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Organotypic Models for Functional Drug testing of Human Cancers

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Biomedical Engineering Frontiers 2023年第1期4卷 103-112页

作者： Yu Ling Huang Lindsay K.dickerson Heidi Kenerson Xiuyun Jiang Venu Pillarisetty Qiang tian Leroy Hood taranjit S.Gujral Raymond S.Yeung Division of Human Biology Fred Hutchinson Cancer CenterSeattleWAUSA Department of Surgery University of WashingtonSeattleWAUSA National Research Center for translational Medicine Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Institute for Systems Biology Phenome Health InstituteSeattleWAUSA

In the era of personalized oncology,there have been accelerated efforts to develop clinically relevant platforms to test drug sensitivities of individual *** ideal assay will serve as a diagnostic companion to inform the oncologist of the various treatments that are sensitive and insensitive,thus improving outcome while minimizing unnecessary toxicities and *** date,no such platform exists for clinical use,but promising approaches are on the horizon that take advantage of improved techniques in creating human cancer models that encompass the entire tumor microenvironment,alongside technologies for assessing and analyzing tumor *** review summarizes a number of current strategies that make use of intact human cancer tissues as organotypic cultures in drug sensitivity testing.

关键词： Cancer horizon Human

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向未来进发

疯狂英语（新悦读） 2015年第6期 32-36页

作者： Ali Velshi Caitlin dickerson t Boy

有了日新月异的科技手段,面对不一样的劳动大军,企业管理者该如何应对?与时俱进不能停留在口头上,要付诸行动,才不会被时代淘汰。Carrots for the Millennials让Y世代尝到甜头H o s t:W h y i n a n environment like ours,where there... 详细信息

有了日新月异的科技手段,面对不一样的劳动大军,企业管理者该如何应对?与时俱进不能停留在口头上,要付诸行动,才不会被时代淘汰。Carrots for the Millennials让Y世代尝到甜头H o s t:W h y i n a n environment like ours,where there’s high unemployment,do these kids get to call the shots?Nadira Hira(Journalist,

关键词：谷歌公司克雷格 employment something employee inexpensive 午休时间硬件开发洛伊一键式

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Comparison of Antibody Detection with Yeast Lysate Antigens Prepared from Blastomyces dermatitidis Dog Isolates from Wisconsin and tennessee

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Open Journal of Veterinary Medicine 2013年第1期3卷 67-72页

作者： Jessica J. Roberts Michael V. Madrid Lindsy dickerson Bradi Hutchison Gene M. Scalarone Department of Biological Sciences Idaho State University Pocatello USA

Blastomyces dermatitidis, the causative agent of blastomycosis, a potentially lethal dimorphic fungal disease of humans and animals has been difficult to diagnose in the clinical laboratory. We are attempting to develop and improve immunodiagnostic assays by producing novel yeast lysate reagents for the detection of antibodies in blastomycosis. the objective of this study was to use lysate antigens prepared from four B. dermatitidis antigens isolated from dogs infected with blastomycosis from two different endemic areas (Wisconsin and tennessee) testing for the detection of antibodies in serum specimens from immunized rabbits and infected dogs using the indirect ELISA. In the dog sera, absorbance values ranged from 0.774 to 1.350, while the rabbit sera values ranged from 0.533 to 1.191. Antigen t-58 appeared to lack any geographical specificity in antibody detection, which could prove useful in future immunodiagnostic detection of blastomycosis infections.

关键词： Blastomyces dermatitidis Blastomycosis ELISA Lysate Antigen Antibody Detection

复发性结肠憩室炎:确定Ct预测征象——回顾性队列研究

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国际医学放射学杂志 2018年第1期 102-102页

作者： E.C.dickerson S.t.Chong J.H.Ellis K.Watcharotone B.Nan M.S.Davenport 周波 Division of Abdominal Radiology Department of RadiologyUniversity of Michigan Health System

摘要目的确定可以预测结肠憩室炎复发的Ct影像征象。材料与方法本研究获得机构伦理委员会批准并符合HIPAA法案。6名经过专科医师培训的腹部放射医生对2004

关键词：肠憩室炎预测因素 Ct

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选择性卵巢静脉取样定位Leydig细胞瘤

世界核心医学期刊文摘（妇产科学分册） 2005年第11期1卷 32-32页

作者： dickerson R.D. Putman M.J. Black M.E. A.B. Pinto 李跃萍 Barnett tower 502 3600 Gaston Avenue Dallas TX 75246 United States Dr.

Objective: to describe a patient with recent onset of rapidly progressive virilization who was diagnosed with an androgen-secreting tumor of the left ovary, localized by selective ovarian vein catheterization and hormonal sampling (SOVHS). Design: Case report. Setting: tertiary community-based medical center. Patient(s): A 32-year-old woman presenting with progressive virilization over a period of 4 months was found to have a Leydig cell tumor of the left ovary. Intervention(s): transvaginal ultrasound of the pelvis, followed by contrast-enhanced computerized tomography of the abdomen and the pelvis. Selective ovarian vein sampling was performed to localize the tumor. Laparoscopic left salpingo-oophorectomy and washings were also performed. Main Outcome Measure(s): Initial serum total t levels were 1,505 ng/dL, and the free serum t levels were 234 ng/dL. After SOVHS, the total serum t levels in the left ovarian vein is reported to be 20,967 ng/dL, and in the right ovarian vein, they were reported to be 1,351 ng/dL. three months after laparoscopic left oophorectomy, the serum total t levels were 11 ng/dL. Institutional review board approval was obtained. Result(s): Patient’ s ovarian tumor removed laparoscopically was reported to be a Leydig cell tumor. Rapid decreases in free and total t followed tumor removal. Conclusion(s): Selective ovarian vein catheterization and hormonal sampling is an effective diagnostic modality that can help localizesmall ovarian tumors.

关键词： Leydig细胞卵巢切除卵巢肿瘤右侧卵巢左卵巢左侧卵巢左侧输卵管雄激素分泌阴道超声检查镜下切除

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