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Pedestrian trajectory prediction method based on the Social-LSTM model for vehicle collision

Transportation Safety and Environment 2024年第3期6卷 140-151页

作者： Yong Han Xujie Lin di pan Yanting Li Liang Su Robert Thomson Koji Mizuno School of Mechanical and Automotive Engineering Xiamen University of TechnologyXiamen 361024China Fujian Province Key Laboratory of Advanced Design and Manufacturing of Buses Xiamen 361024China Engineering Research Institute of Xiamen Kinglong United Automobile Industry Co. Ltd.Xiamen 361000China Chalmers University of Technology Gothenburg 41296Sweden Department of Mechanical Systems Engineering Nagoya UniversityNagoya 464-8603Japan

Techniques for predicting the trajectory of vulnerable road users are important to the development of perception systems for autonomous vehicles to avoid *** most effective trajectory prediction methods,such as Social-LSTM,are often used to predict pedestrian trajectories in normal passage ***,they can produce unsatisfactory prediction results and data redundancy,as well as difficulties in predicting trajectories using pixel-based coordinate systems in collision avoidance *** is also a lack of validations using real vehicle-to-pedestrian *** address these issues,some insightful approaches to improve the trajectory prediction scheme of Social-LSTM were proposed,such methods included transforming pedestrian trajectory coordinates and converting image coordinates to world *** YOLOv5 detection model was introduced to reduce target loss and improve prediction *** DeepSORT algorithm was employed to reduce the number of target transformations in the tracking *** Perspective Transformation(IPT)and direct Linear Transformation(DLT)theories were combined to transform the coordinates to world coordinates,identifying the collision location where the accident could *** performance of the proposed method was validated by training tests using MS COCO(Microsoft Common Objects in Context)and ETH/UCY *** results showed that the target detection accuracy was more than 90%and the prediction loss tends to decrease with increasing training steps,with the final loss value less than 1%.The reliability and effectiveness of the improved method were demonstrated by benchmarking system performance to two video recordings of real pedestrian accidents with different lighting conditions.

关键词： vehicle-to-pedestrian collisions pedestrian trajectory prediction YOLOvB DeepSORT Social-LSTM

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Impact of baseline hepatitis B virus viral load on the long-term prognosis of advanced hepatocellular carcinoma treated with immunotherapy

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2504-2519页

作者： di pan Hao-Nan Liu Zhi-Yuan Yao Xiao-Xiao Chen Yu-Qi Li Jing-Jing Zhu Zheng-Xiang Han Xiao-Bing Qin Department of Oncology The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

BACKGROUND Although the combination of lenvatinib and PD-1 inhibitors has become the standard regimen for the treatment of advanced hepatocellular carcinoma(HCC),real data on the impact of baseline hepatitis B virus(HBV)-DNA levels on the clinical efficacy of this regimen is still *** To evaluate the effectiveness of camrelizumab combined with lenvatinib in patients with HCC at varying levels of *** One hundred and twenty patients with HCC who received camrelizumab and lenvatinib treatment were categorized into two cohorts:HBV-DNA≤2000(n=66)and HBV-DNA>2000(n=54).The main outcomes measured were overall survival(OS)and progression-free survival(PFS),while additional outcomes included the rate of objective response rate(ORR),disease control rate(DCR),and any negative *** proportional hazards regression analysis revealed independent predictors of OS,leading to the creation of a nomogram incorporating these *** The median PFS was 8.32 months for the HBV-DNA≤2000 group,which was similar to the 7.80 months observed for the HBV DNA>2000 group(P=0.88).Likewise,there was no notable variation in the median OS between the two groups,with durations of 13.30 and 14.20 months respectively(P=0.14).The ORR and DCR were compared between the two groups,showing ORR of 19.70%vs 33.33%(P=0.09)and DCR of 72.73%vs 74.07%(P=0.87).The nomogram emphasized the importance of antiviral treatment as the main predictor of patient results,with portal vein tumor thrombus and Barcelona Clinic Liver Cancer staging following closely *** The clinical outcomes of patients with HBV-associated HCC treated with camrelizumab in combination with lenvatinib are not significantly affected by HBV viral load.

