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A Multilayer Network Constructed for Herb and Prescription Efficacy Analysis

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Computer Systems Science & Engineering 2024年第3期48卷 691-704页

作者： Xindi Huang liwei Liang Sakirin Tam Hao Liang Xiong Cai Changsong ding School of Informatics Hunan University of Chinese MedicineChangsha410208China Faculty of Science and Information Technology Phnom Penh International UniversityPhnom Penh12253Cambodia institute of TCM Diagnostics Hunan University of Chinese MedicineChangsha410208China institute of Innovation and Applied Research in Chinese Medicine Hunan University of Chinese MedicineChangsha410208China Big Data Analysis Laboratory of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha410208China

Chinese Medicine(CM)has been widely used as an important avenue for disease prevention and treatment in china especially in the form of CM prescriptions combining sets of herbs to address patients’symptoms and ***,the selection and compatibility of herbs are complex and abstract due to intrinsic relationships between herbal properties and their overall *** analysis is applied to demonstrate the complex relationships between individual herbal efficacy and the overall function of CM *** illustrate their connections and correlations,prescription function(PF),prescription herb(PH),and herbal efficacy(HE)intranetworks are proposed based on CM theory to identify relationships between herbs and *** three networks are then connected by PF-PH and PH-HE interlayer networks adopting herb dosage to form a multidimensional heterogeneous network,a Prescription-Herb-Function Network(PHFN).The network is applied to 112.classic prescriptions from Treatise on Exogenous Febrile and Miscellaneous Diseases to illustrate the application of *** PHFN is constructed including 146 functions in PF intra network,89 herbs in the PH intra network,and 163 herbal efficacies in the HE intra *** results show that herb pairs with synergistic actions have stronger relevance,such as licorice-cassia twig,licorice-Chinese date,fresh ginger-Chinese date,*** integration of dosage to the network helps to indicate the main herbs for cluster analysis and automatic *** also reveals the internal relationships between the functions of prescriptions and composed herbal efficacies.

关键词： Chinese medicine herb formula network analysis herb dosage

Natural vibration and critical velocity of translating Timoshenko beam with non-homogeneous boundaries

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Applied Mathematics and Mechanics(English Edition) 2024年第9期45卷 1523-1538页

作者： Yanan LI Jieyu ding Hu ding Liqun CHEN Shanghai institute of Applied Mathematics and Mechanics Shanghai Key Laboratory of Mechanics in Energy EngineeringShanghai Frontier Science Center of MechanoinformaticsSchool of Mechanics and Engineering ScienceShanghai UniversityShanghai 200072China School of Mathematics and Statistics Qingdao UniversityQingdao 266071Shandong ProvinceChina

In most practical engineering applications,the translating belt wraps around two fixed *** boundary conditions of the dynamic model are typically specified as simply supported or fixed *** this paper,non-homogeneous boundaries are introduced by the support *** the translating belt as the mechanical prototype,the vibration characteristics of translating Timoshenko beam models with nonhomogeneous boundaries are investigated for the first *** governing equations of Timoshenko beam are deduced by employing the generalized Hamilton's *** effects of parameters such as the radius of wheel and the length of belt on vibration characteristics including the equilibrium deformations,critical velocities,natural frequencies,and modes,are numerically calculated and *** numerical results indicate that the beam experiences deformation characterized by varying curvatures near the *** radii of the wheels play a pivotal role in determining the change in trend of the relative difference between two beam *** the results unearths that the relative difference in equilibrium deformations between the two beam models is more pronounced with smaller-sized *** the two wheels are of equal size,the critical velocities of both beam models reach their respective *** addition,the relative difference in natural frequencies between the two beam models exhibits nonlinear variation and can easily exceed 50%.Furthermore,as the axial velocities increase,the impact of non-homogeneous boundaries on modal shape of translating beam becomes more *** dealing with non-homogeneous boundaries is challenging,beam models with non-homogeneous boundaries are more sensitive to parameters,and the differences between the two types of beams undergo some interesting variations under the influence of non-homogeneous boundaries.

