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Enhanced Crystallization Kinetics of PLLA by Ethoxycarbonyl Ionic Liquid Modified Graphene

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Chinese Journal of Polymer science 2019年第3期37卷 243-252页

作者： Pei Xu zhao-Pei Cui gang Ruan Yun-Sheng ding department of Polymer science and engineering School of Chemistry and Chemical Engineering and Anhui Key Laboratory of Advanced Functional Materials and Devices Hefei University of Technology

To investigate the performance of graphene(Gra) modified with ethoxycarbonyl ionic liquid(IL), chain mobility and crystallization kinetics of poly(L-lactic acid)(PLLA), a series of PLLA nanocomposites have been prepared using solution-cast *** can improve the dispersion of Gra in PLLA matrix and the samples containing IL have higher growth rate of PLLA spherulite than neat PLLA does. PLLA/IL/Gra and PLLA/2 Gra exhibit the same relaxation strength and time of αN relaxation that corresponds to the longest normal mode motion at 110-140 °C. PLLA/IL/Gra shows a faster crystallization rate than PLLA/2 Gra does, which might be attributed to the Gra-imidazolium cation interaction in IL modified Gra, the significant dispersion effect of IL at Gra surface, and the increase of nuclei density of PLLA/IL/Gra.

关键词： Ionic liquid Graphene PLLA Crystallization Dielectric behavior

Effect of Heat Treatment on Microstructure and Mechanical Properties of Quenching and Partitioning Steel

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Acta Metallurgica Sinica(English Letters) 2018年第2期31卷 216-224页

作者： Shao-Heng Sun Ai-Min zhao Ran ding Xiao-gang Li Collaborative Innovation Center of Steel Technology University of Science and Technology Beijing Key Laboratory for Advanced materials of Ministry of Education School of Materials Science and EngineeringTsinghua University New Technology department Beijing Electric Vehicle CO.LTD

In order to investigate the effect of microstructural characterization on the mechanical properties and retained austenite stability, a different type of quenching and partitioning steel（I-Q＆P） through intercritical annealing before the quenching and partitioning process was designed, which can realize lamellar intercritical microstructure compared to the conventional quenching and partitioning（Q＆P） process. The morphology of ferrite and martensite/retained austenite is lamellar in the I-Q＆P steel while it is equiaxed after being heat-treated by conventional Q＆P process. The I-Q＆P steel is proved to have better formability and mechanical properties than conventional Q＆P steel, which is due to the highervolume fraction of retained austenite in the I-Q＆P steel and confirmed by electron backscattering diffraction patterns and X-ray diffraction. Furthermore, the stability of retained austenite in I-Q＆P steel is also higher than that in conventional Q＆P steel, which is investigated by tensile tests and differential scanning calorimetry.

关键词： Quenching and partitioning steel Heat treatment Retained austenite Stability Activation energy

Precise nanomedicine for intelligent therapy of cancer

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science China Chemistry 2018年第12期61卷 1503-1552页

作者： Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing zhao Weihong Tan Xi Zhang Yuliang zhao State Key Laboratoiy of Radiation Medicine and Protection Jiangsu Key Laboratoiy of Neuropsychiatric Diseases College of Pharmaceutical Sciences Soochow University Suzhou 215123 China Key Laboratoiy of Biomedical Polymers of Ministry of Education Department of Chemistiy Wuhan University Wuhan 430072 China Laboratoiy of Molecular Imaging and Nanomedicine National Institute of Biomedical Imaging and Bioengineering National Institutes of Health Bethesda MD 20892 USA Molecular science and Biomedicine Laboratoiy State Key Laboratory of Chemo/Bio-Sensing and Chemometrics College of Chemistiy and Chemical Engineering Aptamer Engineering Center of Hunan Province Hunan University Changsha 410082 China Jiangsu Key Laboratoiy for Carbon-Based Functional materials & Devices Institute of Functional Nano & Soft Materials Soochow University Suzhou 215123 China department of Polymer science and engineering College cf Chemistry and Chemical Engineering Nanjing University Nanjing 210093 China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University Xiamen 361102 China department of Chemistiy Tsinghua University Beijing 100084 China National engineering Research Center for Nanomedicine College of Life Science and Technology Huazhong University of Science and Technology Wuhan 430074 China department of Chemistiy and department of Physiology and Functional Genomics Center for Research at Bio/nano Interface Health Cancer Center UF Genetics Institute and McKnight Brain Institute University of Florida Gainesville FL 32611-7200 USA institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China CAS Key Laboratoiy for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of China Beijing 100190 China university of Chinese Academy of sciences Beijing 100049 China Key Labo

Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations.