关键词： Hepatitis B virus Hepatocellular carcinoma Camrelizumab Lenvatinib Efficacy

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Progress in the treatment of advanced hepatocellular carcinoma with immune combination therapy

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 273-286页

作者： di pan Hao-Nan Liu Peng-Fei Qu Xiao Ma Lu-Yao Ma Xiao-Xiao Chen Yu-Qin Wang Xiao-Bing Qin Zheng-Xiang Han Department of Oncology The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of General Surgery The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

Advanced hepatocellular carcinoma(HCC)is a severe malignancy that poses a serious threat to human *** to challenges in early diagnosis,most patients lose the opportunity for radical treatment when ***,recent advancements in cancer immunotherapy provide new directions for the treatment of *** instance,monoclonal antibodies against immune check-point inhibitors(ICIs)such as programmed cell death protein 1/death ligand-1 inhibitors and cytotoxic t-lymphocyte associated antigen-4 significantly improved the prognosis of patients with ***,tumor cells can evade the immune system through various *** the rapid development of genetic engineering and molecular biology,various new immunotherapies have been used to treat HCC,including ICIs,chimeric antigen receptor T cells,engineered cytokines,and certain cancer *** review summarizes the current status,research progress,and future directions of different immunotherapy strategies in the treatment of HCC.

关键词： Hepatocellular carcinoma Immunotherapies Immune checkpoint inhibitor Clinical efficacy Adverse reactions

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Quantitative analysis of the protective performance of bicycle helmet with multidirection impact protection system in oblique impact tests

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Chinese Journal of Traumatology 2024年第4期27卷 226-234页

作者： Yong Han Hao Yang He Wu di pan Bing-Yu Wang School of Mechanical and Automotive Engineering Xiamen University of TechnologyXiamen361024Fujian provinceChina Fujian Key Laboratory of Bus Advanced Design and Manufacturing Xiamen361024Fujian provinceChina School of Aerospace Engineering Xiamen UniversityXiamen361005Fujian provinceChina

Purpose:The current study aimed to assess the protective performance of helmets equipped with multidirectional impact protection system(MIPS)under various oblique impact ***:Initially,a finite element model of a bicycle helmet with MIPS was developed based on thescanned geometric parameters of an actual bicycle ***,the validity of model wasconfirmed using the KASK WG11 oblique impact test *** different impact angles(30°,45°,and 60°)and 2 varying impact speeds(5 m/s and 8 m/s)were employed in oblique tests to evaluateprotective performance of MIPS in helmets,focusing on injury assessment parameters such as peaklinear acceleration(PLA)and peak angular acceleration(PAA)of the ***:The results demonstrated that in all impact simulations,both assessment parameters werelower during impact for helmets equipped with MIPS compared to those *** PAA wasconsistently lower in the MIPS helmet group,whereas the difference in PLA was not significant in the noMIPS helmet *** instance,at an impact velocity of 8 m/s and a 30°inclined anvil,the MIPS helmetgroup exhibited a PAA of 3225 rad/s^(2) and a PLA of 281 *** contrast,the no-MIPS helmet group displayeda PAA of 8243 rad/s^(2) and a PLA of 292 ***,both PAA and PLA parameters decreased with theincrease of anvil *** a 60°anvil angles,PAA and PLA values were 664 rad/s^(2) and 20.7 g,respectively,reaching their ***:The findings indicated that helmets incorporating MIPS offer enhanced protection againstvarious oblique impact *** assessing helmets for oblique impacts,the utilization of larger angleanvils and rear impacts might not adequately evaluate protective performance during an impact *** findings will guide advancements in helmet design and the refinement of oblique impact testprotocols.

关键词： Oblique impact Multi-direction impact protection system WG11 oblique impact test Angular acceleration

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Broadband and fabrication-tolerant 3-dB couplers with topological valley edge modes

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Light(Science & Applications) 2024年第8期13卷 1623-1630页

作者： Guo-Jing Tang Xiao-Dong Chen Lu Sun Chao-Heng Guo Meng-Yu Li Zhong-Tao Tian Hou-Hong Chen Hong-Wei Wang Qi-Yao Sun Ying-di pan Xin-Tao He Yi-Kai Su Jian-Wen Dong School of Physics&State Key Laboratory of Optoelectronic Materials and Technologies Sun Yat-sen UniversityGuangzhou 510275China State Key Laboratory of Advanced Optical Communication Systems and Networks Department of Electronic EngineeringShanghai Jiao Tong UniversityShanghai 200240China

3-dB couplers,which are commonly used in photonic integrated circuits for on-chip information processing,precision measurement,and quantum computing,face challenges in achieving robust performance due to their limited 3-dB bandwidths and sensitivity to fabrication *** address this,we introduce topological physics to nanophotonics,developing a framework for topological 3-dB *** couplers exhibit broad working wavelength range and robustness against fabrication dimensional *** leveraging valley-Hall topology and mirror symmetry,the photonic-crystal-slab couplers achieve ideal 3-dB splitting characterized by a wavelength-insensitive scattering *** analysis confirms the superiority on broad bandwidth of 48 nm and robust splitting against dimensional errors of 20 *** further propose a topological interferometer for on-chip distance measurement,which also exhibits robustness against dimensional *** extension of topological principles to the fields of interferometers,may open up new possibilities for constructing robust wavelength division multiplexing,temperature-drift-insensitive sensing,and optical coherence tomography applications.

