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Dataset of Comparative Observations for Land Surface Processes over the Semi-Arid Alpine Grassland against Alpine Lakes in the Source Region of the Yellow River

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Advances in Atmospheric Sciences 2023年第6期40卷 1142-1157页

作者： Xianhong MENG Shihua LYU Zhaoguo LI Yinhuan AO Lijuan WEN Lunyu SHANG Shaoying WANG Mingshan DENG Shaobo ZHANG Lin ZHAO Hao CHEN di ma Suosuo LI Lele SHU Yingying AN Hanlin NIU Key Laboratory of Land Surface Process and Climate Change in Cold and Arid Regions Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Zoige Plateau Wetland Ecosystem Research Station Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Plateau Atmosphere and Environment Key Laboratory of Sichuan Province School of Atmospheric SciencesChengdu University of Information TechnologyChengdu 610225China Collaborative Innovation Center on Forecast and Evaluation of Meteorological disasters Nanjing University of Information Science and TechnologyNanjing 210044China University of Chinese Academy of Sciences Beijing 100049China

Thousands of lakes on the Tibetan Plateau(TP) play a critical role in the regional water cycle, weather, and climate. In recent years, the areas of TP lakes underwent drastic changes and have become a research hotspot. However, the characteristics of the lake-atmosphere interaction over the high-altitude lakes are still unclear, which inhibits model development and the accurate simulation of lake climate effects. The source region of the Yellow River(SRYR) has the largest outflow lake and freshwater lake on the TP and is one of the most densely distributed lakes on the TP. Since 2011,three observation sites have been set up in the Ngoring Lake basin in the SRYR to monitor the lake-atmosphere interaction and the differences among water-heat exchanges over the land and lake surfaces. This study presents an eight-year(2012–19), half-hourly, observation-based dataset related to lake–atmosphere interactions composed of three sites. The three sites represent the lake surface, the lakeside, and the land. The observations contain the basic meteorological elements,surface radiation, eddy covariance system, soil temperature, and moisture(for land). Information related to the sites and instruments, the continuity and completeness of data, and the differences among the observational results at different sites are described in this study. These data have been used in the previous study to reveal a few energy and water exchange characteristics of TP lakes and to validate and improve the lake and land surface model. The dataset is available at National Cryosphere Desert Data Center and Science Data Bank.

关键词： field observation dataset lake-atmosphere interaction energy and water exchanges the source region of the Yellow River Tibetan Plateau

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Impact of crizotinib on long-term survival of ALK-positive advanced non-small-cell lung cancer: A Chinese multicenter cohort study

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Chinese Journal of Cancer Research 2019年第3期31卷 481-488页

作者： Puyuan Xing di ma Qiang Wang Xuezhi Hao Mengzhao Wang Yan Wang Li Shan Tao Xin Li Liang Hongge Liang Yang Du Zhaohui Zhang Junling Li Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Pulmonary Medicine (Inpatient Area 1) Affiliated Tumor Hospital of Xinjiang Medical UniversityUrumqi 830000China Department of Respiratory Medicine Peking Union Medical College HospitalBeijing 100730China Department of Oncology the Second Affiliated Hospital of Harbin Medical UniversityHarbin 150001China Department of Tumor Chemotherapy and Radiation Sickness Peking University Third HospitalBeijing 100191China

Objective: Crizotinib has demonstrated promising efficacy in patients with anaplastic lymphoma kinase(ALK)-positive non-small-cell lung cancer(NSCLC) in clinical trials. We conducted this retrospective multicenter study to assess the outcomes of crizotinib therapy in, to our knowledge, a large sample cohort of patients with ALKpositive advanced ***: We reviewed the medical records of 484 unselected ALK-positive NSCLC patients treated with crizotinib at 5 cancer centers in China from January 2013 to November 2017. Clinical data were collected from the initiation of crizotinib therapy to Response Evaluation Criteria in Solid Tumors(RECIST)-defined progressive disease(PD).Results: A total of 428 eligible ALK-positive NSCLC patients were enrolled, 273(63.8%) of whom received crizotinib as first-line treatment. The median progression-free survival(PFS) and overall survival(OS) from the initiation of crizotinib treatment were 14.4 [95% confidence interval(95% CI), 12.4-16.4] months and 53.4(95%CI, 33.7-73.1) months, respectively. In subgroup analyses, patients who received crizotinib as first-line treatment showed a higher disease control rate(DCR) and a longer median OS compared with second-/later-line crizotinib treatment(94.8% and OS not reached vs. 89.0% and 40.5 months, respectively). For 261 patients with RECISTdefined PD, multivariate Cox analysis revealed that in patients who received first-line crizotinib therapy, continued crizotinib beyond progressive disease(CBPD) and next-generation ALK inhibitors after crizotinib failure were associated with improved ***: This study has demonstrated the clinically meaningful benefit of crizotinib treatment in a large cohort of Chinese ALK-positive NSCLC patients. CBPD and next-generation ALK inhibitor treatment may provide improved survival after RECIST-defined progression on crizotinib.

