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Flow-directed assembly of non-spherical titania nanoparticles into superhydrophilic thin films

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Frontiers of Materials Science 2016年第1期10卷 1-7页

作者： Abhijeet OJHA Manish THAKKER dinesh O. SHAH Prachi THAREJA Department of Biological Engineering Indian Institute of Technology Gandhinagar Ahmedabad 382424 Gujarat India Department of Instrumentation and Control Engineering Dharmsinh Desai University Nadiad 387001 Gujarat India Shah-Schulman Center for Surface Science and Nanotechnology Dharmsinh Desai University Nadiad 387001 Gujarat India Department of Chemical Engineering and Department of Anesthesiology University of Florida Gainesville FL 32608 USA Department of Chemical Engineering Indian Institute of Technology Gandhinagar Ahmedabad 382424 Gujarat India

Superhydrophilic thin films of 21 nm sized non-spherical titania nanoparticles are fabricated from a colloidal suspension by fixed blade flow coating without UV illumination. At a blade angle of a= 36° and a gap of d= 300 μm, hierarchically structured films with increasing surface roughness along with microscopic voids are formed depending on the substrate velocity and the titania volume fraction. Increasing the roughness is shown to be concomitant to an increase in the hydrophilicity, eventually leading to superhydrophilicity or water contact angle less than 5°.

关键词： superhydrophilicity titania flow coating thin films

Harnessing the potential of gene editing technology using CRISPR in inflammatory bowel disease

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World Journal of Gastroenterology 2019年第18期25卷 2177-2187页

作者： Viktor Limanskiy Arpita Vyas Lakshmi Shankar Chaturvedi dinesh Vyas Department of Surgery San Joaquin General Hospital College of Medicine CNSU College of Medicine and College of Pharmacy California Northstate University

The molecular scalpel of clustered regularly interspersed short palindromic repeats/CRISPR associated protein 9(CRISPR/Cas9) technology may be sharp enough to begin cutting the genes implicated in inflammatory bowel disease(IBD) and consequently decrease the 6.3 billion dollar annual financial healthcare burden in the treatment of IBD. For the past few years CRISPR technology has drastically revolutionized DNA engineering and biomedical research field. We are beginning to see its application in gene manipulation of sickle cell disease,human immunodeficiency virus resistant embryologic twin gene modification and IBD genes such as Gatm(Glycine amidinotransferase, mitochondrial),nucleotide-binding oligomerization domain-containing protein 2, KRT12 and other genes implicated in adaptive immune convergence pathways have been subjected to gene editing, however there are very few publications. Furthermore,since Crohn's disease and ulcerative colitis have shared disease susceptibility and share genetic gene profile, it is paramount and is more advantageous to use CRISPR technology to maximize impact. Although, currently CRISPR does have its limitations due to limited number of specific Cas enzymes, off-target activity,protospacer adjacent motifs and crossfire between different target sites. However,these limitations have given researchers further insight on how to augment and manipulate enzymes to enable precise gene excision and limit crossfire between target sites.

关键词： Clustered regularly interspersed short palindromic repeats Inflammatory bowel disease Crohn’s disease Ulcerative colitis Gene excision Gene editing Gene therapy Financial impact of inflammatory bowel disease on healthcare Clustered regularly interspersed short palindromic repeats crossfire

Nonlocal-Means Image Denoising Technique Using Robust M-Estimator

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Journal of Computer Science & Technology 2010年第3期25卷 623-631页

作者： dinesh J. Peter V. K. Govindan Abraham T. Mathew Department of Computer Science National Institute of Technology Calicut Department of Electrical Engineering National Institute of Technology Calicut

Edge preserved smoothing techniques have gained importance for the purpose of image processing applications A good edge preserving filter is given by nonlocal-means filter rather than any other linear model based approaches. This paper explores a different approach of nonlocal-means filter by using robust M-estimator function rather than the exponential function for its weight calculation. Here the filter output at each pixel is the weighted average of pixels with surrounding neighborhoods using the chosen robust M-estimator function. The main direction of this paper is to identify the best robust M-estimator function for nonlocal-means denoising algorithm. In order to speed up the computation, a new patch classification method is followed to eliminate the uncorrelated patches from the weighted averaging process. This patch classification approach compares favorably to existing techniques in respect of quality versus computational time. Validations using standard test images and brain atlas images have been analyzed and the results were compared with the other known methods. It is seen that there is reason to believe that the proposed refined technique has some notable points.