关键词： nanomedicine nanoparticles cancer therapy cancer imaging intelligent therapy

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran ding Siqin dingl Yadong ding Haiyi Dong Jianin AGH university of science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui university HefeiAnhui Applied Physics department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu university Institute of ScienceVaranasi Bandirma Onyedi Eylul university Bandirma Beihang university Beijing Beijing Computational science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal university Beijing Brown university ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad university Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo university Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal university WuhanHubei Central South university ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang university HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China university of Geosciences Beijing China university of Geosciences WuhanHubei China university of Mining and Technology XuzhouJiangsu China West Normal university NanchongSichuan Chongqing university Department of PhysicsChongqing Chulalongkorn university Bangkok City university of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell university IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu university DalianLiaoning Dalian university of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China university Of science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

纳米器件空间辐射效应机理和模拟试验技术研究进展

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科学通报 2018年第13期63卷 1211-1222页

作者：陈伟刘杰马晓华郭刚赵元富郭晓强罗尹虹姚志斌丁李利王晨辉陈荣梅何宝平赵雯张凤祁马武英翟鹏飞王祖军刘天奇郭红霞刘建德杨海亮胡培培丛培天李宗臻西北核技术研究所强脉冲辐射环境模拟与效应国家重点实验室西安710024 中国科学院近代物理研究所兰州730000 西安电子科技大学微电子学院西安710126 中国原子能研究院抗辐照应用技术创新中心北京102413 北京微电子技术研究所北京100076 清华大学工程物理系北京100084

电子器件空间辐射效应是影响航天器在轨长期可靠运行的重要因素之一,一直是国际上抗辐射加固技术领域研究的热点和难点.高可靠、高集成度、高性能、低功耗、低成本是未来新一代先进电子系统发展的必然要求,采用更高性能的抗辐射加固纳... 详细信息

电子器件空间辐射效应是影响航天器在轨长期可靠运行的重要因素之一,一直是国际上抗辐射加固技术领域研究的热点和难点.高可靠、高集成度、高性能、低功耗、低成本是未来新一代先进电子系统发展的必然要求,采用更高性能的抗辐射加固纳米器件是必然的趋势.本文在深入调研国内外研究现状的基础上,分析了纳米器件辐射效应面临的新问题.纳米工艺存在着很多不同于大尺寸工艺的特点,沟道长度缩小到十几个纳米,栅氧化层等效厚度小于1 nm.在工艺上引入了纵向逆掺杂阱或横向晕环掺杂技术,以降低栅极诱导漏极漏电效应;在材料上引入了多元半导体材料、应变硅、锗硅、高k栅介质、金属栅极等,以降低器件功耗;在结构上引入了三维Fin FET结构,以增强栅的控制能力.这种趋于物理极限的工艺特点、新材料和新结构的采用产生了许多新的辐射效应现象和机制,模拟试验技术更加复杂,给抗辐射加固技术研究带来了新的挑战.本文综述了纳米器件辐射效应的研究现状和趋势,重点针对28 nm及以下特征工艺纳米器件辐射效应研究及模拟试验的需求,提出了需要研究的科学问题和关键技术,希望能为纳米器件抗辐射加固与空间应用提供参考.

关键词：纳米器件空间辐射效应抗辐射加固模拟试验

基于磁共振灌注加权成像和支持向量机鉴别脑泡型包虫病与脑转移瘤

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磁共振成像 2022年第4期13卷 26-31页

作者：努尔比耶姆·阿布力克木杨静刘珺迪高欣王刚赵晶晶张亚菲吉思慧姜春晖丁爽王云玲刘文亚贾文霄王俭新疆医科大学第一附属医院影像中心磁共振室乌鲁木齐830000 浙江大学医学院附属第一医院北仑分院放射科宁波315800 上海大学计算机工程与科学学院上海200444

目的探讨磁共振灌注加权成像(perfusion weighted imaging,PWI)及支持向量机(support vector machine,SVM)在脑泡型包虫病(cerebral alveolar echinococcosis,CAE)和脑转移瘤(brain metastase,BMT)鉴别诊断的效能。材料与方法回顾性收集经病理或临床诊断为CAE与BMT的病例各15例,测量两组病灶实性区、灶周水肿和对侧相对正常实质灌注参数,包括相对脑血容量(relative cerebral blood volume,rCBV)、相对脑血流量(relative cerebral blood flow,rCBF)、平均通过时间(mean transit time,MTT)和达峰时间(time to peak,TTP),评估各参数诊断CAE与BMT的效能,并基于灌注参数,运用SVM等机器学习方法鉴别两种疾病。结果CAE病灶实性区rCBF,rCBV诊断曲线下面积(area under curve,AUC)为0.739,0.710,BMT病灶实性区rCBF,rCBV诊断AUC为0.960,0.913,CAE与BMT病灶实性区rCBF和rCBV的诊断效率高于MTT和TTP;CAE与BMT病灶实性区rCBF、rCBV、TTP值差异有统计学意义(P<0.01)。CAE水肿区与BMT水肿区rCBF、rCBV值差异有统计学意义(P<0.01);基于病灶实性区灌注参数,运用SVM分类器可提高鉴别准确率。结论PWI可为CAE与BMT的鉴别诊断提供客观依据。SVM分类方法可提高PWI鉴别两种病灶的准确率。

关键词：脑泡型包虫病脑转移瘤磁共振成像灌注加权成像支持向量机