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A Selective‑Response Hypersensitive Bio‑Inspired Strain Sensor Enabled by Hysteresis Effect and Parallel Through‑Slits Structures

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Nano-Micro Letters 2024年第2期16卷 139-153页

作者： qun Wang Zhongwen Yao Changchao Zhang Honglie Song Hanliang ding Bo Li Shichao Niu Xinguan Huang Chuanhai Chen Zhiwu Han Luquan Ren Key Laboratory of Bionic Engineering(Ministry of Education) Jilin UniversityChangchunJilin 130022People’s Republic of China Liaoning Academy of Materials LiaoningShenyang 110167People’s Republic of China Key Laboratory of CNC Equipment Reliability(Ministry of Education) Jilin UniversityChangchunJilin 130022People’s Republic of China

Flexible strain sensors are promising in sensing minuscule mechanical signals,and thereby widely used in various advanced fields.However,the effective integration of hypersensitivity and highly selective response into one flexible strain sensor remains a huge challenge.Herein,inspired by the hysteresis strategy of the scorpion slit receptor,a bio-inspired flexible strain sensor(BFSS)with parallel through-slit arrays is designed and fabricated.Specifically,BFSS consists of conductive monolayer graphene and viscoelastic styrene–isoprene–styrene block copolymer.Under the synergistic effect of the bio-inspired slit structures and flexible viscoelastic materials,BFSS can achieve both hypersensitivity and highly selective frequency response.Remarkably,the BFSS exhibits a high gage factor of 657.36,and a precise identification of vibration frequencies at a resolution of 0.2 Hz through undergoing different morphological changes to high-frequency vibration and low-frequency vibration.Moreover,the BFSS possesses a wide frequency detection range(103 Hz)and stable durability(1000 cycles).It can sense and recognize vibration signals with different characteristics,including the frequency,amplitude,and waveform.This work,which turns the hysteresis effect into a"treasure,"can provide new design ideas for sensors for potential applications including human–computer interaction and health monitoring of mechanical equipment.

关键词： Bio-inspired strain sensors Hysteresis effect Hypersensitivity Selective frequency response Health monitoring applications

A systematic review of the inequality of health burdens related to climate change

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Frontiers of Environmental Science & Engineering 2024年第5期18卷 137-153页

作者： Xinke Song Shihui Zhang Hai Huang qun ding Fang Guo Yaxin Zhang Jin Li Mingyu Li Wenjia Cai Can Wang State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing100084China Department of Earth System Science Tsinghua UniversityBeijing100084China

Climate change significantly impacts human health,exacerbating existing health inequalities and creating new ones.This study addresses the lack of systematic review in this area by analyzing 2440 publications,focusing on four key terms:health,disparities,environmental factors,and climate change.Strict inclusion criteria limited the selection to English-language,peer-reviewed articles related to climate health hazards,ensuring the relevance and rigor of the synthesized studies.This process synthesized 65 relevant studies.Our investigation revealed that recent research,predominantly from developed countries,has broadened its scope beyond temperature-related impacts to encompass diverse climate hazards,including droughts,extreme weather,floods,mental health issues,and the intersecting effects of Coronavirus Disease 2019.Research has highlighted exposure as the most studied element in the causal chain of climate change-related health inequalities,followed by adaptive capability and inherent sensitivity.The most significant vulnerabilities were observed among populations with low socioeconomic status,ethnic minorities,and women.The study further reveals research biases and methodological limitations,such as the paucity of attention to underdeveloped regions,a narrow focus on non-temperature-related hazards,challenges in attributing climate change effects,and a deficit of large-scale empirical studies.The findings call for more innovative research approaches and a holistic integration of physical,socio-political,and economic dimensions to enrich climate-health discourse and inform equitable policy-making.

