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Children with obesity have poorer circadian health as assessed by a global circadian health score

World Journal of Pediatrics 2024年第8期20卷 787-800页

作者： María Rodríguez-Martín nuria Martínez-Lozano Vicente Santaclara-Maneiro Antonio Gris-Peñas diego salmerón Rafael Ríos Asta Tvarijonaviciute Marta Garaulet Department of Physiology Regional Campus of International Excellence University of Murcia Murcia Spain Biomedical Research Institute of Murcia IMIB-Arrixaca-UMU University Clinical Hospital Murcia Spain Health Area of Lorca Lorca Spain Health and Social Sciences Department University of Murcia Murcia Spain Consortium for Biomedical Research in Epidemiology and Public Health Madrid Spain Interdisciplinary Laboratory of Clinical Analysis (Interlab-UMU) University of Murcia Murcia Spain Division of Sleep and Circadian Disorders Brigham and Women’s Hospital (BWH) and Division of Sleep Medicine Harvard Medical School Boston USA

Background Circadian health refers to individuals’well-being and balance in terms of their circadian *** is influenced by external *** adults,a close relationship between circadian-related alterations and obesity has been ***,studies in children are scarce,and circadian health and its association with obesity have not been evaluated *** aimed to assess whether circadian health differed between children with and without obesity as determined by a global circadian score(GCS)in a school-age *** Four hundred and thirty-two children(7–12 years)were recruited in ***-invasive tools were used to calculate the GCS:(1)7-day rhythm of wrist temperature(T),activity(A),position(P),an integrative variable that combines T,A,and P(TAP);(2)cortisol;and(3)7-day food and sleep *** mass index,body fat percentage,waist circumference(WC),melatonin concentration,and cardiometabolic marker levels were *** Circadian health,as assessed by the GCS,differed among children with obesity,overweight,and normal weight,with poorer circadian health among children with *** with obesity and abdominal obesity had 3.54 and 2.39 greater odds of having poor circadian health,respectively,than did those with normal weight or low *** percentage of rhythmicity,a marker of the robustness of the TAP rhythm,and the amplitude,both components of the GCS,decreased with increasing *** lifestyle behaviors were involved in the association between circadian health and obesity,particularly protein intake(P=0.024),physical activity level(P=0.076)and chronotype(P=0.029).Conclusions The GCS can capture the relationship between circadian health and obesity in school-age *** intake,physical activity level,and chronotype were involved in this *** intervention based on improving circadian health may help to prevent childhood obesity.

关键词： Children Chronodisruption Circadian Lifestyle Obesity

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Sustained adenosine release:Revealing its impact on osteogenic signalling pathways of human mesenchymal stromal cells

Engineered Regeneration

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Engineered Regeneration 2024年第2期5卷 255-268页

作者： Hadi Hajiali Jane McLaren Cristina Gonzalez-García Salah Abdelrazig Dong-Hyun Kim Matthew J.Dalby Manuel salmerón-Sánchez Felicity R.A.J.Rose School of Pharmacy Nottingham Biodiscovery InstituteUniversity of NottinghamNottinghamUK Healthcare Technologies Institute School of Chemical EngineeringUniversity of BirminghamBirminghamUK Centre for the Cellular Microenvironment University of GlasgowGlasgowUK Centre for Analytical Bioscience Advanced Materials&Healthcare Technologies DivisionSchool of PharmacyUniversity of NottinghamNottinghamUK Marine Microbiomics Program in BiologyDivision of Science and MathematicsNew York University Abu Dhabi(NYUAD)P.O.Box 129188Abu DhabiUnited Arab Emirates

