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Cardiovascular disease and COVID-19,a deadly combination:A review about direct and indirect impact of a pandemic

World Journal of Clinical Cases 2022年第27期10卷 9556-9572页

作者： Rafael Vidal-perez Mariana Brandão Michal Pazdernik Karl-Patrik Kresoja Myriam Carpenito Shingo Maeda Rubén Casado-Arroyo Saverio Muscoli Janine Poss Ricardo Fontes-Carvalho Jose Manuel Vazquez-rodriguez Servicio de Cardiología Unidad de Imagen y Función CardíacaComplexo Hospitalario Universitario A Coruña Centro de Investigación Biomédica en Red-Instituto de Salud Carlos ⅢA Coruña 15006Spain Department of Cardiology Centro Hospitalar de GaiaGaia 4400-020Portugal Intensive Care Unit Department of CardiologyInstitute for Clinical and Experimental Medicine PraguePrague 14021Czech Republic Heart Center Leipzig University of LeipzigLeipzig 04289Germany Unit of Cardiac Sciences Department of MedicineCampus Bio-Medico University of RomeRome 00128Italy Arrhythmia Advanced Therapy Center AOI Universal HospitalKawasaki 210-0822Japan Department of Cardiology Hôpital ErasmeUniversitéLibre de BruxellesBrussels 1070Belgium Unit of Cardiology Policlinico Tor VergataRome 00133Italy Department of Surgery and Physiology Faculty of Medicine of the University of PortoPorto 4200-319Portugal

Coronavirus disease 2019(COVID-19) is known to present with respiratory symptoms,which can lead to severe pneumonia and respiratory ***,it can have multisystem complications such as cardiovascular *** cardiovascular manifestations reported comprise myocarditis,cardiogenic shock,arrhythmias,pulmonary embolism,deep vein embolism,acute heart failure,and myocardial *** is also an indirect impact of the pandemic on the management of cardiovascular care that has been shown clearly in multiple *** this review,we summarize the deadly relation of COVID-19 with cardiovascular events and the wider impact on several cardiovascular care areas by the pandemic situation。

关键词： COVID-19 Cardiovascular diseases Pandemic Heart failure Telemedicine Prognosis

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Optimizing the delivery of combination therapy for tumors： A mathematical model

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International Journal of Biomathematics 2017年第3期10卷 179-194页

作者： Clara Rojas rodriguez Juan Belmonte-Beitia Departamento de Matematicas E. T. S. de Ingenieros Industriales Universidad de CastiUa-La Mancha 13071 Ciudad Real Spain Instituto de Matemdtica Aplicada a la Ciencia y la Ingenierla (IMA CI) Universidad de Castilla-La Mancha 13071 Ciudad Real Spain

We present in this paper a new mathematical model for the scheduling of angiogenic inhibitors in combination with a chemotherapeutic agent for a tumor. Our model takes into account the process of angiogenesis and the quality of the vasculature discriminating between stable blood vessels and unstable blood vessels. We characterize theoretically the optimal controls on drug distribution to minimize the number of cancer cells at the end of the treatment in a free horizon time problem with restrictions on the total amount of drug doses. Finally, we solve the optimal control problem by using numerical simulations, obtaining as a result that, despite the number of the tumor cells decrease with anti-angiogenic treatment, the best results are reached at the end of the chemotherapy treatment.

关键词： Mathematical modeling of tumor growth anti-angiogenic treatment chemotherapy singular control bang bang control.

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Production of electrical energy from living plants in microbial fuel cells

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Clean Energy 2023年第2期7卷 408-416页

作者： Raymond Daniel rodriguez Martinez Maria Eugenia Alvarez Bermudez Department of Industrial Production Faculty of EngineeringUniversidad Metropolitana1073 CaracasVenezuela Department of Energy and Automation Faculty of EngineeringUniversidad Metropolitana1073 CaracasVenezuela

Growing energy demand is a current problem with greater incidence in the *** research objective is to establish seed bases to give a leading role to plants used in anthropogenic production activities and consumption,and even plants belonging to wildlife in terms of energy *** use of living plants to obtain electrical energy through a microbial-vegetable fuel cell is proposed as a mech-anism to supply the energy demand with easy access worldwide,especially in areas far from urban *** this work,the voltage produced by microbial-vegetable fuel cells was measured using graphite electrodes and plants belonging to the species of aloe(Aloe vera),corn(Zea mays),black beans(Phaseolus vulgaris),tomato(Solanum lycopersicum)and moss(Dicranidae).They were selected for their presence in everyday life and their great commercial and agricultural value,reaching a maximum voltage of 884 mV from *** is evidence that all plants can be a source of energy to a greater or lesser extent and that their performance is given by the plant root interactions at the ***,an extensive root system can favour the accumulation of substrate after the hydrolysis of dead roots,provided that their presence does not interfere with microbial activity on the anodic *** this,using plants with low resistance to thermal stress can lead to a substrate richer in substances that can be ***,it is recommended to use plants according to their life cycle and the morphology of their roots,and plants that can grow in waterlogged conditions or without direct contact with the Sun.

