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Focusing on the tetra-partite synapse in Parkinson’s disease research using human patient-derived neurons

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Neural Regeneration Research 2024年第5期19卷 979-981页

作者： diogo Cordeiro Tchelet Stern Shani Stern University of Haifa Sagol Department of NeurobiologyHaifaIsrael

Parkinson’s disease(PD)was first described as a neurological disease by *** Parkinson in 1817 as a“shaking palsy”.Since that time,much more is known about the pathophysiology of PD yet the disease is still *** hallmark of the disease is often considered Lewy body neural inclusions in the substantia nigra pars compacta and other brain areas,although not all patients have these *** patients exhibit massive neuronal cell loss in the substantia nigra pars compacta,which is associated with the motor symptoms of tremor,bradykinesia,rigidity,and postural *** is the second most common neurodegenerative disease after Alzheimer’s disease with a prevalence of around 1%of individuals over the age of 60.

关键词： patients Alzheimer Focus

Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ramiro D.Almeida iBimED-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

High-resolution multi-scale air pollution system:Evaluation of modelling performance and emission control strategies

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Journal of Environmental Sciences 2024年第3期137卷 65-81页

作者： diogo Lopes Joana Ferreira Sandra Rafael Ka In Hoi Xin Li Yuan Liu Ka-Veng Yuen Kai meng mok Ana Isabel miranda Department of Environment and Planning&CESAm University of AveiroAveiroPortugal Department of Civil&Environmental Engineering Faculty of Science and TechnologyUniversity of MacaoMacao SARChina

A high percentage of the world's population lives in areas where air pollutant concentrations exceed the World Health Organization *** work aims to develop and test,a high-resolution multi-scale air pollution modelling system by integrating a set of adequate *** system is able to provide detailed air pollutant concentrations in urban areas and support air quality management strategies through a better identification of different atmospheric *** also allows furthering the design and assessment of air pollution control measures for a specific *** evaluate its performance and suitability,the system was applied to the macao Special Administrative Region(SAR),China,one of the most densely populated areas on earth,during a winter period when this area is affected by high levels of Particulate matter(Pm).Although the developed system tends to underestimate the Pm concentrations,it revealed a good performance in reproducing the temporal and spatial air pollution *** exceedances of the Chinese air quality standards were calculated and high population exposure to Pm pollution was *** tested urban atmospheric emission reduction scenarios have shown air quality improvements,indicating that emission reduction measures at urban level should focus on the domestic ***,it is crucial to implement joint pollution prevention strategies with neighbouring regions to improve the air quality in macao *** approach developed in this work can support policymakers in defining new strategies to reduce atmospheric pollution in urban areas.

关键词： Urban areas High-resolution emission inventory Particulate matter Population exposure

What is the effect of Tribulus terrestris on testicular morphology and sperm production?An experimental study in the rat model

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Asian Journal of Andrology 2024年第1期26卷 67-70页

作者： marcello Henrique Araujo Da Silva Gabriela Faria Buys-Goncalves Joao Henrique Duque Reis Estrada Francisco Jose Barcellos Sampaio diogo Benchimol de Souza Urogenital Research Unit Rio de Janeiro State UniversityRio de Janeiro 20551-030RJBrazil

The objective of this study was to investigate whether treatment with Tribulus terrestris(Tt)has any impact on the testicular morphology and function in a rodent *** male rats were divided into a control group and a group receiving 100 mg kg^(-1) body weight of Tt *** 4o days of experiment,the animals were submitted to euthanasia;epididymal tail spermatozoa were collected;and spermatozoa concentration,motility,and viability were *** addition,testicles were collected and processed for histomorphometrical *** were compared using the Student's t-test and considered significant when Pmotility,and viability showed no difference between the ***,testicular weight and volume,seminiferous tubule diameter,tunica propria surface density,seminiferous epithelium surface density,and intertubular compartment surface density were statistically similar between the ***,seminiferous epithelium height and tubular lumen surface density were augmented in animals treated with *** with Tt does not cause a major impact on testicular morphology,promoting only subtle *** difference on spermatozoa parameters was observed.

关键词： morphometry testicle Tribulus terrestris

European legal framework related to underground mining and tunnelling concerning commission directive (EU) 2017/164, 31 January establishing a fourth list of indicative occupational exposure limit values

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International Journal of mining Science and Technology 2020年第4期30卷 541-545页

作者： miguel Tato diogo Department of mining Engineering Faculty of EngineeringUniversity of PortoPorto 4200-465Portugal

Directive(EU)2017/164 establishes a fourth list of indicative occupational exposure limit values(IOELVs)to protect workers from risks of exposure to hazardous *** states that in underground mining and tunnelling,member States may benefit from a transitional period regarding IOELVs for nitrogen monoxide,nitrogen dioxide,and carbon monoxide,during which the existing established IOELVs may be *** European Advisory Committee on Health and Safety at Work questions the technical feasibility of the proposed IOELVs in underground mining(CO,NO and NO2)and tunnelling(NO and NO2).Challenges arise concerning the availability of measurement methodologies for compliance with proposed IOELVs(NO2)in underground mining and tunnelling environments.

