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Bioimaging Based on Nucleic Acid Nanostructures

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Chemical Research in Chinese Universities 2021年第4期37卷 823-828页

作者： HAN Lin WANG Yuang TANG Wantao LIU Jianbing ding baoquan School of Materials Science and Engineering Henan Institute of Advanced TechnologyZhengzhou UniversityZhengzhou450001P.R.China CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing100190P.R.China

Nucleic acid nanostructures with structural programmability, spatial addressability and excellent biocompatibility have drawn much attention in various biomedical applications, such as bioimaging, biosensing and drug delivery. In this review, we summarize the recent research progress in the field of bioimaging based on nucleic acid nanostructures with different imaging models, including fluorescent imaging(FI), magnetic resonance imaging(MRI), photoacoustic imaging(PAI) and positron emission tomography/computed tomography(PET/CT) imaging. We also discuss the remaining challenges and further opportunities involved in the bioimaging research based on nucleic acid nanostructures.

关键词： Nucleic acid nanostructure DNA self-assembly Bioimaging Multimodal imaging

Shape-controllable Synthesis of Functional Nanomaterials on DNA Templates

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Chemical Research in Chinese Universities 2020年第2期36卷 171-176页

作者： ZHU Jinjinu SHANG Yingxu YU Haiyin LI Na ding baoquan College of Chemistry and Materials Science Anhui Normal UniversityWuhu 241002P.R China CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190P.R China

DNA nanotechnology enables precise organization of nanoscale objects with extraordinarily structural ***-assembled DNA nanostructures possess a lot of interesting features,such as designable size and shape,and structural addressability at nanometer *** advantage of these properties,DNA nanostructures could work as templates or molds for the controllable synthesis of functional nanomaterials,such as organic macromolecules,metallic or inorganic nonmetallic *** this review,we summarize the recent progress in the shape-controllable synthesis of functional nanomaterials on DNA *** potential application fields of these nanomaterials are also discussed.

关键词： DNA origami Templated synthesis Organic macromolecule Metallic nanomaterial Inorganic nonmetallic nanomaterial

Nucleic acid-based aggregates and their biomedical applications

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Aggregate 2021年第1期2卷 133-144页

作者： Run Tian ZhaoranWang Jianbing Liu Qiao Jiang baoquan ding CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in NanoscienceNational Center for NanoScience and TechnologyBeijingChina University of Chinese Academy of Sciences BeijingChina

The more than three decades of research in nucleic acid nanotechnology has led to the thrilling progress in rationally designed structures and artificial molecular devices with programmable functions and various *** acid–based aggregates feature precise molecular recognition and sequence programmability,versatility,as well as marked biocompatibility,providing promising candidates for biomedical *** this minireview,we summarize the recent,successful efforts to construct and employ nucleic acid–based aggregates for biomedical applications,including drug delivery,bioimaging,biosensing,cell analysis,and combined cancer *** also discuss the remaining challenges and opportunities in the field.

关键词： biomedical applications fabrication nucleic acid-based aggregates self-assembly

Logic devices based on nucleic acid self-assembly

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InfoMat 2021年第10期3卷 1070-1082页

作者： Xuehui Xu Yingxu Shang Fengsong Liu Qiao Jiang baoquan ding CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijingChina University of Chinese Academy of Sciences BeijingChina School of Materials Science and Engineering Henan Institute of Advanced TechnologyZhengzhou UniversityZhengzhouChina

Nucleic acids are natural macromolecules with the ability to store and transmit information based on the strict base-pairing *** the natural nucleic acid double helixes,various DNA/RNA nanostructures with customized geometries and functionalities have been *** with programmability and sequence-dependent responsiveness,DNA/RNA nanostructures have been employed for the rational design and construction of logic *** stimulated by internal molecular triggers and/or external stimuli,these logic gate devices can operate at nanoscale level in complex biological environments,performing logic operations and producing corresponding *** this minireview,we summarize the recent advances of nucleic acid logic devices,which are responsive to various stimuli,including DNA/RNA strands,metal ions,small molecules,peptides,proteins,photo-irradiation,pH changes,and so *** applications of these devices in biosensing and biofunction regulation are also *** the last part of the present study,we discuss the remaining challenges and perspectives of nucleic acid logic devices.

关键词： biosensing logic devices nucleic acids self-assembly

Self-Assembled DNA Nanostructures for Drug Delivery

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Chinese Journal of Chemistry 2016年第3期34卷 265-272页

作者： Ruokun Jia Ting Wang Qiao Jiang Zhengang Wang Chen Song baoquan ding College of Chemical Engineering Northeast Dianli University Jilin Jilin 132012 China National Center for Nanoscience and Technology 11 Bei YiTiao ZhongGuanCun 100190 Beijing China

Due to the uniform nanoscale sizes, well-defined shapes, precise spatial addressability and prominent biocom- patibility, self-assembled DNA nanostructures have been intensively studied for their biomedical applications. This review summarizes the recent development ofDNA nanotechnology in cancer therapy, and discusses the challenges and potential strategies to advance the methodologies of cancer treatments.