non-healing fractures,a global health concern arising from trauma,osteoporosis,and tumours,can lead to severe ***,integral to cellular energy metabolism,gains prominence in bone regeneration via adeno-sine A2 B receptor *** study introduces a controlled-release system for localized adenosine delivery,fostering human mesenchymal stromal cell(hMSC)differentiation into functional bone *** study investi-gates how the ratio of lactic acid to glycolic acid in microparticles can influence adenosine release and explores the downstream effects on gene expression and metabolic profiles of osteogenic differentiation in hMSCs cultured in growth and osteoinductive *** into adenosine-modulated signalling pathways during MSC differenti-ation,with osteogenic factors,provide a comprehensive understanding of the pathways *** gene expression and metabolic profiles unravels adenosine’s regulatory mechanisms in MSC *** adenosine release from microparticles induces mineralization,synergizing with osteogenic media supplements,showcasing the potential of adenosine for treating critical bone defects and metabolic *** study high-lights the efficacy of a polymeric microparticle-based delivery system,offering novel strategies for bone *** adenosine’s roles and associated signalling pathways advances our comprehension of molecular mech-anisms steering bone regeneration,propelling innovative biomaterial,combined with metabolites,approaches for clinical use.

关键词： Adenosine release Osteogenic signalling pathways Human mesenchymal stromal cells Bone regeneration

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Risk factors for liver disease among adults of Mexican descent in the United States and Mexico

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World Journal of Gastroenterology 2018年第37期24卷 4281-4290页

作者： Yvonne n Flores Zuo-Feng Zhang Roshan Bastani Mei Leng Catherine M Crespi Paula Ramírez-Palacios Heather Stevens Jorge salmerón Unidad de Investigación Epidemiológica y en Servicios de Salud Delegación MorelosInstituto Mexicano del Seguro SocialCuernavacaMorelos 62000México UCLA Department of Health Policy and Management and Kaiser Permanente Center for Health Equity Fielding School of Public HealthLos AngelesCA 90095United States UCLA Cancer Prevention and Control Research Center Fielding School of Public Health and Jonsson Comprehensive Cancer CenterLos AngelesCA 90095United States UCLA Division of General Internal Medicine and Health Services Research Los AngelesCA 90095United States UCLA Department of Biostatistics Fielding School of Public HealthLos AngelesCA 90095United States University of Washington School of MedicineSeattleWA 98195United States Universidad nacional Autónoma de México Academic Epidemiology Research UnitAvenida Universidad 3000Ciudad UniversitariaCoyoacánMexico City 04510México Centro de Investigación en Salud Poblacional Instituto Nacional de Salud PúblicaCuernavacaMorelos 62100México

AIM To compare the prevalence of chronic liver disease(CLD) risk factors in a representative sample of MexicanAmericans born in the United States(US) or Mexico, to a sample of adults in *** Data for Mexican-Americans in the US were obtained from the 1999-2014 national Health and nutrition Examination Survey(nHAnES), which includes persons of Mexican origin living in the US(n = 4274). The nHAnES sample was restricted to Mexican-American participants who were 20 years and older, born in the US or Mexico, not pregnant or breastfeeding, and with medical *** data in Mexico were obtained from the 2004-2013 Health Worker Cohort Study in Cuernavaca, Mexico(n =9485). The following known risk factors for liver disease/cancer were evaluated: elevated aminotransferase levels(elevated alanine aminotransferase was defined as > 40 IU/L for males and females; elevated aspartate aminotransferase was defined as > 40 IU/L for males and females), infection with hepatitis B or hepatitis C,metabolic syndrome, high total cholesterol, diabetes,obesity, abdominal obesity, and heavy alcohol use. The main independent variables for this study classified individuals by country of residence(i.e., Mexico vs the US) and place of birth(i.e., US-born vs Mexico-born).Regression analyses were used to investigate CLD risk *** After adjusting for socio-demographic characteristics,Mexican-American males were more likely to be obese,diabetic, heavy/binge drinkers or have abdominal obesity than males in Mexico. The adjusted multivariate results for females also indicate that Mexican-American females were significantly more likely to be obese, diabetic, be heavy/binge drinkers or have abdominal obesity than Mexican females. The prevalence ratios and prevalence differences mirror the multivariate analysis findings for the aforementioned risk factors, showing a greater risk among US-born as compared to Mexico-born MexicanAmericans. COnCLUSIOn In this study, Mexican-Americans i

