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Adoptive transfer of T cells transduced with a chimeric antigen receptor to treat relapsed or refractory acute leukemia: efficacy and feasibility of immunotherapy approaches

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Science China(Life Sciences) 2016年第10期59卷 673-677页

作者： guoliang ding Hu Chen Department of Hematopoietic Stem Cell Transplantation Affiliated Hospital of Academy of Military Medical Sciences

Treatment outcomes of acute leukemia(AL) have not improved over the past several decades and relapse rates remain high despite the availability of aggressive therapies. Conventional relapsed leukemia treatment includes second allogeneic hematopoietic stem cell transplantation(allo-HSCT) and donor lymphocyte infusion(DLI), which in most cases mediate, at best, a modest graft-versus-leukemia effect, although their clinical efficacy is still limited. Although allo-HSCT following myeloablative conditioning is a curative treatment option for younger patients with acute myeloid leukemia(AML) in a first complete remission(CR), allo-HSCT as a clinical treatment is usually limited because of treatment-related toxicity. The overall DLI remission rate is only 15%–42% and 2-year overall survival(OS) is approximately 15%–20%, with a high(40%–60%) incidence of DLI-related graft-versus-host disease(gVHD). Therefore, development of new, targeted treatment strategies for relapsed and refractory AL patients is ongoing. Adoptive transfer of T cells with genetically engineered chimeric antigen receptors(CARs) is an encouraging approach for treating hematological malignancies. These T cells are capable of selectively recognizing tumor-associated antigens and may overcome many limitations of conventional therapies, inducing remission in patients with chemotherapy-refractory or relapsed AL. In this review, we aimed to highlight the current understanding of this promising treatment modality, discussing its adverse effects and efficacy.

关键词： chimeric antigen receptor acute leukemia efficacy feasibility

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PARAMETER IDENTIFICATION IN HEMODYNAMIC MODEL OF CEREBRAL CIRCULATION

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Journal of Hydrodynamics 2001年第1期13卷 34-38页

作者： Yao, W. ding, g.H. Liu, H. Wang, S.Z. Lu, C.Z. Chen, S.H. Dep. of Mech. and Eng. Sci. Fudan Univ. Shanghai 200040 China

With a hemodynamic model of the Willis circulation, we developed a mathematical method to solve the inverse problem and obtained the values of indices in the model. Compared with the clinical data from hospital, most ... 详细信息

关键词： Mathematical models

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Effect of Feeding Rate on the Loads Measured Along the Wall of a Full-Scale Hopper During Filling

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Effect of Feeding Rate on the Loads Measured Along the Wall ...

An Expert System Based on Multi-reasoning Mechanism for Port Machine Diagnosis

The Sixth International Conference on Measurement and Control of granular Materials

作者： S.ding g.g.Enstad Tel-Tek Dept.POSTEC Telemark University CollegePorsgrunnNorway

It has been shown that the filing method affects the loads along the wall of a container such as a silo when it is filled with granular *** issue has been addressed by comparing a concentric with a distributed filling as representative examples of filling *** effect of the filling rate on the load along the wall of a conical full-scale hopper was examined during a concentric *** order to measure the loads,seven pressure transducers were mounted at given positions on the hopper wall. Sand was filled axi-symmetrically into the hopper at different rates,and the loads during filling on the wall were measured *** kinds of surface flow movement were categorically seen in the process of piling-up. The distribution of the filling loads along the wall developed differently under different feeding rates at the end of *** cause of such differences was explored to some *** was found that the loads measurement made on one line along the hopper as carried out in the present study was only a chance sample value, and appeared to be higher when the feeding rates were higher.

关键词： Hopper filling loads measurement feeding rate

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Journal of Shipping and Ocean Engineering 2011年第2期1卷 101-108页

作者： Y. ding g.L. Lin Logistics Research Center Shanghai Maritime University Shanghai 200135 China

Expert system plays an important role in port machine diagnosis, which aims at automatic equipment test for higher availability and efficiency of port operations. In this study, a port machine diagnosis expert system is proposed based on multi-reasoning mechanism. Relying on the knowledge acquired from the experienced experts in the port machine engineering, the system builds a library of relative experience and a set of rules of reasoning and estimating. Multi-reasoning mechanism that simulates the decision-making process of domain experts is employed to achieve reliable diagnosis results. The reasoning machine integrates artificial neural network, uncertain decision making and decision tree, which complements each other by sustainable growing voting mechanism. The effect of this multi-reasoning mechanism is evaluated and validated by means of Matthew＇s Correlation Coefficient （MCC）. The system incorporating the mechanism is successfully designed, implemented and applied in Shanghai Port.

关键词： Port machine diagnosis multi-reasoning mechanism ANN uncertain decision making decision tree.

