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Pharmacokinetics of Lithium in Egyptian Bipolar Patients: Dosage Adjustment Approach

Pharmacology & Pharmacy 2014年第4期5卷 425-432页

作者： abdel-Hameed Ibrahim Mohamed Ebid dina awny tawfik abd-allah Mahmoud Mamdouh Mohamed Elhabiby Pharmacy Practice Department Faculty of Pharmacy Helwan University Cairo Egypt Psychiatry Department Faculty of Medicine Ain-Shams University Cairo Egypt

Due to its proven clinical effectiveness, lithium has been considered as a corner stone for the long-term treatment of Bipolar Disorder (BPD) for more than half a century. The objective of this study was to evaluate the effect of patients’ different co-variables on lithium pharmacokinetics and the development of a pharmacokinetic model for the estimation of lithium clearance in Egyptian bipolar patients;this model can be used afterwards during dosage adjustment to achieve target’s steady-state plasma concentrations in similar settings. The study was conducted on 65 adult Egyptian bipolar patients of both genders, in both the in- and out-patient settings in the Institute of Psychiatry, Faculty of Medicine, Ain Shams University, Cairo, Egypt. Patients’ full profiles were prepared, containing all their data. Single daily dose regimen was followed by all patients and one blood sample was drawn 12 ± 0.5 hours post dose for steady-state lithium concentration, sodium level and serum creatinine determinations. Lithium trough levels were determined using Flame Emission Photometry technique. Data analysis and regression modeling revealed a significant correlation between total body weight (TBW), body surface area (BSA) and lithium clearance. Due to multicollinearity, BSA was excluded from the basic non-linear regression equation and TBW was found to be the only covariate affecting lithium clearance. Mean lithium clearance was found to be 0.243 ± 0.097 Lit/Kg/day, ranging from 0.091 to 0.71 Lit/Kg/day.

关键词： Lithium Pharmacokinetics Bipolar Disorder

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Contrast-Enhanced CT-Guided Core Biopsy of Retroperitoneal Masses

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Open Journal of Radiology 2014年第1期4卷 130-135页

作者： Adel El-Badrawy Ahmed tawfik Sherif abdelfattah Amir Monir Manal Salah-Eldin Emad Eldin Azmy dina El-Tantawy Amro El-Karef Clinical Hematology Department Mansoura Faculty of Medicine Mansoura Egypt Medical Oncology Department Mansoura Faculty of Medicine Mansoura Egypt Pathology Department Mansoura Faculty of Medicine Mansoura Egypt Radiology Department Mansoura Faculty of Medicine Mansoura Egypt

Objective: To evaluate the efficacy, feasibility and safety of contrast-enhanced CT-guided core biopsy of retroperitoneal masses. Materials and Methods: Contrast-enhanced CT-guided biopsy of retroperitoneal masses was performed in 26 patients. Histopathological diagnosis was obtained and accuracy was calculated. Two blinded radiologists determined feasibility of biopsy procedures on routine CT-guidance, and compared accessibility of target lesions using contrast-enhanced and non-contrast-enhanced CT. Results: Satisfactory samples were obtained in all 26 patients and pathological diagnosis was made in 24. Accuracy was 95.5%. Routine CT-guided biopsy punctures were not satisfaction in 4/26 patients, and contrast-enhanced CT scans rendered the target lesions more accessible in 16 patients. Conclusion: Contrast-enhanced CT-guided biopsy increases the feasibility of biopsy of retroperitoneal masses.

关键词： Contrast-Enhanced CT-Guided Biopsy Retroperitoneal Masses

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