关键词： Liver disease Risk factors Health disparities Mexico Mexican Americans Latinos

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Hepatitis C virus nS5A region mutation in chronic hepatitis C genotype 1 patients who are non-responders to two or more treatments and its relationship with response to a new treatment

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World Journal of Gastroenterology 2017年第25期23卷 4538-4547页

作者： Paloma Munoz de Rueda José Manuel Fuentes RodríguezRosa Quiles Pérez Ana Gila Medina Ana Belén Martínálvarez Jorge Casado Ruíz ángeles Ruíz Extremera Javier salmerón Research Support Unit San Cecilio University Hospital of Granada Instituto de Investigación Biosanitaria CIBERehd Instituto de Salud Carlos III Unit for Clinical Management of Digestive Diseases San Cecilio University Hospital of Granada Granada University

To determine the number of mutations in the nS5A region of the hepatitis C virus (HCV) and its relationship to the response to antiviral therapy in patients with chronic hepatitis C genotype 1 who are non-responders to two or more treatments. METHODSSequences within HCV nS5A [PKR binding domain (PKRBD) and the interferon-sensitivity-determining region (ISDR)] were analysed via direct sequencing in a selected cohort of 72 patients, with a total of 201 treatments [interferon-alpha (IFn-α), n = 49; IFn-α + ribavirin (RBV), n = 75; pegylated (peg) IFn-α + RBV, n = 47; first-generation direct-acting antivirals (DAAs), n = 13; and second-generation DAAs, n = 17]. Of these, 48/201 achieved a sustained virological response (SVR) and 153/201 achieved no virological response (nVR). RESULTSFor both regions, treatments resulting in SVR were associated with more baseline mutations than were treatments resulting in nVR (SVR vs nVR; PKRBD: 5.82 ± 3 vs 4.86 ± 2 mutations, P = 0.045; ISDR: 2.65 ± 2 vs 1.51 ± 1.7 mutations, P = 0.005). A decrease or no change in the number of mutations over time between treatments in the PKRBD or ISDR, as shown by sequencing, was associated with patients who usually failed to respond to treatment (PKRBD, P = 0.02; ISDR, P = 0.001). Moreover, patients showing a post-treatment baseline viral load > 600000 IU/mL and increased ISDR mutations with respect to the previous treatment were 9.21 times more likely to achieve SVR (P = 0.001). COnCLUSIOnThe obtained results show that among patients who have shown no response to two or more antiviral treatments, the likelihood of achieving SVR increases with the genetic variability in the ISDR region (≥ 2 mutations or number of substitutions from the HCV-J and HCV-1 prototype), especially when the viral load is greater than 600000 IU/mL.

关键词： Interferon-based therapy Interferon-free therapy Chronic hepatitis C nS5A region Sustained virological response number of mutations

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Tenofovir vs lamivudine plus adefovir in chronic hepatitis B:TEnOSIMP-B study

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World Journal of Gastroenterology 2017年第41期23卷 7459-7469页

作者： Manuel Rodríguez Juan Manuel Pascasio Enrique Fraga Javier Fuentes Martín Prieto Gloria Sánchez-Antolín Jose Luis Calleja Esther Molina María Luisa García-Buey María Angeles Blanco Javier salmerón María Lucía Bonet Jose Antonio Pons Jose Manuel González Miguel Angel Casado Francisco Jorquera 无 Division of Gastroenterology and Hepatology.Hospital Universitario Central de Asturias Unit for the Clinical Management of Digestive Diseases IBISHospital Universitario Virgen del Rocío Liver Transplantation and Hepatology Unit Gastroenterology ServiceHospital Universitario Reina Sofía Digestive Medicine Service Hospital Universitario Miguel Servet Hepatology Unit Digestive Medicine ServiceHospital Universitari i Politècnic La Fe Hepatology Unit Hospital Universitario Rio Hortega Liver Unit Hospital Universitario Puerta de Hierro de MajadahondaUniversidad Autónoma de Madrid Digestive Medicine Service Hospital Clínico de Santiago de Compostela Liver Unit Hospital Universitario de La Princesa Digestive Medicine Service Hospital General Universitario Gregorio Maranon Digestive Medicine Unit Complejo Hospitalario de Granada Digestive Medicine Service Hospital Universitario Son Espases Hepatology Unit IMIB Hospital Universitario Virgen de la Arrixaca Digestive Medicine Service Hospital Clínico Universitario de Valladolid Pharmacoeconomics and Outcomes Research Iberia Division of Gastroenterology and Hepatology Complejo Asistencial Universitario de León the TEnOSIMP-B Research Group

