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Non-unique Probe Selection with Group Testing

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Non-unique Probe Selection with Group Testing

Rock fracture mechanism of buffer blasting with cushion layer at the borehole bottom

第一届最优化与系统生物学国际研讨会

作者： Ping Deng Feng Wang ding-zhu du Department of Computer Science University of Texas at Dallas Department of Computer Science University of Minnesota School of Science Xi'an Jiaotong University

Non-unique probe selection is an important research problem in computational molecular biology. One of approaches to study it is group testing. A minization problem arosen from such study is as follows: Give a binary matrix, find a d-disjunct submatrix with the minimum number of rows and the same number of columns. We give a mini survey on its computational complexityshow and approximation algorithms.

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 325-334页

作者： Xinguang zhu Chenxi ding Zhe Sui Hong Su Xu Guo School of Civil and Resources Engineering University of Science and Technology BeijingBeijing 100083China Key Laboratory for Mechanics in Fluid Solid Coupling Systems Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Mechanics and Civil Engineering China University of Mining and Technology(Beijing)Beijing 100083China School of Chemical and Blasting Engineering Anhui University of Science and TechnologyHuainan 232001China

This study primarily investigates the rock fracture mechanism of bottom cushion layer blasting and explores the effects of the bottom cushion layer on rock *** involves analyses of the evolution patterns of blasting stress,characteristics of crack distribution,and rock fracture features in the ***,blasting model experiments were carried out using the dynamic caustics principle to investigate the influence of bottom cushion layers and initiation methods on the integrity of the bottom rock *** experimental results indicate that the combined use of bottom cushion layers and inverse initiation effectively protects the integrity of the bottom rock ***,the process of stress wave propagation and dynamic crack propagation in rocks was simulated using the continuum-discontinuum element method(CDEM)and the Landau explosion source model,with varying thicknesses of bottom cushion *** numerical simulation results indicate that with increasing cushion thickness,the absorption of energy generated by the explosion becomes more pronounced,resulting in fewer cracks in the bottom rock *** illustrates the positive role of the cushion layer in protecting the integrity of the bottom rock mass.

关键词： bottom cushion layer blasting crack propagation continuum-discontinuum element method dynamic stress intensity factor

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非线性规划中的梯度投影方法

贵州工学院学报 1988年第S1期 1-10页

作者：堵丁柱中国科学院应用数学所

这是一篇对非线性规划中梯度投影法的综述。通过对以前工作的讨论,我们为今后的研究提出几个有趣的问题。

关键词：梯度投影整体收敛不可微最优化

Staged dendrite suppression for high safe and stable lithium-sulfur batteries

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Journal of Energy Chemistry 2025年第1期100卷 674-683页

作者： Jun Jiang Zhenjie Lu Yanwen ding Shujun Liu Zhijie Qi Tian Tang Yunfan Zhang Zhiyuan Ma Jingwen Sun Liang Xue Wenyao Zhang Pan Xiong Xin Wang Junwu zhu Yongsheng Fu Key Laboratory for Soft Chemistry and Functional Materials of Ministry of Education Nanjing University of Science and Technology Jiangsu Pylon Battery Co.Ltd

The unavoidable dendrite growth and shuttle effect have long been stranglehold challenges limiting the safety and practicality of lithium-sulfur ***,we propose a dual-action strategy to address the lithium dendrite issue in stages by constructing a multifunctional surface-negatively-charged nanodiamond layer with high ductility and robust puncture resistance on polypropylene （PP） *** uniformly loaded compact negative layer can not only significantly enhance electron transmission efficiency and promote uniform lithium deposition,but also reduce the formation of dendrite during early deposition *** importantly,under the strong puncture stress encountered during the deterioration of lithium dendrite growth under limiting current,the high ductility and robust puncture resistance（145.88 MPa） of as-obtained nanodiamond layer can effectively prevent short circuits caused by unavoidable lithium *** Li||Li symmetrical cells assembled with nanodiamond layer modified PP demonstrated a stable cycle of over 1000 h at 2 mA cm-2with a polarization voltage of only 29.3 ***,the negative charged layer serves as a physical barrier blocking lithium polysulfide ions,effectively mitigating capacity *** improved cells achieved a capacity decay of only 0.042%per cycle after 700 cycles at 3 C,demonstrating effective suppression of dendrite growth and capacity attenuation,showing promising prospect.

