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Journal of Rare Earths 2024年第8期42卷 1604-1609,I0007页

作者： Daiming Liu Fei Wang Yongtao Zhang Ya'nan ding Shandong Engineering Llaboratony for Preparation and Application of High performance Carbon-Materials College of Electromechanical EngineeringQingdao University of Science&TechnologyQingdao266061China College of Electronic and Information Engineering Shandong University of Science and TechnologyQingdao266590China

The use of high-permittivity(high-k) thin films as gate dielectrics is essential in the development of lowpower electronics,In this work,rare-earth thulium oxide(Tm_(2)O_(3)) thin films were prepared by a facile solution process and annealed at various temperatures from 400 to 700℃.The evolution of the physical and dielectric properties of Tm_(2)O_(3) thin film with annealing temperature was *** is demonstrated that the Tm_(2)O_(3) thin film annealed at 600℃ exhibits the optimal performance,including a low leakage current of 3×10^(-10) A/cm^(2),a large areal capacitance of 250 nF/cm^(2) at 100 Hz,and a high permittivity value of *** Tm_(2)O_(3) thin film as a gate insulator was integrated into the thin film transistor(TFT) employing In_(2)O_(3)-based semiconducting *** In_(2)O_(3) TFT with 600℃-annealed Tm_(2)O_(3) dielectric exhibits the superior perfo rmance,with a high I_(on)/I_(off) of 1.65×10^(7),a small subthre shold swing(SS) value of 0.2 V/dec,a V_(TH) of+1.8 V,and a mobility of 1.68 cm^(2)/(V·s).Furthermore,an inverter constructed by connecting the TFT with a resistor exhibits full-swing *** work provides a facile and appealing method for preparing the high-k Tm_(2)O_(3) thin films as alternative gate dielectrics with the potential for use in low-power electronics and logic circuit applications.

关键词： Rare earths Tm_(2)O_(3) Dielectric Transistor Inverter

Conditioned medium from human dental pulp stem cells treats spinal cord injury by inhibiting microglial pyroptosis

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Neural Regeneration Research 2024年第5期19卷 1105-1111页

作者： Tao Liu Ziqian Ma Liang Liu Yilun Pei Qichao Wu Songjie Xu Yadong Liu nan ding Yun Guan Yan Zhang Xueming Chen Department of Orthopedic Surgery Beijing Luhe HospitalCapital Medical UniversityBeijingChina Department of Orthopedic Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijingChina Department of Stomatology Beijing Luhe HospitalCapital Medical UniversityBeijingChina Department of Anesthesiology and Critical Care Medicine School of MedicineJohns Hopkins UniversityBaltimoreMDUSA Department of Neurological Surgery School of MedicineJohns Hopkins UniversityBaltimoreMDUSA

Human dental pulp stem cell transplantation has been shown to be an effective therapeutic strategy for spinal cord ***,whether the human dental pulp stem cell secretome can contribute to functional recovery after spinal cord injury remains *** the present study,we established a rat model of spinal cord injury based on impact injury from a dropped weight and then intraperitoneally injected the rats with conditioned medium from human dental pulp stem *** found that the conditioned medium effectively promoted the recovery of sensory and motor functions in rats with spinal cord injury,decreased expression of the microglial pyroptosis markers NLRP3,GSDMD,caspase-1,and interleukin-1β,promoted axonal and myelin regeneration,and inhibited the formation of glial *** addition,in a lipopolysaccharide-induced BV2 microglia model,conditioned medium from human dental pulp stem cells protected cells from pyroptosis by inhibiting the NLRP3/caspase-1/interleukin-1β*** results indicate that conditioned medium from human dental pulp stem cells can reduce microglial pyroptosis by inhibiting the NLRP3/caspase-1/interleukin-1βpathway,thereby promoting the recovery of neurological function after spinal cord ***,conditioned medium from human dental pulp stem cells may become an alternative therapy for spinal cord injury.