TOROIDALSHEARFLOWDRIVIENINSTABILITY

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核聚变与等离子体物理 1996年第4期 50-57页

作者： L.Huang N.ding g.D.Jian Southwestern Institute of Physics, P.O.Box 432, Chengdu 610041, China

ＴＯＲＯＩＤＡＬＳＨＥＡＲＦＬＯＷＤＲＩＶＩＥＮＩＮＳＴＡＢＩＬＩＴＹＬ．ＨｕａｎｇＮ．ＤｉｎｇＧ．Ｄ．ＪｉａｎＳｏｕｔｈｗｅｓｔｅｒｎＩｎｓｔｉｔｕｔｅｏｆＰｈｙｓｉｃｓ，Ｐ．Ｏ．Ｂｏｘ４３２，Ｃｈｅｎｇｄｕ６１０... 详细信息

ＴＯＲＯＩＤＡＬＳＨＥＡＲＦＬＯＷＤＲＩＶＩＥＮＩＮＳＴＡＢＩＬＩＴＹＬ．ＨｕａｎｇＮ．ＤｉｎｇＧ．Ｄ．ＪｉａｎＳｏｕｔｈｗｅｓｔｅｒｎＩｎｓｔｉｔｕｔｅｏｆＰｈｙｓｉｃｓ，Ｐ．Ｏ．Ｂｏｘ４３２，Ｃｈｅｎｇｄｕ６１００４１，ＣｈｉｎａＡＢＳＴＲＡＣＴ...

关键词： Toroidal shear flow Ion temperature η i mode

CRYSTAL STRUCTUER OF DEHYDRODICENTRINE

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Chinese Journal of Structural Chemistry 1989年第3期 209-211页

作者： Xu Ben-Jie Chen Yuan-ZhuFujian Institute of Research on the Structure of Matter, Academia Sinica, FuzhouChen Zheng-Qin.g ding Xu-LangDepartment of Chemistry, Nanjing Medical College, Nanjing

C20H19O4N,Mr= 337. 38,monoclinic,P21/n,a= 16. 567(3),b= 6. 353 (13),c=15. 085(4)A,B=93. 74(2)0,V=1584. 1(7) A3,Z=4,Z)c= 1. ***-3,F (000) = 712, (MoKa) = 0. 71073A ,u=0. 92cm-1,R=0. 058(Ru= 0. 056) for 2643 observed re... 详细信息

关键词： CRYSTAL STRUCTUER OF DEHYDRODICENTRINE

Enhanced post-combustion CO2 capture and direct air capture by plasma surface functionalization of graphene adsorbent

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Journal of Energy Chemistry 2025年第1期100卷 653-664页

作者： Rahul Navik Eryu Wang Xiao ding Huang Yunyi Yiyu Liu Jia Li guangdong-Hong Kong Joint Laboratory for Carbon Neutrality Jiangmen Laboratory of Carbon and Science and Technology guangzhou HKUST Fok Ying Tung Research Institute The Hong Kong University of Science and Technology (guangzhou) Carbon Neutrality and Climate Change Thrust Society Hub The Hong Kong University of Science and Technology (Guangzhou) Stoddart Institute of Molecular Science Department of Chemistry Zhejiang University

graphene has enormous potential to capture CO2due to its unique properties and ***,graphene-based adsorbents have drawbacks of lower CO2adsorption capacity and poor *** work demonstrates a one-step rapid and sustainable N2/H2plasma treatment process to prepare graphene-based sorbent material with enhanced CO2adsorption *** treatment directly enriches amine species,increases surface area,and improves textural *** CO2adsorption capacity increases from 1.6 to 3.3 mmol/g for capturing flue gas,and from 0.14 to 1.3 mmol/g for direct air capture （DAC）.Importantly,the electrothermal property of the plasma-modified aerogels has been significantly improved,resulting in faster heating rates and significantly reducing energy consumption compared to conventional external heating for regeneration of *** aerogels display improved selectivity of 42 and 87 after plasma modification for 5 and 10 min,*** plasma-treated aerogels display minimal loss between 17%and 19% in capacity after 40 adsorption/desorption cycles,rendering excellent *** N2/H2plasma treatment of adsorbent materials would lower energy expenses and prevent negative effects on the global economy caused by climate change.

关键词： Carbon neutrality CO 2 capture Climate change Plasma treatment graphene aerogel

Breaking new ground in photocatalysis: lutetium texaphyrin as a trigger for pyroptosis through biomolecular photoredox reactions

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Science China Chemistry 2025年第1期 1-2页

作者： Qihang ding Mengrong He Meijia gu Department of Chemistry Korea University Department of Ultrasound Medicine Union Hospital Tongji Medical College Huazhong University of Science and Technology Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE) School of Pharmaceutical Sciences Wuhan University

Malignant neoplasms consistently pose a significant threat to global public health [1,2]. In recent years, immunotherapy has demonstrated remarkable clinical success; however, its efficacy is limited by the scarcity of immune cell infiltration within tumor microenvironments. Cell pyroptosis, a gasdermin-mediated process characterized by cellular swelling,rupture, and the release of intracellular contents such as IL-1β, IL-18, ATP, HMgB1, plays a crucial role in this context[3,4].

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BHP公司改进润滑维护技术,大幅节约R＆M成本

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BHP公司改进润滑维护技术,大幅节约R＆M成本