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Assessment of muscle strength in para-athletes:A systematic review of observational studies

Sports Medicine and Health Science 2022年第4期4卷 225-238页

作者： Sean R.O'Connor Kristina Fagher Samuel Williamson Babette M.Pluim Clare L.Ardern dina C.Janse van Rensburg Neil Heron Centre for Public Health Queen's University BelfastBelfastUK School of Psychology Queen's University BelfastBelfastUK Rehabilitation Medicine Research Group Department of Health SciencesLund UniversityLundSweden English Institute of Sport ManchesterUK Royal Netherlands Lawn Tennis Association AmstelveenNetherlands Section Sports Medicine Faculty of Health SciencesUniversity of PretoriaPretoriaSouth Africa Amsterdam Collaboration on Health&Safety in Sports(ACHSS) IOC Research Center of ExcellenceAmsterdam UMCAmsterdamNetherlands Department of Family Practice University of British ColumbiaVancouverCanada Medical Board Member World NetballManchesterUK School of Medicine Keele UniversityStaffordshireUK

Accurate and reliable evaluation of muscle strength in para-athletes is essential for monitoring the effectiveness of strength training and/or rehabilitation programmes,and sport *** aim is to synthesise evidence related to assessing muscle strength in *** databases were searched from January 1990 to July 2021 for observational studies focusing on strength *** screening,data extraction,and quality assessment were performed in duplicate.A total of 1764 potential studies were *** met the inclusion criteria and were included in the *** mean age of participants was 30.7 years(standard deviation[SD]:2.4).The majority were men(88%)participating in wheelchair sports,including basketball,rugby,and tennis(23/30:76%).Overall quality varied,with more than half of the studies failing to identify strategies for dealing with confounding *** manual muscle testing being a standard component of para-sport classification systems,evidence examining strength characteristics in para-athletes is derived primarily from isometric and isokinetic *** studies that included comparative strength data,findings were *** studies found strength values were similar to or lower than able-bodied athletic ***,an important observation was that others reported higher shoulder strength in para-athletes taking part in wheelchair sports than both able-bodied and disabled *** need to develop accessible,standardised strength testing methods that account for training influence and establish normative strength values in *** is also a need for additional studies that include female para-athletes and para-athletes with greater functional impairments.

关键词： Systematic review Para-athletes Disabled sport Muscle strength Assessment

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Aryl Hydrocarbon Receptor is Involved in the Proinflammatory Cytokine Response to Cadmium

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Biomedical and Environmental Sciences 2021年第3期34卷 192-202页

作者： KULAS Jelena TUCOVIC dina ZELJKOVIC Milica POPOVIC Dusanka POPOV ALEKSANDROV Aleksandra KATARANOVSKI Milena MIRKOV Ivana Immunotoxicology Group Department of EcologyInstitute for Biological Research‘Sinisa Stankovic'-National Institute of Republic of SerbiaUniversity of Belgrade142 Bulevar despota StefanaBelgrade 11000Serbia

Objective To investigate involvement of the aryl hydrocarbon receptor(Ah R)in the immunomodulatory effects of cadmium(Cd).Methods The effect of Cd on Ah R activation(CYP1 A1 and CYP1 B1 m RNA expression)was examined in lung leukocytes of Cd-exposed rats(5 and 50 mg/L,30 d orally)and by in vitro leukocyte *** involvement of Ah R signaling in the effects of Cd on the interleukin(IL)-1β,IL-6,and tumor necrosis factor(TNF)lung leukocyte response was investigated in vitro using the receptor antagonist *** Cd increased CYP1 B1(in vivo and in vitro)and CYP1 A1(in vitro)m RNA,indicating Ah R involvement in the action of *** response to Cd,lung leukocytes increased IL-6 and decreased TNF at the gene expression and protein levels,but decreased IL-1βproduction due to reduced *** Ah R antagonist CH-223191 abrogated the observed effects of Cd on the cytokine *** absence of Ah R reactivity and cytokine response to Cd of leukocytes from the lungs of a rat strain that is less sensitive to Cd toxicity coincided with a high Ah R repressor m RNA *** Ah R signaling is involved in the lung leukocyte proinflammatory cytokine response to *** relevance of the Ah R to the cytokine response to Cd provides new insight into the mechanisms of Cd immunotoxicity.

