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Treatment of Chronic Viral Hepatitis with Pegylated Interferon in Ivory Coast

Open Journal of Gastroenterology 2016年第3期6卷 65-74页

作者： Henriette Ya Kissi Anzouan-Kacou Aboubacar Demba Bangoura Djenabou Diallo Yacouba Adéhouni Adjeka Stanislas Doffou Hartrydt dimitri Kouamé Alassan Kouamé Mahassadi Mamert Fulgence Yao Bathaix Alain Koffi Attia Aya Thérèse Ndri-Yoman Hepatogastroenterology Unit Yopougon Teaching Hospital Yopougon Ivory Coast Pharmacy Unit Yopougon Teaching Hospital Yopougon Ivory Coast

Background: In the Ivory Coast, chronic infection by hepatitis B and C virus is the leading cause of cirrhosis and hepatocellular carcinoma. The absence of universal health coverage makes the treatment inaccessible to all. Objectives: To assess the efficacy of Pegylated Interferon in clinical practice in patients with chronic viral hepatitis B and C and determine the hematologic side effects. Patients and Methods: A descriptive retrospective study from January 2012 to November 2013 on a cohort of patients chronic carriers of hepatitis B virus (n = 11) treated with Pegylated Interferon to 180 mcg per week and hepatitis C virus (n = 30) treated with a combination therapy associating pegylated Interferon to 180 mcg per week and Ribavirin assayed according to the genotype. Results: Out of 1860 patients seen in hepatogastroenterology consultation 422 had viral hepatitis B or C that is a prevalence of 22.7% and 41 patients were treated (9.7%) by Pegylated Interferon. Among these 41 patients mentioned earlier, 30 had HCV (73.17%) with a case of HIV + HVC co-infection, 11 patients had HBV (26.83%) including 3 cases of HBV + HDV co-infection. Patients’ age ranged from 24 - 69 years with an average of 49.2 ± 12.2 years including 46.5 years for HBV and 51.9 years for HCV. The sex ratio was 1.56. The original transaminases were on average 93.37 IU/l for AST and 110.47 for ALT. The average RNA HCV was 1,685,331 IU/ml and the DNA HBV 33,312,767 IU/ml. Patients with HCV were of genotype 1 in 56.66%, genotype 2 in 40% and one case of genotype 4 (3.34%) from Central Africa. Fibrosis score at institution of treatment was significant (≥A2 and/or ≥F2) in 86.9% of cases of Fibrotest®, 100% of cases of Fibrometer®. We observed 48.8% of neutropenia < 750/mm3, 33.3% of anemia and 29.3% of thrombocytopenia < 100,000/mm3. There was no dose reduction of Pegylated Interferon and Ribavirin. For HBV there were 3 partial responses, 3 responders including 1 HBV + HDV co-infected non responder to H

关键词： HBV HCV Pegylated Interferon Ribavirine Africa

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Prostatic sarcoma of the Ewing family in a 33-year-old male e A case report and review of the literature

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Asian Journal of Urology 2016年第2期3卷 103-106页

作者： Lukas Esch dimitri Barski Reinhold Bug Thomas Otto Department of Urology Stadtische Kliniken NeussLukaskrankenhaus GmbHNeussGermany Department of Pathology Stadtische Kliniken NeussLukaskrankenhaus GmbHNeussGermany

Ewing sarcoma is the second most common primary bone tumor seen in children and adolescents,typically presenting between 10 and 20 years of *** sarcomas of the Ewing family in adults are *** report a manifestation of this tumor entity in the periprostatic tissue of a 33-year-old male and discuss our treatment *** biopsy is a feasible and simple diagnostic tool for unclear pelvic ***-modal therapy and central registries are needed to gain knowledge of rare pelvic tumors like Ewing sarcoma.

