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miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie zhu Xiao-Jia Yang Qian-Ru He Fei ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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A dynamic peripheral immune landscape during human pregnancy

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Fundamental Research 2025年第1期5卷 391-406页

作者： Liu, Xiuxing zhu, Lei Huang, Zhaohao Li, Zhaohuai duan, Runping Li, He Xie, Lihui Chen, Xiaozhen ding, Wen Chen, Binyao Gao, Yuehan Su, Juan Wang, Xianggui Su, Wenru State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science Sun Yat-Sen University Guangzhou 510060 China Eye Center of Xiangya Hospital Central South University Changsha 410078 China Hunan Key Laboratory of Skin Cancer and Psoriasis Xiangya Hospital Central South University Changsha 410008 China Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou 510623 China Department of Dermatology Xiangya Hospital Central South University Changsha 410008 China Hunan Engineering Research Center of Skin Health and Disease Central South University Changsha 410008 China National Clinical Research Center for Geriatric Disorders Xiangya Hospital Central South University Changsha 410008 China Hunan Key Laboratory of Ophthalmology Changsha 410078 China

Extensive immune adaptations occur during pregnancy to ensure successful delivery. However, these changes can increase the risk of disease in the mother. Here, we conducted single-cell RNA sequencing on peripheral blood mononuclear cells from pregnant women at different stages of pregnancy to elucidate the dynamic transcriptional changes in the maternal immune system. Gradual reduced cytotoxicity phenotype in highly variable cytotoxic T and natural killer cell types were observed during pregnancy. Reduced T- and B-cell response-related MHC-II and CD40 signaling as well as enhanced protolerance inducible costimulator and activin signaling may underlie the pregnancy-related weakening of adaptive immunity. Conversely, pro-inflammatory genes and pathways were upregulated in monocytes, possibly to compensate for the reduced T-cell response. Moreover, the transition from adaptive immune reduction to activation in late pregnancy in dendritic cells and CD4+ T cells was also detected. Notably, we proposed a novel view of the pro-aging effect of pregnancy from the perspective of immunity, and this effect may be restored postpartum. This work expands our knowledge of pregnancy immunity and may provide insights into the altered disease risks during pregnancy. © 2022

关键词： Aging Dampened adaptive immunity Immune tolerance Maternal immune system Pregnancy Single-cell RNA sequencing

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Integrated analysis of single-cell and bulk transcriptomes uncovers clinically relevant molecular subtypes in human prostate cancer

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Chinese Journal of Cancer Research 2025年第01期 90-126页

作者： Tao ding Lina He Guowen Lin Lei Xu Yanjun zhu Xinan Wang Xuefei Liu Jianming Guo Fanghong Lei Zhixiang Zuo Jianghua Zheng Department of Urology Yuebei People's Hospital Shantou University Medical College Department of Urology Southern Medical University Affifiliated Fengxian Hospital School of Life Sciences State Key Laboratory of Oncology in South China Cancer Center Collaborative Innovation Center for Cancer Medicine Sun Yat-sen University Department of Urology Fudan University Shanghai Cancer Center Department of Urology Zhongshan HospitalFudan University Department of Urology Tongji Hospital School of Medicine Tongji University Department of Biochemistry School of Medicine Southern University of Science and Technology Department of Pathology Yuebei People's Hospital Shantou University Medical College Central Laboratory Tongji HospitalSchool of Medicine Tongji University Department of Laboratory Medicine Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital

Objective: Prostate cancer(PCa) is a complex disease characterized by diverse cellular ecosystems within the tumor microenvironment(TME) and high tumor heterogeneity, which challenges clinically stratified management and reinforces the need for novel strategies to fight against castration-resistant PCa(CRPC).Methods: We performed single-cell RNA sequencing(scRNA-seq) on 10 untreated primary PCa tissues and integrated public scRNA-seq resources from three normal prostate tissues, two untreated primary PCa tissues, and six CRPC tumors to portray a comprehensive cellular and molecular interaction atlas of PCa. We further integrated the single-cell and bulk transcriptomes of PCa to establish a molecular classification ***: scRNA-seq profiles revealed substantial inter-and intra-tumoral heterogeneity across different cell subpopulations in untreated PCa and CRPC tumors. In the malignant epithelial reservoir, cells evolved along decoupled paths in treatment-naive PCa and CRPC tumors, and distinct transcriptional reprogramming processes were activated, highlighting anti-androgen therapy-induced lineage plasticity. Based on the specifically expressed markers of the epithelial subpopulations, we conducted unsupervised clustering analysis in The Cancer Genome Atlas prostate adenocarcinoma(TCGA-PRAD) cohort and identified three molecularly and clinically distinct subtypes. The C1 subtype, characterized by high enrichment of CRPC-enriched epithelial cells, had a high risk of rapid development of anti-androgen resistance and might require active surveillance and additional promising intervention treatments, such as integrin A3(ITGA3) + integrin B1(ITGB1) inhibition. The C2 subtype resembled the immune-modulated subtype that was most likely to benefit from anti-LAG3 immunotherapy. The C3 subtype had a favorable ***: Our study provides a comprehensive and high-resolution landscape of the intricate architecture of the PCa TME, and our trichotomic molecu

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Characterization and correlation of engineering properties with microstructure in peanuts:A microscopic to macroscopic analysis

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Journal of Integrative Agriculture 2025年第1期24卷 339-352页

作者： Fei Xiang Zhenyuan Li Yichen Zheng Caixia ding Benu Adhikari Xiaojie Ma Xuebing Xu Jinjin zhu Bello Zaki Abubakar Aimin Shi Hui Hu Qiang Wang Institute of Food Science and Technology Chinese Academy of Agricultural Sciences/Comprehensive Utilization Laboratory of Cereal and Oil ProcessingMinistry of Agriculture and Rural AffairsBeijing 100193China Wilmar(Shanghai)Biotechnology Research&Development Center Co. Ltd.Shanghai 200137China School of Science RMIT UniversityMelbourne 3083VICAustralia School of Food Science and Engineering Nanjing University of Finance and Economics/Jiangsu Modern Food Circulation and Safety Collaborative Innovation CenterNanjing 210023China College of Food Science and Pharmacy Xinjiang Agricultural UniversityUrumqi 830052China Department of Agricultural Extension and Rural Development Faculty of AgricultureUsmanu Danfodiyo UniversitySokoto 840101Nigeria

Peanut varieties are diverse globally,with their characters and nutrition determining the product ***,the comparative analysis and statistical analysis of key quality indicators for peanut kernels across the world remains relatively limited,impeding the comprehensive evaluation of peanut quality and hindering the industry development on a global *** study aimed to compare and analyze the apparent morphology,microstructure,single-cell structure,engineering and mechanical properties,as well as major nutrient contents of peanut kernels from 10 different cultivars representing major peanut-producing *** surface and cross-section microstructure of the peanut kernels exhibited a dense“blocky”appearance with a distinct cellular *** lipid droplets were predominantly spherical with a regular distribution within the *** single-cell structure of the kernels from these 10 peanut cultivars demonstrated varying morphologies and dimensions,which exhibited correlations with their mechanical and engineering ***,the mass loss versus temperature profiles of the peanut kernels revealed five distinct stages,corresponding to moisture loss,volatile loss,protein denaturation,and the degradation of various *** were also observed in the lipid,protein,and sucrose contents,texture,bulk density,true density,porosity,geometric mean diameter,and sphericity among the diferent peanut *** study establishes relationships and correlations among microstructure,engineering properties,and nutritional composition of commonly grown peanut varieties in major peanut-processing *** findings provide valuable insights into peanut quality evaluation,empowering the peanut industry to enhance their processing and product development efforts.

关键词： peanut kernels apparent morphology microstructure engineering properties mechanical properties

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Boosting aqueous nickel-zinc battery stability with bimetallic ion-integrated 1D metal-organic nanowires

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Science China Chemistry 2025年

作者： Yihao Chen Jin Liang Yichun Su Guoyin zhu Hengyue Xu Hongye ding Guangxun Zhang Dianheng Yu Zizhou Shen Yizhou Zhang Wei Huang Huan Pang School of Chemistry and Chemical Engineering Yangzhou University Key Laboratory of Flexible Electronics (KLoFE) & Institute of Advanced Materials (IAM) School of Flexible Electronics (Future Technologies) Nanjing Tech University (NanjingTech) Institute of Advanced Materials and Flexible Electronics (IAMFE) School of Chemistry and Materials Science Nanjing University of Information Science & Technology Department of Chemistry Tsinghua University State Key Laboratory of Coordination Chemistry Nanjing University