关键词： Cadmium Lung leukocytes Aryl hydrocarbon receptor Cytokine(IL-6,TNF,IL-1β)response

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Investigation of SARS-CoV-2 Main Protease Potential Inhibitory Activities of Some Natural Antiviral Compounds Via Molecular Docking and Dynamics Approaches

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Phyton-International Journal of Experimental Botany 2022年第5期91卷 1089-1104页

作者： Nada M.Mostafa Muhammad I.Ismail Amr M.El-Araby dina M.Bahgat Ahmed M.Elissawy Ahmed M.Mostafa Omayma A.Eldahshan Abdel Nasser B.Singab Department of Pharmacognosy Faculty of PharmacyAin Shams UniversityCairo11566Egypt Department of Pharmaceutical Chemistry Faculty of PharmacyThe British University in EgyptCairo11837Egypt Department of Pharmaceutical Chemistry Faculty of PharmacyAin Shams UniversityCairo11566Egypt Department of Biochemistry Faculty of PharmacyAin Shams UniversityCairo11566Egypt Center for Drug Discovery and Development Research Ain Shams UniversityCairo11566Egypt

Coronaviruses caused an outbreak pandemic disease characterized by a severe acute respiratory distress syndrome leading to the infection of more than 200 million patients and the death of more than 4 million *** primary treatment is either supportive or *** products have an important role in the development of various ***,screening of natural compounds with reported antiviral activities can lead to the discovery of potential inhibitory entities against *** the current study,an in-silico molecular docking experiment was conducted on the effects of some of these natural antiviral phytoconstituents,(e.g.,procyanidin B2,theaflavin,quercetin,ellagic acid,caffeoylquinic acid derivatives,berginin,eudesm-1β,6α,11-triol and arbutin),on the crystal structure of SARS-CoV-2 main protease(PDB ID:6w63)using AutoDock-Vina *** of the docked compounds revealed good binding affinity,with procyanidin B2(–8.6 Kcal/mol)and theaflavin(–8.5 Kcal/mol)showing a better or similar binding score as the ligand(–8.5 Kcal/mol).Molecular dynamics simulations were carried out at 100 ns and revealed that procyanidin B2 forms a more stable complex with SARS-CoV-2 main protease than *** B2,theaflavin,and 4,5-dicaffeoylquinic acid were evaluated for toxicity by ProTox-II webserver and were non-toxic according to the predicted LD50 values and safe on different organs and ***,these phytoconstituents showed good ADME properties and acceptable lipophilicity,as evaluated using *** the tested compounds,procyanidin B2 showed the highest lipophilic *** is worth mentioning that these natural inhibitiors of SARS-CoV-2 main protease are components of green and black tea that can be used as a supporting supplement for COVID patients or as potential nuclei for further drug design and development campaigns.

关键词： Coronavirus natural products SARS-CoV-2 main protease molecular docking molecular dynamics tea

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Serum leptin and ghrelin in chronic hepatitis C patients with steatosis

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World Journal of Gastroenterology 2011年第46期17卷 5097-5104页

作者： Christos Pavlidis Georgios I Panoutsopoulos dina Tiniakos Sotirios Koutsounas John Vlachogiannakos Irini Zouboulis-Vafiadis First Department of Propaedeutic Medicine"LAIKO"General Hospital Department of Nursing University of PeloponneseOrthias Artemidos and PlateonSparta Laboratory of Histology and Embryology Medical SchoolNational and Kapodistrian University of Athens Reference Center for Viral Hepatitis