AIM To demonstrate the non-inferiority(15% non-inferiority limit) of monotherapy with tenofovir disoproxil fumarate(TDF) vs the combination of lamivudine(LAM) plus adefovir dipivoxil(ADV) in the maintenance of virologic response in patients with chronic hepatitis B(CHB) and prior failure with *** This study was a Phase IV prospective, randomized, open, controlled study with 2 parallel groups(TDF and LAM+ADV) of adult patients with hepatitis B e antigen(HBe Ag)-negative CHB, prior failure with LAM, on treatment with LAM+ADV for at least 6 mo, without prior resistance to ADV and with an undetectable viral load at the start of the study, in 14 Spanish hospitals. The follow-up time for each patient was 48 wk after randomization, with quarterly visits in which the viral load, biochemical and serological parameters, adverse effects, adherence to treatment and consumption of hospital resources were *** Forty-six patients were evaluated [median age: 55.4 years(30.2-75.2); 84.8% male], including 22 patients with TDF and 24 with LAM+ADV. During study development, hepatitis B virus DnA(HBV-DnA) remained undetectable, all patients remained HBe Ag negative, and hepatitis B surface antigen(HBs Ag) positive. Alanine aminotransferase(ALT) values at the end of the study were similar in the 2 groups(25.1± 7.65, TDF vs 24.22 ± 8.38, LAM+ADV, P = 0.646). no significant changes were observed in creatinine or serum phosphorus values in either group. no significant differences between the 2 groups were noted in the identification of adverse effects(AEs)(53.8%, TDF vs 37.5%, LAM+ADV, P = 0.170), and none of the AEs which occurred were serious. Treatment adherence was 95.5% and 83.3% in the TDF and the LAM+ADV groups, respectively(P = 0.488). The costs associated with hospital resource consumption were significantly lower with the TDF treatment than the LAM+ADV treatment(€4943 ± 1059 vs €5811 ± 1538, respectively, P nCLUSIOn TDF monotherapy proved to be safe

关键词： Tenofovir Lamivudine+Adefovir Efficacy Safety Adherence Costs Hepatitis B

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Detection of Antibodies against Mycoplasma mycoides subsp. capri in Goats with the Complement Fixation Test

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Advances in Microbiology 2016年第13期6卷 959-964页

作者： José L. Corona-Vargas Myrna A. Vicencio-Mallén Frida salmerón-Sosa Erika M. Carrillo-Casas Francisco J. Trigo-Tavera Rosa E. Miranda-Morales Departamento de Microbiología e Inmunología Facultad de Medicina Veterinaria y Zootecnia Universidad Nacional Autónoma de México Circuito Exterior s/n Ciudad Universitaria Coyoacán México Departamento de Biología Molecular e Histocompatibilidad Dirección de Investigación Hospital General Dr. Manuel Gea González Calz Tlalpan México Departamento de Patología Facultad de Medicina Veterinaria y ZootecniaUniversidad Nacional Autónoma de México Circuito Exterior s/n Ciudad Universitaria Coyoacán México

Mycoplasma mycoides subsp. capri is the causative agent of severe and acute respiratory problems in goats, which spreads rapidly and represents high mortality. The serological profile of the goat population, from nine regions in seven states of Mexico, was screened by the Complement Fixation test (CF) in sera from asymptomatic goats and animals with mild respiratory symptoms. Sera and nasal swabs of 827 goats were collected for the isolation of the organism. An antiserum was prepared against a previously isolated field strain of Mycoplasma mycoides subsp. capri. CF Antibody titers were associated with the results of the isolates to determine the cutoff point. The CF was considered as positive if its result was ≥1/16. The CF registered 251 positive goats (30.35%) and 576 (69.65%) negative;the test showed high sensitivity (93.33%) and specificity (72.27%). In the specific case of diagnosis for mycoplasmosis associated with respiratory problems in goats, the CF proved to be a good diagnosis test, this study determined that 30% of the goat population showed antibody titers against Mycoplasma mycoides subsp. capri and revealed those animals who have had contact with this microorganism during their lives regardless of the presence or absence of respiratory symptoms.

