahriar Koochekpour Stanley S Scott Cancer Center Louisiana State University Health Sciences Center New Orleans LA 70112 USA Department of Genetics Louisiana State University Health Sciences Center New Orleans LA 70112 USA School of Public Health Louisiana State University Health Sciences Center New Orleans LA 70112 USA 4Department of microbiology and Immunology Department of Urology Department of Biochemistry and Molecular Biology Louisiana State University Healt Sciences Center New Orleans LA 70112 USA

Race, family history and age are the unequivocally accepted risk factors for prostate cancer （PCa）. Androgen receptor （AR）-dependent signaling is an important element in prostate carcinogenesis and its progression to metastatic disease. We examined the possibility of genomic changes in the AR in association with familial PCa in African Americans who have a higher incidence and mortality rate and a clinically more aggressive disease presentation than Caucasians. Genomic DNAs of 60 patients from 30 high-risk African American and Caucasian families participating in the Louisiana State University Health Sciences Center genetic linkage study of PCa were studied. Exon-specific polymerase-chain reaction, bi-directional automated sequencing and restriction enzyme genotyping were used to analyze for mutations in the coding region of the AR gene. We identified a germline AR （A1675T）（T559S） substitution mutation in the DNA-binding domain in three PCa-affected members of an African- American family with a history of early-onset disease. The present study describes the first AR germline mutation in an African-American family with a history of familial PCa. The AR （T559S） mutation may contribute to the disease by altering AR DNA-binding affinity and/or its response to androgens, non-androgenic steroids or anti-androgens. Additional studies will be required to define the frequency and contribution of the AR （A 1675T） allele to early-onset and/or familial PCa in African Americans.

关键词： African Americans androgen receptor familial prostate cancer germline mutation

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Effect of metal fractions on rice grain metal uptake and biological parameters in mica mines waste contaminated soils

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Journal of Environmental Sciences 2024年第2期136卷 313-324页

作者： Saibal Ghosh Sandip mondal Jajati mandal Abhishek mukherjee Pradip Bhattacharyya Agricultural and Ecological Research Unit Indian Statistical InstituteGiridihJharkhand 815301India School of Science Engineering&EnvironmentUniversity of SalfordManchester M54WTUK

Heavy metals from mica waste not only deteriorate the soil quality but also results in the uptake of metals in the *** present investigation was conducted to evaluate the effects of different fractions of metals on the uptake in rice,soil microbial and biochemical properties in mica waste-contaminated soils of Jharkhand,*** each active mine,soil samples were randomly collected at distances ofm(zone 1),50–100 m(zone 2),and>100 m(zone 3).Sequential metal extraction was used to determine the fractions of different metals(nickel(Ni),cadmium(Cd),chromium(Cr)and lead(Pb))including water-soluble(Ws)and exchangeable metals(Ex),carbonate-bound metals(CBD),Fe/mn oxide(OXD)bound metals,organically bound metals(ORG),and residues(RS).The Ni,Cr,Cd and Pb in rice grain were 0.83±0.41,0.41±0.19,0.21±0.14 and 0.17±0.08 mg/kg *** the variable importance plot of the random forest(RF)algorithm,the Ws fraction of Ni,Cr and Cd and Ex fraction of Pb was the most important predictor for rice grain metal ***,the partial dependence plots(PDP)give us an insight into the role of the two most important metal fractions on rice grain metal *** microbial and enzyme activity was significantly and negatively correlated with Ws and Ex metal fractions,indicating that water-soluble and exchangeable fractions exert a strong inhibitory effect on the soil microbiological parameters and enzyme activities.