关键词： BV2 conditioned medium dental pulp stem cells GSDMD microglia neuroinflammation NLRP3 pyroptosis spinal cord injury

Invisible and semi-invisible decays of bottom baryons

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Chinese Physics C 2024年第8期48卷 127-139页

作者： Yong Zheng Jian-nan ding Dong-Hao Li Lei-Yi Li Cai-Dian Lü Fu-Sheng Yu MOE Frontiers Science Center for Rare Isotopes Lanzhou UniversityLanzhou 730000China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China Center for High Energy Physics Peking UniversityBeijing 100871China Institute of High Energy Physics CASBeijing 100049China School of Physical Sciences University of Chinese Academy of SciencesBeijing 101408China

The similar densities of dark matter and baryons in the universe imply that they may arise from the same ultraviolet model.B-Mesogenesis,which assumes dark matter is charged under the baryon number,attempts to simultaneously explain the origin of baryon asymmetry and dark matter in the *** particular,B-Mesogenesis may induce bottom-baryon decays into invisible or semi-invisible final states,which provide a distinctive signal for probing this *** this work,we systematically study the invisible decays of bottom baryons into dark matter and the semi-invisible decays of bottom baryons into a meson or a photon together with a dark matter *** particular,the fully invisible decay can reveal the stable particles in *** QCD-based frameworks are used to calculate the hadronic matrix elements under the B-Mesogenesis *** estimate the constraints on the Wilson coefficients or the product of some new physics couplings with the Wilson coefficients according to the semi-invisible and invisible decays of bottom baryons detectable at future colliders.

关键词： baryon asymmetry dark matter B-Mesogenesis invisible and semi-invisible decay bottom baryons

Multidimensional regulation of Ti-Zr-Cr-Mn hydrogen storage alloys via Y partial substitution

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nano Research 2024年第5期17卷 4211-4220页

作者： Haixiang Xiu Wanqiang Liu Dongming Yin nan ding Wenfeng Qiao Shaolei Zhao Long Liang Cong Liu Shaohua Wang Qingshuang Wang Bingbing Chen Limin Wang Yong Cheng School of Materials Science and Engineering Changchun University of Science and TechnologyChangchun 130022China State Key Laboratory of Rare Earth Resources Utilization Changchun Institute of Applied ChemistryChinese Academy of Sciences(CAS)Changchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China Department of Energy Science and Engineering Nanjing Tech UniversityNanjing 211816China National Engineering Research Center of Nonferrous Metals Materials and Products for New Energy GRINM Group Co.Ltd.Beijing 100088China GRIMAT Engineering Institute Co. Ltd.Beijing 101407China College of Life Science and Technology Changchun University of Science and TechnologyChangchun 130022China

High density and safe storage of hydrogen are the preconditions for the large-scale application of hydrogen ***,the hydrogen storage properties of Ti_(0.6)Zr_(0.4)Cr_(0.6)Mn_(1.4) alloys are systematically studied by introducing Y element instead of Ti element through vacuum arc *** the partial substitution of Y,a second phase of rare earth oxide is added in addition to the main suction hydrogen phase,C14 Laves *** to the unique properties of rare earth elements,the partial substitution of Y can not only improve the activation properties and plateau pressure of the alloys,but also increase the effective hydrogen storage capacity of the *** comprehensive properties of hydrogen storage alloys are improved by multidimensional regulation of rare earth *** them,Ti_(0.552)Y_(0.048)Zr_(0.4)Cr_(0.6)Mn_(1.4) has the best comprehensive *** alloy can absorb hydrogen without activation at room temperature and 5 MPa,with a maximum hydrogen storage capacity of 1.98 wt.%.At the same time,it reduces the stability of the hydride and the enthalpy change value,making it easier to release *** theoretical analysis and first-principle simulation,the results show that the substitution of Y element reduces the migration energy barrier of hydrogen and the structural stability of the system,which is conducive to hydrogen *** alloy has superior durability compared to the original alloy,and the capacity retention rate was 96.79%after 100 hydrogen absorption/desorption cycles.

关键词： AB_(2)-type hydrogen storage alloy rare earth element first-principles simulation multidimensional regulation

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考虑滑移的钢-混凝土组合箱梁畸变效应研究

计算力学学报 2024年第2期41卷 328-334页

作者：赵丰丁南宏冀伟兰州交通大学土木工程学院兰州730070

通过引入滑移转角位移函数,建立考虑滑移的畸变翘曲正应力,基于势能驻值原理,推导考虑滑移效应的畸变微分方程。定义了一个畸变的滑移影响系数κ,此系数仅与混凝土与钢材材料特性、栓钉类型及栓钉布置形式有关,并给出均布荷载和集中荷... 详细信息

通过引入滑移转角位移函数,建立考虑滑移的畸变翘曲正应力,基于势能驻值原理,推导考虑滑移效应的畸变微分方程。定义了一个畸变的滑移影响系数κ,此系数仅与混凝土与钢材材料特性、栓钉类型及栓钉布置形式有关,并给出均布荷载和集中荷载作用下的微分方程初参数解。建立一个考虑滑移的钢-混凝土组合箱梁的Ansys有限元模型,均布荷载作用下畸变应力与畸变角与本文理论吻合良好,验证了本文理论的正确性。将考虑滑移与不考虑滑移的结果进行对比,分析表明,均布荷载作用下考虑滑移的畸变角与畸变翘曲均小于不考虑滑移的情况,且考虑滑移的畸变角更加接近于有限元计算结果。重新定义了考虑滑移的畸变矩和畸变双力矩且考虑滑移影响的结果均大于不考虑滑移的结果。