关键词： Crizotinib anaplastic lymphoma kinase non-small-cell lung cancer real-world study

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CXCR3 Chemokine Axis Regulates T cell Function in Autoimmune Cholangitis

CXCR3 Chemokine Axis Regulates T cell Function in Autoimmune...

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第十届全国免疫学学术大会

作者： Hong-di ma Qing-Zhi Liu Wen-Tao ma Zhe-Xiong Lian Liver Immunology Laboratory Institute of Immunology and The CAS Key Laboratory of Innate Immunity and Chronic Disease School of Life Sciences and Medical Center University of Science and Technology of China

Background:CXCR3 is a chemokine receptor that is highly expressed on effector T cells and plays an important role in T cell trafficking and *** cholangitis,primary biliary cirrhosis(PBC)among which,is a progressive autoimmune liver *** a mouse model of PBC,dn TGF-βRⅡmice fully mimic the clinical character of PBC patients including lymphocytic infiltration in portal vein and hepatic bile duct ***:Our study aims at investigating how CXCR3 and its ligands regulate T cell function in autoimmune liver *** and Results:First,we use q-PCR and ELISA to determine the level of CXCR3 ligands CXCL9 and *** found that there is a high level of CXCR3 ligands in the liver of PBC mouse model-dn TGF-βRⅡmice(TG mice).By flow cytometry we found that the frequency and number of CXCR3 expressing T cells are higher in liver of TG mice compared with wild type *** order to determine the role of CXCR3 in the progress of PBC,we crossed CXCR3knockout mice with TG *** analysis showed that TGC3(CXCR3-/-dn TGF-βRⅡ)mice have more severe infiltrations in the moderate portal vein in *** analysis showed that the level of anti-mitochondria antibody,which is the serological marker of this disease,and inflammatory cytokines are higher in TGC3 ***,T cells,especially IFN-r producing T cells and terminated KLRG1+T cells increased after CXCR3 knockout in TG ***:From the above results,we know that CXCR3 chemokine axis may balance the choice between driving inflammation and dampening over-exuberant responses in liver *** study is needed to illustrate the detailed mechanism of this regulation.

关键词： CXCR3 autoimmune cholangitis dnTGF-βR Ⅱ mice T cell function

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基于O2O与电子商务的理论背景下的食用菌产品运营模式

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中国食用菌 2019年第4期38卷 101-103页

作者：马迪广州大学数学与信息科学学院广东广州510006

电子商务模式的发展开始逐步渗透到生活的各个方面,例如我们的研究、工作、生活。随着消费者在电子商务业务的接受程度,食用菌的电子商务业务也迅速增长。但由于单一的市场渠道,许多高品质的食用菌并没有很好的发挥其正常的市场价值。这... 详细信息

电子商务模式的发展开始逐步渗透到生活的各个方面,例如我们的研究、工作、生活。随着消费者在电子商务业务的接受程度,食用菌的电子商务业务也迅速增长。但由于单一的市场渠道,许多高品质的食用菌并没有很好的发挥其正常的市场价值。这时O2O销售模式的出现,无疑在一定程度上突破了食用菌在电子商务业务发展中的瓶颈。

关键词： O2O 电子商务食用菌操作模式

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Resource enrichment combined with biomass removal maintains plant diversity and community stability in a long-term grazed grassland

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Journal of Plant Ecology 2020年第5期13卷 611-620页

作者： Feng-Wei Xu Jian-Jun Li Li-Ji Wu Xiao-Ming Lu Wen Xing di-ma Chen Biao Zhu Shao-Peng Wang Lin Jiang Yong-Fei Bai State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of SciencesBeijing 100093China Collaborative Innovation Center of Jiangxi Typical Trees Cultivation and Utilization College of ForestryJiangxi Agricultural UniversityNanchang 330045China College of Ecology and Environmental Science Inner Mongolia Agricultural UniversityHohhot 010011China Institute of Environment and Sustainable Development in Agriculture Chinese Academy of Agricultural SciencesBeijing 100081China College of Biological and Pharmaceutical Sciences China Three Gorges UniversityYichang 443002China Department of Ecology College of Urban and Environmental Scienceand Key Laboratory for Earth Surface Processes of the Ministry of EducationPeking UniversityBeijing 100871China School of Biology Georgia Institute of TechnologyAtlantaGA 30332USA College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China

