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Lessons from rare tumors: Hepatic lymphoepithelioma-like carcinomas

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World Journal of Gastroenterology 2015年第12期21卷 3472-3479页

作者： Antonio Solinas diego f.calvisi Department of Biomedical Sciences University of Sassari Department of Clinical and Experimental Medicine University of Sassari Institute of Pathology University of Greifswald

In this review we focus on lymphoepitheliomalike hepatocellular carcinomas(LEL-HCC) and lymphoepithelioma-like cholangiocarcinomas(LEL-ICC). Despite their rarity, these tumors are of general interest because of their epidemiological and clinical features, and because they represent a distinct model of interaction between the immune systemand neoplastic cells. Approximately half of LELHCC arise in the context of chronic hepatitis C virus(HCV) infection and have been described both in Eastern and Western patients. By contrast, LEL-ICC is associated in almost all cases with Epstein-Barr virus(EBV) infection and exhibits the same epidemiological features of EBV related malignancies. Compared with classical hepatocellular carcinoma and intrahepatic cholangiocarcinoma of corresponding stage, both LEL-HCC and LEL-ICC are characterized by lower rates of recurrence after surgery and better overall survival. How this behavior is related to distinct genetic alterations and tumor microenvironment is unclear. The pathophysiological mechanisms of lymphoid infiltrations seem to be different among the two groups of tumors. In fact, LEL-HCC frequently arises in the context of inflammatory changes driven by HCV infection, and has been recognized as a variant of classical hepatocellular carcinoma. At variance, lymphocyte recruitment of LEL-ICC is similar to that described in nasopharyngeal carcinoma and gastric LEL, and possibly depends on the expression pattern of latent EBV infection.

关键词： Lymphoepithelioma Lymphoepithelioma-like carcinoma

5DGWO-GAN:A Novel five-Dimensional Gray Wolf Optimizer for Generative Adversarial Network-Enabled Intrusion Detection in IoT Systems

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Computers, Materials & Continua 2025年第1期82卷 881-911页

作者： Sarvenaz Sadat Khatami Mehrdad Shoeibi Anita Ershadi Oskouei diego Martín Maral Keramat Dashliboroun Department of Data Science Engineering University of HoustonHoustonTX 77204USA The WPI Business School Worcester Polytechnic InstituteWorcesterMA 01609USA School of Systems and Enterprises Stevens Institute of TechnologyHobokenNJ 07030USA Department of Computer Science Escuela de Ingeniería Informática de SegoviaUniversidad de ValladolidSegovia40005Spain Ernest G.Welch School of Art&Design Georgia State UniversityAtlantaGA 30303USA

The Internet of Things(IoT)is integral to modern infrastructure,enabling connectivity among a wide range of devices from home automation to industrial control *** the exponential increase in data generated by these interconnected devices,robust anomaly detection mechanisms are *** detection in this dynamic environment necessitates methods that can accurately distinguish between normal and anomalous behavior by learning intricate *** paper presents a novel approach utilizing generative adversarial networks(GANs)for anomaly detection in IoT ***,optimizing GANs involves tuning hyper-parameters such as learning rate,batch size,and optimization algorithms,which can be challenging due to the non-convex nature of GAN loss *** address this,we propose a five-dimensional Gray wolf optimizer(5DGWO)to optimize GAN *** 5DGWO introduces two new types of wolves:gamma(γ)for improved exploitation and convergence,and theta(θ)for enhanced exploration and escaping local *** proposed system framework comprises four key stages:1)preprocessing,2)generative model training,3)autoencoder(AE)training,and 4)predictive model *** generative models are utilized to assist the AE training,and the final predictive models(including convolutional neural network(CNN),deep belief network(DBN),recurrent neural network(RNN),random forest(Rf),and extreme gradient boosting(XGBoost))are trained using the generated data and AE-encoded *** evaluated the system on three benchmark datasets:NSL-KDD,UNSW-NB15,and *** conducted on diverse IoT datasets show that our method outperforms existing anomaly detection strategies and significantly reduces false *** 5DGWO-GAN-CNNAE exhibits superior performance in various metrics,including accuracy,recall,precision,root mean square error(RMSE),and convergence *** proposed 5DGWO-GAN-CNNAE achieved the lowest RMSE values across the NSL-KDD,UNSW-NB15,and

关键词： Internet of things intrusion detection generative adversarial networks five-dimensional binary gray wolf optimizer deep learning

CD147/Basigin:a Warburg oncogene in hepatocellular carcinoma?