关键词： Complement Fixation Indirect Agglutination Mycoplasmosis Mycoplasma mycoides Mycoplasma mycoides subsp. capri

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Use of subcutaneous tocilizumab to prepare intravenous solutions for COVID-19 emergency shortage:Comparative analytical study of physicochemical quality attributes

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Journal of Pharmaceutical Analysis 2020年第6期10卷 532-545页

作者： natalia navas Jesús Hermosilla Anabel Torrente-Lopez Jose Hernandez-Jimenez Jose Cabeza Raquel Perez-Roblesa Antonio salmeron-García Department of Analytical Chemistry Science Faculty/Biomedical Research Institute ibs.GranadaUniversity of GranadaGranadaE-18071Spain UGC Farmacia Hospitalaria Biomedical Research Institute ibs.Granada.Hospital Universitario San Cecilio de GranadaGranadaE-18012Spain

COVID-19,a disease caused by the novel coronavirus SARS-Co V-2,has produced a serious emergency for global public health,placing enormous stress on national health systems in many *** studies suggest that cytokine storms(interleukins)may play an important role in severe cases of *** key inflammatory factors in cytokine release syndrome(CRS)could therefore be of great value in reducing the mortality ***(TCZ)in its intravenous(IV)form of administration-Ro Actemra?20 mg/m L(Roche)-is indicated for treatment of severe CRS *** investigations have concluded that inhibition of IL-6 with TCZ appears to be efficacious and safe,with several ongoing clinical *** has led to a huge increase in demand for IV TCZ for treating severe COVID-19 patients in hospitals,which has resulted in drug ***,we present a comparability study assessing the main critical physicochemical attributes of TCZ solutions used for infusion,at 6 mg/m L and 4 mg/m L,prepared from Ro Actemra?20 mg/m L(IV form)and from Ro Actemra?162 mg(0.9 m L solution pre-filled syringe,subcutaneous(SC)form),to evaluate the use of the latter for preparing clinical solutions required for IV administration,so that in a situation of shortage of the IV medicine,the SC form could be used to prepare the solutions for IV delivery of *** is important to remember that during the current pandemic all the medicines are used off-label,since none of them has yet been approved for the treatment of COVID-19.

关键词： COVID-19 Tocilizumab Critical quality attributes IV and SC medicines

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PATRICI研究:HPV-16/18 AS04佐剂疫苗预防HPV相关宫颈癌前病变效果观察

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中国处方药 2009年第9期8卷 42-42页

作者： J Paavonen P naud J salmerón 阴慧娟李天星

背景及目的：PATRICI研究是一项评价人乳头瘤病毒（HPV）-16／18AS04佐剂疫苗有效性的随机、双盲、对照Ⅲ期临床试验，其中期结果分析表明，该疫苗具有免疫原性和良好的耐受性，能够有效预防HPV—16或HPV-18感染和癌前病变。本文对该研... 详细信息

背景及目的：PATRICI研究是一项评价人乳头瘤病毒（HPV）-16／18AS04佐剂疫苗有效性的随机、双盲、对照Ⅲ期临床试验，其中期结果分析表明，该疫苗具有免疫原性和良好的耐受性，能够有效预防HPV—16或HPV-18感染和癌前病变。本文对该研究的最终结果进行了分析。

关键词： HPV-16 宫颈癌前病变疫苗预防佐剂疫苗人乳头瘤病毒 Ⅲ期临床试验 HPV-18 免疫原性

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