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Surface Acoustic Wave Device with Reduced Insertion Loss by Electrospinning P(VDF–TrFE)/ZnO Nanocomposites

Nano-Micro Letters 2016年第3期8卷 282-290页

作者： Robin Augustine Frederic Sarry Nandakumar Kalarikkal Sabu Thomas Laurent Badie didier rouxel International and Inter University Centre for Nanoscience and Nanotechnology Mahatma Gandhi University Department of Materials Science and Engineering Technion-Israel Institute of Technology Institut Jean Lamour Universiéde Lorraine CNRS School of Pure and Applied Physics Mahatma Gandhi University School of Chemical Sciences Mahatma Gandhi University

Surface acoustic wave(SAW) devices have been utilized for the sensing of chemical and biological phenomena in microscale for the past few decades. In this study, SAW device was fabricated by electrospinning poly(vinylidenefluoride-co-trifluoroethylene)(P(VDF-TrFE)) incorporated with zinc oxide(ZnO) nanoparticles over the delay line area of the SAW device. The morphology, composition, and crystallinity of P(VDF-TrFE)/ZnO nanocomposites were investigated. After measurement of SAW frequency response, it was found that the insertion loss of the SAW devices incorporated with ZnO nanoparticles was much less than that of the neat polymer-deposited device. The fabricated device was expected to be used in acoustic biosensors to detect and quantify the cell proliferation in cell culture systems.

关键词： Surface acoustic wave SAW P(VDF-TrFE) ZnO Biosensor

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Electrospun poly（vinylidene fluoride-trifluoroethylene）/ zinc oxide nanocomposite tissue engineering scaffolds with enhanced cell adhesion and blood vessel formation

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Nano Research 2017年第10期10卷 3358-3376页

作者： Robin Augustine Pan Dan Alejandro Sosnik Nandakumar Kalarikkal Nguyen Tran Brice Vincent Sabu Thomas Patrick Menu didier rouxel Laboratory of Pharmaceutical Nanomaterials Science Department of Materials Science and Engineering Technion-lsrael Institute of Technology De-Jur Building Technion City Haifa 3200003 Israel Intemationaland Inter University Centre for Nanoscience and Nanotechnology Mahatma Gandhi University Kottayam Kerala 686560 India Ingenierie Moleculaire et Physiopathologie Articulaire UMR 7365 CNRS-Universite de Lorraine Vandoeuvre-Ies Nancy F-54500 France School of Pure and Applied Physics Mahatma Gandhi University Kottayam Kerala 686560 India School of Surgery Faculty of Medicine Universite de Lorraine Vandoeuvre-Ies-Nancy F-54500 France Institut Jean Lamour UMR 7198 CNRS-Universite de Lorraine Vandoeuvre-Ies-Nancy F-54500 France School of Chemical Sciences Mahatma Gandhi University Kottayam Kerala 686560 India

Piezoelectric materials that generate electrical signals in response to mechanical strain can be used in tissue engineering to stimulate cell proliferation. Poly （vinylidene fluoride-trifluoroethylene）（P（VDF-TrFE））, a piezoelectric polymer, is widely used in biomaterial applications. We hypothesized that incorporation of zinc oxide （ZnO） nanoparticles into the P（VDF-TrFE） matrix could promote adhesion, migration, and proliferation of cells, as well as blood vessel formation （angiogenesis）. In this study, we fabricated and comprehensively characterized a novel electrospun P（VDF-TrFE）/ZnO nanocomposite tissue engineering scaffold. We analyzed the morphological features of the polymeric matrix by scanning electron microscopy, and utilized Fourier transform infrared spectroscopy, X-ray diffraction, and differential scanning calorimetry to examine changes in the crystalline phases of the copolymer due to addition of the nanoparticles. We detected no or minimal adverse effects of the biomaterials with regard to blood compatibility in vitro, biocompatibility, and cytotoxicity, indicating that P（VDF-TrFE）/ZnO nanocomposite scaffolds are suitable for tissue engineering applications. Interestingly, human mesenchymal stem cells （hMSCs） and human umbilical vein endothelial cells cultured on the nanocomposite scaffolds exhibited higher cell viability, adhesion, and proliferation compared to cells cultured on tissue culture plates or neat P（VDF-TrFE） scaffolds. Nanocomposite scaffolds implanted into rats with or without hMSCs did not elicit immunological responses, as assessed by macroscopic analysis and histology. Importantly, nanocomposite scaffolds promoted angiogenesis, which was increased in scaffolds pre-seeded with hMSCs. Overall, our results highlight the potential of these novel P（VDF-TrFE）/ZnO nanocomposites for use in tissue engineering, due to their biocompatibility and ability to promote cell adhesion and angiogenesis.

关键词： scaffolds electrospinning poly(vinylidene fluoride-trifluoroethylene) (P(VDF-TrFE)) ZnO angiogenesis cell adhesion stem cells

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