关键词： Ewing sarcoma Pelvic neoplasms Adult Surgery Chemotherapy Prostate

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欧洲血管外科学会指南：第1部分——颈动脉狭窄患者的预防

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国际脑血管病杂志 2011年第6期19卷 401-409页

作者： Christos D. Liapis Sir Peter F. Bell dimitri P. Mikhailidis Juhani Sivenius Andrew Nicolaides Jose Femandes e Fernandes Giorgio Biasi Lars Norgren 董大伟(译) 刘小艳(译) 徐安定(译) 不详暨南大学附属第一医院神经内科 510630

在此，我们呈献颈动脉狭窄患者脑血管事件二级预防的欧洲血管外科学会指南，包括降脂治疗、抗血小板治疗以及其他危险因素控制。这些推荐均基于现有的临床试验证据。对颈动脉疾病患者需要采取积极的预防性治疗。我们还讨论了颈动脉狭窄... 详细信息

在此，我们呈献颈动脉狭窄患者脑血管事件二级预防的欧洲血管外科学会指南，包括降脂治疗、抗血小板治疗以及其他危险因素控制。这些推荐均基于现有的临床试验证据。对颈动脉疾病患者需要采取积极的预防性治疗。我们还讨论了颈动脉狭窄的诊断和分级。

关键词：颈动脉狭窄他汀类药物抗血小板药物高血压危险因素诊断

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Hepatitis B Surface Antigen Serum Level Is Correlated with Fibrosis Severity in Treatment-Naïve, Chronic Hepatitis B Patients in Côte d’Ivoire (West Africa)?

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Open Journal of Gastroenterology 2015年第11期5卷 164-172页

作者： Mamert Fulgence Yao Bathaix Dramane Soro Aboubacar Demba Bangoura Adjéka Stanislas Doffou Siaka Koné Ya Henriette Kissy dimitri Hartrydt Kouamé Aoudi Ousmane Dé Mahassadi Kouamé Alassane Attia Koffi Alain Aya Thérèse N’dri Yoman Department of Hepatology and Gastroenterology of the Centre Hospitalier Universitaire de Yopougon (CHU-Y) Abidjan Cote d’Ivoire Department of Hepatology and Gastroenterology of the Centre Hospitalier Universitaire de Cocody (CHU-C) Abidjan Cote d’Ivoire

HBsAg serum level (quantification) may be useful for managing hepatitis B virus (HBV) infection patients. However few studies especially in Africa have evaluated the association between HBsAg serum level and liver fibrosis severity. The objective of this study was to estimate the correlation between HBsAg serum level and liver fibrosis severity with treatment naive chronic hepatitis B patients in Cote d’Ivoire. Methodology: It is a prospective study covering from February 1st, 2014 to April 30st, 2015 at Centre Hospitalier et Universitaire de Yopougon and a private medical office in Abidjan, Cote d’Ivoire. Inclusion criteria for patients were: HBsAg positive, known HBeAg status, serum HBsAg levels, serum HBV DNA levels, complex serum markers and absence of HCV, HDV, or HIV co-infection, drinking more than 30 g/day for men and 20 g/day in women over 10 years, metabolic disease and/or hepatic overload. Pearson’s Chi-square test (r2), Anova, Spearman, T-Student, Pearson’s (r) correlations and Mann Withney’s Test were carried out as appropriate. A p value < 0.05 was taken as significant. Results: We recruited, 105 patients (77 men) of whom the medium age was 39.01 ± 9.72 years. Predominant hepatitis B viral genotype was E (93%). Less than 10% patients had an inactive HBV in HBeAg-negative. Patients had an average high HBsAg serum level (mean 12111.2 ± 10617.4 IU/ml) as well as the one viral load (mean 4.4 e7 ± 7.5 e7). Serum ALAT levels averaged at the upper limit of normal value. The average liver fibrosis score was 0.34 ± 0.22 and the degree of viral activity was 0.19 ± 0.20. Half of our patients had no fibrosis (35.24%) or had mild fibrosis (20.95%). No significant association was observed between HBsAg serum level and patient age (p = 0.3994), genre (p = 0.8075) or serum ALT levels (p = 0, 0787). In multivariate analysis, there’s a significant correlation (r = 0.239, p = 0.014) between HBV DNA levels and HBsAg serum level. There’s a significant correlation (r = 0.92