AIM:To determine the associations between leptin and ghrelin concentrations and sustained virological response(SVR)in chronic hepatitis C patients with ***:We retrospectively assessed 56 patients infected with hepatitis C virus(HCV)genotype-1 and 40 with HCV *** with decompensated cirrhosis,and those with other causes of chronic liver disease,were *** HCV-RNA concentra-tions were measured before the initiation of treatment;at weeks 12(for genotype 1 patients),24 and 48 during treatment;and 24 wk after the end of *** was determined using INNO-LIPA HCV as-says,and serum leptin and ghrelin concentrations were measured using enzyme-linked immunosorbent *** specimens were scored according to the Ishak system and steatosis was graded as mild,moderate,or severe,according to the Brunt classif ***:Overall,SVR was positively related to the presence of genotype-3,to biopsy-determined lower histological stage of liver disease,and lower grade of *** ≥ 40 years old tended to be less responsive to *** genotype-1 infected pa-tients,SVR was associated with a lower grade of liver steatosis,milder fibrosis,and an absence of insulin ***-1 infected patients who did not achieve SVR had significantly higher leptin concen-trations at baseline,with significant increases as the severity of steatosis worsened,whereas those who achieved SVR had higher ghrelin *** genotype-3 infected patients,SVR was associated only with fibrosis stage and lower homeostasis model as-sessment insulin resistance at baseline,but not with the degree of steatosis or leptin ***-type-3 infected patients who achieved SVR showed signif icant decreases in ghrelin concentration at end of *** ghrelin concentrations were elevat-ed in responders of both genotypes who had moderate and severe ***:Increased serum leptin before treat-ment may predict non

关键词：丙型肝炎病毒生长素低脂肪患者瘦素血清慢性 ghrelin

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Effect of iridium loading on HZSM-5 for isomerization of n-heptane

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Journal of Natural Gas Chemistry 2011年第5期20卷 477-482页

作者： Herma dina Setiabudi Sugeng Triwahyono Aishah Abdul Jalil Nur Hidayatul Nazirah Kamarudin Muhammad Arif Ab Aziz Department of Chemical Engineering Faculty of Chemical Engineering Universiti Teknologi Malaysia Ibnu Sina Institute for Fundamental Science Studies Faculty of Science Universiti Teknologi Malaysia

The effect of iridium loading on the properties and catalytic isomerization of n-heptane over Ir-HZSM-5 is studied. Ir-HZSM-5 was prepared by impregnation method and subjected to isomerization process in the presence of flowing hydrogen gas. XRD and BET studies show that the presence of iridium stabilizes the crystalline structure of HZSM-5, leading to more ordered framework structure and larger surface area. TGA and FTIR results substantiate that iridium species interacts with OH group on the surface of HZSM-5. Pyridine FT-IR study verifies the interaction between iridium and surface OH group slightly increased the Bro¨nsted and Lewis acid sites without changing the lattice structure of HZSM-5. The presence of iridium and the increase of strong Lewis acid sites on HZSM-5 were found to bring an increase about 4.1%, 33.2% and 11.8% in conversion, selectivity and yield of n-heptane isomerization, respectively.

关键词： Ir-HZSM-5 n-heptane isomerization Lewis acid sites protonic acid sites

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Scalable batch fabrication of ultrathin flexible neural probes using a bioresorbable silk layer

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Microsystems & Nanoengineering 2022年第1期8卷 305-315页

作者： Clement Cointe Adrian Laborde Lionel G.Nowak dina N.Arvanitis David Bourrier Christian Bergaud Ali Maziz LAAS-CNRS 7 Avenue du Colonel RocheF-31400 ToulouseFrance CerCo UniversitéToulouse 3CNRSPavillon BaudotCHU PurpanBP 2520231052 ToulouseFrance UMR Institut National de la Santéet de la Recherche Médicale 1048 Institut des Maladies Métaboliques et CardiovasculairesToulouseFrance

Flexible intracerebral probes for neural recording and electrical stimulation have been the focus of many research works to achieve better compliance with the surrounding tissue while minimizing *** have been explored to find the best way to insert flexible probes into the brain while maintaining their flexibility once ***,we present a novel and versatile scalable batch fabrication approach to deliver ultrathin and flexible probes consisting of a silk-parylene *** biodegradable silk layer,whose degradation time is programmable,provides a temporary and programmable stiffener to allow the insertion of ultrathin parylene-based flexible *** innovative and robust batch fabrication technology allows complete freedom over probe design in terms of materials,size,shape,and *** demonstrate successful ex vivo insertion of the probe with acute high-fidelity recordings of epileptic seizures in field potentials as well as single-unit action potentials in mouse brain *** novel technological solution for implanting ultraflexible devices in the brain while minimizing rejection risks shows high potential for use in both brain research and clinical therapies.

