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严重室性心律失常患者的心肌肠病毒RNA检测

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中国心脏起搏与心电生理杂志 2004年第Z1期18卷 183-页

作者：姜红饶丹 Roger Marx dieter Niederac her Frauke Picard Mic hael Bre hm Rolf Mic hael Klein 上海复旦大学中山医院心内科上海200032 上海复旦大学中山医院心内科上海200032 上海复旦大学中山医院心内科上海200032 上海复旦大学中山医院心内科上海200032 上海复旦大学中山医院心内科上海200032 上海复旦大学中山医院心内科上海200032 上海复旦大学中山医院心内科上海200032

　　肠病毒是成人病毒性心肌炎最常见的病因,已证实心肌的炎症可增加发生室性心动过速和心室颤动的危险性.本研究旨在探讨肠病毒感染的心肌是否为不明原因严重室性心律失常的病因之一.……

关键词：严重室性心律失常患者病毒性心肌炎室性心动过速肠病毒感染心室颤动病因危险性炎症成人

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基于HIAF装置的高能量密度物理研究

中国科学：物理学、力学、天文学 2020年第11期50卷 31-53页

作者：赵永涛张子民程锐 HOFFMANN dieter 马步博王友年王瑜玉王兴邓志刚任洁茹刘巍齐伟齐新苏有武杜应超李福利李锦钰杨杰杨建成杨磊肖国青吴栋何斌宋远红张小安张世政张琳张雅张艳宁陈本正陈燕红周征周贤明周维民赵红卫赵全堂赵宗清赵晓莹胡章虎弯峰栗建兴徐忠锋高飞唐传祥黄文会曹树春曹磊峰盛丽娜康炜雷瑜詹文龙中国科学院近代物理研究所兰州730000 西安交通大学物理学院教育部物质非平衡合成与调控重点实验室西安710049 大连理工大学物理与光电工程学院大连116024 中国工程物理研究院激光聚变中心绵阳621999 清华大学工程物理系北京100084 浙江大学物理学系杭州310027 北京应用物理与计算数学研究所北京100088 咸阳师范学院物理与电子工程学院咸阳712000 武汉理工大学理学院武汉430070 北京大学应用物理与技术研究中心北京100871

高能量密度物理的研究对象是能量密度超过1011J/m3或压强超过100 GPa极端状态的物质,这种物质广泛存在于恒星和大质量行星内部,同时也短暂存在于核弹爆炸和惯性约束聚变等高功率加载过程中.高能量密度物理研究是科技强国在国防安全、天... 详细信息

高能量密度物理的研究对象是能量密度超过1011J/m3或压强超过100 GPa极端状态的物质,这种物质广泛存在于恒星和大质量行星内部,同时也短暂存在于核弹爆炸和惯性约束聚变等高功率加载过程中.高能量密度物理研究是科技强国在国防安全、天体物理及聚变科学技术等重大领域竞相追逐的前沿热点,也是国内外大型高功率激光装置、Z箍缩装置以及重离子加速装置的重要科学目标.本文将主要介绍基于强流重离子加速器装置(High Intensity heavy-ion Accelerator Facility,HIAF)的高能量密度物理研究.HIAF装置将可以提供极高功率的强流重离子束,单脉冲能量和功率将分别达到100 kJ和TW量级.如此高功率的离子束直接加热金、铅等固体材料,可以产生密度接近原固体密度、温度约10 eV、空间尺度mm–cm量级的状态均匀的高能量密度物质(能量密度达到1013J/m^(3)量级),为实验室研究高能量密度物质的产生、物态性质及其演化规律提供先进的研究平台.基于HIAF的高能量密度物理研究主要包括:(1)强流离子束驱动高能量密度物质的产生及其发展规律;(2)离子束在稠密物质或等离子体中的能量沉积与输运性质;(3)离子束驱动高能量密度物质关键诊断技术.本文还将重点介绍上述三个关键科学技术问题的研究现状和进展.

