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复合混杂因素校正R2*mapping在肝脏铁MRI定量中的应用

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国际医学放射学杂志 2021年第2期44卷 241-241页

作者： D.Hernando R.J.cook N.Qazi c.A.Longhurst c.A.diamond S.B.Reeder 王萱

摘要目的基于MRI的R2*mapping可以可靠、快速地定量肝脏铁浓度（LIc）。然而,R2*在不同采集协议中的表现和可重复性仍然未知。因此,本研究旨在评估复合混杂因素

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Postbiotics from Saccharomyces cerevisiae fermentation stabilize microbiota in rumen liquid digesta during grain-based subacute ruminal acidosis(SARA) in lactating dairy cows

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Journal of Animal Science and Biotechnology 2024年第5期15卷 2059-2080页

作者： Junfei Guo Zhengxiao Zhang Le Luo Guan Ilkyu Yoon Jan c.Plaizier Ehsan Khafipour Department of Animal Science University of ManitobaWinnipegMB R3T 2N2Canada Present Address:college of Food and Biological Engineering Jimei UniversityXiamenFujian 361021China Department of Agriculture Food and Nutrition DepartmentUniversity of AlbertaEdmontonAB T6G 2R3Canada Faculty of Land and Food Systems University of British ColumbiaVancouverBC V6T 1Z4Canada diamond V Cedar RapidsIA 52404United States Present Address:cargill Animal Nutrition 15407 McGinty Road WestWayzataMN 55391USA

Background Subacute ruminal acidosis(SARA)is a common metabolic disorder of high yielding dairy cows,and it is associated with dysbiosis of the rumen and gut microbiome and host *** study evaluated the impact of two postbiotics from Saccharomyces cerevisiae fermentation products(ScFP)on rumen liquid associated microbiota of lactating dairy cows subjected to repeated grain-based SARA challenges.A total of 32 rumen cannulated cows were randomly assigned to 4 treatments from 4 weeks before until 12 weeks after *** groups included a control diet or diets supplemented with postbiotics(ScFPa,14 g/d Original XPc;ScFPb-1X,19 g/d Nutri Tek;ScFPb-2X,38 g/d Nutri Tek,diamond V,cedar Rapids,IA,USA).Grain-based SARA challenges were conducted during week 5(SARA1)and week 8(SARA2)after parturition by replacing 20%DM of the base total mixed ration(TMR)with pellets containing 50%ground barley and 50%ground *** DNA from rumen liquid samples was subjected to V3–V416S r RNA gene amplicon *** of rumen microbiota were compared among treatments and SARA *** Both SARA challenges reduced the diversity and richness of rumen liquid microbiota,altered the overall composition(β-diversity),and its predicted functionality including carbohydrates and amino acids metabolic *** SARA challenges also reduced the number of significant associations among different taxa,number of hub taxa and their composition in the microbial co-occurrence *** with ScFP postbiotics,in particular ScFPb-2X,enhanced the robustness of the rumen *** ScFP supplemented cows had less fluctuation in relative abundances of community members when exposed to SARA *** ScFP supplementation promoted the populations of lactate utilizing and fibrolytic bacteria,including members of Ruminococcaceae and Lachnospiraceae,and also increased the numbers of hub taxa during non-SARA and SARA *** with S

关键词： Postbiotics Rumen microbiota Saccharomyces cerevisiae fermentation products SARA

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Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

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Properties of SN Ia progenitors from light curves and spectra

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Frontiers of physics 2013年第2期8卷 144-167页

作者： P. Hoflich P. Dragulin J. Mitchell B. Sadler T. diamond c. Gerardy Department of Physics Florida State University Talahassee USA FL 32306 Department of Physics Astronomy Clemson University Clemson USA SC 29634

With recent advances in theory and observations, direct connections emerge between the progenitors of Type Ia Supernovae （SNe Ia） and the observed light curves and spectra. A direct link is important for our understanding of the supernovae physics, the diversity of SNe Ia and the use of SNe Ia for high-precision cosmology because the details of the explosion depends sensitively on the initial conditions and the explosion scenario（s） realized in nature. Do SNe Ia originate from SD- or DD systems, and do they lead to Mcu mass explosions or dynamical mergers？ Does the statistical distribtion of SNe Ia depend on their environment which can be expected to change with redshift？ In this contribution, we will exam from the theoretical point of view the tell-tails for this connection, their consistency with the observations, and future directions. In a first section, we present the physics of the explosion, light curves and spectral formation in a nutshell to help understanding the connection. For details of the progenitor evolution and explosion physics, we refer to reviews and the other contributions in this issue. Each of the topical sections starts with a brief general review followed by a more detailed discussion of specific results. Because the youth of the field, some bias is unavoidable towards results obtained within our collaborations （and FSU）. The imprint of the metallicity, progenitor stars and properties such as the central density of the exploding WD are presented. IR spectroscopy, polarimetry and imaging of SNR remnants are discussed as a tool to test for the WD properties, magnetic fields and asymmetries. We discuss different classes of Type Ia supernovae, and their environment. Possible correlations between the spectroscopic and light curve properties of SN Ia are discussed. Finally, the overall emerging picture and future developments are discussed.