关键词： Climate change Health impact Human well-being Inequality Vulnerability

CALD1 facilitates epithelial-mesenchymal transition progression in gastric cancer cells by modulating the PI3K-Akt pathway

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 1029-1045页

作者： Wen-Qian Ma Ming-Chang Miao Ping-An ding Bi-Bo Tan Wen-Bo Liu Shuo Guo Li-Mian Er Zhi-Dong Zhang qun Zhao Department of Endoscopy The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina Hebei Key Laboratory of Precision Diagnosis and Comprehensive Treatment of Gastric Cancer Shijiazhuang 050011Hebei ProvinceChina Department of Radiotherapy The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina The Third Department of Surgery The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina

BACKGROUND CALD1 has been discovered to be abnormally expressed in a variety of malignant tumors,including gastric cancer(GC),and is associated with tumor progression and immune infiltration;however,the roles and mechanisms of CALD1 in epithe-lial-mesenchymal transition(EMT)in GC are unknown.AIM To investigate the role and mechanism of CALD1 in GC progression,invasion,and migration.METHODS In this study,the relationship between CALD1 and GC,as well as the possible network regulatory mechanisms of CALD1,was investigated by bioinformatics and validated by experiments.CALD1-siRNA was synthesized and used to trans-fect GC cells.Cell activity was measured using the CCK-8 method,cell migration and invasive ability were measured using wound healing assay and Transwell assay,and the expression levels of relevant genes and proteins in each group of cells were measured using qRT-PCR and Western blot.A GC cell xenograft model RESULTS Bioinformatics results showed that CALD1 was highly expressed in GC tissues,and CALD1 was significantly higher in EMT-type GC tissues than in tissues of other types of GC.The prognosis of patients with high expression of CALD1 was worse than that of patients with low expression,and a prognostic model was constructed and evaluated.The experimental results were consistent with the results of the bioinformatics analysis.The expression level of CALD1 in GC cell lines was all higher than that in gastric epithelial cell line GES-1,with the strongest expression found in AGS and MKN45 cells.Cell activity was significantly reduced after CALD1-siRNA trans-fection of AGS and MKN45 cells.The ability of AGS and MKN45 cells to migrate and invade was reduced after CALD1-siRNA transfection,and the related mRNA and protein expression was altered.According to bioinfor-matics findings in GC samples,the CALD1 gene was significantly associated with the expression of members of the PI3K-AKT-mTOR signaling pathway as well as the EMT signaling pathway,and was closely related to the PI3K-Akt signaling pathway.Experimen

关键词： Gastric tumor CALD1 Epithelial-mesenchymal transition Gene disruption Invasion Migration Bioinformatics

Comparative analysis of two digestive tract reconstruction methods in total laparoscopic radical total gastrectomy

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1109-1120页

作者： Tian-Xiang Dong Dong Wang qun Zhao Zhi-Dong Zhang Xue-Feng Zhao Bi-Bo Tan Yu Liu Qing-Wei Liu Pei-Gang Yang Ping-An ding Tao Zheng Yong Li Zi-Jing Liu Third Department of Surgery of the Fourth Hospital of Hebei Medical University Hebei Key Laboratory of Precision Diagnosis and Comprehensive Treatment of Gastric CancerShijiazhuang 050011Hebei ProvinceChina

BACKGROUND The incidence of gastric cancer has significantly increased in recent years.Surgical resection is the main treatment,but the method of digestive tract reconstruction after gastric cancer surgery remains controversial.In the current study,we sought to explore a reasonable method of digestive tract reconstruction and improve the quality of life and nutritional status of patients after surgery.To this end,we statistically analyzed the clinical results of patients with gastric cancer who underwent jejunal interposition double-tract reconstruction(DTR)and esophageal jejunum Roux-en-Y reconstruction(RY).AIM To explore the application effect of DTR in total laparoscopic radical total gastrectomy(TLTG)and evaluate its safety and efficacy.METHODS We collected the relevant data of 77 patients who underwent TLTG at the Fourth Hospital of Hebei Medical University from October 2021 to January 2023.Among them,35 cases were treated with DTR,and the remaining 42 cases were treated with traditional RY.After 1:1 propensity score matching,the cases were grouped into 31 cases per group,with evenly distributed data.The clinical characteristics and short-and long-term clinical outcomes of the two groups were statistically analyzed.RESULTS The two groups showed no significant differences in basic data,intraoperative blood loss,number of lymph node dissections,first defecation time after operation,postoperative hospital stay,postoperative complications,and laboratory examination results on the 1st,3rd,and 5th days after operation.The operation time of the DTR group was longer than that of the RY group[(307.58±65.14)min vs(272.45±62.09)min,P=0.016],but the first intake of liquid food in the DTR group was shorter than that in the RY group[(4.45±1.18)d vs(6.0±5.18)d,P=0.028].The incidence of reflux heartburn(Visick grade)and postoperative gallbladder disease in the DTR group was lower than that in the RY group(P=0.033 and P=0.038).Although there was no significant difference in body weight,hemoglobin,prealbumin,and albumin betwe