关键词：钢-混凝土组合梁滑移效应畸变效应变分法初参数解

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新时代我国高等工程教育基层教学组织改革走向——基于扎根理论的多案例研究

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高等工程教育研究 2024年第4期 153-158页

作者：陈·巴特尔丁楠南开大学周恩来政府管理学院三亚学院社会学院

运用基于扎根理论的多案例研究方法,发现新时代我国高等工程教育基层教学组织在提升工程教育教学质量的多层次目标体系、依托课程革新发挥教学效能、特色化的形态和以合作制为核心的权力结构、多元开放和协同高质的组织成员构成等方面... 详细信息

运用基于扎根理论的多案例研究方法,发现新时代我国高等工程教育基层教学组织在提升工程教育教学质量的多层次目标体系、依托课程革新发挥教学效能、特色化的形态和以合作制为核心的权力结构、多元开放和协同高质的组织成员构成等方面开展了有益的改革探索。进而提出确立贯通政策逻辑与育人逻辑的组织目标定位、以教学学术推进组织职能的科教融合、基于人才培养目标分类重构组织形态、对接新兴产业需求创新组织架构体系、以基层教学自治为核心优化权力结构、形成多元的组织成员构成、提升组织成员质量等未来发展的建议。

关键词：高等工程教育基层教学组织扎根理论多案例研究

过去30年气候和土地利用变化对海河流域径流、泥沙及氮磷流失的影响

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自然资源学报 2024年第7期39卷 1720-1734页

作者：丁楠李义博陶福禄中国科学院地理科学与资源研究所北京100101 中国科学院大学北京100049

海河流域在国民经济可持续发展中发挥着重要作用,同时也是中国水资源最为短缺的地区之一。人口密集、长期不适当的人类活动和气候变化加剧了该区水土流失和水资源短缺等问题。因此,研究气候变化和土地利用对海河流域径流、泥沙以及氮磷... 详细信息

海河流域在国民经济可持续发展中发挥着重要作用,同时也是中国水资源最为短缺的地区之一。人口密集、长期不适当的人类活动和气候变化加剧了该区水土流失和水资源短缺等问题。因此,研究气候变化和土地利用对海河流域径流、泥沙以及氮磷流失的影响,不仅可为流域水沙灾害的预警提供理论支撑,也可为理解流域生态环境演变规律提供重要科学依据。对1985-2015年海河流域气候、土地利用、蒸散发(ET)、归一化植被指数(NDVI)和净初级生产力(NPP)等时空演变规律及其影响机制进行了解析。研究结果表明:(1)海河流域六个子流域中,各变量(ET、NDVI、NPP、径流、泥沙、氮磷等)之间的相关性存在显著的地域差异;(2)温度和降雨直接影响径流,从而间接地影响泥沙和氮磷流失;(3)蒸散发受到温度和降雨影响,直接影响径流,并间接影响泥沙和氮磷流失。由此揭示了过去30年气候和土地利用变化对径流、泥沙及氮磷流失的影响机制,对于理解流域生态环境演变规律及其调控具有重要意义。

关键词：海河流域土地利用气候变化生态水文

以咀嚼肌无力为首发和主要症状的肯尼迪病1例

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中华神经科杂志 2024年第2期57卷 176-179页

作者：鲁明南丁安红胡文立首都医科大学附属北京朝阳医院神经内科北京100020 首都医科大学附属北京朝阳医院高压氧科北京100020

肯尼迪病多以肢体无力特别是下肢无力、萎缩起病,同时伴有舌肌萎缩。文中报道1例以咀嚼肌无力、萎缩为首发和主要症状的肯尼迪病患者。患者为中年男性,咀嚼无力7年,且进行性加重,咀嚼或说话时需要用手托住下颌。病情发展过程中始终无明... 详细信息

肯尼迪病多以肢体无力特别是下肢无力、萎缩起病,同时伴有舌肌萎缩。文中报道1例以咀嚼肌无力、萎缩为首发和主要症状的肯尼迪病患者。患者为中年男性,咀嚼无力7年,且进行性加重,咀嚼或说话时需要用手托住下颌。病情发展过程中始终无明显肢体无力。体格检查:四肢肌力Ⅴ级,仅有轻度舌肌萎缩,但咀嚼肌严重萎缩无力。经基因检测,患者最终被确诊为肯尼迪病。以咀嚼肌无力、萎缩为主要临床表型的肯尼迪病较为罕见,本例患者有助于加强临床医生对这一少见临床表型的认识。