关键词：高能量密度物理强流重离子加速器装置离子束与等离子体相互作用尾场调制高能电子成像

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IPNA临床实践建议:儿童激素敏感型肾病综合征的诊断和治疗

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中国合理用药探索 2023年第2期20卷 1-35页

作者： Agnes Trautmann Olivia Boyer Elisabeth Hodson Arvind Bagga Debbie S.Gipson Susan Samuel Jack Wetzels Khalid Alhas an Sushmita Banerjee Rajendra Bhimma Melvin Bonilla-Felix Francisco Cano Martin Christian Deirdre Hahn Hee Gyung Kang Koichi Nakanishi Hesham Safouh Howard Trachtman Hong Xu Wendy Cook Marina Vivarelli dieter Hafner on behalf of the International Pediatric Nephrology Association 韩思雨(翻译) 季丽娜(翻译) 不详清华大学附属北京清华长庚医院儿科北京102218

特发性肾病综合征是最常见的儿童肾小球疾病,其特征是大量蛋白尿、低蛋白血症和(或)伴有水肿,全球每年儿童患病率为(1.15~16.90)每10万例。约有85%~90%的患者在接受糖皮质激素治疗的4~6周内可达到蛋白尿完全缓解,表现为激素敏感型肾病... 详细信息

特发性肾病综合征是最常见的儿童肾小球疾病,其特征是大量蛋白尿、低蛋白血症和(或)伴有水肿,全球每年儿童患病率为(1.15~16.90)每10万例。约有85%~90%的患者在接受糖皮质激素治疗的4~6周内可达到蛋白尿完全缓解,表现为激素敏感型肾病综合征(SSNS)。约70%~80%的SSNS患者在随访期间至少复发1次,其中多达50%的患者出现频繁复发或依赖糖皮质激素以维持蛋白尿缓解。为延长复发间隔时间,激素治疗的用药剂量和用药时长始终是热点问题之一,且患者出现激素相关并发症的概率较高。临床已应用多种激素助减药物(免疫抑制药物),但在疾病治疗过程中这些药物的选择和用药时机存在明显差异。因此,需要国际循证临床实践建议(CPRs)来指导临床实践、减少实践差异。国际儿科肾脏病学会(IPNA)召集专家小组通过对12个临床相关PICO(研究对象、干预措施、对照、结果/结局)问题进行系统的文献回顾,制定了关于儿童SSNS诊断和治疗的建议和分级。对治疗转归提出了新的定义,有助于指导治疗改变,并为重要的研究问题提供了参考。

关键词：激素敏感型肾病综合征儿童频复发型肾病综合征激素依赖型肾病综合征激素毒性儿科免疫抑制治疗

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低能粒子束与低密度等离子体相互作用研究(英文)

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IMP & HIRFL Annual Report 2012年 43-43页

作者：程锐 Zhao Yongtao Sergey Savin Roman Gavrilin dieter Hoffmann Zhou Xianming Wang Yuyu Peng Haibo Lei Yu Sun Yuanbo Ren Jieru Xiao Guoqing Institute for Theoretical and Experimental Physics

The interaction process between ion beam and plasma is a very important aspect in Ion-Beam-Driven High Energy Density Physics and Inertial Confinement Fusion[1-4].Considering the important role of the low energy regime in fast-ignition and target-cell burning[5-6],we present recent results about the slow ion beam interaction with plasma *** the 320kV Highly Charged Ions Platform at IMP,a new experimental setup was installed for the

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Cholecystographic documentation and follow-up of gallstone fragment migration during the percutaneous treatment of cholelithiasis

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介入放射学杂志 1995年第3期 182-182页

作者： R.O’Laoide~* E.vanSonnenberg~ H.R.D’Agostino~* S.B.Oglevie~* L.J.Fundell~* B.Goodacre~ O.Esch~ A.F.hofmann~+ Departments of Radiology~* and Medicine,Division of Gastroenterology,~+ University of California,San Diego Medical Center,San Diego,California.~ Departments of Radiology,Medicine,and Surgery University of Texas Medical Branch,Galveston,Texas,USA

*** this paper we evaluated the frequency,consequences of,and therapeuticapproach to fragment migration after percutaneous treatment of *** migra-tion occurred in 10(17 %)of 58 patients undergoing either percutaneous contact dissolutionor mechanical stone removal,Fragments impacted in the cystic duct in five patients,whilefragments passed into the common bile duct(CBD)in six patients(one patient had both si-multaneously),Cystic duct fragments were symptomatic in four of the five patients;threepatients were symptomatic at the time of fragment detection and were treated immediately(two with further contact dissolution and one by flushing the fragment from the cystic ductto the duodenum).CBD fragments were asymptomatic and passed spontaneously in four ofthe six *** patients with CBD fragments had endoscopic retrograde cholangio-graphy and sphincterrotomy to remove fragments,as they were unwilling to await possiblespontaneous passage of fragments.