关键词： Nitrogen monoxide Nitrogen dioxide Carbon monoxide IOELVs European Directive 2017/164 Underground mining Tunnelling

Flight initiation distance, color and camouflage

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Current Zoology 2019年第5期65卷 535-540页

作者： Anders Pape mOLLER Wei LIANG diogo S.m.SAmiA Laboratoire d'Ecologie Systematique et EvolutionCNRS UMRUniversite Paris-SudBatiment 362Orsay CedexFrance ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering College of Life SciencesBeijing Normal UniversityBeijing 100875China ministry of Education Key Laboratory for Ecology of Tropical Islands College of Life SciencesHainan Normal UniversityHaikouChina Department of Ecology Federal University of GoiasGoianiaBrazil

Camouflage is widespread throughout the animal kingdom allowing individuals to avoid detection and hence save time and energy rather than escape from an approaching ***,camouflage is likely to have co-evolved with antipredator ***,we propose that camouflage results in dichotomous escape behavior within and among species with classes of individuals and species with cryptic coloration having shorter flight initiation distances(FIDs;the distance at which an individual takes flight when approached by a human).We report the results of 2 tests of this ***,bird species with cryptically colored plumage have consistently shorter FID than closely related species without such *** species with sexually dimorphic plumage,brightly colored adult male common pheasants Phasianus colchicus and golden pheasants Chrysolophus pictus have long and variable FID,whereas cryptically colored juveniles and adult females have short and invariable ***,FID in females was predicted by presence or absence of cryptic color,FID in males and their *** findings are consistent with the hypothesis that risk-taking behavior has been attuned to camouflage,and that species with different levels of camouflage differ consistently in their FID.

关键词： anti-predator behavior birds camouflage crypsis sexual dichromatism

Solutions for submucosal injection: What to choose and how to do it

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World Journal of Gastroenterology 2019年第7期25卷 777-788页

作者： Rui Castro diogo Libanio Inês Pita mário Dinis-Ribeiro Department of Gastroenterology Portuguese Oncology Institute of Porto CIDES/CINTESIS Faculty of Medicine University of Porto

During the past decades, endoscopic resection techniques have gradually improved and gained more importance for the management of premalignant lesions and early cancers. These endoscopic resection techniques can be divided in 3 major groups: snare polipectomy, endoscopic mucosal resection(EmR) and endoscopic submucosal dissection(ESD). The use of submucosal injection is essential for the majority of EmR techniques and is an integral part of ESD,whereas during polipectomy it is not crucial in most cases except to prevent bleeding in large polyps and/or those with large stalks as an alternative to mechanical methods. Injection provides a lifting up effect of the lesion separating it from the muscular layer, thereby reducing thermal injury and the risk of perforation and bleeding while also facilitating en-bloc resection by improving technical feasibility. With this work, we aim to review the most common endoscopic resection techniques and the importance of submucosal injection in each one of them. For that, we present some of the most commonly used submucosal injection solutions, taking into account their advantages and disadvantages. We also discuss, based on current recommendations and our own experience, how and when to preform submucosal injection, depending on lesions features and endoscopic resection technique that′s being used, to assure complete resection and to prevent associated adverse events. Finally, we also present and discuss some new proposed submucosal injection solutions,endoscopic resection techniques and devices that may have a major impact on the future of therapeutic endoscopy.

关键词： Snare polipectomy Endoscopic mucosal resection Endoscopic submucosal dissection Submucosal injection Submucosal injection solution

Towards the automation of book typesetting

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Visual Informatics 2023年第2期7卷 1-12页

作者： Sérgio m.Rebelo Tiago martins diogo Ferreira Artur Rebelo University of Coimbra Centre for Informatics and Systems of the University of CoimbraDepartment of Informatics EngineeringCoimbraPortugal

This paper proposes a generative approach for the automatic typesetting of books in desktop *** presented system consists in a computer script that operates inside a widely used design software tool and implements a generative process based on several typographic rules,styles and principles which have been identified in the *** performance of the proposed system is tested through an experiment which included the evaluation of its outputs with *** results reveal the ability of the system to consistently create varied book designs from the same input content as well as visually coherent book designs with different contents while complying with fundamental typographic principles.

关键词： Design tools Data-driven design Generative design Graphic design Typography

Intelligent negotiation model for ubiquitous group decision scenarios

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Frontiers of Information Technology & Electronic Engineering 2016年第4期17卷 296-308页

作者： Joao CARNEIRO diogo mARTINHO Goreti mARREIROS Paulo NOVAIS GECAD-Knowledge Engineering and Decision Support Group Institute of EngineeringPolytechnic of PortoPorto 4200-072Portugal ALGORITmI Centre University of MinhoGuimaraes 4800-058Portugal

Supporting group decision-making in ubiquitous contexts is a complex task that must deal with a large amount of factors to succeed. Here we propose an approach for an intelligent negotiation model to support the group decision-making process specifically designed for ubiquitous contexts. Our approach can be used by researchers that intend to include arguments, complex algorithms, and agents' modeling in a negotiation model. It uses a social networking logic due to the type of communication employed by the agents and it intends to support the ubiquitous group decision-making process in a similar way to the real process, which simultaneously preserves the amount and quality of intelligence generated in face-to-face meetings. We propose a new look into this problem by considering and defining strategies to deal with important points such as the type of attributes in the multicriterion problems, agents' reasoning, and intelligent dialogues.

关键词： Group decision support systems Ubiquitous computing Automatic negotiation Social networks multi-agent systems