关键词： supernovae: general progenitors light curves spectra

A History of the Urban Underground Tunnel (4000 B.c.E. - 1900 c.E.)

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Journal of Transportation Technologies 2018年第1期8卷 11-43页

作者： Robert Steven diamond Brian Garret Kassel Brooklyn Historic Railway Association Columbia University New York NY USA

Generally hidden from public view, out of our daily thoughts, and literally under our feet, are myriad urban underground tunnels that make our modern megacities possible. From their ancient beginnings in antiquity, as a means of supplying fresh water and draining waste water from cities, underground tunnels evolved into a means of providing high capacity rail mass transit in our most densely populated urban centers. This paper provides a broad overview of the evolution of urban tunnels across a 6000 year time span and includes the specific engineering formulas/computations for the earliest 19th century subways/infrastructure projects based on the Roman vaulted arch tunnel.

关键词： Subway Subterranean Passageway Ancient Underground Mesopotamia Greece Rome cut and cover cloaca Maxima cryptoporticus croton Aq-ueduct Arch Tunnel Atlantic Avenue Tunnel London Railway London Tube Beach/Greathead Shield 19th century Arched Tunnel calculations

Estimating rock properties using sound signal dominant frequencies during diamond core drilling operations

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Journal of Rock Mechanics and Geotechnical Engineering 2019年第4期11卷 850-859页

作者： ch.Vijaya Kumar Harsha Vardhan ch.S.N.Murthy N.c.Karmakar Department of Mining Engineering National Institute of Technology KarnatakaSurathkalIndia Indian Institute of Technology (BHU) VaranasiIndia

In many engineering applications such as mining,geotechnical and petroleum industries,drilling operation is widely *** drilling operation produces sound by-product,which could be helpful for preliminary estimation of the rock ***,determination of rock properties is very difficult by the conventional methods in terms of high accuracy,and thus it is expensive and *** this context,a new technique was developed based on the estimation of rock properties using dominant frequencies from sound pressure level generated during diamond core drilling ***,sound pressure level was recorded and sound signals of these sound frequencies were analyzed using fast Fourier transform (FFT).Rock drilling experiments were performed on five different types of rock samples using computer numerical control (cNc) drilling machine BMV 45 *** simple linear regression analysis,mathematical equations were developed for various rock properties,*** compressive strength,Brazilian tensile strength,density,and dominant frequencies of sound pressure *** developed models can be utilized at early stage of design to predict rock properties.

关键词： Rock properties Sound pressure level Fast Fourier transform (FFT) Sound signal core drilling Dominant frequencies

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Temperature and structure measurements of heavy-ion-heated diamond using in situ X-ray diagnostics

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Matter and Radiation at Extremes 2024年第4期9卷 80-89页

作者： J.Lutgert P.Hesselbach M.Schorner V.Bagnoud R.Belikov P.Drechsel B.Heuser O.SHumphries P.Katrik B.Lindqvist c.Qu R.Redmer D.Riley G.Schaumann S.Schumacher A.Tauschwitz D.Varentsov K.Weyrich X.Yu B.Zielbauer Zs.Major P.Neumayer D.Kraus Institut fur Physik Universitat RostockAlbert-Einstein-Str.2318059 RostockGermany GSI Helmholtzzentrum fur Schwerionenforschung Planckstr.164291 DarmstadtGermany Institut für Angewandte Physik Goethe-Universität Frankfurt am MainMax-von-Laue-Str.160438 Frankfurt am MainGermany Institut fur Geowissenschaften Goethe-Universitat Frankfurt am MainAltenhoferallee 160438 Frankfurt am MainGermany Helmholtz-Zentrum Dresden-Rossendorf Bautzner Landstr.40001328 DresdenGermany European XFEL GmbH Holzkoppel 422869 SchenefeldGermany centre for Plasma Physics School of Mathematics and PhysicsQueen’s University BelfastUniversity RoadBelfast BT71NNUnited Kingdom Institut für Kernphysik Technische Universität DarmstadtSchlossgartenstr.964289 DarmstadtGermany State Key Laboratory of Nuclear Physics and Technology Institute of Heavy Ion PhysicsPeking UniversityBeijing 100871China Helmholtz Institut Jena Frobelstieg 307743 JenaGermany

We present in situ measurements of spectrally resolved X-ray scattering and X-ray diffraction from monocrystalline diamond samples heatedwith an intense pulse of heavy *** this way,we determine the samples’heating dynamics and their microscopic and macroscopic structuralintegrity over a timespan of several *** the ratio of elastic to inelastic scattering with state-of-the-art density functionaltheory molecular dynamics simulations allows the inference of average temperatures around 1300 K,in agreement with predictions fromstopping power *** simultaneous diffraction measurements show no hints of any volumetric graphitization of the material,butdo indicate the onset of fracture in the diamond *** experiments pave the way for future studies at the Facility for Antiproton andIon Research,where a substantially increased intensity of the heavy ion beam will be available.

关键词： heated intense structure

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沃顿商学院最受欢迎的谈判课

作者： (美)斯图尔特·戴蒙德(Stuart diamond)

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