关键词： metal fractions microbial parameters mica waste soil Soil enzymes Rice Random forest

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model dependent analysis of D^(+)_(s)→η^(′)l+v_(l) decays in beyond standard model

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Chinese Physics C 2024年第9期48卷 82-95页

作者： S.mahata m.mandal H.mahapatra S.Biswas S.Sahoo Department of Physics National Institute of Technology Durgapur Durgapur 713209West BengalIndia

motivated by the recent experimental results of branching fractions for D^(+)_(s)→η^(′)l+v_(l) decays,which deviate from their Sm predictions,we hve investigated these decays in W' model and scalar leptoquark model to determine potential signatures of new physics(NP) in semileptonic charm decays induced by c→(s,d)l+v_(l) *** recent experimental results of branching fractions for semileptonic D meson decays,new coupling parameters are predicted for the aforementioned NP *** fraction,forward-backward asymmetry,and lepton polarization asymmetry are examined by considering the predicted NP coupling *** results of branching fractions in scalar leptoquark model are found very close to the experimental results and exist around the range of 1σ *** presented a comparative study of the NP models to check their sensitivity on these *** anticipate that further research on these decays will significantly support our findings.

关键词： charm decay new physics W′boson scalar leptoquark flavour changing charged current

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model dependent analysis of ■→■ decays in beyond standard model

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Chinese Physics C 2024年第9期48卷 86-99页

作者： S.mahata m.mandal H.mahapatra S.Biswas S.Sahoo Department of Physics National Institute of Technology Durgapur

motivated by the recent experimental results of branching fractions for ■→■ decays,which deviate from their Sm predictions,we hve investigated these decays in W' model and scalar leptoquark model to determine potential signatures of new physics(NP) in semileptonic charm decays induced by c→■ *** recent experimental results of branching fractions for semileptonic D meson decays,new coupling parameters are predicted for the aforementioned NP *** fraction,forward-backward asymmetry,and lepton polarization asymmetry are examined by considering the predicted NP coupling *** results of branching fractions in scalar leptoquark model are found very close to the experimental results and exist around the range of 1σ *** presented a comparative study of the NP models to check their sensitivity on these *** anticipate that further research on these decays will significantly support our findings.

关键词： $ W' $ boson charm decay flavour changing charged current new physics scalar leptoquark

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Appraisal of pollution and health risks associated with coal mine contaminated soil using multimodal statistical and Fuzzy-TOPSIS approaches

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Frontiers of Environmental Science & Engineering 2024年第5期18卷 101-115页

作者： Sumit Kumar Sonali Banerjee Saibal Ghosh Santanu majumder Jajati mandal Pankaj Kumar Roy Pradip Bhattacharyya Agricultural and Ecological Research Unit Indian Statistical InstituteGiridih815301India Department of Life and Environmental Sciences Bournemouth University(Talbot Campus)Fern BarrowPooleBH12 5BBUK School of Sciences Engineering & EnvironmentUniversity of SalfordSalfordM5 4QJUK School of Water Resource Engineering Jadavpur UniversityKolkata700032India School of Environmental Studies Jadavpur UniversityKolkata700032India

The present study assesses the concentration,probabilistic risk,source classification,and dietary risk arising from heavy metal(Hms)pollution in agricultural soils affected by coal mining in eastern part of *** of soil and rice plant indicated significantly elevated levels of Hms beyond the permissible limit in the contaminated zones(zone 1:PbSoil:108.24±72.97,CuSoil:57.26±23.91,CdSoil:8.44±2.76,CrSoil:180.05±46.90,NiSoil:70.79±25.06 mg/kg;PbGrain:0.96±0.8,CuGrain:8.6±5.1,CdGrain:0.65±0.42,CrGrain:4.78±1.89,NiGrain:11.74±4.38 mg/*** 2:PbSoil:139.56±69.46,CuSoil:69.89±19.86,CdSoil:8.95±2.57,CrSoil:245.46±70.66,NiSoil:95.46±22.89 mg/kg;PbGrain:1.27±0.84,CuGrain:7.9±4.57,CdGrain:0.76±0.43,CrGrain:8.6±1.58,NiGrain:11.50±2.46 mg/kg)compared to the uncontaminated zone(zone 3).Carcinogenic and non-carcinogenic health risks were computed based on the Hms concentration in the soil and rice grain,with Pb,Cr,and Ni identified as posing a high risk to human *** Carlo simulation,the solubility-free ion activity model(FIAm),and severity adjusted margin of exposure(SAmOE)were employed to predict health *** hazard quotient(HQ)values for Ni,Cr,Cd,and Pb were>1,indicating a significant non-carcinogenic ***(risk thermometer)results for contaminated zones ranged from low to moderate risk(CrSAmOE:0.05,and NiSAmOE:0.03).Fuzzy-TOPSIS and variable importance plots(from random forest)showed that Ni and Cr were mostly responsible for the toxicity in the rice plant,respectively.A self-organizing map for source classification revealed common origin for the studied Hms with zone 2 exhibiting the highest *** positive matrix factorization model for the source apportionment identified coal mining and transportation as the predominant sources of *** distribution analysis indicated higher contamination near mining sites as compared to distant sampling ***,this study will aid environmental scientists and policymakers controllin