关键词： ecosystems microorganisms renewable energy photosynthesis sustainability

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Wavelet-based deconvolution of ultrasonic signals in nondestructive evaluation

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第10期7卷 1748-1756页

作者： HERRERA Roberto Henry OROZCO Rubén rodriguez Manuel Department of Informatics University of Cienfuegos Cienfuegos 59430 Cuba CEETI Central University of Las Villas Santa Clara 54830 Cuba Department of Physics Central University of Las Villas Santa Clara 54830 Cuba

In this paper, the inverse problem of reconstructing reflectivity function of a medium is examined within a blind deconvolution framework. The ultrasound pulse is estimated using higher-order statistics, and Wiener filter is used to obtain the ultrasonic reflectivity function through wavelet-based models. A new approach to the parameter estimation of the inverse filtering step is proposed in the nondestructive evaluation field, which is based on the theory of Fourier-Wavelet regularized deconvolution (ForWaRD). This new approach can be viewed as a solution to the open problem of adaptation of the ForWaRD framework to perform the convolution kernel estimation and deconvolution interdependently. The results indicate stable solutions of the esti- mated pulse and an improvement in the radio-frequency (RF) signal taking into account its signal-to-noise ratio (SNR) and axial resolution. Simulations and experiments showed that the proposed approach can provide robust and optimal estimates of the reflectivity function.

关键词： Blind deconvolution Ultrasonic signals processing Wavelet regularization

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Evaluation of different machine learning methods for land cover mapping of a Mediterranean area using multi-seasonal Landsat images and Digital Terrain Models

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International Journal of Digital Earth 2014年第6期7卷 492-509页

作者： Victor F.rodriguez-Galiano Mario Chica-Rivas Departamento de Geodinamica Universidad de GranadaGranadaSpain Departamento de Analisis Matematico Universidad de GranadaGranadaSpain

Land cover monitoring using digital Earth data requires robust classification methods that allow the accurate mapping of complex land cover *** paper discusses the crucial issues related to the application of different up-to-date machine learning classifiers:classification trees(CT),artificial neural networks(ANN),support vector machines(SVM)and random forest(RF).The analysis of the statistical significance of the differences between the performance of these algorithms,as well as sensitivity to data set size reduction and noise were also ***-5 Thematic Mapper data captured in European spring and summer were used with auxiliary variables derived from a digital terrain model to classify 14 different land cover categories in south ***,statistically similar accuracies of over 91%were obtained for ANN,SVM and ***,the findings of this study show differences in the accuracy of the classifiers,being RF the most accurate classifier with a very simple ***,followed by RF,was the most robust classifier to noise and data *** differences in their performances were only reached for thresholds of noise and data reduction greater than 20%(noise,SVM)and 25%(noise,RF),and 80%(reduction,SVM)and 50%(reduction,RF),respectively.

关键词： land cover remote sensing classification trees random forest neural networks support vector machines

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Topical Applications of Thiosulfinate-Enriched Allium sativum Extract Accelerates Acute Cutaneous Wound Healing in Murine Model

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Chinese Journal of Integrative Medicine 2020年第11期26卷 812-818页

作者： Juan Luis Santiago Eva Maria Galan-Moya Jose Ramon Munoz-rodriguez Miguel Angel de la Cruz-Morcillo Francisco Javier Redondo-Calvo Ignacio Gracia-Fernandez Peter M.Elias Jose Manuel perez-Ortiz Mao-Qiang Man Dermatology Service Hospital General Universitario de Ciudad RealCiudad Real(13004)Spain Translational Research Unit Hospital General Universitario de Ciudad RealCiudad Real(13004)Spain Translational Oncology Laboratory Centro Regional de Investigaciones BiomedicasUniversidad de Castilla-La ManchaAlbacete(02008)Spain Instituto de Tecnologia Quimica y Medioambiental Universidad de Castilla-La ManchaCiudad Real(13004)Spain Dermatology Service Vetera ns Affairs Medical Centerand Department of DermatologyUniversity of CaliforniaSan FranciscoCA(94121)USA Dermatology Hospital Southern Medical UniversityGuangzhou(510091)China