Aims Long-term heavy grazing reduces plant diversity and ecosystem function by intensifying nitrogen(N)and water *** contrast,the absence of biomass removal can cause species loss by elevating light competition and weakening community stability,which is exacerbated by N and water ***,how to maintain species diversity and community stability is still a huge challenge for sustainable management of worldwide *** We conducted a 4-year manipulated experiment in six long-term grazing blocks to explore combination of resource additions and biomass removal(increased water,N and light availability)on species richness and community stability in semiarid grasslands of Inner Mongolia,*** Findings In all blocks treated with the combination of resource additions and biomass removal,primary productivity increased and species richness and community stability were maintained over 4 years of *** both species and plant functional group(PFG)levels,the aboveground biomass of treated plants remained temporally stable in treatments with the combination of N and/or water addition and biomass *** maintenance of species richness was primarily caused by the biomass removal,which could increase the amount of light exposure for grasses under resource *** species asynchrony and stability of PFGs contributed to the high temporal stability observed in these *** results indicate that management practices of combined resource enrichment with biomass removal,such as grazing or mowing,could not only enhance primary productivity but also maintain plant species diversity,species asynchrony and community ***,as overgrazing-induced degradation and resource enrichment-induced biodiversity loss continue to be major problems worldwide,our findings have important implications for adaptive management in semiarid grasslands and beyond.

关键词： biomass removal resource addition species richness community stability plant functional groups(PFGs) species asynchrony

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An improvement of soil temperature simulations on the Tibetan Plateau

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Research in Cold and Arid Regions 2018年第1期10卷 80-94页

作者： SiQiong Luo BoLi Chen ShiHua Lyu XueWei Fang JingYuan Wang XianHong Meng LunYu Shang ShaoYing Wang di ma Key Laboratory of Land Surface Process and Climate Change in Cold and Arid Regions Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhouGansu 730000China Changzhou Meteorological Bureau ChangzhouJiangsu 213000China School of Atmospheric Sciences Plateau Atmosphere and Environment Key Laboratory of Sichuan ProvinceChengdu University of Information TechnologyChengduSichuan 610225China Collaborative Innovation Center on Forecast and Evaluation of Meteorological disasters Nanjing University of Information Science and TechnologyNanjingJiangsu 210044China

The simulation of soil temperature on the Tibetan Plateau(TP) plays a dominant role in the performance of both global climate and numerical weather forecast models. To improve the simulation of soil temperature on the TP, the Johansen soil thermal conductivity parameterization scheme was introduced into Community Land Model 3.5(CLM3.5) and Regional Climatic Model 4(Reg CM4). The improved CLM3.5 and Reg CM4-CLM were utilized to conduct offline and regional simulation experiments on the TP. Comparison of the new and old schemes revealed that CLM3.5 provides high thermal conductivity parameters of mineral soil solid on the TP. The Johansen scheme is more practical for the TP than the soil thermal conductivity parameterization in CLM3.5. The simulation of soil temperature and liquid water content was improved in offline experiment. The improved parameterization scheme can also reduce the simulation error of soil temperature in winter throughout the entire TP.

关键词： soil temperature soil thermal conductivity parameterization scheme Tibetan Plateau CLM3.5 RegCM4

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Pedogenic Carbonate and Soil Dehydrogenase Activity in Response to Soil Organic matter in Artemisia ordosica Community

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Pedosphere 2010年第2期20卷 229-235页

作者： ZHANG Ning HE Xing-Dong GAO Yu-Bao LI Yong-Hong WANG Hai-Tao ma di ZHANG Rui S. YANG College of Life Sciences Nankai University Tianjin 300071 (China) Research Institute of Elemento-Organic Chemistry Nankai University Tianjin 300071 (China) Department of Biology Pennsylvania State University Pennsylvania 16802 (USA)

Little attention has been paid to the role of soil organic matter （OM） in the formation of pedogenic carbonate in desert soils. The relationships among soil OM, soil dehydrogenase activity （DHA）, and soil CaCO3 in a plant community dominated by Artemisia ordosica, located on the eastern boundary of Tcngger Desert in the Alxa League, Inner Mongolia, China, were studied to understand whether OM was directly involved in the formation of pedogenic carbonate. The results showed that DHA and CuCO3 positively correlated with OM content, and DHA, OM, and CaCO3 were correlated with each other in their spatial distribution, indicating that abundant OM content contributed to the formation of CaCO3. Therefore, the formation of pedogenic CaCO3 was a biotic process in the plant community dominated by A. ordosica.