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Chinese Journal of Cancer Research 2016年第3期28卷 377-379页

作者： diego francesco calvisi Institute of Pathology University Medicine of Greifswald

Hepatocellular carcinoma （HCC） is one of the most common malignancies worldwide, ranking fifth in incidence and second in mortality （1）. Although HCC cases mainly occurred in South-East Asia and Southern Africa in the past, the incidence of this disease has been on the rise in the Western countries over the forty last years （1）. Despite the advances in the diagnostic techniques and novel therapies, HCC remains a tumor with a dismal prognosis （2-4）. While the detection of HCC at an early stage allows the employment of potentially curative treatments, such as liver transplantation, surgical resection and tumor ablation, over two thirds of patients are diagnosed at a late stage of the disease, when conventional therapeutic approaches are ineffective （2-4）. furthermore, administration of the multikinase inhibitor Sorafenib, the only drug approved by the food and Drug Administration （fDA） for targeted therapy of advanced HCC, provides only limited benefits to HCC patients in terms of overall survival （2-4）. Thus, in order to improve significantly the effectiveness of therapeutic strategies against liver cancer, a deeper understanding of the molecular pathogenesis of this deadly disease is necessary.

关键词： HCC CD147/Basigin

Development of Aircraft Maintenance Glossaries in Higher Education:Exploring Methodological Paths to Corpus-Driven Analysis of Key Keywords

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中国科技术语 2025年第1期27卷 83-93页

作者： Malila PRADO Daniela TERENZI diego BRITO BNU-HKBU United International College Zhuhai 519087 federal Institute of Education Science and Technology of São PauloSão Carlos 13.565-820

This paper presents a project aimed at developing a trilingual visual dictionary for aircraft maintenance professionals and *** project addresses the growing demand for accurate communication and technical terminology in the aviation industry,particularly in Brazil and *** study employs a corpus-driven approach,analyzing a large corpus of aircraft maintenance manuals to extract key technical terms and their *** specialized subcorpora and a comparative analysis,this paper demonstrates challenges and solutions into the identification of high-frequency keywords and explores their contextual use in aviation documentation,emphasizing the need for clear and accurate technical *** incorporating these findings into a trilingual visual dictionary,the project aims to enhance the understanding and usage of aviation terminology.

关键词： aircraft maintenance corpus keyword extraction

The health benefits of selenium in food animals:a review

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Journal of Animal Science and Biotechnology 2022年第6期13卷 1623-1633页

作者： Brittany M.Pecoraro diego f.Leal Alba frias-De-diego Matthew Browning Jack Odle Elisa Crisci College of Veterinary Medicine Department of Population Health and PathobiologyNorth Carolina State UniversityRaleighNorth CarolinaUSA Laboratory of Developmental Nutrition Department of Animal ScienceNorth Carolina State UniversityRaleighNorth CarolinaUSA

Selenium is an essential trace mineral important for the maintenance of homeostasis in animals and *** evinces a strong antioxidant,anti-inflammatory and potential antimicrobial *** biological function is primarily achieved by its presence in selenoproteins as a form of *** deficiency may result in an array of health disorders,affecting many organs and systems;to prevent this,dietary supplementation,mainly in the forms of organic(i.e.,selenomethionine and selenocysteine)inorganic(i.e.,selenate and selenite)sources is *** pigs as well as other food animals,dietary selenium supplementation has been used for improving growth performance,immune function,and meat quality.A substantial body of knowledge demonstrates that dietary selenium supplementation is positively associated with overall animal health especially due to its immunomodulatory activity and protection from oxidative *** also possesses potential antiviral activity and this is achieved by protecting immune cells against oxidative damage and decreasing viral *** this review we endeavor to combine established and novel knowledge on the beneficial effects of dietary selenium supplementation,its antioxidant and immunomodulatory actions,and the putative antimicrobial effect ***,our review demonstrates the gaps in knowledge pertaining to the use of selenium as an antiviral,underscoring the need for further in vivo and in vitro studies,particularly in pigs.