关键词： DNA nanostructures DNA nanotechnology drug delivery tumor targeting cancer therapy

DNA-assembled bimetallic plasmonic nanosensors

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Light(Science & Applications) 2014年第1期3卷 1-4页

作者： Na Li Andreas Tittl Song Yue Harald Giessen Chen Song baoquan ding Na Liu National Center for Nanoscience and Technology Beijing 100190China th Physics Institute and Research Center Scope University of StuttgartD-70569 StuttgartGermany Max Planck Institute for Intelligent Systems D-70569 StuttgartGermany

Plasmonic hybrid nanomaterials are highly desirable in advanced sensing *** components in these materials undertake distinct roles and work *** material component may act as an efficient light concentrator and optical probe,whereas another provides specific chemical or biological *** this work,we present DNA-assembled bimetallic plasmonic nanostructures and demonstrate their application for the all-optical detection of ***(Au)nanorods are functionalized with DNA strands,which serve both as linkers and seeding sites for the growth of palladium(Pd)nanocrystals and facilitate reliable positioning of Pd satellites around an Au nanorod at an ultrashort spacing in the nanometer ***-field scattering spectra of single Au–DNA–Pd nanorods were recorded during controlled cycles of hydrogen gas exposure,and an unambiguous concentration-dependent optical response was *** method enables,for the first time,the all-optical detection of hydrogen-induced phase-change processes in sub-5-nm Pd nanocrystals at the single-antenna *** substituting the Pd satellites with other functional materials,our sensor platform can be extended to plasmonic sensing of a multitude of chemical and biological reagents,both in liquid and gaseous phases.

关键词： DNA self-assembly hydrogen sensing palladium plasmonics

Efficient Construction of a Polyaniline-coated DNA Nanoparticle for Photothermal Therapy

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Chemical Research in Chinese Universities 2023年第6期39卷 884-890页

作者： AQIB Raja Muhammad YANG Changping WU Xiaohui WANG Yuang FAN Jing SHANG Yingxu LIU Jianbing ding baoquan CAS Key Laboratory of Nanosystem and Hierarchical Fabrication National Center for NanoScience and TechnologyBeijing 100190P.R.China University of Chinese Academy of Sciences Beijing 100049P.R.China School of Materials Science and Engineering Henan Institute of Advanced TechnologyZhengzhou UniversityZhengzhou 450001P.R.China

Photothermal therapy is a direct and non-invasive therapeutic ***,we report a general strategy for the construction of polyaniline-coated DNA nanoparticles for efficient photothermal *** our design,two G4/hemin-based DNAzymes are precisely organized in a DNA template to mimic the function of horseradish peroxidase(HRP)for the catalytic oxidation of *** polymerization,the polyaniline-coated DNA nanoparticles(PANI/DNA NPs)can be efficiently obtained as the photothermal agent to elicit a pronounced photothermal *** cellular uptake,the noticeable photothermal effect from 808 nm laser irradiation can achieve an efficient proliferation inhibition of tumor *** rationally developed photothermal agent based on DNA template-assisted polymerization presents a new avenue for the development of photothermal therapy.

关键词： Nucleic acid nanostructure Self-assembly Polymeriza-tion Polyaniline Photothermal therapy

Chemically modified DNA nanostructures for drug delivery

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The Innovation 2022年第2期3卷 38-48页

作者： Yuang Wang Xuehe Lu Xiaohui Wu Yan Li Wantao Tang Changping Yang Jianbing Liu baoquan ding School of Materials Science and Engineering Henan Institute of Advanced TechnologyZhengzhou UniversityZhengzhou 450001China CAS Key Laboratory of Nanosystemand Hierarchical Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Based on predictable,complementary base pairing,DNA can be artificially pre-designed into versatile DNA nanostructures of well-defined shapes and *** excellent addressability and biocompatibility,DNA nanostructures have been widely employed in biomedical research,such as biosensing,bio-imaging,and drug *** the development of the chemical biology of nucleic acid.

关键词： DNA versatile pairing

Self-assembly multifunctional DNA tetrahedron for efficient elimination of antibiotic-resistant bacteria

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Aggregate 2024年第1期5卷 204-215页

作者： Tiantian Wu Yu Fu Shuang Guo Yanqiang Shi Yuxin Zhang Zhijin Fan Bin Yang baoquan ding Yuhui Liao Molecular Diagnosis and Treatment Center for Infectious Diseases Dermatology HospitalSouthern Medical UniversityGuangzhouChina CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijingChina Longgang District Central Hospital of Shenzhen ShenzhenChina

Antibiotic resistance is a major challenge in the clinical treatment of bacterial infectious ***,we constructed a multifunctional DNA nanoplatform as a versatile carrier for bacteria-specific delivery of clinical antibiotic ciprofloxacin(CIP)and classic nanoantibiotic silver nanoparticles(AgNP).In our rational design,CIP was efficiently loaded in the self-assembly double-bundle DNA tetrahedron through intercalation with DNA duplex,and single-strand DNA-modified AgNP was embedded in the cavity of the DNA tetrahedron through *** the site-specific assembly of targeting aptamer in the well-defined DNA tetrahedron,the bacteria-specific dual-antibiotic delivery system exhibited excellent combined bactericidal *** enhanced antibiotic accumulation through breaking the out membrane of bacteria,the antibiotic delivery system effectively inhibited biofilm formation and promoted the healing of infected wounds in *** DNAbased antibiotic delivery system provides a promising strategy for the treatment of antibiotic-resistant infections.

关键词： antibiotic resistance anti-infection therapy biofilm DNA nanotechnology targeted delivery