关键词： Coal mine Free ion activity model monto Carlo Simulation Pollution and Health risk Fuzzy-TOPSIS

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Solid fraction evolution characteristics of semi-solid A356 alloy and in-situ A356–TiB_2 composites investigated by differential thermal analysis

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International Journal of minerals,metallurgy and materials 2015年第4期22卷 389-394页

作者： S.Deepak Kumar A.mandal m.Chakraborty School of mechanical Sciences Indian Institute of Technology Bhubaneswar School of minerals Metallurgical and Materials Engineering Indian Institute of Technology Bhubaneswar

The key factor in semi-solid metal processing is the solid fraction at the forming temperature because it affects the microstructure and mechanical properties of the thixoformed components. Though an enormous amount of data exists on the solid fraction-temperature re- lationship in A356 alloy, information regarding the solid fraction evolution characteristics of A356-TiB2 composites is scarce. The present article establishes the temperature-solid fraction correlation in A356 alloy and A356-xTiB2 （x = 2.5wt% and 5wt%） composites using dif- ferential thermal analysis （DTA）. The DTA results indicate that the solidification characteristics of the composites exhibited a variation of 2℃ and 3℃ in liquidus temperatures and a variation of 3℃ and 5℃ in solidus temperatures with respect to the base alloy. moreover, the eutectic growth temperature and the solid fraction（fs） vs. temperature characteristics of the composites were found to be higher than those of the base alloy. The investigation revealed that in-situ formed TiB2 particles in the molten metal introduced more nucleation sites and reduced undercooling.

关键词： particle reinforced composites aluminum alloys titanium boride casting solid fraction differential thermal analysis

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Characterization,spectroscopic investigation of defects by positron annihilation,and possible application of synthesized PbO nanoparticles

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Chinese Physics B 2021年第2期30卷 400-407页

作者： Sk Irsad Ali Anjan Das Apoorva Agrawal Shubharaj mukherjee maudud Ahmed P m G Nambissan Samiran mandal Atis Chandra mandal Department of Physics University of BurdwanGolapbagBurdwan 713104West BengalIndia Department of Physics A.P.C.Roy Government CollegeSiliguriDarjeeling 734010West BengalIndia Applied Nuclear Physics Division Saha Institute of Nuclear Physics1/AF BidhannagarKolkata 700064India Department of Physics Government General Degree College at PedongKalimpong 734311West BengalIndia

Nanocrystalline samples of highly pure lead oxide were prepared by the sol-gel route of synthesis.X-ray diffraction and transmission electron microscopic techniques confirmed the nanocrystallinity of the samples,and the average sizes of the crystallites were found within 20 nm to 35 *** nanocrystallites exhibited specific anomalous properties,among which a prominent one is the increased lattice parameters and unit cell *** optical band gaps also increased when the nanocrystallites became smaller in *** latter aspect is attributable to the onset of quantum confinement effects,as seen in a few other metal oxide *** annihilation was employed to study the vacancy type defects,which were abundant in the samples and played crucial roles in modulating their *** defect concentrations were significantly larger in the samples of smaller crystallite *** results suggested the feasibility of tailoring the properties of lead oxide nanocrystallites for technological applications,such as using lead oxide nanoparticles in batteries for better performance in discharge rate and *** also provided the physical insight into the structural build-up process when crystallites were formed with a finite number of atoms,whose distributions were governed by the site stabilization energy.

