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In vitro investigation of cellular effects of magnesium and magnesium-calcium alloy corrosion products on skeletal muscle regeneration

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Journal of Materials Science & Technology 2019年第11期35卷 2503-2512页

作者： diana maradze Andrew Capel Neil Martin Mark PLewis Yufeng Zheng Yang Liu Centre of Biological Engineering Wolfson School of MechanicalElectrical and Manufacturing EngineeringLoughborough UniversityLoughboroughLeicestershireLE113TUUK School of Sport Exercise and Health SciencesLoughborough UniversityLoughboroughLeicestershireLE113TUUK Department of Materials Science and Engineering College of EngineeringPeking UniversityBeijing 100871China

Biodegradable magnesium(Mg)has garnered attention for its use in orthopaedic implants due to mechanical properties that closely match to those of *** have been undertaken to understand the corrosion behaviour of these materials and their effects on bone forming ***,there is lack of research on how the corrosion of these biomaterials affect surrounding tissues such as skeletal *** plays an important role in the structural and functional properties of skeletal *** is therefore important to investigate the response of skeletal muscle cells to both soluble(Mg ions)and insoluble(corrosion granules)corrosion *** in vitro studies it is possible to observe the effects of corrosion products on myotube formation by the fusion of single muscle precursor cells known as *** achieve this goal,it is important to determine if these corrosion products are toxic to *** it was noted that although there was a slight decrement in cellular viability after initial exposure,this soon recovered to control levels.A high Ca/Mg ratio resulted in the formation of large myotubes and a low Ca/Mg ratio negatively affected myotube ***^2+and Ca^2+ions are important in the process of myogenesis,and the concentration of these ions and the ratio of the ions to each other played a significant role in myotube cellular *** outcomes of this study could pave the way to a bio-informed and integrated approach to the design and engineering of Mg-based orthopaedic implants.

关键词： Magnesium alloy Corrosion Biocompatibility Muscle Cellular response In vitro

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Corrosion of magnesium and magnesium–calcium alloy in biologically-simulated environment

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Progress in Natural Science:Materials International 2014年第5期24卷 539-546页

作者： Richard Harrison diana maradze Simon Lyons Yufeng Zheng Yang Liu Wolfson Centre for Stem Cells Tissue Engineering and Modelling (STEM) Centre for Biomolecular Sciences University of Nottingham College of Engineering Peking University Wolfson School of Mechanical and Manufacturing Engineering Loughborough University Loughborough

A study of biocompatibility and corrosion of both metallic magnesium(Mg) and a magnesium alloy containing 1% calcium(Mg–Ca) were investigated in in vitro culture conditions with and without the presence of bone marrow derived human mesenchymal stem cells(h MSCs).Chemical analysis of the degraded samples was performed using XRD and FEGSEM. The results from the XRD analysis strongly suggested that crystalline phase of magnesium carbonate was present on the surface of both the Mg and Mg–Ca samples. Flame absorption spectrometry was used to analyse the release of magnesium and calcium ions into the cell culture medium. Magnesium concentration was kept consistently at a level ranging from 40 to 80 m M for both Mg and Mg–Ca samples. No cell growth was observed when in direct contact with the metals apart from a few cells observed at the bottom of culture plate containing Mg–Ca alloy. In general, in vitro study of corrosion of Mg–Ca in a biologicallysimulated environment using cell culture medium with the presence of h MSCs demonstrated close resemblances to in vivo corrosion. Although in vitro corrosion of Mg–Ca revealed slow corrosion rate and no immediate cytotoxicity effects to h MSCs, its corrosion rate was still too high to achieve normal stem cell growth when cells and alloys were cultured in vitro in direct contact.

关键词： Magnesium Biometal Corrosion Biocompatibility Stem cells In vitro

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