关键词：肯尼迪病咀嚼肌咀嚼无力

Stepped-up development of accelerator mass spectrometry method for the detection of ^(60)Fe with the HI-13 tandem accelerator

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Nuclear Science and Techniques 2024年第4期35卷 136-143页

作者： Yang Zhang Sheng-Quan Yan Ming He Qing-Zhang Zhao Wen-Hui Zhang Chao-Xin Kan Jian-Ming Zhou Kang-Ning Li Xiao-Fei Wang Jian-Cheng Liu Zhao-Hua Peng Zhuo Liang Ai-Ling Li Jian Zheng Qi-Wen Fan Yun-Ju Li You-Bao Wang Zhi-Hong Li Yang-Ping Shen ding nan Wei nan Yu-Qiang Zhang Jia-Ying-Hao Li Jun-Wen Tian Jiang-Lin Hou Chang-Xin Guo Zhi-Cheng Zhang Ming-Hao Zhu Yu-Wen Chen Yu-Chen Jiang Tao Tian Jin-Long Ma Yi-Hui Liu Jing-Yu Dong Run-Long Liu Mei-Yue-nan Ma Yong-Shou Chen Wei-Ping Liu Bing Guo China Institute of Atomic Energy P.O.Box 275(10)Beijing 102413China College of Science Southern University of Science and TechnologyShenzhen 518055China School of Physics Xi’an Jiaotong UniversityXi’an 710049China

The Moon provides a unique environment for investigating nearby astrophysical events such as *** samples retain valuable information from these events,via detectable long-lived“fingerprint”radionuclides such as^(60)*** this work,we stepped up the development of an accelerator mass spectrometry(AMS)method for detecting^(60)Fe using the HI-13tandem accelerator at the China Institute of Atomic Energy(CIAE).Since interferences could not be sufficiently removed solely with the existing magnetic systems of the tandem accelerator and the following Q3D magnetic spectrograph,a Wien filter with a maximum voltage of±60 kV and a maximum magnetic field of 0.3 T was installed after the accelerator magnetic systems to lower the detection background for the low abundance nuclide^(60)Fe.A 1μm thick Si_(3)N_(4) foil was installed in front of the Q3D as an energy *** particle detection,a multi-anode gas ionization chamber was mounted at the center of the focal plane of the ***,an^(60)Fe sample with an abundance of 1.125×10^(-10)was used to test the new AMS *** results indicate that^(60)Fe can be clearly distinguished from the isobar^(60)*** sensitivity was assessed to be better than 4.3×10^(-14)based on blank sample measurements lasting 5.8 h,and the sensitivity could,in principle,be expected to be approximately 2.5×10^(-15)when the data were accumulated for 100 h,which is feasible for future lunar sample measurements because the main contaminants were sufficiently separated.

关键词： Accelerator mass spectrometry Wien filter Isobar separation Supernovae Chang'e-5 lunar samples

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万古霉素治疗药物监测的热点与进展

海军军医大学学报 2024年第2期45卷 135-144页

作者：范淑盼丁楠陈美琪王卓海军军医大学(第二军医大学)第一附属医院药学部上海200433

治疗药物监测是维持万古霉素疗效和预防不良反应的重要手段,并有助于制定个体化的给药剂量方案。随着中国和美国指南关于治疗药物监测指标的更新,以24 h药-时曲线下面积(AUC_(24 h))引导的治疗药物监测逐渐成为热点。与谷浓度引导的治... 详细信息

治疗药物监测是维持万古霉素疗效和预防不良反应的重要手段,并有助于制定个体化的给药剂量方案。随着中国和美国指南关于治疗药物监测指标的更新,以24 h药-时曲线下面积(AUC_(24 h))引导的治疗药物监测逐渐成为热点。与谷浓度引导的治疗药物监测相比,AUC_(24 h)引导的治疗药物监测能够降低万古霉素引起的急性肾损伤的发生率。临床上可以通过贝叶斯法和线性药代动力学方法来实施AUC_(24 h)引导的治疗药物监测,这2种方法均可以实现AUC_(24 h)的预测,达到早期干预的目的。各医疗机构有必要根据机构实际情况选择合适的监测方法。

关键词：万古霉素治疗药物监测药-时曲线下面积谷浓度