关键词： topological splitting insensitive

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Impact of baseline body mass index on the long-term prognosis of advanced hepatocellular carcinoma treated with immunotherapy

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World Journal of Gastroenterology 2024年第37期30卷 4132-4148页

作者： Yu-Qin Wang di pan Zhi-Yuan Yao Yu-Qi Li Peng-Fei Qu Run-Bang Wang Qing-Hao Gu Jie Jiang Zheng-Xiang Han Hao-Nan Liu Department of General Surgery The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of Oncology The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina The First College of Clinical Medicine Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of Oncology Suining County People’s HospitalXuzhou 221000Jiangsu ProvinceChina

BACKGROUND Primary liver cancer is the sixth most common cancer worldwide,with hepato-cellular carcinoma(HCC)being the most prevalent *** the current availability of multiple immune or immune combination treatment options,the prognosis is still poor,so how to identify a more suitable population is extremely *** To evaluate the clinical effectiveness of combining lenvatinib with camrelizumab for patients with hepatitis B virus(HBV)-related HCC in Barcelona Clinic Liver Cancer(BCLC)stages B/C,considering various body mass index(BMI)in diffe-rent *** Retrospective data were collected from 126 HCC patients treated with lenvatinib plus *** were divided into two groups based on BMI:The non-overweight group(BMIding to the development of a column-line graph *** subgroup analyses for non-overweight(BMI:18.5-24.9 kg/m2),overweight(BMI:25-30 kg/m2),and obese(BMI≥30 kg/m2)patients.A Cox proportional hazards regression analysis identified independent prognostic factors for overall survival(OS),leading to the development of a column-line graph *** Median progression-free survival was significantly longer in the obese/overweight group compared to the non-overweight ***,the median OS was significantly prolonged in the obese/overweight group than in the non-overweight *** objective remission rate and disease control rate for the two groups of patients were,respectively,objective remission rate(5.88%vs 28.00%)and disease control rate(39.22%vs 62.67%).Fatigue was more prevalent in the obese/overweight group,while other adverse effects showed n

关键词： Hepatocellular carcinoma Camrelizumab Lenvatinib Efficacy Safety

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AEB工况下驾驶员姿态对损伤风险的影响

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汽车工程 2024年第10期46卷 1920-1927页

作者：韩勇张悦苁李明旺潘迪张海洋厦门理工学院机械与汽车工程学院厦门361024 福建省客车先进设计与制造重点实验室厦门361024 浙江吉利汽车研究院有限公司宁波315336

有无紧急制动(AEB)的正面碰撞工况中驾驶员姿态对运动学响应及损伤风险具有重要影响。本文采用THUMS(Ver.6.1)人体有限元模型建立了标准、后仰和前倾等3种驾驶姿态,搭建了正面碰撞约束系统模型,进行了6组50 km/h的仿真实验,对比分析驾... 详细信息

有无紧急制动(AEB)的正面碰撞工况中驾驶员姿态对运动学响应及损伤风险具有重要影响。本文采用THUMS(Ver.6.1)人体有限元模型建立了标准、后仰和前倾等3种驾驶姿态,搭建了正面碰撞约束系统模型,进行了6组50 km/h的仿真实验,对比分析驾驶员不同姿态在有和无AEB作用下的运动学响应以及驾驶员头、胸部损伤参数。结果表明:在有和无AEB介入时,后仰姿态的头部损伤风险均最高,其中有和无AEB介入的HIC_(15)分别为817.5和626.9。AEB的介入对驾驶员胸部压缩量影响最大,3种姿态的胸部压缩量分别增大了89%、115%和22%,后仰姿态胸部压缩量损伤最严重。研究结果厘清了驾驶姿态与AEB对驾驶员运动学响应以及头、胸部损伤的影响,为汽车约束系统和AEB的开发与设计提供了参考价值。

关键词：正面碰撞驾驶员姿态紧急制动运动学响应损伤风险

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MPDB工况下驾驶员姿态对损伤风险的研究

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汽车工程 2024年第5期46卷 874-881页

作者：韩勇李明旺张悦苁徐国超潘迪厦门理工学院机械与汽车工程学院厦门361024 福建省客车先进设计与制造重点实验室厦门361024

为研究MPDB工况下驾驶员不同姿态的运动学响应及损伤风险,首先搭建了雅阁整车50%重叠移动渐进变形壁障(mobile progressive deformable barrier,MPDB)碰撞仿真模型,采用THUMS(Ver 6.1)人体有限元模型模拟了4种驾驶姿态:头部正常(HN)、... 详细信息