关键词： Hepatitis B Surface Antigen Serum Level Liver Fibrosis Chronic Hepatitis B Viral Africa

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Study of the Potential for the Solar Concentrating Sector in Burkina Faso

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Journal of Energy and Power Engineering 2022年第3期16卷 114-120页

作者： Stanislas Sanfo Serge dimitri Bazyomo Tizane Dao Abdoulaye Ouedraogo Laboratory of Physics and Chemistry of Environment(LPCE) Department of PhysicsUnit of Training and Research on Exact and Applied SciencesBP 7021University Joseph KI-ZERBOOuagadougouBurkina Faso Laboratory of Thermal and Renewable Energies Department of PhysicsUnit of Training and Research on Exact and Applied SciencesBP 7021University Joseph KI-ZERBOOuagadougouBurkina Faso

The results of atmospheric effect characterization on the town of Ouagadougou in Burkina Faso are presented and the link with the availability of the direct component of solar radiation is *** meteorological data are treated to set a system of constant references which are used to extrapolate the likely atmospheric effect given by the other experimental meteorological data from 1976 to *** results the periods of strong monthly attenuation of the solar potential are pointed out.

关键词： Solar radiation direct component solar potential Burkina Faso experimental data.

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欧洲血管外科学会指南：第二部分——颈动脉狭窄患者的诊断和检查

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国际脑血管病杂志 2011年第7期19卷 488-497页

作者： Christos D. Liapis Sir Peter F. Bell dimitri P. Mikhailidis Juharli Sivenius Andrew Nicolaides Jose Femandes e Fernandes Giorgio Biasi Ears Norgrer 赵颖(译) 谭泽锋(译) 徐安定(译) ESVS指南协作组暨南大擎附属第一医院神经内科 510630

在此，我们呈献颈动脉狭窄患者脑血管事件二级预防的欧洲血管外科学会指南，包括降脂治疗、抗血小板治疗以及其他危险因素控制。这些推荐均基于现有的临床试验证据。对颈动脉病患者需要采取积极的预防性治疗。我们还讨论了颈动脉狭窄的... 详细信息

在此，我们呈献颈动脉狭窄患者脑血管事件二级预防的欧洲血管外科学会指南，包括降脂治疗、抗血小板治疗以及其他危险因素控制。这些推荐均基于现有的临床试验证据。对颈动脉病患者需要采取积极的预防性治疗。我们还讨论了颈动脉狭窄的诊断和分级。

关键词：颈动脉狭窄他汀类药物抗血小板药高血压危险因素诊断

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Assessment of the Efficacy of Rifaximin in the Management of Irritable Bowel Syndrome (IBS)

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Open Journal of Gastroenterology 2017年第10期7卷 261-270页

作者： Stanislas A. Doffou Kissi Henriette Anzouan-Kacou Eugene K. Messou Demba A. Bangoura dimitri H. Kouamé Kouame M. Alassan Constant Assi Fulgence Mamert Y. Bathaix Alain K. Attia Marie-Jeanne K. Lohoues Yopougon University Hospital Abidjan C&ocirc te d’Ivoire Treichville University Hospital Abidjan C&ocirc te d’Ivoire Cocody University Hospital Abidjan C&ocirc te d’Ivoire