关键词： Gastric cancer Jejunal interposition double-tract reconstruction Roux-en-Y reconstruction Laparoscope

基于工业燃机多级轴流压气机特性预测方法研究

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机械工程学报 2024年第8期60卷 299-307页

作者：闫巍郑群位景山姜斌丁骏哈尔滨工程大学动力与能源工程学院哈尔滨150001 杭州汽轮动力集团股份有限公司杭州310022

为了预测多级压气机的特性,通过逐级进行三维计算来修正一维计算程序内部的落后角计算模型、效率计算模型及轮缘功计算模型,使得一维计算预测的级特性曲线更加贴合所使用的叶型,降低了三维计算动静交界面传递数据而产生的误差。以此缩... 详细信息

为了预测多级压气机的特性,通过逐级进行三维计算来修正一维计算程序内部的落后角计算模型、效率计算模型及轮缘功计算模型,使得一维计算预测的级特性曲线更加贴合所使用的叶型,降低了三维计算动静交界面传递数据而产生的误差。以此缩放方法来实现压气机特性的更好预测,同时也降低了压气机采用三维计算预测性能所消耗的资源与时间。选取某8级压气机作为计算模型来验证提出的方法。结果表明,相较原模型的一维计算预测,经过缩放修正后的一维预测方法更接近试验结果。在相同压比下,三维计算与试验结果流量相差约1.18%,而缩放修正后的一维计算与试验结果流量偏差降低至0.29%。经过修正后的一维计算对于压气机叶片攻角落后角的预测也更加精准。提出的基于维度缩放修正一维程序方法能够更好地预测多级压气机特性。

关键词：特性预测多级轴流压气机一维计算级叠加法动静交界面

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居民医保门诊统筹对医患行为的影响

江西财经大学学报 2024年第2期 56-68页

作者：丁少群周宇轩西南财经大学公共管理学院四川成都611130

医保门诊统筹改革对优化患者就医秩序和引导医院功能定位发挥关键作用。以四川省21个市(州)2008—2021年城乡居民医保门诊统筹区县数据为基础,并匹配wind数据库地方中观数据,采取渐进双重差分方法实证检验门诊统筹改革对居民就医选择、... 详细信息

医保门诊统筹改革对优化患者就医秩序和引导医院功能定位发挥关键作用。以四川省21个市(州)2008—2021年城乡居民医保门诊统筹区县数据为基础,并匹配wind数据库地方中观数据,采取渐进双重差分方法实证检验门诊统筹改革对居民就医选择、医疗机构诊疗行为的影响。结果发现:门诊统筹改革使得医院的诊疗人次占比和入院人次占比减少了1.3%和1.8%,同时基层医疗机构的诊疗人次和入院人次占比提高了1.4%和1.8%。改革促使公立医院住院病人手术率提高了2.4%,同时病床工作日和病床使用率显著下降,门诊统筹引导公立医院进一步职能归位。建议进一步强化基层医疗资源配置,监督公立医院诊疗行为,尽快推广紧密型医疗共同体的建设经验。

关键词：门诊统筹就医选择门诊住院资源配置

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微塑料对土壤中养分和镉淋失的影响

环境科学 2024年第1期45卷 489-495页

作者：赵群芳褚龙威丁原红王发园青岛科技大学环境与安全工程学院青岛266042

微塑料作为新兴污染物,具有尺寸小、比表面积大、吸附能力强和降解慢等特点,其环境效应受到越来越多的关注.微塑料会改变土壤性质,影响土壤中养分和污染物的迁移能力,但是微塑料对土壤养分和重金属淋失的影响尚缺乏研究.通过土壤柱浸滤... 详细信息

