检索结果-南通市图书馆

Human development diane E. Papalia, Sally Wendkos Olds, Ruth Duskin Feldman ; in consultation with Dana Gross. 9th ed.

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Structural engineering of antimicrobials for optimal broad-spectrum activity

2004年

作者： diane E. Papalia Sally Wendkos Olds Ruth Duskin Feldman in consultation with Dana Gross.

Accompanied by student CD-ROM.

ISBN: (数字)0072820306

ISBN: (纸本)9780072820300

Accompanied by student CD-ROM.

关键词： Developmental psychology.

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

Green Chemical Engineering 2024年第4期5卷 473-482页

作者： Arunmozhiarasi Armugam diane S.W.Lim Siti Nurhanna Riduan Shook Pui Chan Jerome Asugan Yugen Zhang Institute of Bioengineering and Bioimaging Institute of Sustainability for Chemicals Energy and Environment(ISCE2) Agency for Science Technology and Research (A*STAR) Diploma in Biomedical Science School of Chemical and Life SciencesSingapore Polytechnic

Antimicrobial materials are a crucial component in eradicating and managing the spread of infectious *** are expected to act on a broad-spectrum of microbes, including emerging pathogens which could cause the next Disease X. Herein, we reassessed a series of antimicrobial imidazolium polymers on our shelves and uncovered extended functionality through dual modes of action. By redesigning their structures, a truly broadspectrum antimicrobial material with optimized activity against bacteria(G +ve, G-ve) and fungi, as well as enveloped and non-enveloped viruses was developed. We demonstrated that the imidazolium polymer exhibits dual modes of function against microbes: targeting the microbial membrane and binding DNA. The latter DNA binding affinity was found to be key against non-enveloped viruses. With this insight, we designed small molecule compounds that exhibited optimum broad-spectrum antimicrobial activity and excellent efficacy against ESKAPE group of pathogens that are responsible for some of the deadliest nosocomial infections worldwide. Our results could also shed light on the design of broad-spectrum antimicrobial compounds against Disease X.

关键词： Broad-spectrum Antimicrobial Polyimidazolium Structure-function Membrane active

Stress response silencing by an E3 ligase mutated in neurodegeneration

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

四川生理科学杂志 2024年第1期46卷 21-21页

作者： diane L Haakonsen Department of Molecular and Cell Biology University of California at Berkeley Berkeley CA USA Howard Hughes Medical Institute University of California at Berkeley Berkeley CA USA California Institute for Quantitative Biosciences (QB3) University of California at Berkeley Berkeley CA USA Institute for Stem Cell Biology and Regenerative Medicine Stanford University School of Medicine Stanford CA USA Department of Pathology Stanford University School of Medicine Stanford CA USA

Stress response pathways detect and alleviate adverse conditions to safeguard cell and tissue homeostasis,yet their prolonged activation induces apoptosis and disrupts organismal *** stress responses are turned off at the right time and place remains poorly *** we report a ubiquitin-dependent mechanism that silences the cellular response to mitochondrial protein import stress.

关键词： homeostasis silence turned

A near-complete cucumber reference genome assembly and Cucumber-DB,a multi-omics database

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2024年第8期17卷 1178-1182页

作者： Jiantao Guan Han Miao Zhonghua Zhang Shaoyun Dong Qi Zhoul Xiaoping Liu diane M.Beckles Xingfang Gul Sanwen Huang Shengping Zhang State Key Laboratory of Vegetable Biobreeding Institute of Vegetables and FlowersChinese Academy of Agricultural SciencesBeijing 100081China Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhenChina Engineering Laboratory of Genetic Improvement of Horticultural Crops of Shandong Province College of HorticultureQingdao Agricultural UniversityQingdao266109China Department of Plant Sciences University of CaliforniaDavisOne Shield AvenueDavisCA95616USA

Dear Editor,Cucumber(Cucumis sativus)is a key vegetable crop and an essential model for genetics and genomics research in Cucurbitaceae,especially in studies on plant sex determination and vascular *** the first sequenced genome among vegetable crops,the cucumber reference genome has been a crucial genetic resource for comparative genomics and genetic ***,the latest version of the cucumber *** Long reference genome(CLv3.0),generated using PacBio long-reads data,is *** a predicted genome size of 350-367 Mb,CLv3.0 encompasses only 226.2 Mb,leaving 72 gaps and over 120 Mb of unknown *** low assembly completeness(approximately 62%)is primarily due to the high proportion(~30%)of heterochromatic satellite and rDNA sequences in cucumber,substantially higher than that observed in many other species such as Arabidopsis,rice,maize,and watermelon,where it is less than 5%(Han et al.,2008;Huang et al.,2009;Li et al.,2019).

关键词： crops incomplete cucumber

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

教师重新思考编程授课方式

科技纵览 2024年第7期 7-9页

作者： Rina diane Caballar 不详

很明显,生成式人工智能正在改变软件开发行业。人工智能驱动的编写代码工具正在程序员的工作流程中提供帮助,人工智能领域的工作岗位数量也在不断增加。这种转变在学术界也很明显,这是下一代软件工程师学习如何编写代码的主要途径之一... 详细信息

很明显,生成式人工智能正在改变软件开发行业。人工智能驱动的编写代码工具正在程序员的工作流程中提供帮助,人工智能领域的工作岗位数量也在不断增加。这种转变在学术界也很明显,这是下一代软件工程师学习如何编写代码的主要途径之一。计算机科学专业的学生正在接受这项技术,使用生成式人工智能帮助理解复杂的概念、概括复杂的研究论文、集思广益寻找解决问题的方法、提出新的研究方向,当然,还有学习如何编写代码。

关键词：人工智能软件工程师计算机科学专业编写代码工作岗位生成式授课方式程序员

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

增强现实眼镜带来社会影响

科技纵览 2024年第1期 10-11,4页

作者： Rina diane Caballar 不详

还记得那次病毒视频通话事件吗?一名律师因为猫咪滤镜被打开而陷入困境。设身处地想象一样吧!假设和你交谈的人戴着类似的“智能”墨镜,这种眼镜可以在你不知情的情况下偷偷地在你的脸上应用猫咪滤镜,你会有什么感觉?

关键词：视频通话滤镜增强现实眼镜设身处地