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A Plant Immune Receptor Adopts a Two-Step Recognition Mechanism to Enhance Viral Effector Perception

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Molecular Plant 2019年第2期12卷 248-262页

作者： Jia Li Haining Huang Min Zhu Shen Huang Wenhua Zhang Savithramma P. dinesh-kumar Xiaorong Tao Department of Plant Pathology Nanjing Agricultural University Nanjing 210095 P. R. China College of Life Science Nanjing Agricultural University Nanjing 210095 P. R. China Department of Plant Biology and The Genome Center College of Biological Sciences University of California Davis CA USA

Plant intracellular nucleotide binding leucine-rich repeat (NLR) immune receptors play critical roles in pathoge n surveillance. Most plant NLRs characterized so far were found to use a single domain/sensor to recognize pathogen effectors. Here we report that the Sw-5b NLR immune receptor uses two distinct domains to detect the viral movement protein NSm encoded by tospovirus. In addition to its leucine-rich repeat (LRR) domain that has been previously reported, the N-terminal Solanaceae domain (SD) of Sw- 5b also interacts with NSm and a conserved 21-amino-acid region of NSm (NSm^21). The specific interaction between Sw-5b SD and NSm is required for releasing the inhibitory effect of coiled-coil domain on the NBARC- LRR region. Furthermore, we found that the binding of NSm affects the nucleotide binding activity of the NB-ARC-LRR in vitro, while Sw-5b NB-ARC-LRR is activated only when NSm and NSm^21 levels are high. Interestingly, Sw-5b SD could significantly enhanee the ability of the NB-ARC-LRR to detect low levels of NSm effector and facilitate its activation and induction of defense response. An Sw-5b SD mutant that is disrupted in NSm recognition failed to enhance the ability of the NB-ARC-LRR to sense low levels of NSm and NSm^21 . Taken together, our results suggest that Sw-5b SD functions as an extra sensor and the NB-ARC-LRR as an activator, and that Sw-5b NLR adopts a two-step recog nition mechanism to enhance viral effector perception.

关键词： plant innate immunity nucleotide binding leucine-rich repeat (NLR) immune receptors Solanaceae domain (SD) pathogen perception two-step recognition defense response

Implementation of Interrogation Systems for Fiber Bragg Grating Sensors

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Photonic Sensors 2013年第3期3卷 283-288页

作者： Benjamin VARGHESE P. dinesh kumar R. Mittu RAJU K. N. MADHUSOODANAN Department of Instrumentation Cochin University of Science and Technology Cochin lndia

The development of two simple methods for wavelength-optical intensity modulation techniques for fiber Bragg grating （FBG） sensors is presented. The performance is evaluated by measuring the strain and temperature. The first method consists of a narrow band source, an optical circulator, an FBG; and a power meter. The source and Bragg reflected signal from the FBG need to be matched to get linear results with good power levels. The source spectral power levels are very critical in this study. The power reflected from a matched reference FBG is fed into the measuring FBG in the second method. Since the FBGs are matched, the entire power is reflected back initially. During the measurement, the change in the measurand causes the reflected power from the sensing FBG to vary. A costly high resolution spectrum analyzer is required only during the characterization of the FBG and source. The performances of two interrogators are compared by measuring the strain and temperature. In the second method, the strain measurements can be made insensitive to the temperature variation by selecting a source with a flat spectrum at the measurement range. Highlights of these methods are the portability, cost effectiveness and better resolution.

关键词： Fiber Bragg grating interrogator reflected power strain and temperature measurement

Structural,Dielectric,and Magnetic Studies on Electrospun Magnesium Ferrite-Polyvinylidene Fluoride Core–Shell Composite Fibers

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Acta Metallurgica Sinica(English Letters) 2014年第4期27卷 557-562页

作者： V.Revathi S.dinesh kumar P.Chithra Lekha V.Subramanian T.S.Natarajan C.Muthamizhchelvan New Horizon College of Engineering Bangalore 560103India Microwave Laboratory Department of PhysicsIIT MadrasChennai 600036India SRM University KattankulathurChennai 603203India

The sub-micron（of the order of 150 nm） thick core–shell composite fibers of magnesium ferrite-polyvinylidene fluoride are prepared by *** loading of magnesium ferrite is varied from 1 to 10 wt%.The study results by X-ray diffraction,scanning electron microscope,and infra-red spectroscopy indicate the formation of core–shell structure and an enhancement in the amount of b-phase compared to a-phase in the polyvinylidene *** particle size of the magnesium ferrite in the fiber is evaluated to be 30 *** low frequency dielectric studies indicate that the addition of the magnesium ferrite increases the polarization resulting in the increase in the dielectric constant but decreases the dielectric *** magnetization measurements indicate an increased value of coercivity compared to bulk due to the nano-size of the magnesium *** microwave absorption at the ferromagnetic resonance increases with the increase in the concentration of magnesium *** resonance field is found to vary with the loading of MFO.