关键词： lead oxide nanocrystals positron annihilation sol-gel processes

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Electronic correlation in nearly free electron metals with beyond-DFT methods

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npj Computational materials 2022年第1期8卷 1756-1762页

作者： Subhasish mandal Kristjan Haule Karin m.Rabe David Vanderbilt Department of Physics and Astronomy West Virginia UniversityMorgantownWVUSA Department of Physics and Astronomy Rutgers UniversityPiscatawayNJUSA

For more than three decades,nearly free-electron elemental metals have been a topic of debate because the computed bandwidths are significantly wider in the local density approximation to density-functional theory(DFT)than indicated by angle-resolved photoemission(ARPES)***,we systematically investigate this using first principles calculations for alkali and alkaline-earth metals using DFT and various beyond-DFT methods such as meta-GGA,G0W0,hybrid functionals(YS-PBE0,B3LYP),and LDA+*** find that the static non-local exchange,as partly included in the hybrid functionals,significantly increase the bandwidths even compared to LDA,while the G0W0 bands are only slightly narrower than in *** agreement with the ARPES is best when the local approximation to the self-energy is used in the LDA+eDmFT *** infer that even moderately correlated systems with partially occupied s orbitals,which were assumed to approximate the uniform electron gas,are very well described in terms of short-range dynamical correlations that are only local to an atom.

关键词： metals assumed narrow

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Effect of size on momentum distribution of electrons around vacancies in NiO nanoparticles

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Chinese Physics B 2015年第4期24卷 296-299页

作者： Anjan Das Atis Chandra mandal P.m.G.Nambissan Department of Physics A.P.C.Roy Government College Department of Physics University of Burdwan Applied Nuclear Physics Division Saha Institute of Nuclear Physics

Very small nickel oxide nanoparticles were prepared by a sol-gel procedure using nickel nitrate hexahydrate and ammonium hydroxide as precursors. The particles are in the range of 5 nm-11 rim. The x-ray diffraction （XRD） crystallography and high resolution transmission electron microscopy （HRTEm） were employed to characterize the samples. They were found to be polycrystalline in nature and fcc （NaCl-type） in structure, with the lattice parameter varying with annealing temperature. HRTEm pictures show that the as-prepared samples are hexagonal in shape. Positron annihilation spectroscopy was used to investigate the Doppler-broadened spectra of the samples. The S and W parameters revealed that the chemical surroundings and momentum distribution of the vacancy clusters vary with crystallite size.

关键词： nanoparticles semiconductor defect cluster positron annihilation sol-gel

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Hydrogeochemical characteristics and its role in controlling arsenic mobilization in a shallow aquifer

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Acta Geochimica 2021年第6期40卷 912-925页

作者： Ayan Das Abhijit mandal Department of Chemistry University of KalyaniKalyaniWest BengalIndia Department of General Science and Humanities GKCIETMaldaWest BengalIndia

The relevance of groundwater hydrogeochemistry to explain the occurrence and distribution of arsenic in groundwater is of great *** insightful discussions on the control of shallow groundwater(m)hydrogeochemistry in arsenic mobilization are known to be a viable tool to explain the arsenic menace in shallow *** present investigation emphasizes the hydrogeochemical driver and/or control over the reductive dissolution of Fe-bearing host minerals and thereby releasing arsenic into the shallow groundwater of the study *** study suggests that hydrogeochemical evolution is mainly governed by carbonate minerals dissolution,silicate weathering,and competitive ion-exchange processes in the shallow aquifers(m).The present study also indicates the prevalence of carbonate minerals dissolution over silicate *** emergence of Cl^(-)concentration in the shallow groundwater founds the possibilities of anthropogenic inputs into the shallow aquifers(m).The reducing environment in shallow aquifers(m)of the study area is evident in the reductive dissolution of Febearing shallow aquifer minerals which absorb arsenic in the solid phase and mobilize arsenic onto shallow *** study opted for many statistical approaches to delineate the correlation among major and minor ionic constituents of the groundwater which are very helpful to understand the comprehensive mechanism of arsenic mobilization into shallow groundwater.

关键词： Arsenic mobilization Groundwater hydrogeochemistry Aquifer sediments Shallow aquifers Redox environment

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