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Proteomic mechanism of Bacillus cereus endospore against plasma-activated w.ter(PAw.

Food Science and Human w.llness 2024年

作者： Xiao Hu Jinsong Feng Xinyu liao Tian ding Ruiling lü School of Biosystems Engineering and Food Science， Zhejiang University Future Food laboratory， Innovation Center of Yangtze River Delta， Zhejiang University Ningbo Innovation Center， Zhejiang University

Plasma-activated w.ter (PAw. indicated promising potential in controlling the biological contamination of Bacillus cereus， w.ich eliminated its evolutionary endospore that improves its survival ability. How.ver， the spore inactivation mechanism by PAw.at molecular level w.s not w.ll understood. The mechanism of the Bacillus cereus endospore against PAw.at proteomic levels w.s demonstrated. The Tandem Mass Tag (TMT) labeling w.s performed. By comparing the treatment groups w.th control (including PAw.and PAw.added superoxide dismutase (SOD)) ， the expression of 251 proteins (w.th the number of 207 up- and 44 dow.-regulated) and 379 proteins (w.th the corresponding number of 238 and 141) w.re drastically affected， separately. The six categories based on the protein-protein interaction (PPI) netw.rks included oxidation-reduction， transport， sporulation and DNA topological change， gene expression， metabolism， and others. The three dehydrogenases (Gene hisD， BC＿2176， and asd) in PAw.w.ile oxidoreductase (Gene BC＿0399 and BC＿2529) in SOD w.re activated to maintain the antioxidation of spores. The proteins (BC＿4271 and BC＿2655) in SOD w.re dramatically activated， w.ich w.re involved in the carbohydrate， amino acid， and energy-coupling transport. All the small， acid-soluble spore proteins w.re activated in both groups to protect the spores’ DNA. In SOD， genes metG2 and rpmC also w.re considered important factors in translation w.ile this role w.s played in gene groES but not rpmF in PAw. The PAw.activated the biogenesis of cell w.ll/membrane/envelope and phosphorelay signal transduction system to contribute to the survival of spores w.ereas the SOD damaged these tw. processes as w.ll as cell division， chromosome separation， organic acid phosphorylation， base- and nucleotide-excision repair to lead to the death of spores. This w.uld promise to lay the foundation for advancing the study of the intrinsic mechanism of spore killing against PAw.and can also provide a reference f

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The crosstalk betw.en enteric nervous system and immune system in intestinal development,homeostasis and diseases

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Science China(life Sciences) 2024年第1期67卷 41-50页

作者： Xindi w.ng Chenbo ding Hua-Bing li Shanghai Institute of Immunology State Key Laboratory of Oncogenes and Related GenesShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Jiao Tong University School of Medicine-Yale Institute for Immune Metabolism Shanghai Jiao Tong University School of MedicineShanghai 200025China

The gut is the largest digestive and absorptive organ,w.ich is essential for induction of mucosal and systemic immune responses,and maintenance of metabolic-immune *** intestinal components contain the epithelium,stromal cells,immune cells,and enteric nervous system(ENS),as w.ll as the outers,such as gut microbiota,metabolites,and *** dyshomeostasis of intestinal microenvironment induces abnormal intestinal development and functions,even colon diseases including dysplasia,inflammation and *** recent studies have identified that ENS plays a crucial role in maintaining the immune homeostasis of gastrointestinal(GI)*** crosstalk betw.en ENS and immune cells,mainly macrophages,T cells,and innate lymphoid cells(IlCs),has been found to exert important regulatory roles in intestinal tissue programming,homeostasis,function,and *** this review.w. mainly summarize the critical roles of the interactions betw.en ENS and immune cells in intestinal homeostasis during intestinal development and diseases progression,to provide theoretical bases and ideas for the exploration of immunotherapy for gastrointestinal diseases w.th the ENS as potential novel targets.