关键词： Lithium-sulfur batteries Staged dendrite suppression Shuttle effect Surface-negatively-charged nanodiamond

Residual stresses of polycrystalline CBN abrasive grits brazed with a high-frequency induction heating technique

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Chinese Journal of Aeronautics 2019年第4期32卷 1020-1029页

作者： Wei XU Yejun zhu Baicun du Wenfeng ding College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and Astronautics Department of Computer Engineering Chongqing Aerospace Polytechnic

Residual stresses produced in polycrystalline CBN abrasive grits during a high-frequency induction brazing process are calculated by using ?nite element analysis, with a consideration of the nonuniform temperature distribution in the induction brazing model. The in?uences of induction brazing parameters on the residual stresses of polycrystalline CBN abrasive grits have been analyzed, including the embedding depth, grit side length, etc. Results obtained show that the tensile stress with a 40% embedding depth is 292 MPa, which is the minimum on the bonding interface compared with other embedding depths. Meanwhile, the maximum tensile stress is 575 MPa, with an increase of 59% compared with that of a grit side length of 50 mm. Finally, the simulation results of the brazing residual stress of polycrystalline CBN abrasive grits have been con?rmed valid based on the residual stress measurement of the brazed monocrystalline CBN grit.

关键词： Brazing residual stress Finite element analysis High-frequency induction heating Polycrystalline CBN grit

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie zhu Xiao-Jia Yang Qian-Ru He Fei ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

敲低DAB2相互作用蛋白(DAB2IP)促进膀胱癌细胞增殖并抑制其凋亡

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细胞与分子免疫学杂志 2017年第5期33卷 668-676页

作者：张凯王崴屹吴开杰丁晨朱建宁杜依青管振锋王新阳范晋海西安交通大学第一附属医院泌尿外科陕西西安710061 西安交通大学环境与疾病相关基因教育部重点实验室陕西西安710061

目的研究残疾基因同源物2(DAB2)相互作用蛋白(DAB2IP)在人膀胱癌组织中的表达并分析与肿瘤病理分级、临床分期的相关性,同时观察DAB2IP与膀胱癌化疗耐药的关系。方法通过免疫组织化学染色方法检测初发和复发膀胱癌中DAB2IP的表达差异。... 详细信息

目的研究残疾基因同源物2(DAB2)相互作用蛋白(DAB2IP)在人膀胱癌组织中的表达并分析与肿瘤病理分级、临床分期的相关性,同时观察DAB2IP与膀胱癌化疗耐药的关系。方法通过免疫组织化学染色方法检测初发和复发膀胱癌中DAB2IP的表达差异。应用RNA干涉(RNAi)技术敲低5637和253J膀胱癌细胞中DAB2IP的表达后,采用MTT法、克隆形成实验验证癌细胞对吡柔比星的敏感性的变化,流式细胞术检测吡柔比星处理后DAB2IP低表达细胞的凋亡率。结果 DAB2IP的表达与膀胱癌TNM分期、病理分级及淋巴结转移等负相关,复发的膀胱癌组织DAB2IP的表达低于初发膀胱癌组织。DAB2IP的低表达与膀胱癌细胞抗药性相关,敲低DAB2IP的水平增强膀胱癌细胞的集落形成能力,促凋亡蛋白PARP和caspase-3表达减少,抑制凋亡蛋白Bcl-2和Mcl-1的表达增加,癌细胞凋亡能力降低、引起化疗耐受。结论敲低DAB2IP的水平可促进膀胱癌细胞的增殖并抑制凋亡,同时增强其化疗耐受性。

关键词：膀胱癌 DAB2相互作用蛋白(DAB2IP) 化疗耐药

A Simplified Nonlinear Model of Vertical Vortex-Induced Force on Box Decks for Predicting Stable Amplitudes of Vortex-Induced Vibrations