为研究MPDB工况下驾驶员不同姿态的运动学响应及损伤风险,首先搭建了雅阁整车50%重叠移动渐进变形壁障(mobile progressive deformable barrier,MPDB)碰撞仿真模型,采用THUMS(Ver 6.1)人体有限元模型模拟了4种驾驶姿态:头部正常(HN)、头部后仰(HR)、头部前倾(HF)、身体前倾(BF)。对比分析了碰撞速度为50 km/h时,4种驾驶姿态下驾驶员头部线性加速度、颅内压力、最大主应变以及胸部最大压缩量、肋骨塑性应变、心肺压力分布等参数。结果表明:HF和BF姿态下的头部损伤风险更高,其中颅内压力分别为474和744 kPa,超过重度颅脑损伤阈值235 kPa。4种驾驶姿态的心肺压力均超过严重损伤阈值170 kPa,心肺产生严重损伤概率较大。该研究结果理清了MPDB工况下驾驶员不同姿态的损伤风险,为汽车安全技术研究提供重要参考依据。

关键词：驾驶员 MPDB试验驾驶姿态头部损伤胸部损伤

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治疗肝内胆管癌新药:泛FGFR抑制剂福巴替尼

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中国新药与临床杂志 2024年第7期43卷 510-513页

作者：狄潘潘邢晓勤梁海贾淑云安徽医科大学附属亳州医院药学部安徽亳州236800

肝内胆管癌(ICC)是一种发生于胆管系统的恶性肿瘤,起病隐匿,患者总体预后较差,死亡率较高。福巴替尼是一种泛成纤维细胞生长因子受体(FGFR)抑制剂,于2022年被美国食品和药物管理局批准上市,用于既往治疗过的、不可切除的局部晚期或转移... 详细信息

肝内胆管癌(ICC)是一种发生于胆管系统的恶性肿瘤,起病隐匿,患者总体预后较差,死亡率较高。福巴替尼是一种泛成纤维细胞生长因子受体(FGFR)抑制剂,于2022年被美国食品和药物管理局批准上市,用于既往治疗过的、不可切除的局部晚期或转移性且伴有FGFR2基因融合或其他重排的ICC成年患者。Ⅰ期和Ⅱ期临床试验表明,福巴替尼对ICC具有良好的治疗效果,可显著提高ICC患者的客观缓解率并延长患者的生存时间;其常见不良事件包括高磷血症、腹泻、便秘及口干等,不良事件发生率较高。

关键词：肝内胆管癌福巴替尼成纤维细胞生长因子抗肿瘤药

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基于FAERS数据库的雷莫西尤单抗不良事件信号挖掘

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中国新药与临床杂志 2024年第5期43卷 394-400页

作者：狄潘潘梁海邢晓勤贾淑云王杰安徽医科大学附属亳州医院药学部安徽亳州236800 蚌埠医学院公共基础学院安徽蚌埠233030

目的基于美国食品和药物管理局(FDA)不良事件报告系统(FAERS)数据库挖掘雷莫西尤单抗的药品不良事件(ADE)信号,为临床安全用药提供参考。方法收集FAERS数据库2014年第2季度至2023年第4季度的雷莫西尤单抗ADE报告数据,利用比例失衡法中... 详细信息

目的基于美国食品和药物管理局(FDA)不良事件报告系统(FAERS)数据库挖掘雷莫西尤单抗的药品不良事件(ADE)信号,为临床安全用药提供参考。方法收集FAERS数据库2014年第2季度至2023年第4季度的雷莫西尤单抗ADE报告数据,利用比例失衡法中的报告比值比法和英国药品和保健品管理局的综合标准法进行数据挖掘。结果共获得雷莫西尤单抗ADE报告4704份,患者年龄集中于65~85岁(40.45%),以男性为主(58.38%),上报国家以日本为主(46.64%)。共检测到ADE信号140个,涉及18个系统和器官分类。报告数较多的有全身性疾病及给药部位各种反应(18.04%),良性、恶性及性质不明的肿瘤(15.82%),呼吸系统、胸及纵隔疾病(13.32%)和胃肠系统疾病(12.83%)。发生频次较高的ADE信号与药品说明书中的基本一致。临床需关注的ADE信号主要为胃肠道出血、肿瘤出血、大肠出血及脑干出血等出血性ADE和脏器穿孔ADE。结论临床使用雷莫西尤单抗前应做好患者的用药评估,治疗期间应密切关注患者出血和穿孔ADE发生情况,发现异常时应及时干预。

关键词：雷莫西尤单抗药物不良反应数据挖掘血管内皮生长因子受体2 安全

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