Objective To determine whether topical applications of thiosulfinate-enriched Allium sativum extract(TASE)can accelerate acute cutaneous wound healing(WH)in a murine *** Keratinocyte viability and in vitro wound closure were assessed in keratinocyte *** of topical TASE(0.5μg/mL of allicin in 97%ethanol)on acute cutaneous WH were determined in a murine model of acute cutaneous *** mice were alternately assigned to the vehicle-and TASE-treated groups(n=6 per group).Expression levels of mRNA for keratinocyte differentiation marker-related proteins(filaggrin,loricrin and involucrin)and lipid synthetic enzymes(elongation of very long chain fatty acids protein 4(ELOVL4),fatty acid synthase(FA2H),3-hydroxy-3-methyl-glutaryl-coenzyme A reductase(HMGCoA),and serine palmitoyltransferase(SPT))were assessed using real-time quantitative polymerase chain reaction on day 3 and 8 after wounding,while transepidermal water loss(TEWL)rates were measured in wounded *** TASE accelerated WH both in vivo(40%vs.22%reduction in wound area,P<0.01)and in vitro(90%vs.65%reduction in wound area,P<0.01).Moreover,topical applications of TASE upregulated the expression levels of epidermal mRNA for ELOVL4,HMGCoA,SPT,filaggrin,loricrin and involucrin(P<0.05 ***-treated controls)on day 3 after ***,TASE significantly lowered TEWL rates in comparison with vehicle alone on day 8(33.06±2.09 g/(m^2·h)vs.24.60±2.04 g/(m^2·h),P<0.01).Conclusions Topical applications of TASE stimulated keratinocyte proliferation and formation of epidermal permeability barrier function,leading to acceleration of acute cutaneous *** products containing TASE could be used to manage acute cutaneous WH.

关键词： Allium sativum thiosulfinate wound healing permeability barrier keratinocytes proliferation

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On a Classical Theorem on the Diameter and Minimum Degree of a Graph

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Acta Mathematica Sinica,English Series 2017年第11期33卷 1477-1503页

作者： Veronica HERNANDEZ Domingo PESTANA Jose M. rodriguez Universidad CarlosⅢde Madrid Avenida de la Universidad3028911 LeganesSpain

In this work, we obtain good upper bounds for the diameter of any graph in terms of its minimum degree and its order, improving a classical theorem due to Erdos, Pach, Pollack and Tuza. We use these bounds in order to study hyperbolic graphs （in the Gromov sense）. To compute the hyperbolicity constant is an almost intractable problem, thus it is natural to try to bound it in terms of some parameters of the graph. Let H（n, δ0） be the set of graphs G with n vertices and minimum degree 50, and J（n, Δ） be the set of graphs G with n vertices and maximum degree A. We study the four following extremal problems on graphs： a（n,δ0） = min{δ（G）｜ G ∈H（n, δ0）}, b（n, δ0） =- max{δ（G）｜ e ∈H（n, δ0）}, α（n, Δ） = min{δ（G） [ G ∈ J（n, Δ）} and β（n,Δ） = max{δ（G） ] G∈Π（n,Δ）}. In particular, we obtain bounds for b（n, δ0） and we compute the precise value of a（n, δ0）, α（n, Δ） and w（n, Δ） for all values of n, r0 and A, respectively.

关键词： Extremal problems on graphs diameter minimum degree maximum degree Gromov hyperbolicity hyperbolicity constant finite graphs

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Treatment, residual chlorine and season as factors affecting variability of trihalomethanes in small drinking water systems

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Frontiers of Environmental Science & Engineering 2015年第1期9卷 171-179页

作者： Roberta DYCK Genevieve COOL Manuel rodriguez Rehan SADIQ School of Engineering University of British Columbia Okanagan Kelowna V1V 1V7 Canada Ecole superieure d'amenagement du territoire Universite Laval Quebec G1V 0A6 Canada