关键词： CBD

Dense matter with eXTP

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Science China(Physics,Mechanics & Astronomy) 2019年第2期62卷 28-44页

作者： Anna L.Watts WenFei Yu Juri Poutanen Shu Zhang Sudip Bhattacharyya Slavko Bogdanov Long Ji Alessandro Patruno Thomas E.Riley Pavel Bakala Altan Baykal Federico Bernardini Ignazio Bombaci Edward Brown Yuri Cavecchi Deepto Chakrabarty Jér?me Chenevez Nathalie Degenaar Melania Del Santo Tiziana Di Salvo Victor Doroshenko Maurizio Falanga Robert D.Ferdman Marco Feroci Angelo F.Gambino MingYu Ge Svenja K.Greif Sebastien Guillot Can Gungor dieter H.Hartmann Kai Hebeler Alexander Heger Jeroen Homan Rosario Iaria Jean in 't Zand Oleg Kargaltsev Aleksi KurkelaTheoretical Physics Department CERN XiaoYu Lai Ang Li XiangDong Li ZhaoSheng Li Manuel Linares FangJun Lu Simin Mahmoodifar Mariano Méndez M.Coleman Miller Sharon Morsink Joonas N?ttil? Andrea Possenti Chanda Prescod-Weinstein JinLu Qu Alessandro Riggio Tuomo Salmi Andrea Sanna Andrea Santangelo Hendrik Schatz Achim Schwenk LiMing Song Eva?rámková Benjamin Stappers Holger Stiele Tod Strohmayer Ingo Tews Laura Tolos Gabriel T?r?k David Tsang Martin Urbanec Andrea Vacchi RenXin Xu YuPeng Xu Silvia Zane GuoBao Zhang ShuangNan Zhang WenDa Zhang ShiJie Zheng Xia Zhou Anton Pannekoek Institute for Astronomy University of Amsterdam Shanghai Astronomical Observatory Tuorla Observatory Department of Physics and Astronomy University of Turku Nordita KTH Royal Institute of Technology and Stockholm University Institute of High Energy Physics Chinese Academy Sciences Tata Institute of Fundamental Research Columbia Astrophysics Laboratory Columbia University Institut für Astronomie und Astrophysik Tübingen Universit?t Tübingen Leiden Observatory Leiden University Research Center for Computational Physics and Data Processing Silesian University in Opava Physics Department Middle East Technical University INAF Osservatorio Astronomico di Roma New York University Abu Dhabi Dipartimento di Fisica Enrico Fermi University of Pisa INFN Italian National Institute for Nuclear Physics Department of Physics and Astronomy Michigan State University Department of Astrophysical Sciences Princeton University Mathematical Sciences and STAG Research Centre University of Southampton MIT Kavli Institute for Astrophysics and Space Research DTU Space Technical University of Denmark INAF/IASF Palermo via Ugo La Malfa 153 Universita degli Studi di Palermo Dipartimento di Fisica e Chimica International Space Science Institute (ISSI) Faculty of Science University of East Anglia INAF Istituto di Astrofisica e Planetologie Spaziali Institut für Kernphysik Technische Universit?t Darmstadt ExtreMe Matter Institute EMMI GSI Helmholtzzentrum für Schwerionenforschung GmbH Instituto de Astrof'?sica Pontificia Universidad Católica de Chile Department of Physics & Astronomy Kinard Lab of Physics Clemson University School of Physics and Astronomy Monash University SRON Netherlands Institute for Space Research Department of Physics The George Washington University Faculty of Science and Technology University of Stavanger School of Physics and Mechanical & Electrical Engineering Hubei University of Education Department of Astronomy Xiamen University (Haiyun Campus) School of Astronomy and Space

In this White Paper we present the potential of the Enhanced X-ray Timing and Polarimetry(eXTP) mission for determining the nature of dense matter; neutron star cores host an extreme density regime which cannot be replicated in a terrestrial laboratory. The tightest statistical constraints on the dense matter equation of state will come from pulse profile modelling of accretion-powered pulsars, burst oscillation sources, and rotation-powered pulsars. Additional constraints will derive from spin measurements, burst spectra, and properties of the accretion flows in the vicinity of the neutron star. Under development by an international Consortium led by the Institute of High Energy Physics of the Chinese Academy of Sciences, the eXTP mission is expected to be launched in the mid 2020 s.