关键词： Electrospinning Polymer composites Dielectric properties Magnetic properties X-ray diffraction(XRD) Microwave absorption

Ascaridole: A phytochemical of modern medicinal perspective

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Journal of Coastal Life Medicine 2017年第2期5卷 88-94页

作者： dinesh kumar Patel Christian School of Pharmacy Faculty of Health SciencesSam Higginbottom Institute of AgricultureTechnology and Sciences(SHIATS)Deemed-to-be UniversityAllahabad211007Uttar PradeshIndia

American wormseed oil, also known as Chenopodium ambrosioides oil, is obtained from the herbs of the genus Chenopodium which comprises more than 200 species and belongs to the geographical region of Asia, Europe, China, India, America and other *** has been traditionally used for digestive, respiratory, diabetes, uro-genital, nervous and vascular disorders and has antihelminthic, vermifuge, emmenagogue sedative, antipyretic, antirheumatic and abortifacient activities. Ascaridole is a bicyclic monoterpene commonly known as ascarisin or 1,4-epidioxy-p-menth-2-ene which have sedative, antifungal and pain-relieving properties. It is a potent inhibitor of Trypanosoma cruzi,Plasmodium falciparum, and Leishmania amazonensis and is well known for its worm-expelling potential. Ascaridole was firstly isolated by a German pharmacist in the 1900's and at that time it was one of the best antihelmintics for the treatment of ascarids and hookworms in humans and other species like cats, dogs, horses and pigs. Ascaridole could be extracted by using a non-polar solvent hexane due to its very poor solubility in water. From the literature support, it has been proved that ascaridole have very high potential in the modern and other system of medicine for the treatment of various disorders. So on the basic of its uses, here we have collected and compiled all the data regarding its medicinal uses, pharmacological activities and analytical techniques of the ascaridole in the present review and expected that this review will be beneficial for the researcher in the field of medicine and other allied science.

关键词： Analytical techniques Antihelminthic Ascaridole Chenopodium ambrosioides Medicinal uses Pharmacological uses

Deep learning based computer vision approaches for smart agricultural applications

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Artificial Intelligence in Agriculture 2022年第1期6卷 211-229页

作者： V.G.Dhanya A.Subeesh N.L.Kushwaha dinesh kumar Vishwakarma T.Nagesh kumar G.Ritika A.N.Singh ICAR-Indian Institute of Seed Science MauUttar Pradesh 275101India ICAR-Central Institute of Agricultural Engineering BhopalMadhya Pradesh 462038India ICAR-Indian Agricultural Research Institute New Delhi 110012India Govind Ballabh Pant University of Agriculture and Technology PantnagarUttarakhand 263145India ICAR-National Institute of Natural Fibre Engineering and Technology Kolkata 700040India

The agriculture industry is undergoing a rapid digital transformation and is growing powerful by the pillars of cutting-edge approaches like artificial intelligence and allied *** the core of artificial intelligence,deep learning-based computer vision enables various agriculture activities to be performed automatically with utmost precision enabling smart agriculture into *** vision techniques,in conjunction with high-quality image acquisition using remote cameras,enable non-contact and efficient technology-driven solutions in *** review contributes to providing state-of-the-art computer vision technologies based on deep learning that can assist farmers in operations starting from land preparation to *** works in the area of computer vision were analyzed in this paper and categorized into(a)seed quality analysis,(b)soil analysis,(c)irrigation water management,(d)plant health analysis,(e)weed management(f)livestock management and(g)yield *** paper also discusses recent trends in computer vision such as generative adversarial networks(GAN),vision transformers(ViT)and other popular deep learning ***,this study pinpoints the challenges in implementing the solutions in the farmer’s field in *** overall finding indicates that convolutional neural networks are the corner stone of modern computer vision approaches and their various architectures provide high-quality solutions across various agriculture activities in terms of precision and ***,the success of the computer vision approach lies in building the model on a quality dataset and providing real-time solutions.

关键词： Agriculture automation Computer vision Deep learning Machine learning Smart agriculture Vision transformers

A review on medicinal importance,pharmacological activity and bioanalytical aspects of beta-carboline alkaloid "Harmine"

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Asian Pacific Journal of Tropical Biomedicine 2012年第8期2卷 660-664页

作者： K Patel M Gadewar R Tripathi SK Prasad dinesh kumar Patel G.L.A Institute of Pharmaceutical Research S.K.I.P.S Department of Pharmaceutics Institute of TechnologyBanaras Hindu University

Harmine,a beta-carboline alkaloid,is widely distributed in the plants,marine creatures,insects, mammalians as well as in human tissues and body *** was originally isolated from seeds of Peganum harmal in 1847 having a core indole structure and a pyridine *** has various types of pharmacological activities such as antimicrobial,antifungal,antitumor,cytotoxic, antiplasmodial,antioxidaant,antimutagenic,antigenotoxic and hallucinogenic *** acts on gamma-aminobutyric acid type A and monoamine oxidase A or B receptor,enhances insulin sensitivity and also produces vasorelaxant *** prevents bone loss by suppressing *** current review gives an overview on pharmacological activity and analytical techniques of harmine,which may be useful for researcheres to explore the hidden potential of harmine and and will also help in developing new drugs for the treatment of various diseases.