关键词： arid area biotic process soil calcium carbonate spatial heterogeneity Tengger Desert

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Holistic evaluation of San-Huang Tablets using a combination of multi-wavelength quantitative fingerprinting and radical-scavenging assays

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Chinese Journal of Natural Medicines 2017年第4期15卷 310-320页

作者： WANG Yan SUN Guo-Xiang JIN Yang XIE Xiu-man LIU Ying-Chun ma di-di ZHANG Jing GAO Jia-Yue LI Yan-Fei College of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China College of Pharmacy and Chemistry Dali UniversityDali 671000China College of Pharmacy China Pharmaceutical UniversityNanjing 210009China Department of Pharmacy Traditional Chinese Medicine Hospital of DaliDali 671000China

The present study was designed to establish a multi-wavelength quantitative fingerprinting method for San-Huang Tablets(SHT), a widely used and commercially available herbal preparation, where high performance liquid chromatography(HPLC) with a diode array detector(DAD) was employed to obtain the fingerprint profiles. A simple linear quantitative fingerprint method(SLQFM)coupled with multi-ingredient simultaneous determination was developed to evaluate the quality consistency of the tested samples qualitatively and quantitatively. Additionally, the component–activity relationship between chromatographic fingerprints and total radical-scavenging capacity in vitro(as assessed using the 1, 1-diphenyl-2-picrylhydrazyl(DPPH) assay) was investigated by partial least squares regression(PLSR) analysis to predict the antioxidant capacity of new samples from the chromatographic fingerprints and identify the main active constituents that can be used as the target markers for the quality control of SHT. In conclusion, the strategy developed in the present study was effective and reliable, which can be employed for holistic evaluation and accurate discrimination for the quality consistency of SHT preparations and other traditional Chinese medicine(TCM) and herbal preparations as well.

关键词： San-Huang Tablets Radical-scavenging activity Simple linear quantitative fingerprint method Quality evaluation

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黑龙江省明水县中心城区公共服务设施配置探讨

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规划师 2019年第S2期35卷 111-115,129页

作者：麻迪黑龙江省城市规划勘测设计研究院

公共服务设施是公共服务得以良好运转的基础保障,是从特定的公共利益出发,在公众对于社会达成一定共同认识后,以维护国家和地区经济及社会稳定为目的,为保护不同个体的基本生存权益及发展权益而提供的公共服务.从黑龙江省绥化市明水县... 详细信息

公共服务设施是公共服务得以良好运转的基础保障,是从特定的公共利益出发,在公众对于社会达成一定共同认识后,以维护国家和地区经济及社会稳定为目的,为保护不同个体的基本生存权益及发展权益而提供的公共服务.从黑龙江省绥化市明水县中心城区城乡统筹发展及空间规划建设的视角看,公共服务设施的发展可以作为其重要的技术支持,同时对拉近城市与乡村的发展差距、平衡地区间的发展等方面有着重要的作用.文章总结了公共服务设施现状建设问题、配置影响因素与未来建设趋势,并结合居民需求的实际调查,对明水县中心城区公共服务设施的配置、布局、建设与管理等方面展开研究,希望能为东北地区城镇规划提供参考.

关键词：公共服务设施配置体系规划布局中心城区

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工业机器人变导纳自适应主动容错控制方法研究

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航空制造技术 2024年第18期67卷 20-27页

作者：王君马迪兰州理工大学兰州730050

针对受外界干扰、执行器故障及环境交互影响的工业机器人系统,提出一种位置控制为自抗扰的工业机器人变导纳自适应主动容错控制方法。首先,设计自抗扰控制器,在实现位置跟踪的同时消除外部干扰对执行器的影响。其次,为获得实际作业中除... 详细信息

针对受外界干扰、执行器故障及环境交互影响的工业机器人系统,提出一种位置控制为自抗扰的工业机器人变导纳自适应主动容错控制方法。首先,设计自抗扰控制器,在实现位置跟踪的同时消除外部干扰对执行器的影响。其次,为获得实际作业中除外部干扰的关节内部精确故障信息,在位置控制基础上引入自适应主动容错机制,对机器人的控制过程中出现的故障进行检测和补偿。最后,利用变导纳控制器,通过在线调整导纳参数实现对机器人的末端柔顺性能的优化,以提高机器人系统的稳定性。经过仿真验证所提方法能够有效提高工业机器人的容错能力和柔顺性,在机器人控制过程中具有良好的鲁棒性和可靠性,为工业机器人的智能化和自动化提供了新思路和方法。

关键词：工业机器人位置跟踪自抗扰控制主动容错控制变导纳控制

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