关键词： image processing denoising technique nonlocal-means filter robust M-estimators

Prediction of COVID-19 Confirmed, Death, and Cured Cases in India Using Random Forest Model

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Big Data Mining and Analytics 2021年第2期4卷 116-123页

作者： Vishan Kumar Gupta Avdhesh Gupta dinesh Kumar Anjali Sardana Department of Computer Science and Engineering(CSE) Graphic Era Deemed to be UniversityDehradun 248002India Department of CSE IMS Engineering CollegeGhaziabad 201009India Department of CSE KIET Group of InstitutionsGhaziabad 201206India

A novel coronavirus(SARS-CoV-2) is an unusual viral pneumonia in patients, first found in late December 2019, latter it declared a pandemic by World Health Organizations because of its fatal effects on public health. In this present, cases of COVID-19 pandemic are exponentially increasing day by day in the whole world. Here, we are detecting the COVID-19 cases, i.e., confirmed, death, and cured cases in India only. We are performing this analysis based on the cases occurring in different states of India in chronological dates. Our dataset contains multiple classes so we are performing multi-class classification. On this dataset, first, we performed data cleansing and feature selection, then performed forecasting of all classes using random forest, linear model, support vector machine,decision tree, and neural network, where random forest model outperformed the others, therefore, the random forest is used for prediction and analysis of all the results. The K-fold cross-validation is performed to measure the consistency of the model.

关键词： coronavirus COVID-19 respiratory tract multi-class classification random forest

A Review on Pharmacological and Analytical Aspects of Diosmetin:A Concise Report

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Chinese Journal of Integrative Medicine 2013年第10期19卷 792-800页

作者： Kanika Patel Manoj Gadewar Vijay Tahilyani dinesh Kumar Patel GLA Institute of Pharmaceutical Research Mathura(281406)India SKIPS Warangal-Andhra Pradesh(506015)India Sonekar College of Pharmacy KoradiNagpur(440001)India Department of Pharmaceutics Institute of TechnologyBanaras Hindu UniversityVaranasi(221005)India

Plants have been used as a source for food material and natural remedies for the treatment of vast range of diseases. Nature provides us remedies for the treatment of various types of disorders ranging from simpte aitments to complicated diseases. Plants are known to possess different pharmacological activities due to the presence of various phytoconstituents, Flavonoids are one of the main active phytoconstituents found in fruits, vegetables, wines, tea and cocoa. Flavonoids exhibit various pharmacological activities such as antioxidant, anti-inflammatory, anti-allergic, antibacterial, oestrogenic, cytotoxic antitumoural, hepatoprotective, antithrombotic and antiviral activity. Diosmetin （3＇, 5, 7-trihydroxy-4＇-methoxyflavone）, the aglycone part of the flavonoid glycosides diosmin occurs naturally in citrus fruit. Although it is found in herbal medicines and plays an important role in the treatment of various ailments, only limited scientific researches have been conducted. The aim of this review is to collect all available scientific literature published on diosmetin and combine it into this paper. This review contains an overview of pharmacological activities, isolation techniques and analytical techniques for diosmetin. Thus, valuable information provided in the present review will help researchers in developing alternative methods for the treatment of diseases from diosmetin.

关键词： analytical techniques diosmetin flavonoid pharmacological activity phytoconstituents

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World Journal of Clinical Cases 2018年第8期6卷 161-166页

作者： Flyn Kaida-Yip Kaivalya Deshpande Trishla Saran dinesh Vyas College of Medicine California Northstate University Kaivalya Deshpande Department Of SurgeryMichigan State University Trishla Saran Department of Medicine the University of Texas of the Permian Basin dinesh Vyas Department of SurgeryTexas Tech University

Biosimilars are a growing drug class designed to be used interchangeably with *** are cr-eated in living cells and are typically large,complex pr-oteins that may have a variety of *** the field of gastroenterology alone,biologics are used to treat inflammatory bowel diseases,cancers,and endocrine *** biologics have proven to be effective in treating or managing many diseases,patient acce-ss is often limited by high *** development of biosimilars is an attempt to reduce treatment *** must be nearly identical to their reference biologics in terms of efficacy,side effect risk profile,and *** the manufacturing process still involves production within living cells,biosimilars undergo fewer clinical trials than do their reference *** ultimately reduces the cost of production and the cost of the biosimilar drug compared to its reference ***,seven biosimilars have been approved by the United States Food and Drug Administration(FDA)for use in Crohn’s disease,ulcerative colitis,and colorectal *** are other biologics involved in treating gastroenterologic diseases for which there are no FDA approved *** biosimilars have the po-tential to reduce healthcare costs in chronic disease management,they face challenges in establishing a sig-nificant market *** comfort in prescribing reference biologics instead of biosimilars and patient reluctance to switch from a biologic to a biosimilar are two common contributing factors to biosimilars’slow in-crease in *** time will be needed for biosimilars to establish a larger and more consistent market share compared to their reference *** da-ta confirming the safety and efficacy of biosimilars,increased number of available biosimilars,and further cost reduction of biosimilars will all be necessary to im-prove physician confidence in biosimilars and patient comfort with biosimilars.