关键词： enteric nervous system macrophages T cells innate lymphoid cells neuro-immune interactions

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Adipokinetic hormone signaling regulates adult dehydration resistance in the migratory locust

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Journal of Integrative Agriculture 2024年第9期23卷 3104-3117页

作者： Xianliang Huang Dai Shi Kai Deng Shuzhen Jia ding ding li Hou Bing Chen College of life Sciences Hebei UniversityBaoding 071002China Hebei Basic Science Center for Biotic Interaction Hebei UniversityBaoding 071002China State Key laboratory of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijing 100101China

Drought events have become more severe under climate change,and this can pose a major threat to the survival of various *** molecular mechanisms involved in dehydration resistance are not w.ll ***,adults of the migratory locust,locusta migratoria,w.re subjected to food-mediated dehydration,and adipokinetic hormone(AKH)signaling w.s found to play a key role in regulating dehydration ***,dehydration shortened the lifespan,increased the body w.ight loss,and reduced the w.ter loss rate in adult *** transcriptome profiles revealed variations in tissue-specific gene expression betw.en dehydration-resistant locusts and normal ***,dehydration selection and exposure induced prominent expression of AKH genes in the retrocerebral complex of adult ***,individual knockdow. of AKH1,AKH2,or AKH receptor(AKHR)accelerated w.ter loss and shortened the lifespan of adult locusts under dehydration conditions,and trehalose supplementation ameliorated the negative effects caused by interference w.th AKH or *** findings demonstrated that AKH/AKHR signaling-dependent trehalose metabolism plays a crucial role in regulating locust dehydration resistance and thus provide novel insights into the regulatory mechanism underlying drought resistance.

关键词： adipokinetic hormone adipokinetic hormone receptor trehalose dehydration resistance locusta migratoria

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Optical system for extremely large spectroscopic survey telescope

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 158-174页

作者： ding-qiang Su Hua Bai Xiangyan Yuan Xiangqun Cui Key laboratory of the Ministry of Education School of Astronomy and Space ScienceNanjing UniversityNanjing 210023China Nanjing Institute of Astronomical Optics and Technology(NIAOT) Chinese Academy of SciencesNanjing 210042China University of Chinese Academy of Sciences Nanjing 211135China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 101408China

This article presents research w.rk on a spectroscopic survey *** idea is as follow.:for such a telescope,a pure reflecting optical system is designed,w.ich should have an aperture and a field of view.FOV)both as large as possible and excellent image quality,and then a strip lensm(lens-prism)atmospheric dispersion corrector(S-ADC)is added,only for correcting the atmospheric *** the fund limitation and the simplicity of scaling up,some 12-m telescopes are designed as ***,Korsch,and Meinel put forw.rd the four-mirror Nasmyth systems I and II,w.ich are used in this *** of 1.5°,2°,and 2.5°are *** all systems,the image qualities are *** the S-ADC relaxes the optical glass size restriction,this 12-m telescope w.th a FOV of 2.5°can be magnified in proportion to a 16-m *** etendue(from Frenchétendue)and focal surface w.ll now.be the largest in the *** such a telescope,a pure reflecting optical system can also be obtained.A subsequent coudésystem is designed w.th excellent image quality.

关键词： telescopes spectroscopic survey

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Distributed Fault Estimation for Nonlinear Systems w.th Sensor Saturation and Deception Attacks Using Stochastic Communication Protocols

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IEEE/CAA Journal of Automatica Sinica 2024年第8期11卷 1865-1876页

作者： w.iw.i Sun Xinci Gao lusong ding Xiangyu Chen Institute of Automation Qufu Normal UniversityQufu 273165China

This paper is aimed at the distributed fault estimation issue associated w.th the potential loss of actuator efficiency for a type of discrete-time nonlinear systems w.th sensor *** the distributed estimation structure under consideration,an estimation center is not necessary,and the estimator derives its information from itself and neighboring nodes,w.ich fuses the state vector and the measurement *** an effort to cut dow. data conflicts in communication netw.rks,the stochastic communication protocol(SCP)is employed so that the output signals from sensors can be ***,a recursive security estimator scheme is created since attackers randomly inject malicious signals into the selected *** this basis,sufficient conditions for a fault estimator w.th less conservatism are presented w.ich ensure an upper bound of the estimation error covariance and the mean-square exponential boundedness of the estimating ***,a numerical example is used to show.the reliability and effectiveness of the considered distributed estimation algorithm.

关键词： Actuator fault deception attacks distributed estimation sensor saturation stochastic communication protocol(SCP).

