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Next-generation surgicalmeshes for drug delivery and tissue engineering applications:materials,design and emerging manufacturing technologies

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Bio-Design and Manufacturing 2021年第2期4卷 278-310页

作者： Francesca Corduas dimitrios a.lamprou Elena Mancuso Nanotechnology and Integrated Bio-Engineering Centre(NIBEC) Ulster UniversityJordanstown CampusNewtownabbey BT370QBUK School of Pharmacy Queen’s University BelfastBelfast BT97BLUK

Surgical meshes have been employed in the management of a variety of pathological conditions including hernia,pelvic floor dysfunctions,periodontal guided bone regeneration,wound healing and more recently for breast plastic surgery after *** common pathologies affect a wide portion of the worldwide population;therefore,an effective and enhanced treatment is crucial to ameliorate patients’living conditions both from medical and aesthetic points of *** present,non-absorbable synthetic polymers are the most widely used class of biomaterials for the manufacturing of mesh implants for hernia,pelvic floor dysfunctions and guided bone regeneration,with polypropylene and poly tetrafluoroethylene being the most *** prostheses,such as surgical grafts,have been employed mainly for breast plastic surgery and wound healing *** the advantages of mesh implants to the treatment of these conditions,there are still many drawbacks,mainly related to the arising of a huge number of post-operative complications,among which infections are the most *** a mesh that could appropriately integrate with the native tissue,promote its healing and constructive remodelling,is the key aim of ongoing research in the area of surgical mesh *** this end,the adoption of new biomaterials including absorbable and natural polymers,the use of drugs and advanced manufacturing technologies,such as 3D printing and electrospinning,are under investigation to address the previously mentioned challenges and improve the outcomes of future clinical *** aim of this work is to review the key advantages and disadvantages related to the use of surgical meshes,the main issues characterizing each clinical procedure and the future directions in terms of both novel manufacturing technologies and latest regulatory considerations.

关键词： 3D printing Electrospinning Manufacturing technologies Biomaterials Drug delivery Surgical mesh implants

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A perspective on high photon flux nonclassical light and applications in nonlinear optics

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High Power Laser Science and Engineering 2020年第4期8卷 98-103页

作者： Th.lamprou I.Liontos N.C.Papadakis P.Tzallas Foundation for Research and Technology-Hellas Institute of Electronic Structure and Laser70013 Heraklion(Crete)Greece Department of Physics University of Crete70013 Heraklion(Crete)Greece Mechanical Engineering Department School of Applied SciencesHellenic Mediterranean University71410 HeraklionGreece ELI-ALPS ELI-Hu Non-Profit Ltd.H-6720 SzegedHungary

Nonclassical light sources have a vital role in quantum optics as they offer a unique resource for studies in quantum ***,their applicability is restricted by their low intensity,while the development of new schemes producing intense nonclassical light is a challenging *** this perspective article,we discuss potential schemes that could be used towards the development of high photon flux nonclassical light sources and their future prospects in nonlinear optics.

关键词： quantum optics nonlinear optics high-power lasers

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Structural Analysis of a RC Shear Wall by Use of a Truss Model

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Open Journal of Civil Engineering 2022年第3期12卷 320-352页

作者： Panagis G. Papadopoulos Periklis E. lamprou Division of Structural Engineering Department of Civil Engineering Aristotle University of Thessaloniki Thessaloniki Greece

Purpose of present work is to develop a reliable and simple method for structural analysis of RC Shear Walls. The shear wall is simulated by a truss model as the bar of a truss is the simplest finite element. An iterative method is used. Initially, there are only concrete bars. Repeated structural analyses are performed. After each structural analysis, every concrete bar exceeding tensile strength is replaced by a steel bar. For every concrete bar exceeding compressive strength, first its section area is increased. If this is not enough, a steel bar is placed at the side of it. For every steel bar exceeding tensile or compressive strength, its section area is increased. After the end of every structural analysis, if all concrete and steel bars fall within tensile and compressive strengths, the output data are written and the analysis is terminated. Otherwise, the structural analysis is repeated. As all the necessary conditions (static, elastic, linearized geometric) are satisfied and the stresses of ALL concrete and steel bars fall within the tensile and compressive strengths, the results are acceptable. Usually, the proposed method exhibits a fast convergence in 4 - 5 repeats of structural analysis of the RC Shear Wall.

关键词： Reinforced Concrete Shear Wall Structural Analysis Truss Model Iterative Method Computer Program Boundary Columns and Beam Grid of Horizontal and Diagonal Reinforcing Steel Bars

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