微塑料作为新兴污染物,具有尺寸小、比表面积大、吸附能力强和降解慢等特点,其环境效应受到越来越多的关注.微塑料会改变土壤性质,影响土壤中养分和污染物的迁移能力,但是微塑料对土壤养分和重金属淋失的影响尚缺乏研究.通过土壤柱浸滤实验比较研究了在模拟降雨条件下不同质量分数(0%、0.2%和2%)的聚苯乙烯(PS)和聚乳酸(PLA)微塑料对土壤中养分和镉淋失的影响.总体上,降雨强度增加会促进土壤中养分和镉的淋失.2%PS在大暴雨时显著增加总氮的淋失和土壤中有效磷含量,减少了无机磷的淋失和土壤铵态氮含量,大雨时增加土壤速效钾含量.大雨和暴雨时2%PLA减少了硝态氮的淋失,暴雨和大暴雨时降低土壤铵态氮含量,大暴雨时降低土壤总氮的含量,且大暴雨时0.2%PLA显著增加镉的淋失.结果显示,微塑料对土壤养分和镉淋失的影响与微塑料的种类和质量分数有关,并受到降雨水平的影响.研究表明,难降解微塑料聚苯乙烯和可降解微塑料聚乳酸都会对土壤中养分和重金属的淋失产生影响.

关键词：微塑料(MP) 重金属养分淋失硝态氮镉(Cd)

西方哲学研究:从“我注六经”到“六经注我”

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吉林大学社会科学学报 2024年第3期64卷 16-22,5页

作者：丁立群周文迪黑龙江大学哲学学院哈尔滨150006 浙江大学哲学学院

如果从16世纪末西方传教士开始在中国传播西方哲学算起,西方哲学传入中国迄今已历400余年,这同时也是中国的西方哲学研究400余年。这一过程特别在清末中国的现代化过程开始后,引起了西方思想与中国传统思想的无尽纠缠。这一历史事实既... 详细信息

如果从16世纪末西方传教士开始在中国传播西方哲学算起,西方哲学传入中国迄今已历400余年,这同时也是中国的西方哲学研究400余年。这一过程特别在清末中国的现代化过程开始后,引起了西方思想与中国传统思想的无尽纠缠。这一历史事实既产生于西方现代化携带的“文化殖民”活动基因,也产生于中国知识分子面向西方求取“真经”的主动接受行为。因此,西方哲学研究在中国的发展和展望,关系到中国近现代思想的发展以及中国的自主知识体系的建构问题,在更加宏大的视野里,也关系到中国式现代化如何超越西方现代化的问题。

关键词：文化殖民西方哲学研究中国传统思想中国式现代化六经注我西方现代化西方传教士近现代思想

基于非相干光频域反射的多芯光纤网络链路缺陷智能检测

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激光杂志 2024年第5期45卷 164-169页

作者：丁小峰夏群阴艳丽南昌工学院信息与人工智能学院南昌330108

为了保证通信安全稳定、数据传输完整,提出了一种基于非相干光频域反射的多芯光纤网络链路缺陷智能检测。先构建多芯光纤网络数学模型,约束光纤节点映射和频谱分配,使频谱数量最少的同时占用的频隙数最大。然后利用分簇检测建立数据传... 详细信息

为了保证通信安全稳定、数据传输完整,提出了一种基于非相干光频域反射的多芯光纤网络链路缺陷智能检测。先构建多芯光纤网络数学模型,约束光纤节点映射和频谱分配,使频谱数量最少的同时占用的频隙数最大。然后利用分簇检测建立数据传输链路模型,得出通信传输函数,根据相关匹配滤波器调整链路,通过波特间隔均衡完成链路数据采集。最后运用非相干光频域反射步进频率调制产生的瑞利散射光波,结合傅里叶逆变换获得网络健康状况空间分布位置,实现多芯光纤网络链路缺陷智能检测。实验结果表明,所提方法能够准确检测出链路缺陷,对链路阻塞缺陷检测、链路平均故障风险检测率、链路频谱利用率缺陷检测误差分别小于0.4%、0.2%和0.5,且检测时长控制在1.5 s以内,可帮助网络及时恢复运行。

关键词：非相干光频域反射多芯光纤网络网络链路缺陷链路数据采集载频编码