关键词： Biosimilars Inflammatory bowel disease Biologics Inflammation Drug class

Evaluation of phytochemical and antioxidant activities of the different fractions of Hybanthus enneaspermus (Linn.) ***. (Violaceae).

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Asian Pacific Journal of Tropical Medicine 2011年第5期4卷 391-396页

作者： dinesh Kumar Patel Rajesh Kumar Damiki Laloo Siva Hemalatha Pharmacognosy Research Laboratory Department of PharmaceuticsInstitute of TechnologyBanaras Hindu UniversityVaranasi-221005.India

Objective:To investigate the naturally occurring antioxidant for the first time from the different solvent fractions of Hybanthus enneaspermus（***） Linn ***（Violaceae）. Methods:Different fractions of *** were tested for total phenolic content,and in vitro antioxidant activity was measured by total antioxidant assay,DPPH assay,reducing power, nitric oxide（NO）,hydrogen peroxide（H2O2） scavenging ***:The ethyl acetate（EA） fraction was found to have high levels of phenolic content[（212.15±0.79） mg GAE/g].The EA fraction exhibited higher total antioxidant capacity,higher percentage of DPPH radical scavenging activity[（127.07±2.29） Fg/mL],nitric oxide[（245.16±1.44）μg/mLJ,hydrogen peroxide[（227.38±7.18）μg/mL],deoxyribose[（270.61±8.72）μg/mL]and higher reducing *** was a significant correlation between total phenolic content and total antioxidant activity（r =0.972）. Conclusions:These results reveal that EA fraction of *** has strong antioxidant potential compared with other *** further study has been extended to the isolation of the possible compound that is responsible for having antioxidant property.

关键词： Hybanthus enneaspermus Antioxidant Total phenolics

MODELING A SOLID BOUNDARY AS A FLUID OF INFINITE VISCOSITY

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Chinese Journal of Mechanical Engineering 2000年第1期13卷 2-9页

作者： Gingold Harry Gera dinesh West Virginia University U. S. A West Virginia University 美国

A new approach to model viscosity in the conservation of momentum equations is presented and discussed. Coefficient of viscosity is modeled in such a way that it reaches asymptotically to infinity at the solid boundary but still yields a finite value for the shear stress at the solid wall. Basic objective of this research is to show that certain combinations of higher order normal velocity gradients become zero at the solid boundary. Malled solutions for the Couette flow and Poiseuille flow between two parallel plates are obtained by modeling the coefficient of viscosity in a novel way. Also, viscous drag computed by our model is expected to yield higher values than the values predicted by the existing models, which matches closely to the experimental data.

关键词： Coefficient of viscosity Solid boundary Viscous drag

Augmented Node Placement Model in t-WSN Through Multiobjective Approach

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Computers, Materials & Continua 2021年第12期69卷 3629-3644页

作者： Kalaipriyan Thirugnansambandam Debnath Bhattacharyya Jaroslav Frnda dinesh Kumar Anguraj Jan Nedoma School of Computer Science and Engineering VIT UniversityChennai CampusTamilnaduIndia Department of Computer Science and Engineering Koneru Lakshmaiah Education FoundationVaddeswaramGunturIndia Department of Quantitative Methods and Economic Informatics Faculty of Operation and Economics of Transport and CommunicationsUniversity of Zilina01026 ZilinaSlovakia Department of Telecommunications Faculty of Electrical Engineering and Computer ScienceVSB-Technical University of Ostrava70833 Ostrava-PorubaCzech Republic

In Wireless Sensor Network(WSN),coverage and connectivity are the vital challenges in the target-based *** linear objective is to find the positions to cover the complete target nodes and connectivity between each sensor for data forwarding towards the base station given a grid with target points and a potential sensor placement *** this paper,a multiobjective problem on target-based WSN(t-WSN)is derived,which minimizes the number of deployed nodes,and maximizes the cost of coverage and sensing *** Evolutionary-based Non-Dominated Sorting Genetic Algorithm-II(NSGA-II)is incorporated to tackle this multiobjective problem *** problems are intended to solve different objectives of a problem ***-inspired algorithms address the NP-hard problem most effectively in recent *** NSGA-II,the Non-Dominated sorting preserves the better solution in different objectives simultaneously using dominance *** the diversity maintenance phase,density estimation and crowd comparison are the two components that balance the exploration and exploitation phase of the *** of NSGA-II on this multiobjective problem is evaluated in terms of performance indicators Overall Non-dominated Vector Generation(ONGV)and Spacing(SP).The simulation results show the proposed method performs outperforms the existing algorithms in different aspects of the model.

关键词： Focused wireless sensor network m-coverage k-connectivity problem non-dominated sorting NSGA-II