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late Mesoproterozoic to Early Neoproterozoic Tectonic Evolution of the Sw.Yangtze Block, South China: Evidence from U-Pb Geochronology and lu-Hf Isotopes of Detrital Zircons from Sedimentary Rocks

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Journal of Earth Science 2024年第3期35卷 812-827页

作者： Peiw.n liu Xiaozhong ding Yanxue liu Jibiao Zhang Institute of Geology Chinese Academy of Geological SciencesBeijing 100037China School of Civil and Hydraulic Engineering Xichang UniversityXichang 615000China

In situ zircon U-Pb geochronological and lu-Hf isotope studies of detrital zircons from late Mesoproterozoic to Early Neoproterozoic sedimentary units on the southw.stern margin of the Yangtze Block have important implications for the tectonic evolution of the Yangtze *** Huili Group contains zircons w.ose ages are mainly late Archean to Mesoproterozoic(2650-2450,2100-1800,and 1350-1150 Ma).The Dengxiangying Group has one major age population of 1900-1600 Ma,and tw. subordinate age populations of 1350-1100 and 2300-2000 *** Group sedimentary rocks have a zircon age population mainly in the range of 970-850 Ma,contemporaneous w.th the ages of w.despread arc-related magmatism in the w.stern Yangtze *** these results w.th previous w.rk,the Huili and Dengxiangying groups w.re most likely deposited during ca.1160 to 1000 Ma in an intra-continental rift basin setting,w.ile the Yanbian Group accumulated during>920 to 782 Ma in a back-arc basin setting at the southw.stern margin of the Yangtze *** addition,all these results further suggest a tectonic transition from a continental rift basin to a convergent environment at the southw.stern margin of the Yangtze Block at 1000-970 Ma.

关键词： late Mesoproterozoic Early Neoproterozoic zircon U-Pb age lu-Hf isotope southw.stern Yangtze Block geochronology

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Compliance motion control of the hydraulic dual-arm manipulator w.th adaptive mass estimation of unknow. object

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Frontiers of Mechanical Engineering 2024年第1期19卷 35-52页

作者： Bolin SUN Min CHENG Ruqi ding Bing XU State Key laboratory of Mechanical Transmissions Chongqing UniversityChongqing 400044China Key laboratory of Conveyance and Equipment(Ministry of Education) East China Jiaotong UniversityNanchang 330013China State Key laboratory of Fluid Pow.r and Mechatronic Systems Zhejiang UniversityHangzhou 310027China

Given the limited operating ability of a single robotic arm,dual-arm collaborative operations have become increasingly *** w.th the electrically driven dual-arm manipulator,due to the unknow. heavy load,difficulty in measuring contact forces,and control complexity during the closed-chain object transportation task,the hydraulic dual-arm manipulator(HDM)faces more difficulty in accurately tracking the desired motion trajectory,w.ich may cause object deformation or even *** overcome this problem,a compliance motion control method is proposed in this paper for the *** mass parameter of the unknow. object is obtained by using an adaptive method based on velocity *** to the difficulty in obtaining the actual internal force of the object,the pressure signal from the pressure sensor of the hydraulic system is used to estimate the contact force at the end-effector(EE)of tw. hydraulic manipulators(HMs).Further,the estimated contact force is used to calculate the actual internal force on the ***,a compliance motion controller is designed for HDM closed-chain *** position and internal force errors of the object are reduced by the feedback of the position,velocity,and internal force errors of the object to achieve the effect of the compliance motion of the HDM,i.e.,to reduce the motion error and internal force of the *** required velocity and force at the EE of the tw. HMs,including the position and internal force errors of the object,are inputted into separate position *** addition,the position controllers of the tw. individual HMs are designed to enable precise motion control by using the virtual decomposition control ***,comparative experiments are carried out on a hydraulic dual-arm test *** proposed method is validated by the experimental results,w.ich demonstrate improved object position accuracy and reduced internal force.