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Engineering 2017年第6期3卷 854-862页

作者： Le-Dong zhu Xiao-Liang Meng Lin-Qing du Ming-Chang ding State Key Laboratory of Disaster Reduction in Civil Engineering & Department of Bridge Engineering College of Civil Engineering & Key Laboratory for Wind Resistance Technology of Bridges of Ministry of Transport Tongji University Shanghai 200092 China Shanghai Urban Construction Municipal Engineering (Croup) Co. Ltd. Shanghai 200065 China Tongji Architectural Design (Group) Co. Ltd. Shanghai 200092 China Highway Planning Survey Design and Research Institute Sichuan Provincial Transport Department Chengdu 610041 China

Wind-tunnel tests of a large-scale sectional model with synchronous measurements of force and vibration responses were carried out to investigate the nonlinear behaviors of vertical vortex-induced forces （VIFs） on three typical box decks （i.e., fully closed box, centrally slotted box, and semi-closed box）. The mechanisms of the onset, development, and self-limiting phenomenon of the vertical vortex-induced vibration （VlV） were also explored by analyzing the energy evolution of different vertical VIF components and their contributions to the vertical VIV responses. The results show that the nonlinear components of the vertical VIF often differ from deck to deck; the most important components of the vertical VIF, governing the stable amplitudes of the vertical VIV responses, are the linear and cubic components of velocity contained in the self-excited aerodynamic damping forces. The former provides a constant negative damping ratio to the vibration system and is thus the essential power driving the development of the VIV amplitude, while the latter provides a positive damping ratio proportional to the square of the vibration velocity and is actually the inherent factor making the VIV amplitude self-limiting. On these bases, a universal simplified nonlinear mathematical model of the vertical VIF on box decks of bridges is presented and verified in this paper; it can be used to predict the stable amplitudes of the vertical VIV of long-span bridges with satisfactory accuracy.

关键词： Box deck of bridge Vertical vortex-induced vibration Vertical vortex-induced force Simplified nonlinear model Wind-tunnel test Large-scale sectional model Synchronous measurement of force and vibration

An integrated geospatial information service system for disaster management in China

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International Journal of Digital Earth 2015年第11期8卷 918-945页

作者： Yulin ding Yida Fan Zhiqiang du Qing zhu Wei Wang Sanchao Liu Hui Lin State Key Laboratory of Information Engineering in Surveying Mapping and Remote SensingWuhan UniversityWuhanP.R.China Institute of Space and Earth Information Science the Chinese University of Hong KongHong KongP.R.China National Disaster Reduction Center of China Ministry of Civil AffairsBeijingP.R.China National-Local Joint Engineering Laboratory of Spatial Information Technology for High-speed Railway Running Safety Southwest Jiaotong UniversityChengduP.R.China

The Chinese Government and citizens face enormous challenges of disaster management as widespread devastation,economic damages,and loss of human lives caused by increasing natural *** management requires a complicated iterative process that includes disaster monitoring,early detection,forecasting,loss assessment,and efficient analysis of disaster *** task typically involves the use of technologists and multiple geospatial information resources,including sensors,data sources,models,geo-tools,software packages,and computing ***,most existing disaster management systems operate in a typical passive data-centric mode,where resources cannot be fully *** impediment is partially being addressed by the increasingly complex application requirements and the growing availability of diverse *** this paper,we summarize and analyze the practical problems experienced by the National Disaster Reduction Application System of *** address the issues of data-centric,centralized,isolated solutions,we propose a novel Focusing Service Mechanism,which is capable of scheduling and allocating for optimum utilization of multiple resources,to dynamically generate collaborative and on-demand disaster information *** also demonstrate the design and implementation of the Integrated Disaster Information Service System(IDISS).Through the service strategies of Virtualizing,Wrapping,and Integrating,disasterrelated resources are constructed into services in the *** services are dynamically aggregated into focusing service chains,for diverse disaster management *** applications illustrate that the proposed service system can significantly improve the capability of disaster management in China.

关键词： disaster management system focusing service mechanism active ondemand disaster information service resource integration and collaboration