Limited by low conductivity,designing cathode materials with excellent electron transfer efficiency for high-performance nickel-zinc batteries （NZBs） remains *** this study,a series of bimetallic metal-organic nanowires were fabricated by doping M ions in NiNTA,resulting in NiMNTA (M=Mg2+,Mn2+,Co2+,Zn2+,Ag+),and NixCo6-xNTA （x=1,2,3,4,5）.The proportions and types of metal ions can be modified without altering the initial coordination structure.X-ray absorption fine structure spectroscopy （XAFS） revealed that only M–O bonds,not metal bonds,were present in the *** performance of Ni2Co4NTA as the cathode for aqueous NZBs was significantly improved,achieving the maximum energy density of 279.17Wh kg-1with the high cycle stability （retention rate of 72.0%after 1,000 cycles）.The flexible Ni2Co4NTA//Zn@carbon cloth battery employing gel electrolyte also exhibits the excellent Coulombic efficiency of 96%after 350 *** approach shows considerable potential for designing one-dimensional materials with bimetallic modifications,providing new strategies for developing cathode materials for NZBs with high specific capacity and cycle stability.

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Evolution of undeformed chip thickness and grinding forces in grinding of K4002 nickel-based superalloy using corundum abrasive wheels

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Chinese Journal of Aeronautics 2025年第1期38卷 131-146页

作者： Yang CAO Biao ZHAO Wenfeng ding Xiaofeng JIA Bangfu WU Fei LIU Yanfang zhu Qi LIU Dongdong XU Jiangsu Key Laboratory of Precision and Micro-Manufacturing Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016China School of Mechanical Engineering Anyang Institute of TechnologyAnyang 455000China Centre for Precision Manufacturing University of StrathclydeGlasgow G11XJUK School of Mechanical Engineering Tongji UniversityShanghai 200240China

The undeformed chip thickness and grinding force are key parameters for revealing the material removal mechanism in the grinding ***,they are difficult to be well expressed due to the ununiformed protrusion height and random position distribution of abrasive grains on the abrasive wheel *** study investigated the distribution of undeformed chip thickness and grinding force considering the non-uniform characteristics of abrasive wheel in the grinding of K4002 nickel-based ***,a novel grinding force model was established through a kinematic-geometric analysis and a grain-workpiece contact ***,a series of grinding experiments were conducted for verifying the *** results indicate that the distribution of undeformed chip thickness is highly consistent with the Gaussian distribution *** increase in the grinding depth mainly leads to an increase in the average value of Gaussian *** the contrary,the increase in the workpiece infeed speed or the decrease in the grinding speed mainly increases the standard deviation of Gaussian *** average and maximum errors of the grinding force model are 4.9%and 14.6%respectively,indicating that the model is of high predication accuracy.

关键词： K4002 nickel-based superalloy Grinding force Material removal mechanism Undeformed chip thickness Quantity of active abrasive grains

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Human cardiac organoid model reveals antibacterial triclocarban promotes myocardial hypertrophy by interfering with endothelial cell metabolism

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Science Bulletin 2025年第3期70卷 342-346页

作者： Nana Yang Jiahong Chen Yujie zhu Wenxin Shan Zheng Cao Yiwen Fu Huanhuan Cao Yanyan Li Yukun Xiang Shusi ding Huiqing Wang Yaobo Zhao Liang Ji Rui Zhan Yufei Wu Zhaomeng Wang Manyuan Dong Lemin Zheng School of Bioscience and Technology Weifang Key Laboratory of Animal Model Research on Cardiovascular and Cerebrovascular DiseasesShandong Second Medical UniversityWeifang 261053China The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine School of Basic Medical SciencesState Key Laboratory of Vascular Homeostasis and RemodelingNHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesBeijing Key Laboratory of Cardiovascular Receptors ResearchHealth Science CenterPeking UniversityBeijing 100191China University of Chinese Academy of Sciences Beijing 100049China Beijing Tiantan Hospital China National Clinical Research Center for Neurological DiseasesAdvanced Innovation Center for Human Brain ProtectionBeijing Institute of Brain DisordersThe Capital Medical UniversityBeijing 100050China Research Center for Cardiopulmonary Rehabilitation University of Health and Rehabilitation Sciences Qingdao Hospital(Qingdao Municipal Hospital)School of Health and Life SciencesUniversity of Health and Rehabilitation SciencesQingdao 266071China