关键词： Antimicrobial Antioxidant food animals Immunomodulation Pig Selenium

Spatial epidemiology of diabetes: Methods and insights

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World Journal of Diabetes 2021年第7期12卷 1042-1056页

作者： diego f Cuadros Jingjing Li Godfrey Musuka Susanne f Awad Geography and Geographic Information Systems University of CincinnatiCincinnatiOH 45221United States Urban Health Collaborative Drexel UniversityPhiladelphiaPA 19104United States ICAP Columbia UniversityHarare 00000Zimbabwe Infectious Disease Epidemiology Group Weill Cornell Medicine–QatarCornell UniversityDoha 24144Qatar World Health Organization Collaborating Centre for Disease Epidemiology Analytics on HIV/AIDS Sexually Transmitted Infectionsand Viral HepatitisWeill Cornell Medicine–QatarCornell UniversityDoha 24144Qatar Department of Population Health Sciences Weill Cornell MedicineCornell UniversityNew YorkNY 10044United States

Diabetes mellitus(DM)is a growing epidemic with global *** is estimated that in 2019,463 million adults aged 20-79 years were living with *** latest evidence shows that DM continues to be a significant global health challenge and is likely to continue to grow substantially in the next decades,which would have major implications for healthcare expenditures,particularly in developing ***,new conceptual and methodological approaches to tackle the epidemic are long *** epidemiology has been a successful approach to control infectious disease epidemics like malaria and human immunodeficiency *** implementation of this approach has been expanded to include the study of non-communicable diseases like cancer and cardiovascular *** this review,we discussed the implementation and use of spatial epidemiology and Geographic Information Systems to the study of *** reviewed several spatial methods used to understand the spatial structure of the disease and identify the potential geographical drivers of the spatial distribution of ***,we discussed the use of spatial epidemiology on the design and implementation of geographically targeted prevention and treatment interventions against DM.

关键词： Diabetes mellitus Spatial epidemiology Risk factors Spatial statistics Disease mapping

Effect of Heat Loss on Laminar flamelet Species Concentration

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Journal of Thermal Science 2016年第5期25卷 418-423页

作者： Marco Boccanera diego Lentini Dipartimento di Ingegneria Meccanica e Aerospaziale Sapienza Università di Roma

The effects of heat loss on the structure of laminar flamelets,which are the constitutive elements of turbulent flames under the most common operating conditions,are investigated for typical aeronautical gas-turbine operating conditions at *** magnitude of heat loss is quantified via the "enthalpy defect" measured with respect to an adiabatic flame.A procedure to generate laminar flamelets with an assigned enthalpy defect at the boundaries is devised and applied to nonpremixed propane/air flames,as propane reproduces the essential features of higher hydrocarbon *** is found,contrary to commonly held beliefs,that the enthalpy defect has a significant effect on the concentration not only of minor species,but also of main reaction *** effects are found in general to be more pronounced for fuel-rich *** impact is anticipated on the formation rate of nitric *** effects of scalar dissipation rate are also discussed.

关键词： Turbulent Combustion Heat Transfer Laminar flamelets Hydrocarbon Combustion Aeroengines Gas Turbines

Nerve growth factor catches copper in neuronal inning

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Neural Regeneration Research 2020年第4期15卷 665-666页

作者： diego La Mendola Department of Pharmacy University of Pisa

The physiological effect of neurotrophic factors and their role in Alzheimer’s disease(AD):Neurotrophins(NTs)are a family of homologues proteins that play an essential role in neuronal cells growth,survival and *** proteins include the nerve growth factor(NGf),the brain derived neurotrophic factor(BDNf),NT-3 and NT-3,also known as NT-4/5.

关键词： Alzheimer copper differentiation.

Merging bound states in the continuum in an open acoustic resonator

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 124-131页

作者： Lujun Huang Bin Jia Artem S.Pilipchuk Sibo Huang Chen Shen Almas f.Sadreev Yong Li Andrey E.Miroshnichenko School of Physics and Electronic Sciences East China Normal University Institute of Acoustics Tongji University L.V.Kirensky Institute of Physics Department of Mechanical Engineering Rowan University School of Engineering and Technology University of New South Wales at Canberra

Bound states in the continuum （BICs） are perfectly localized resonances despite embedding in the continuum ***,an isolated BIC is very sensitive to the structure ***,we report merging acoustic BICs in a single open resonator,robust against the structure *** find that both symmetry-protected BIC and friedrich-Wintgen BIC are sustained in a single coupled waveguide-resonator *** varying the height and length of the resonator,these two BICs move toward each other and merge into a single one at a critical *** to an individual BIC,the merged BIC is robust against fabrication error because its Q-factor is proportional to ΔL-4,whereΔL embodies the structure *** essence of this extraordinary phenomenon is perfectly explained by the two-and three-level approximations of the effective nonHermitian ***,we present direct experimental demonstrations of the moving and merging of BICs in a coupled 3D waveguide-resonator,which are evidenced by the vanishing of the linewidth of fano resonance in the transmission *** results may find exciting applications in designing high-quality acoustic sources,sensors and filters.

关键词： acoustic resonances bound state in the continuum high-Q resonances