关键词： translating beam Timoshenko beam non-homogeneous boundary natural frequency critical velocity

Targeted nanostrategies eliminate pre-metastatic niche of cancer

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Nano Research 2024年第6期17卷 5358-5373页

作者： Juan Wang Ning Zhang Xiuping ding Chengrui Fu Xiaodong Li Baosheng Li Jianxun ding Tianmeng Sun Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education Institute of ImmunologyThe First HospitalJilin University1 Xinmin StreetChangchun 130061China Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of Sciences5625 Renmin StreetChangchun 130022China Department of Radiation Oncology Shandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical Sciences440 Jiyan RoadJinan 250117China Department of orthopaedics The Second Hospital of Shandong UniversityShandong University247 Beiyuan StreetJinan 250033China State Key Laboratory of Molecular Engineering of Polymers Fudan University220 Handan RoadShanghai 200433China

Establishing a pre-metastatic niche(PMN)in secondary organs is a prerequisite for cancer *** advances in cancer therapy,the efficient inhibition of PMN formation remains a clinical *** advances in understanding the specific characteristics of PMN and advances in nanotechnology have provided hope for manipulating their microenvironments.A series of nanostrategies have been designed to eliminate the PMN,including the removal of pro-metastatic exosomes from the bloodstream for excretion via the intestines,the targeting and scavenging of myeloid-derived suppressor cells,fibroblasts,and critical extracellular matrix components,and the elimination of circulating tumor cells prior to colonization in distant *** review summarizes the underlying mechanisms of PMN formation,high{2.s the anti-PMN efficacy of currently reported nanostrategies,and underlines the unresolved questions.

关键词： nanoparticle controlled drug delivery pre-metastatic niche elimination metastasis suppression cancer therapy

MYB2.and MYB108 regulate lateral root development by interacting with LBD2. in Arabidopsis thaliana

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Journal of Integrative Plant Biology 2024年第8期66卷 1675-1687页

作者： Feng Zhang Junxia Wang Tingting ding Xuefeng Lin Haiying Hu Zhaojun ding Huiyu Tian The Key Laboratory of Plant Development and Environmental Adaptation Biology Ministry of EducationSchool of Life SciencesShandong UniversityQingdao 266237China Advanced Medical Research institute Cheeloo College of MedicineShandong UniversityJinan 250012China

AUXIN RESPONSE FACTOR 7(ARF7)-mediated auxin signaling plays a key role in lateral root(LR)development by regulating downstream LATERAL ORGAN BOUNDARIES DOMAIN(LBD)transcription factor genes,including LBD16,LBD18,and *** proteins are believed to regulate the transcription of downstream genes as homodimers or ***,whether LBD2. forms dimers with other proteins to regulate LR development remains ***,we determined that the Arabidopsis thaliana(L.)*** transcription factors MYB2.and MYB108 interact with LBD2. and regulate auxin-induced LR *** MYB2.and MYB108 were induced by auxin in an ARF7-dependent *** of MYB2.by fusion with an SRDX domain severely affected auxin-induced LR formation and the ability of LBD2. to induce LR *** contrast,overexpression of MYB2.or MYB108 resulted in greater LR numbers,except in the lbd2. mutant *** findings underscore the interdependence and importance of MYB2.MYB108,and LBD2. in regulating LR *** addition,MYB2.LBD2. and MYB108–LBD2. complexes promoted the expression of CUTICLE DESTRUCTING FACTOR 1(CDEF1),a member of the GDSL(Gly-Asp-Ser-Leu)lipase/esterase family involved in LR *** summary,this study identified MYB2.LBD2. and MYB108–LBD2. regulatory modules that act downstream of ARF7 and intricately control auxin-mediated LR development.