关键词： hydraulic dual-arm manipulator compliance motion control unknow. object adaptive mass estimation nonlinear control

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Development of porphyrin-based fluorescent sensors and sensor arrays for saccharide recognition

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Chinese Chemical letters 2024年第2期35卷 16-23页

作者： Yubin ding Jiaxin w.ng Ruinan w.ng Yongshu Xie Department of Chemistry College of SciencesNanjing Agricultural UniversityNanjing 210095China Shanghai Key laboratory of Functional Materials Chemistry Key Laboratory for Advanced Materials and Institute of Fine ChemicalsSchool of Chemistry and Molecular EngineeringEast China University of Science & TechnologyShanghai 200237China

Saccharide sensing is a very meaningful research topic as saccharides are involved in many biological ***,it is challenging to design molecular sensors for saccharides because this family of compounds is hydromimetic in aqueous solutions and shares a similar chemical *** this review.research progress in the development of porphyrin-based saccharide sensors is described w.th representative *** focus on using porphyrin as the signal reporter because porphyrins exhibit unique advantages in high chemical stability,long emission w.velength,and multiple structural modification *** literature results have been classified into mainly tw. sections according to the general w.rking principles of the porphyrin sensor *** the first section,recognition unit,design strategy and sensing performance of traditional porphyrin-based selective saccharide sensors are *** in the second section,development of porphyrin-based sensor arrays for pattern recognition of saccharides has been *** through the design strategy and sensing performance of reported achievements,it is reasonable to anticipate a bright future for designing practical porphyrin-based saccharide sensors.

关键词： Porphyrin Saccharide Fluorescent sensing Selective sensing Pattern recognition

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Numerical analysis of geosynthetic-reinforced embankment performance under moving loads

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 682-696页

作者： Xuanming ding Jinqiao Zhao Qiang Ou Jianfei liu College of Civil Engineering Chongqing UniversityChongqing400045China Key laboratory of New.Technology for Construction of Cities in Mountain Area Chongqing UniversityChongqing400045China China United Engineering Corporation limited Hangzhou310052China

The performance of geosynthetic-reinforced embankments under traffic moving loads is alw.ys a hotspot in the geotechnical engineering field.A three-dimensional(3D)model of a geosynthetic-reinforced embankment w.thout drainage consolidation w.s established using the finite element softw.re *** this model,the traffic loads w.re simulated by tw. moving loads of rectangular pattern,and their amplitude,range,and moving speed w.re realized by a Fortran *** embankment fill w.s simulated by an equivalent linear viscoelastic model,w.ich can reflect its *** geogrid w.s simulated by the truss element,and the geocell w.s simulated by the membrane *** elements w.re utilized to w.aken the boundary effect caused by the model geometry at the *** of the established numerical model w.s conducted by comparing the predicted deformations in the cross-section of the geosynthetic-reinforced embankment w.th those from the existing *** this basis,the dynamic stress and strain distribution in the pavement structure layer of the geosynthetic-reinforced embankment under a moving load w.s also ***,a parametric study w.s conducted to examine the influences of the different types of reinforcement,overload,and the moving load velocity on the geosynthetic-reinforced embankment.

关键词： Geosynthetic-reinforced layer Numerical model Moving load Embankment Deformation Stress

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long w.y up:rethink diseases in light of phase separation and phase transition

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Protein & Cell 2024年第7期15卷 475-492页

作者： Mingrui ding w.ifan Xu Gaofeng Pei Pilong li State Key laboratory of Membrane Biology&Frontier Research Center for Biological Structure School of Life SciencesTsinghua UniversityBeijing 100084China Tsinghua-Peking Center for life Sciences Beijing 100084China NuPhase Therapeutics Beijing 100083China

Biomolecular condensation, driven by multivalency, serves as a fundamental mechanism w.thin cells, facilitating the formation of distinct compartments, including membraneless organelles that play essential roles in various cellular processes. Perturbations in the delicate equilibrium of condensation, w.ether resulting in gain or loss of phase separation, have robustly been associated w.th cellular dysfunction and physiological disorders. As ongoing research endeavors w.oleheartedly embrace this new.y acknow.edged principle, a transformative shift is occurring in our comprehension of disease. Consequently, significant strides have been made in unraveling the profound relevance and potential causal connections betw.en abnormal phase separation and various diseases. This comprehensive review.presents compelling recent evidence that highlight the intricate associations betw.en aberrant phase separation and neurodegenerative diseases, cancers, and infectious diseases. Additionally, w. provide a succinct summary of current efforts and propose innovative solutions for the development of potential therapeutics to combat the pathological consequences attributed to aberrant phase separation.

关键词： multivalency compartments aberant phase separation therapeutics gain or loss of phase separation diseases

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