The aim of our study was to assess in our context, the efficacy of Rifaxim in improving the symptoms of irritable bowel syndrome particularly in its diarrheal (IBS-D) or mixed (IBS-DC) component and therefore assess its impact on patients’ quality of life. Patients and methods: This was an uncontrolled, non-comparative prospective cohort study of a single group of patients. Patients recruitment was done in two University Hospitals for 6 months (September 2015-February 2016). Were included ambulatory patients, male or female, aged 18 - 75 years, with diarrheic IBS (IBS-D) or mixed IBS (IBS-DC) diagnosed according to Rome III criteria and who agreed to participate in the study. Each patient received 400mg Rifaximin × 2/d for 15 days. The overall assessment of the efficacy of treatment at D15 (end of treatment) and D30 (2 weeks post-treatment) was the primary criterion of judgment. The statistical tests used were the Chi-square test and Fisher’s exact test for the qualitative variables and Student’s test for the quantitative variables. Results: A total number of 30 patients (16 women) with an average age of 44.5 ± 13.9 years were included. The overall assessment of symptoms by the patient with the Likert scale found 28 (93.3%) patients, 12 (40%) patients and 10 patients (33.3%) for a scale ≥2 at D0, D15 and D30 respectively. The assessment of the intensity of pain or abdominal discomfort found at D0, D15 and D30 respectively: 27(90%), 13(43.4%) and 6(20.1%) patients who had an EVA score > 2. The mean score for Francis to assess the improved quality of life was 247.1 ± 97.4 at D0, 99.8 ± 63.1 at D15 and 128.8 ± 70.6 at D30. Conclusion: There is a good overall improvement of symptoms in our patients suffering from IBS-D or mixed (IBS-DC) on Rifaximin with improvement of the quality of life.

关键词： Rifaximin Irritable Bowel Diarrhea Quality of Life

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The <i>Helicobacter pylori</i>Eradication Rate in a High Prevalence Area (West Africa): Three Triple Therapy Comparative Study

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Open Journal of Gastroenterology 2015年第12期5卷 200-206页

作者： Adjéka Stanislas Doffou Koffi Alain Attia Mamert Fulgence Yao Bathaix Aboubacar Demba Bangoura Ya Henriette Kissy-Anzouan Hartrydt dimitri Kouamé Kouamé Alassan Mahassadi Kouamé Justin N’Da Mohamed Kouyaté Constant Assi Aya Thérèse N’dri-Yoman Department of Hepatology and Gastroenterology Centre Hospitalier Universitaire de Yopougon (CHU-Y) Abidjan Cote d’Ivoire Anatomopathology Laboratory of the Centre Hospitalier Universitaire de Cocody (CHU-C) Abidjan Cote d’Ivoire Department of Hepatology and Gastroenterology Centre Hospitalier Universitaire de Cocody (CHU-C) Abidjan Cote d’Ivoire

In Western countries, the current trend is to use sequential quadruple therapy or bismuth-based instead of triple therapy for the eradication of Helicobacter pylori (H. pylori). In sub-Saharan Africa, high prevalence area of the H. pylori infection, the effectiveness of these triple therapies widely used in routine has been little evaluated. The purpose of this study was to evaluate and compare the effectiveness of three patterns of first-line triple therapy based on combining a proton pump inhibitors (PPI), and 3 types of antibiotics: omeprazole (O), amoxicillin (A), clarythromycin (C) and metronidazole (M). Patients and Methods: This is a randomized clinical trial opened on 3 parallel arms: OAM (group 1 or G1), OAC (group 2 or G2) or OCM (group 3 or G3). The primary endpoint was H. pylori eradication rate after seven days triple therapy. H. pylori diagnosis infection was based on bacterium detection on the histological examination of the gastric biopsies. Histological control was performed 4 weeks after the end of treatment to assess H. pylori eradication rate. Results: The average age of our 153 patients included in the study (86 men) was 44.33 ± 11.72 years. The main reason of the endoscopy was the dyspeptic syndrome (75.16%). The gastroscopy was normal in 28.76%. A Gastric or duodenal peptic ulcer was found in 17% of cases and gastropathy in 45.75%. Histologically, the GC was active in 90.9% of cases, follicular in 35.3% of cases, atrophic in 22.5% of cases and was associated with intestinal metaplasia (IM) in 5.2% of cases. Patients of these three groups (n = 64 for G1, n = 56 for G2 and n = 33 for G3) were comparable for age, gender, endoscopy indications, alcohol consumption history or smoking, and anti-inflammatory drugs taking. Approximately 23% of patients experienced adverse reactions. The overall H. pylori eradication rate was 22.3%. There was no significant difference H. pylori eradication rate depending on the treatment used (28.1%, 21.4% and 15.1% fo