Environmental pollution is an important but often overlooked risk factor for cardiovascular diseases such as heart ***(3,4,4′-trichlorocarbanilide,TCC)is a broad-spectrum antibacterial agent commonly used in personal care products such as antibacterial soaps,detergents,toothpaste,and cosmetics[1].Unfortunately,due to its widespread use,TCC has become one of the top ten most common water pollutants globally,and it is present in the atmosphere,soil,and aquatic sediments[2].

关键词： metabolism cardiovascular diseases

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Gut microbiota and their metabolites in hemodialysis patients

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中华医学杂志(英文版) 2025年第04期

作者： du Junxia Zhao Xiaolin ding Xiaonan Ren Qinqin Wang Haoran Han Qiuxia Song Chenwen Wang Xiaochen Zhang Dong zhu Hanyu Department of Nephrology First Medical Center of Chinese People’s Liberation Army General Hospital Nephrology Institute of the Chinese People’s Liberation Army National Key Laboratory of Kidney Diseases National Clinical Research Center for Kidney Diseases Beijing Key Laboratory of Kidney Disease Research Beijing China Medical School of Chinese People’s Liberation Army Beijing China Department of Nephrology Beijing Chao-Yang Hospital Capital Medical University Beijing China

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Residual stresses of polycrystalline CBN abrasive grits brazed with a high-frequency induction heating technique

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Chinese Journal of Aeronautics 2019年第4期32卷 1020-1029页

作者： Wei XU Yejun zhu Baicun du Wenfeng ding College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and Astronautics Department of Computer Engineering Chongqing Aerospace Polytechnic

Residual stresses produced in polycrystalline CBN abrasive grits during a high-frequency induction brazing process are calculated by using ?nite element analysis, with a consideration of the nonuniform temperature distribution in the induction brazing model. The in?uences of induction brazing parameters on the residual stresses of polycrystalline CBN abrasive grits have been analyzed, including the embedding depth, grit side length, etc. Results obtained show that the tensile stress with a 40% embedding depth is 292 MPa, which is the minimum on the bonding interface compared with other embedding depths. Meanwhile, the maximum tensile stress is 575 MPa, with an increase of 59% compared with that of a grit side length of 50 mm. Finally, the simulation results of the brazing residual stress of polycrystalline CBN abrasive grits have been con?rmed valid based on the residual stress measurement of the brazed monocrystalline CBN grit.

关键词： Brazing residual stress Finite element analysis High-frequency induction heating Polycrystalline CBN grit

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基于负序电流移置的风电场集电线不对称故障定位方案

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中国电机工程学报 2025年第4期45卷 1436-1449,I0017页

作者：丁嘉朱永利魏源华北电力大学电气与电子工程学院河北省保定市071003

风电场集电线上风机众多,故障定位困难,为此提出一种基于负序电流移置的风电场集电线不对称故障定位方案。首先,从风机故障电流出发,分析风机负序阻抗特性,实现风机负序建模,进而在对风电场负序网络等效的基础上引入移置策略。然后,分... 详细信息

风电场集电线上风机众多,故障定位困难,为此提出一种基于负序电流移置的风电场集电线不对称故障定位方案。首先,从风机故障电流出发,分析风机负序阻抗特性,实现风机负序建模,进而在对风电场负序网络等效的基础上引入移置策略。然后,分析电流移置域边界节点负序注入电流的数值特征与故障位置间的关联关系,构造故障区域识别准则,推导故障子区域辨识公式与故障测距公式。最后,探究节点负序注入电流相位特征,提出无须相量测量的节点负序注入电流有效值计算方法。PSCAD/EMTDC仿真表明,所提方案能够克服过渡电阻、故障初相角、风速分布及风机容量等因素影响,有效实现集电线不对称故障精确定位,且所需测点少,无相量测量,含分支集电线适用性好。

关键词：负序网络负序电流电流移置风电场集电线不对称故障故障定位

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