关键词： batch recording insertion

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新的数字表示方法将改进AI数学运算

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科技纵览 2022年第12期 10-11页

作者： dina Genkina 不详

训练支撑许多现代人工智能(AI)工具的大型神经网络都需要真实强大的计算能力。例如,OpenAI最先进的语言模型GPT-3训练就需要惊人的10亿亿次运算,其计算时间耗资约500万美元。工程师们认为他们已经找到了一种方法。

关键词：数学运算语言模型工程师们计算能力 AI 神经网络训练

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Mesenchymal stem cells transplantation attenuates experimentally induced brain injury after neonatal hypoxia by different two routes of administrations

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BIOCELL 2019年第1期43卷 21-28页

作者： Nesrine EBRAHIM Eman EHSAN Eman Abd EL GHANY dina SABRY Ashraf SHAMAA Histology and Cell Biology Department Faculty of MedicineBenha UniversityBenhaEgypt Pediatrics Department Faculty of MedicineCairo UniversityGizaEgypt Medical Biochemistry and molecular biology Department Faculty of MedicineCairo UniversityGizaEgypt Surgical and Radiology Department Faculty of Veterinary MedicineCairo UniversityGizaEgypt

The neonatal hypoxic-ischemic encephalopathy(HIE)is an important cause of neurological morbidity and mortality in *** therapy is considered a promising method for treating severe neurological disorders such as this *** cells have the capacity for self-renewal and differentiation into certain cell *** present study was aimed to find out the most beneficial route of bone marrow-derived mesenchymal stem cells(BMSCs)administration for the attenuation of experimentally induced HIE in neonatal *** neonatal rats were divided randomly into four *** 1:control *** 2:rats were exposed to bilateral ligation of cephalic *** 3:rats were exposed to bilateral ligation of cephalic arteries and then underwent intravenous(IV)BMSC *** 4:rats were exposed to bilateral ligation of cephalic arteries and then underwent intracerebroventricular(ICV)BMSC *** animals were evaluated by(a)neurobehavioral tests;(b)histopathology,i.e.,histological and immuno-histochemical studies;and(3)gene expression *** BMSC treated groups(3 and 4)showed improvement in neurobehavioral tests,histopathological studies,and gene expression,as compared to non-injected lesioned rats(Group 2)with better improvement in Group 4(ICV injections)than in Group 3(IV injections).

关键词： Cerebral cortex Neonatal hypoxic ischemia Stem cells

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Systematic framework for the efficient integration of wind technologies into buildings

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Frontiers of Architectural Research 2016年第1期5卷 1-14页

作者： Ashraf A. ELMokadem Naglaa A. Megahed dina S. Noaman Architecture and Urban Planning Department Faculty of Engineering Port-Said University Port SaidEgypt

The renewed interest that is being paid by architects, project developers and local governments to integrate wind turbines with buildings is mainly required a framework to unify much data, criteria and variables to ease the design process to many architects. Therefore, this paper introduces and elaborates the systematic framework towards the efficient integration of wind technologies into new building. Moreover, it evaluates the framework effectiveness by comparing the current status of wind technologies integration into a buitding with the suggested status if the framework is followed.

关键词： Building integratedwind technology Integration method Systematic framework

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通过化学更好地实现人工智能

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科技纵览 2023年第2期 7-9页

作者： dina Genkina 不详

我们距离人工大脑还有多远?也许还有很长一段路要走,但如今初步模拟大脑网络的基本要素——突触似乎近在咫尺.这是因为如今有一种灵感来自电池的电化学存储器(ECRAM)设备出人意料地适合运行人工神经网络.令人意想不到的是,它给传统基于... 详细信息

我们距离人工大脑还有多远?也许还有很长一段路要走,但如今初步模拟大脑网络的基本要素——突触似乎近在咫尺.这是因为如今有一种灵感来自电池的电化学存储器(ECRAM)设备出人意料地适合运行人工神经网络.令人意想不到的是,它给传统基于晶体管的人工智能(AI)带来了意料之外的资金竞争压力,在开发理想的人工突触方面,它很快地走向了领先地位.

关键词：人工神经网络大脑网络存储器意料之外基本要素竞争压力人工突触电化学

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