关键词： Helicobacter pylori Triple Therapy Eradication West Africa

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交多少朋友合适?谈亚里士多德对“大量交友”的评论

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第欧根尼 2021年第1期 1-19,158,M0001页

作者：迪米特里·穆尔马胜利(译) 法国高等师范学院-巴黎文理研究大学哲学系

引言结交多少个朋友合适?提出这样的问题似乎是钻牛角尖,也不属于哲学家的兴趣。然而,古代的哲学家并未忽视这个问题的重要性,他们都直接或间接地关注过“友谊”。实际上,提出交多少朋友合适的问题,就是提出友谊的限度问题,更确切地说,... 详细信息

引言结交多少个朋友合适?提出这样的问题似乎是钻牛角尖,也不属于哲学家的兴趣。然而,古代的哲学家并未忽视这个问题的重要性,他们都直接或间接地关注过“友谊”。实际上,提出交多少朋友合适的问题,就是提出友谊的限度问题,更确切地说,是提出了与他人特殊关系的延展问题。我们看到,这种关系并不要求排他性,但将其无限扩展则难免使其变质。

关键词：亚里士多德排他性友谊兴趣朋友哲学家重要性

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Haemorrhagic Lupus: A Diagnosis Emergency, Report about 6 Cases

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Open Journal of Internal Medicine 2021年第4期11卷 231-237页

作者： Fall Biram Codou Walah dimitri Dieng Mouhamed Diaw Bamba Tode Johanita Gaye Ahmadou Salane Aly Ndao Awa Cheikh Cisse Amadou Fall Sow Maimouna M. A. Ndour Djiba Boundia Kane Baidy Sy Fall Seynabou Leye Abdoulaye Pouye Abdoulaye Ndongo Souhaibou Department of Internal Medicine at DalalJamm Hospital Dakar Sénégal Department of Internal Medicine at Dantec Hospital Dakar Sénégal Department of Internal Medicine at Pikine Hospital Dakar Sénégal Department of Hematology at DalalJamm Hospital Dakar Sénégal

Introduction: Haemorrhagic manifestations rarely represent the mode of onset of lupus and are a therapeutical and diagnosis emergency. We report 6 cases of haemorrhagic manifestations disclosing lupus. Patients and methods: It’s about a retrospective, descriptive and multicentric study ranged from 1st January 2014 to 5th January 2019. Were included in the study all cases of lupic disease revealed by hemorrhagic disorders, recorded in 3 Internal Medicine Departments in Dakar: DalalJamm, Dantec, Pikine. The diagnosis of lupus was made on the basis of the 1997 modified classification criteria of ACR for SLE. Results: We gathered 6 cases of women affected by lupic disease. The mean age was 32 years old with extremes ranged from 17 to 56 years. According to haemorrhagic disorders, the diagnosis of lupus was automatically made in 5 of the cases and it took 6 months to confirm the last one. Haemorrhagic features were ruled by purpura (3/6 cases) and nose-bleeding associated with gumbleeding (2/6 cases), epistaxis and melena (1/6 case), hypermenorrhea (1/6 case), cerebral haematoma (1/6case). Cutaneous (5/6), articular (4/6), renal (2/6) and serous (2/6) disorders specially represented the other manifestations. Biological findings showed cytopenia with 3 cases of anaemia, 1 case of leucopenia and 6 cases of thrombopenia. The average of the platelet count was at 20,000 cells/mm3 with extremes ranged from 1000 to 35,000 cells/mm3. Thrombocytopenia was related to autoimmune thrombocytopenic purpura in 3 cases, to Evans’ syndrome in 2 cases, to macrophage activation syndrome in 1 case. Immunological investigations found the presence of antinuclear antibodies (1/6), anti-dsDNA (2/6) and anti-Sm (4/6). All patients received a bolus of Solumedrol followed by an administration of Prednisone at a dosage of 1.5 mg/kg (3 cases) and 1 mg/kg to the other patients. A transfusion of platelet concentrates was performed for all of them. The evolution was favorable in 4 cases. Two

关键词： Haemorrhagic Lupus Emergency

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