关键词： ARF7 auxin lateral roots LBD2. MYB108 MYB2

Dynamical symmetric group approach to potential energy surface of molecule O_3

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Chinese Science Bulletin 2000年第4期45卷 331-334页

作者： ZHENG Yujun & ding Shilianginstitute of Theoretical Chemistry, {2. University, jinan 2.0100, china institute of Theoretical Chemistry Shandong University Jinan China

Hamiltonian of an O3 molecule is classicized by using coherent states, and its potential energy surface is obtained. The surface and the contours are plotted. The calculated force constants and dissociation energies a... 详细信息

关键词： dynamical symmetric group potential energy surface molecule 03.

Distributed Fault Estimation for Nonlinear Systems With Sensor Saturation and Deception Attacks Using Stochastic Communication Protocols

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IEEE/CAA Journal of Automatica Sinica 2024年第8期11卷 1865-1876页

作者： Weiwei Sun Xinci Gao Lusong ding Xiangyu Chen institute of Automation Qufu Normal UniversityQufu 273165China

This paper is aimed at the distributed fault estimation issue associated with the potential loss of actuator efficiency for a type of discrete-time nonlinear systems with sensor *** the distributed estimation structure under consideration,an estimation center is not necessary,and the estimator derives its information from itself and neighboring nodes,which fuses the state vector and the measurement *** an effort to cut down data conflicts in communication networks,the stochastic communication protocol(SCP)is employed so that the output signals from sensors can be ***,a recursive security estimator scheme is created since attackers randomly inject malicious signals into the selected *** this basis,sufficient conditions for a fault estimator with less conservatism are presented which ensure an upper bound of the estimation error covariance and the mean-square exponential boundedness of the estimating ***,a numerical example is used to show the reliability and effectiveness of the considered distributed estimation algorithm.

关键词： Actuator fault deception attacks distributed estimation sensor saturation stochastic communication protocol(SCP).

Recent progress on Sn_(3)O_(4)nanomaterials for photocatalytic applications

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International Journal of Minerals,Metallurgy and Materials 2024年第2期31卷 231-244页

作者： Xin Yu Congcong Li Jian Zhang Lili Zhao Jinbo Pang Longhua ding institute for Advanced Interdisciplinary Research(iAIR) School of Chemistry and Chemical EngineeringUniversity of JinanJinan 250022China School of Sino-German Engineering Shanghai Technical Institute of Electronics and InformationShanghai 201411China Division of Systems and Synthetic Biology Department of Life SciencesChalmers University of Technology41296 GöteborgSweden

Tin(IV)oxide(Sn_(3)O_(4))is layered tin and exhibits mixed valence *** has emerged as a highly promising visible-light pho-tocatalyst,attracting considerable *** comprehensive review is aimed at providing a detailed overview of the latest advance-ments in research,applications,advantages,and challenges associated with Sn_(3)O_(4)photocatalytic *** fundamental con-cepts and principles of Sn_(3)O_(4)are ***_(3)O_(4)possesses a unique crystal structure and optoelectronic properties that allow it to ab-sorb visible light efficiently and generate photoexcited charge carriers that drive photocatalytic ***,strategies for the control and improved performance of Sn_(3)O_(4)photocatalytic nanomaterials are *** control,ion doping,and hetero-structure construction are widely employed in the optimization of the photocatalytic performance of Sn_(3)O_(4)*** effective imple-mentation of these strategies improves the photocatalytic activity and stability of Sn_(3)O_(4)***,the review explores the diverse applications of Sn_(3)O_(4)photocatalytic nanomaterials in various fields,such as photocatalytic degradation,photocatalytic hydro-gen production,photocatalytic reduction of carbon dioxide,solar cells,photocatalytic sterilization,and optoelectronic *** discus-sion focuses on the potential of Sn_(3)O_(4)-based nanomaterials in these applications,highlighting their unique attributes and ***,the review provides an outlook on the future development directions in the field and offers guidance for the exploration and de-velopment of novel and efficient Sn_(3)O_(4)-based *** the identification of emerging research areas and potential avenues for improvement,this review aims to stimulate further advancements in Sn_(3)O_(4)-based photocatalysis and facilitate the translation of this promising technology into practical applications.