关键词： Harmine Alkaloid Pharmacological activity Analytical technique Peganum harmala

No-reflow: Mechanism, Diagnosis and Treatment for Patients with STEMI

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No-reflow: Mechanism, Diagnosis and Treatment for Patients w...

作者：迪那西（Bukhory dinesh kumar）华中科技大学

学位级别：硕士

No-reflow phenomenon in patients with ST-elevated myocardial infarction isassociated with high mortality and morbidity. Indeed it has been noted theincidence of this phenomenon varies from5%to50%in the set up of primarypercutaneous coronary interventions and the outcome in the long run is *** mechanism have been put forward to explain this phenomenon butwithout really revealing its secret. Several diagnostic methods such asangiography, myocardial contrast echography, intravascular ultrasound amongothers, have helped study the changes that occurrence of no-reflow during primarypercutaneous coronary interventions. The treatment are also limited to reperfusionand prevention of embolisation while it is associated with a high long termmortality rate and other cardiac conditions such as malignant arrhythmias, cardiacfailure and sudden death. As such this review will attempt to look into the currentmechanism, diagnostic methods and available modes treatments which includemedical and preventive.

关键词：心肌梗死经皮冠状动脉介入诊断方法无复流现象

The Development of Protein Microarrays and Their Applications in DNA-Protein and Protein-Protein Interaction Analyses of Arabidopsis Transcription Factors

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Molecular Plant 2008年第1期1卷 27-41页

作者： Wei Gong Kun He Mike Covington S. R dinesh-kumar Michael Snyder Stacey L. Harmer Yu-Xian Zhu Xing Wang Denga Peking-Yale Joint Center for Plant Molecular Genetics and Agrobiotechnology Co and Plant Genetic Engineering Peking University Beijing 100871 China Department of Molecular Cellular and Developmental Biology Yale University New Haven Connecticut 06520 USA Section of Plant Biology College of Biological Sciences University of California Davis 95616 USA

We used our collection of Arabidopsis transcription factor （TF） ORFeome clones to construct protein microarrays containing as many as 802 TF proteins. These protein microarrays were used for both protein-DNA and proteinprotein interaction analyses. For protein-DNA interaction studies, we examined AP2/ERF family TFs and their cognate cis-elements. By careful comparison of the DNA-binding specificity of 13 TFs on the protein microarray with previous non-microarray data, we showed that protein microarrays provide an efficient and high throughput tool for genome-wide analysis of TF-DNA interactions. This microarray protein-DNA interaction analysis allowed us to derive a comprehensive view of DNA-binding profiles of AP2/ERF family proteins in Arabidopsis. It also revealed four TFs that bound the EE （evening element） and had the expected phased gene expression under clock-regulation, thus providing a basis for further functional analysis of their roles in clock regulation of gene expression. We also developed procedures for detecting protein interactions using this TF protein microarray and discovered four novel partners that interact with HY5, which can be validated by yeast two-hybrid assays. Thus, plant TF protein microarrays offer an attractive high-throughput alternative to traditional techniques for TF functional characterization on a global scale.

关键词： transcription factor (TF) TF-DNA EE (evening element)

Reversal of doxorubicin resistance in lung cancer cells by neferine is explained by nuclear factor erythroid-derived 2-like 2 mediated lung resistance protein down regulation

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Cancer Drug Resistance 2020年第3期3卷 647-665页

作者： Poornima Paramasivan Jothi dinesh kumar Rathinasamy Baskaran Ching Feng Weng Viswanadha Vijaya Padma Department of Biotechnology School of Biotechnology and Genetic EngineeringBharathiar UniversityCoimbatoreTamil Nadu 641046India. Department of Cellular and Molecular Physiology Institute of Translational MedicineUniversity of LiverpoolLiverpool L35TRUK. Laboratory of Molecular Physiology Institute of BiotechnologyDepartment of Life SciencesNational Dong Hwa UniversityHualien 974Taiwan. Division of Science School of Applied SciencesUniversity of Abertay DundeeDundee DD11HGUK. Department of Bioinformatics and Medical Engineering Asia UniversityTaichung 41354Taiwan.

Aim:Development of multi drug resistance and dose limiting cardiotoxicity are hindering the use of Doxorubicin(Dox)in clinical *** dox efflux induced by lung resistance protein(LRP)over expression has been related to multi drug resistance phenotype in various *** alkaloid from lotus,Neferine(Nef)shows both anticancer and cardioprotective ***,we have investigated the interconnection between nuclear factor erythroid-derived 2-like 2(NRF2)and LRP in Dox resistance and how Nef can overcome Dox resistance in lung cancer cells by altering this ***:Anti-proliferative and apoptotic-inducing effects of Nef and Dox combination in Parental and Dox resistant lung cancer cells were determined in monolayers and 3D *** Dox was analyzed using flow cytometry,siRNA knockdown and western blot analysis were used to elucidate NRF2-LRP crosstalk mechanism.

关键词： Doxorubicin neferine reactive oxygen species lung resistance protein nuclear factor erythroid-derived 2-like 2 multidrug resistance