Seasonal variability in source water can lead to challenges for drinking water providers related to operational optimization and process control in treatment facilities. The objective of this study is to investigate seasonal variability of water quality in municipal small water systems （〈 3000 residents） supplied by surface waters. Residual chlorine and trihalomethanes （THM） were measured over seven years （2003-2009）. Comparisons are made within each system over time, as well as between systems according to the type of their treatment technologies. THM concentrations are generally higher in the summer and autumn. The seasonal variability was generally more pronounced in systems using chlorination plus additional treatment. Chloroform, total THM （TTHM） and residual chlorine concentrations were generally lower in systems using chlorination plus additional treatment. Conversely, brominated THM concentrations were higher in systems using additional treatment. Residual chlorine was highest in the winter and lowest in the spring and summer. Seasonal variations were most pronounced for residual chlorine in systems with additional treatment. There was generally poor correlation between THM concentrations and concentrations of residual chlorine. Further study with these data will be beneficial in finding determinants and indicators for both quantity and variability of disinfection byproducts and other water quality parameters.

关键词： drinking water residual chlorine seasonal variability small municipal systems treatment technologies trihalomethanes

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Influence of metal support in-plane symmetry on the corrugation of hexagonal boron nitride and graphene monolayers

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Nano Research 2018年第9期11卷 4643-4653页

作者： Antonio d. Martinez-Galera Jose M. Gomez-rodriguez Departamento de Fisica de la Matefia Condensada Universidad Autonoma de Madrid Madrid E-28049 Spain Condensed Matter Physics Center (IFIMAC) UniversidadAutdnoma de Madrid Madrid E-28049 Spain Instituto Nicolds Cabrera Universidad Autonoma de Madrid Madrid E-28049 Spain

Predicting the properties of two-dimensional （2D） materials as graphene and hexagonal boron nitride （h-BN） monolayers after their growth on any given substrate is a major challenge. While the influence of the electron configuration of the atoms of the underlying surface is well-understood, the effect of substrate geometry still remains unclear. The structural properties of h-BN monolayers grown on a rectangularly packed Rh（110） surface were characterized in situ by ultrahigh vacuum scanning tunneling microscopy and were compared to those that this material exhibits when grown on substrates showing different crystallographic orientations. Although the h-BN monolayer grown on Rh（110） was dominated by a unique quasiunidimensional moir6 pattern, suggesting considerable interface interaction, the moir6 corrugation was unexpectedly smaller than those reported for strongly interacting interfaces with hexagonal-terminated substrates, owing to differences in the possible binding landscapes at interfaces with differently oriented substrates. Moreover, a rule was derived for predicting how interface corrugation and the existence and extent of subregions within moir6 supercells containing favorable sites for orbital mixing between h-BN monolayers and their supports depend on substrate symmetry. These general symmetry considerations can be applied to numerous 2D materials, including graphene, thereby enabling the prediction of how substrate choice determines the properties of these materials. Furthermore, they could also provide new routes for tuning 2D material properties and for developing nanotemplates showing different geometries for Krowing adsorbate superlattices.

关键词： hexagonal boron nitride graphene two-dimensional materials scanning tunneling microscopy moire superstructures nanotemplates

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Symmetry in optics and photonics:a group theory approach

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Science Bulletin 2018年第4期63卷 244-251页

作者： B.M.rodriguez-Lara Ramy EI-Ganainy Julio Guerrero Tecnologico de Monterrey.Escuela de Ingenieria y Ciencias Monterrey 64849Mexico Instituto Nacional de Astrofisica Optica y Electr6nicaPueblaCP 72840Mexico Department of Physics and Hexes Center for Quantum Phenomena Michigan Technological UniversityHoughton.MI 49931USA Departamento de Matematicas Facultad de Ciendas Experimentales y de la SaludCampus Las LagunillasUniversidad de Jaen23071JaenSpain Departamento de Ingenierfa y Tecnologia de Computadores Facultad de lnformdticaCampus EspinardoUnivesidad de Murcia30100 MurciaSpain

Group theory(GT) provides a rigorous framework for studying symmetries in various disciplines in physics ranging from quantum field theories and the standard model to fluid mechanics and chaos theory. To date, the application of such a powerful tool in optical physics remains limited. Over the past few years however, several quantum-inspired symmetry principles(such as parity-time invariance and supersymmetry) have been introduced in optics and photonics for the first time. Despite the intense activities in these new research directions, only few works utilized the power of group theory. Motivated by this status quo, here we present a brief overview of the application of GT in optics, deliberately choosing examples that illustrate the power of this tool in both continuous and discrete setups. We hope that this review will stimulate further research that exploits the full potential of GT for investigating various symmetry paradigms in optics, eventually leading to new photonic devices.

关键词： Group theoryHelmholtz equationDiscrete opticsParity-time (PT) symmetry

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