关键词： neutron X-rays dense matter equation of state

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Cell:新分子或可有效清除肝脏和血液中的脂肪

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现代生物医学进展 2017年第4期17卷 I0004-I0004页

作者： Brian Finan Christoffer Clemmensen Zhimeng Zhu Kerstin Stemmer Karine Gauthier Luisa M uuml ller Meri De Angelis Kristin Moreth Frauke Neff Diego Perez-Tilve Katrin Fischer Dominik Lutter Miguel A. S aacute nchez-Garrido Peng Liu Jan Tuckermann Mohsen Malehmir Marc E. Healy Achim Weber Mathias Heikenwalder Martin Jastroch Maximilian Kleinert Sigrid Jall Sara Brandt Fr eacute d eacute ric Flamant Karl-Werner Schramm Heike Biebermann Yvonne D ouml ring Christian Weber Kirk M. Habegger Michaela Keuper Vasily Gelfanov Fa Liu Josef K ouml hrle Jan Rozman Helmut Fuchs Valerie Gailus-Durner Martin Hrabě de Angelis Susanna M. hofmann Bin Yang Matthias H. Tsch ouml p Richard DiMarchi Timo D. M uuml ller Institute for Diabetes and Obesity Helmholtz Diabetes Center at Helmholtz Zentrum München German Research Center for Environmental Health (GmbH) 85764 Neuherberg Germany Department of Chemistry Indiana University Bloomington IN 47405 USA Institut de Génomique Fonctionnelle de Lyon Université de Lyon Centre National de la Recherche Scientifique (CNRS) Institut National de la Recherche Agronomique (INRA) École Normale Supérieure de Lyon 69364 Lyon France Molecular EXposomics Helmholtz Zentrum München German Research Center for Environmental Health (GmbH) 85764 Neuherberg Germany German Mouse Clinic Institute of Experimental Genetics Helmholtz Zentrum München German Research Center for Environmental Health 85764 Neuherberg Germany Division of Endocrinology Department of Internal Medicine Metabolic Diseases Institute University of Cincinnati College of Medicine Cincinnati OH 45237 USA Institute of Comparative Molecular Endocrinology University of Ulm 89081 Ulm Germany Department of Pathology and Molecular Pathology University Zurich and University Hospital Zurich 8091 Zurich Switzerland Institute of Virology Technische Universität München 81675 Munich Germany Institute of Experimental Pediatric Endocrinology Charité-Universitätsmedizin Berlin Berlin 13353 Germany Department of Medicine Institute for Cardiovascular Prevention Ludwig-Maximilians-Universität München 80336 Munich Germany Comprehensive Diabetes Center and Department of Medicine-Endocrinology Diabetes & Metabolism University of Alabama at Birmingham Birmingham AL 35294 USA Institute for Diabetes and Regeneration Helmholtz Diabetes Center at Helmholtz Zentrum München German Research Center for Environmental Health (GmbH) Neuherberg 85764 Germany Calibrium LLC Carmel IN 46032 USA Institute for Experimental Endocrinology Charité-Universitätsmedizin Berlin Berlin 13353 Germany German Center for Diabetes Research (DZD) 85764 Neuherberg Germany

肥胖和糖尿病持续上升代表着我们的社会所面临的一个重大的负担。脂肪肝和动脉粥样硬化是这些代谢疾病常见的后果，但是开发一种高效且又安全的能够逆转肥胖、胰岛素抵抗性、脂肪肝和动脉粥样硬化的药物仍然是全球头等的一项重大的科学... 详细信息

肥胖和糖尿病持续上升代表着我们的社会所面临的一个重大的负担。脂肪肝和动脉粥样硬化是这些代谢疾病常见的后果，但是开发一种高效且又安全的能够逆转肥胖、胰岛素抵抗性、脂肪肝和动脉粥样硬化的药物仍然是全球头等的一项重大的科学挑战。

关键词：脂肪肝 Cell 动脉粥样硬化血液肝脏清除分子代谢疾病