关键词： photocatalysis Sn_(3)O_(4)nanomaterials building heterostructures antibacterial therapy water splitting

SS-LASS Zircon Dating Deciphering Multiple Episodes of Anatexis in a Deeply-Subducted Continental Crust:An Example from Sulu Orogen,china

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Journal of Earth Science 2024年第1期35卷 85-98页

作者： Peng Feng Lu Wang Xiawen Li Wenjie ding Zhe Chen School of Resource&Environment and Safety Engineering University of South ChinaHengyang 421001China State Key Laboratory of Geological Processes and Mineral Resources Center for Global TectonicsSchool of Earth SciencesChina University of GeosciencesWuhan 430074China No.8 institute of Geology and Mineral Resources Exploration of shandong Province Rizhao 276826China

‘Single shot'laser-ablation split-stream(SS-LASS)technique analyzing unpolished zircon grains makes their thin rims tenable for determination,which thus offers great potential in deciphering the timing of multiple and short-lived episodes of anatexis and metamorphism in deeplysubducted continental *** granitic gneisses in the deeply subducted continental crust undergoing considerable fluid-melt activities persist multistage growth of ***,a comparative study of SS-LASS and laser ablation inductively coupled plasma mass spectrometer(LA-ICP-MS)zircon dating was conducted on the granitic gneisses from the Sulu belt in this *** mostly show a core-mantle-rim structure with CL-bright rims thinner than 5μ*** LA-ICP-MS dating,relict magmatic zircon cores yield protolith ages of ca.756-747 Ma;whereas the dark mantles record synexhumation anatexis at ca.2.4 *** contrast,according to the U-Pb dates,trace element features,zircon crystallization temperatures and geological context,SS-LASS zircon petrochronology deciphers three episodes of anatectic events,as follows:(i)the first episode of anatexis at ca.2.8-2.7 Ma dominated by phengite-breakdown melting,likely facilitating the exhumation of the UHP slice from mantle depth;(ii)the second episode of anatexis at ca.193–191 Ma indicating part of northern Dabie-Sulu belt was still“hot”because of buried in the thickened orogenic crust at that time;(iii)the third episode of anatexis(ca.162.161 Ma)consistent with the intrusion ages(ca.161–141 Ma)of the Jurassic to Cretaceous granitoids in this orogen,suggesting the initial collapse of the orogenic root of the Sulu belt occurred at Late Jurassic due to the Izanagi plate initially subducting beneath the margin of Eastern *** study sheds new light upon the utilization of SS-LASS petrochronology deciphering multiple anatectic events in the deeply-subducted continental crust and supports us in better understanding the tectonic evolution of Dabie-

关键词： anatexis laser ablation laser-ablation split-stream ultrahigh-pressure metamorphic belt Sulu Orogen

The isotopic effects in the IR-multiphoton excitation of molecules with c_(2.) symmetry

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Chinese Journal of Chemistry 1993年第4期11卷 321-328页

作者： ding,Shi-Liang LIU,Wen-Jian DENG,Cong-Hao institute for theoretical chemistry,{2. University,jinan,{2. 2.0100 institute for theoretical chemistry. shandong University Jinan Shandong 250100

Quantum dynamical calculations for the IR-multiphoton excitation of H_2.,D_2. and T_2. are presented using a generalized Hamiltonian for XY_2.*** energy spectra obtained from this Hamiltonian are in good agreement with those of the *** long time average of the transition probabilities and the isotopic effects are discussed in detail,

关键词： The isotopic effects in the IR-multiphoton excitation of molecules with c symmetry IR